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Wirkungen des Vorhofhormons auf Venentonus und Sympathikusaktivität

  • Conference paper
ANP — Atriales natriuretisches Peptid und das kardiovaskuläre System

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Zusammenfassung

Von vielen Wirkungen des Vorhofhormons, die potentiell für die Regulation von Blutdruck und Extrazellulärvolumen bedeutsam sein könnten, ist noch nicht bekannt, welche physiologische Rolle sie spielen. Als Orientierungshilfe kann ein Vergleich von Plasmakonzentrationen des Hormons dienen, die einerseits im „Steady state“ bei Infusionen des synthetischen Hormons erreicht werden und die andererseits bei Eingriffen in die Blutdruck- und Volumenregulation spontan auftreten. Nach diesem Kriterium muß eine Infusionsrate von 0,1 μ, g/kg/min α-ANP in Hunden als Obergrenze für eine pathophysiologische Relevanz angesehen werden. In diesem Dosisbereich konnte keine direkte Verminderung des Venentonus (gemessen als effektive vaskuläre Dehnbarkeit) in narkotisierten Hunden unter autonomer Blockade festgestellt werden. In wachen Hunden bewirkte α-ANP jedoch eine relative Hemmung der Noradrenalinfreisetzung und eine absolute Hemmung der Adrenalinfreisetzung, und zwar um 24 ± 2% (SEM) pro 10fache Erhöhung des Plasma-ANP. Da die Schwelle für diese Hemmung im Bereich endogener ANP-Plasmakonzentrationen hegt und da diese sich parallel mit der Kochsalzzufuhr ändern, erscheint es möglich, daß diese Hemmung der sympathoadrenalen Aktivität durch αANP an der Blutdruck- und Volumenregulation bei Änderungen der Kochsalzzufuhr beteiligt ist.

Mit Unterstützung durch das Ministerium für Wissenschaft und Kunst Baden-Württemberg, Forschungsschwerpunkt 12.

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Authors and Affiliations

  1. Institut für Angewandte Physiologie und Balneologie, Universität Freiburg, Deutschland

    J. Holtz & T. Münzel

  2. Institut für Angewandte Physiologie und Balneologie, Universität Freiburg, Hermann-Herder-Str. 7, D-7800, Freiburg i.Br., Deutschland

    J. Holtz

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Editors and Affiliations

  1. II. Physiologisches Institut, Universität Heidelberg, Im Neuenheimer Feld 326, 6900, Heidelberg, Deutschland

    Volker A. W. Kreye

  2. Zentrum der Inneren Medizin, Abteilung für Kardiologie, Klinikum der J.W. Goethe-Universität, Theodor-Stern-Kai 7, 6000, Frankfurt/Main 70, Deutschland

    Wulf-Dirk Bussmann

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© 1988 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt

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Holtz, J., Münzel, T. (1988). Wirkungen des Vorhofhormons auf Venentonus und Sympathikusaktivität. In: Kreye, V.A.W., Bussmann, WD. (eds) ANP — Atriales natriuretisches Peptid und das kardiovaskuläre System. Steinkopff. https://doi.org/10.1007/978-3-642-50192-0_10

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  • DOI: https://doi.org/10.1007/978-3-642-50192-0_10

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-642-50193-7

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