Zusammenfassung
Kolorektale Karzinome (KRK) sind die häufigsten bösartigen Tumoren des Gastrointestinaltrakts und die zweithäufigste zum Tod führende Tumorerkrankung in Deutschland. In Deutschland verstarben 1997 29774 Patienten an den Folgen eines kolorektalen Karzinoms. Jährlich treten in Deutschland <55 000 Neuerkrankungen auf.
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Literatur
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Ogunbiyi OA, Goodfellow PJ, Herfarth K et al. (1998) Confirmation that chromosome 18q allelic loss in colon cancer is a prognostic indicator. J Clin Oncol 16:427–433
Olschwang S, Hamelin R, Laurent-Puig P et al. (1997) Alternative genetic pathways in colorectal carcinogenesis. Proc Natl Acad Sci USA 94:12122–12127
Pantel K, Knebel D von (2000) Detection and clinical relevance of micrometastatic cancer cells. Curr Opin Oncol 12:95–101
Paradiso A, Simone G, Petroni S et al. (2000) Thymidilate synthase and p53 primary tumour expression as predictive factors for advanced colorectal cancer patients. Br J Cancer 82:560–567
Parsons R, Myeroff LL, Liu B et al. (1995) Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. Cancer Res 55:5548–5550
Pocard M, Bras-Goncalves R, Hamelin R, Northover J, Poupon MF (2000) Response to 5-fluorouracil of orthotopically xenografted human colon cancers with a microsatellite instability: influence of P53 status. Anticancer Res20:85–90
Polakis P (1997) The adenomatous polyposis coli (APC) tumor suppressor. Biochim Biophys Acta 1332:FI27–FI47
Poller DN, Baxter KJ, Shepherd N.A (1997) p53 and Rbl protein expression: are they prognostically useful in colorectal cancer? Br J Cancer 75:87–93
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Schulmann, K., Schmiegel, W. (2002). Kolorektales Karzinom. In: Ganten, D., Ruckpaul, K., Hahn, S.A., Schmiegel, W. (eds) Molekularmedizinische Grundlagen von nicht-hereditären Tumorerkrankungen. Molekulare Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56297-6_8
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