Abstract
In transplantation lifelong immunosuppressive therapy is usually required. This however increases the risk for infectious disease and the occurrence of de novo or recurrent malignancy. Thus the aim should be to develop new strategies to be able to either substantially decrease or even discontinue immunosuppression in transplantation. Exposure to alloantigens of mother (NIMA) was shown to have a strong beneficial effect on sibling kidney graft survival. An animal model is needed to further investigate this phenomenon. We therefore initiated different breeding schemes in mice to determine which combination best reproduces the clinical NIMA-effect in organ transplantation.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Andrassy, J., Marthaler, B.R., Geissler, E.K., Jauch, K.W., Sollinger, HW., Burlingham, W.J. (2003). Die in utero und orale Exposition zu »Non-inherited Maternal Antigens (NIMA)« bewirkt eine natürliche Transplantationstoleranz in Mäusen. In: Bauer, H. (eds) Zurück in die Zukunft. Deutsche Gesellschaft für Chirurgie, vol 2003. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55611-1_336
Download citation
DOI: https://doi.org/10.1007/978-3-642-55611-1_336
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-20002-4
Online ISBN: 978-3-642-55611-1
eBook Packages: Springer Book Archive