Abstract
Animal models have been used to evaluate the pathogenesis of periodontal diseases and various periodontal treatment modalities. Human longitudinal studies of periodontal diseases pose many problems such as determining the level of disease activity, individuals at risk and susceptibility to disease progression. It is important to choose a laboratory animal model that has similar characteristics of human anatomy and periodontal disease. Features of periodontal diseases in humans and animals vary greatly depending upon which form of the disease is present and the stage of the development. Inflammatory destruction of the periodontium can be spontaneous or experimentally induced in most mammalian species.
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References
Aaboe M, Pinholt EM, Hjørting-Hansen E. Unicortical critical size defect of rabbit tibia is larger than 8 mm. J Craniofac Surg. 1994;5:201–3.
Abukawa H, Zhang W, Young CS, Asrican R, Vacanti JP, Kaban LB, Troulis MJ, Yelick PC. Reconstructing mandibular defects using autologous tissue-engineered tooth and bone constructs. J Oral Maxillofac Surg. 2009;67:335–47.
Achong R, Nishimura I, Ramachandran H, Howell TH, Fiorellini JP, Karimbux NY. Membrane type (MT) 1-matrix metalloproteinase (MMP) and MMP-2 expression in ligature-induced periodontitis in the rat. J Periodontol. 2003;74:494–500.
Aizawa-Abe M, Ogawa Y, Masuzaki H, et al. Pathophysiological role of leptin in obesity-related hypertension. J Clin Invest. 2000;105:1243–52.
Akizuki T, Oda S, Komaki M, Tsuchioka H, Kawakatsu N, Kikuchi A, Yamato M, Okano T, Ishikawa I. Application of periodontal ligament cell sheet for periodontal regeneration: a pilot study in beagle dogs. J Periodontal Res. 2005;40:245–51.
Almeida JM, Theodoro LH, Bosco AF, Nagata MJ, Oshiiwa M, Garcia VG. In vivo effect of photodynamic therapy on periodontal bone loss in dental furcations. J Periodontol. 2008;79(6):1081–8.
Alayan J, Ivanovski S, Gemmell E, Ford P, Hamlet S, Farah CS. Deficiency of iNOS contributes to Porphyromonas gingivalis-induced tissue damage. Oral Microbiol Immunol. 2006;21:360–5.
Albuquerque C, Morinha F, Requicha J, Martins T, Dias I, Guedes-Pinto H, Bastos E, Viegas C. Canine periodontitis: the dog as an important model for periodontal studies. Vet J. 2012;191(3):299–305. Epub 2011 Sep 21.
Alhezaimi K, Al-Shalan T, O’Neill R, Shapurian T, Naghshbandi J, Levi Jr P, Griffin T. Connective tissue-cementum regeneration: a new histologic regeneration following the use of enamel matrix derivative in dehiscence-type defects. A dog model. Int J Periodontics Restorative Dent. 2009;29:425–33.
Alikhani M, Alikhani Z, He H, Liu R, Popek BI, Graves DT. Lipopolysaccharides indirectly stimulate apoptosis and global induction of apoptotic genes in fibroblasts. J Biol Chem. 2003;278:52901–8.
Al-Mashat HA, Kandru S, Liu R, Behl Y, Desta T, Graves DT. Diabetes enhances mRNA levels of proapoptotic genes and caspase activity, which contribute to impaired healing. Diabetes. 2006;55:487–95.
Alnaeeli M, Penninger JM, Teng YT. Immune interactions with CD4+ T cells promote the development of functional osteoclasts from murine CD11c+ dendritic cells. J Immunol. 2006;177:3314–26.
Alnaeeli M, Park J, Mahamed D, Penninger JM, Teng YT. Dendritic cells at the osteo-immune interface: implications for inflammation-induced bone loss. J Bone Miner Res. 2007;22:775–80.
Al-Qareer AH, Afsah MR, Müller HP. A sheep cadaver model for demonstration and training periodontal surgical methods. Eur J Dent Educ. 2004;8:78–83.
Arai K, Tanaka S, Yamamoto-Sawamura T, Sone K, Miyaishi O, Sumi Y. Aging changes in the periodontal bone of F344/N rat. Arch Gerontol Geriatr. 2005;40:225–9.
Araujo MG, Lindhe J. GTR treatment of degree III furcation defects following application of enamel matrix proteins. An experimental study in dogs. J Clin Periodontol. 1998;25:524–30.
Araújo MG, Lindhe J. Dimensional ridge alterations following tooth extraction. An experimental study in the dog. J Clin Periodontol. 2005;32:212–8.
Araujo MG, Berglundh T, Lindhe J. GTR treatment of degree III furcation defects with 2 different resorbable barriers: an experimental study in dogs. J Clin Periodontol. 1998;25:253–9.
Araujo MG, Berglundh T, Albrektsson T, Lindhe J. Bone formation in furcation defects. An experimental study in the dog. J Clin Periodontol. 1999;26:643–52.
Araújo MG, Sukekava F, Wennström JL, Lindhe J. Ridge alterations following implant placement in fresh extraction sockets: an experimental study in the dog. J Clin Periodontol. 2005;32:645–52.
Arce RM, Barros SP, Wacker B, Peters B, Moss K, Offenbacher S. Increased TLR4 expression in murine placentas after oral infection with periodontal pathogens. Placenta. 2009;30:156–62.
Artzi Z, Weinreb M, Tal H, Nemcovsky CE, Rohrer MD, Prasad HS, Kozlovsky A. Experimental intrabony and periodontal defects treated with natural mineral combined with a synthetic cell-binding Peptide in the canine: morphometric evaluations. J Periodontol. 2006;77:1658–64.
Baik DH, Hwang SJ, Kim CS, Lee YK, Cho CS, Chai JK, Kim CK, Choi SH. The effects of noncrystalline calcium phosphate glass on the healing of 1-wall intrabony defcts in beagle dogs. J Korean Acad Periodontol. 2004;34:113–20.
Bain JL, Lester SR, Henry WD, Bishop CM, Turnage AA, Naftel JP, Johnson RB. Comparative gender differences in local and systemic concentrations of proinflammatory cytokines in rats with experimental periodontitis. J Periodontal Res. 2009;44:133–40.
Baker PJ. Genetic control of the immune response in pathogenesis. J Periodontol. 2005;76(11 Suppl):2042–6.
Baker PJ, Evans RT, Roopenian DC. Oral infection with Porphyromonas gingivalis and induced alveolar bone loss in immunocompetent and severe combined immunodeficient mice. Arch Oral Biol. 1994;39: 1035–40.
Baker PJ, Carter S, Dixon M, Evans RT, Roopenian DC. Serum antibody response to oral infection precedes but does not prevent Porphyromonas gingivalis induced alveolar bone loss in mice. Oral Microbiol Immunol. 1999a;14:194–6.
Baker PJ, Dixon M, Evans RT, Dufour L, Johnson E, Roopenian DC. CD4(+) T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice. Infect Immun. 1999b;67:2804–9.
Baker PJ, Dixon M, Evans RT, Roopenian DC. Heterogeneity of Porphyromonas gingivalis strains in the induction of alveolar bone loss in mice. Oral Microbiol Immunol. 2000a;15:27–32.
Baker PJ, Dixon M, Roopenian DC. Genetic control of susceptibility to Porphyromonas gingivalis-induced alveolar bone loss in mice. Infect Immun. 2000b;68: 5864–8.
Baron R, Saffar JL. A quantitative study of bone remodeling during experimental periodontal disease in the golden hamster. J Periodontal Res. 1978;13:309–15.
Baroukh B, Saffar JS. The effect of leukotriene synthesis inhibitors on hamster periodontitis. Arch Oral Biol. 1990;35(Suppl):189S–92.
Baroukh B, Saffar JL. Identification of osteoclasts and their mononuclear precursors. A comparative histological and histochemical study in hamster periodontitis. J Periodontal Res. 1991;26(3 Pt 1):161–6.
Barros SP, Arce RM, Galloway P, Lawter JR, Offenbacher S. Therapeutic effect of a topical CCR2 antagonist on induced alveolar bone loss in mice. J Periodontal Res. 2011;46:246–51.
Bartold PM, Marshall RI, Haynes DR. Periodontitis and rheumatoid arthritis: a review. J Periodontol. 2005;76(11 Suppl):2066–74.
Bartold PM, Marino V, Cantley M, Haynes DR. Effect of Porphyromonas gingivalis-induced inflammation on the development of rheumatoid arthritis. J Clin Periodontol. 2010;37:405–11.
Behbehani MJ, Jordan HV, Heeley JD. Oral colonization and pathogenicity of Actinomyces israelii in gnotobiotic rats. J Dent Res. 1983;62:69–74.
Benatti BB, César-Neto JB, Gonçalves PF, Sallum EA, Nociti Jr FH. Smoking affects the self-healing capacity of periodontal tissues. A histological study in the rat. Eur J Oral Sci. 2005;113:400–3.
Benatti BB, César-Neto JB, Casati MZ, Sallum EA, Sallum AW, Nociti Jr FH. Periodontal healing may be affected by aging: a histologic study in rats. J Periodontal Res. 2006;41:329–33.
Bendyk A, Marino V, Zilm PS, Howe P, Bartold PM. Effect of dietary omega-3 polyunsaturated fatty acids on experimental periodontitis in the mouse. J Periodontal Res. 2009;44:211–6.
Bergenholtz G, Wikesjö UM, Sorensen RG, Xiropaidis AV, Wozney JM. Observations on healing following endodontic surgery in nonhuman primates (Macaca fascicularis): effects of rhBMP-2. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:116–25.
Björnsson MJ, Velschow S, Stoltze K, Havemose-Poulsen A, Schou S, Holmstrup P. The influence of diet consistence, drinking water and bedding on periodontal disease in Sprague–Dawley rats. J Periodontal Res. 2003;38:543–50.
Björnsson MJ, Havemose-Poulsen A, Stoltze K, Holmstrup P. Influence of the matrix metalloproteinase inhibitor batimastat (BB-94) on periodontal bone destruction in Sprague–Dawley rats. J Periodontal Res. 2004;39:269–74.
Blumenthal NM, Alves ME, Al-Huwais S, Hofbauer AM, Koperski RD. Defect-determined regenerative options for treating periodontal intrabony defects in baboons. J Periodontol. 2003;74:10–24.
Bobetsis YA, Barros SP, Offenbacher S. Exploring the relationship between periodontal disease and pregnancy complications. J Am Dent Assoc. 2006;137zc(Suppl):7S–13.
Boyce BF, Aufdemorte TB, Garrett IR, Yates AJ, Mundy GR. Effects of interleukin-1 on bone turnover in normal mice. Endocrinology. 1989;125:1142–50.
Bezerra MM, de Lima V, Alencar VB, Vieira IB, Brito GA, Ribeiro RA, Rocha FA. Selective cyclooxygenase-2 inhibition prevents alveolar bone loss in experimental periodontitis in rats. J Periodontol. 2000 Jun;71(6):1009–14.
Branch-Mays GL, Dawson DR, Gunsolley JC, Reynolds MA, Ebersole JL, Novak KF, Mattison JA, Ingram DK, Novak MJ. The effects of a calorie-reduced diet on periodontal inflammation and disease in a non-human primate model. J Periodontol. 2008;79:1184–91.
Brecx M, Patters MR. Morphology of polymorphonuclear neutrophils during periodontal disease in the cynomolgus monkey. J Clin Periodontol. 1985;12:591–606.
Brecx MC, Nalbandian J, Ooya K, Kornman KS, Robertson PB. Morphological studies on periodontal disease in the cynomolgus monkey. II. Light microscopic observations on ligature-induced periodontitis. J Periodontal Res. 1985;20:165–75.
Breivik T, Opstad PK, Gjermo P, Thrane PS. Effects of hypothalamic-pituitary-adrenal axis reactivity on periodontal tissue destruction in rats. Eur J Oral Sci. 2000a;108:115–22.
Breivik T, Sluyter F, Hof M, Cools A. Differential susceptibility to periodontitis in genetically selected Wistar rat lines that differ in their behavioral and endocrinological response to stressors. Behav Genet. 2000b;30:123–30.
Breivik T, Gundersen Y, Myhrer T, Fonnum F, Osmundsen H, Murison R, et al. Enhanced susceptibility to periodontitis in an animal model of depression: reversed by chronic treatment with the anti-depressant tianeptine. J Clin Periodontol. 2006;33:469–77.
Brodala N, Merricks EP, Bellinger DA, Damrongsri D, Offenbacher S, Beck J, et al. Porphyromonas gingivalis bacteremia induces coronary and aortic atherosclerosis in normocholesterolemic and hypercholesterolemic pigs. Arterioscler Thromb Vasc Biol. 2005;25:1446–51.
Burckhardt JJ, Gaegauf-Zollinger R, Schmid R, Guggenheim B. Alveolar bone loss in rats after immunization with Actinomyces viscosus. Infect Immun. 1981;31:971–7.
Burns E, Bachrach G, Shapira L, Nussbaum G. Cutting Edge: TLR2 is required for the innate response to Porphyromonas gingivalis: activation leads to bacterial persistence and TLR2 deficiency attenuates induced alveolar bone resorption. J Immunol. 2006;177(12):8296-300
Busch L, Sterin-Borda L, Borda E. Beta-adrenoceptor alterations coupled with secretory response and experimental periodontitis in rat submandibular glands. Arch Oral Biol. 2008;16:53–509.
Buser D, Hoffmann B, Bernard JP, Lussi A, Mettler D, Schenk RK. Evaluation of filling materials in membrane – protected bone defects. A comparative histomorphometric study in the mandible of miniature pigs. Clin Oral Implants Res. 1998;9:137–50.
Caffesse RG, Dominguez LE, Nasjleti CE, Castelli WA, Morrison EC, Smith BA. Furcation defects in dogs treated by guided tissue regeneration (GTR). J Periodontol. 1990;61:45–50.
Calvo-Guirado JL, Delgado-Ruíz RA, Ramírez-Fernández MP, Maté-Sánchez JE, Ortiz-Ruiz A, Marcus A. Histomorphometric and mineral degradation study of Ossceram: a novel biphasic B-tricalcium phosphate, in critical size defects in rabbits. Clin Oral Implants Res. 2012;23:667–75.
Cantley MD, Bartold PM, Marino V, Reid RC, Fairlie DP, Wyszynski RN, Zilm PS, Haynes DR. The use of live-animal micro-computed tomography to determine the effect of a novel phospholipase A2 inhibitor on alveolar bone loss in an in vivo mouse model of periodontitis. J Periodontal Res. 2009;44:317–22.
Cantley MD, Haynes DR, Marino V, Bartold PM. Pre-existing periodontitis exacerbates experimental arthritis in a mouse model. J Clin Periodontol. 2011;38:532–41.
Caplanis N, Lee MB, Zimmerman GJ, Selvig KA, Wikesjö UM. Effect of allogenic freeze-dried demineralized bone matrix on guided tissue regeneration in dogs. J Periodontol. 1998;69:851–6.
Cappelli D, Steffen MJ, Holt SC, Ebersole JL. Periodontitis in pregnancy: clinical and serum antibody observations from a baboon model of ligature-induced disease. J Periodontol. 2009;80:1154–65.
Casati MZ, Sallum EA, Caffesse RG, Nociti Jr FH, Sallum AW, Pereira SL. Guided tissue regeneration with a bioabsorbable polylactic acid membrane in gingival recessions: a histometric study in dogs. J Periodontol. 2000;71:238–48.
Caton J, Mota L, Gandini L, Laskaris B. Non-human primate models for testing the efficacy and safety of periodontal regeneration procedures. J Periodontol. 1994;65:1143–50.
César-Neto JB, Benatti BB, Sallum EA, Casati MZ, Nociti Jr FH. The influence of cigarette smoke inhalation and its cessation on the tooth-supporting alveolar bone: a histometric study in rats. J Periodontal Res. 2006;41:118–23.
Chang KM, Ramamurthy NS, McNamara TF, Genco RJ, Golub LM. Infection with a gram-negative organism stimulates gingival collagenase production in non-diabetic and diabetic germfree rats. J Periodontal Res. 1988;23:239–44.
Chang KM, Ramamurthy NS, McNamara TF, Evans RT, Klausen B, Murray PA, Golub LM. Tetracyclines inhibit Porphyromonas gingivalis-induced alveolar bone loss in rats by a non-antimicrobial mechanism. J Periodontal Res. 1994;29:242–9.
Cheng W-C, Huang R-Y, Chiang C-Y, Chen J-K, Liu C-H, Chu C-L, Fu E. Ameliorative effect of quercetin on the destruction caused by experimental periodontitis in rats. J Periodontal Res. 2010;45:788–95.
Chiang CY, Kyritsis G, Graves DT, Amar S. Interleukin-1 and tumor necrosis factor activities partially account for calvarial bone resorption induced by local injection of lipopolysaccharide. Infect Immun. 1999;67:4231–6.
Choi SY, Nilvéus RE, Minutello RD, Zimmerman GJ, Wikesjö UM. Effect of a collagen matrix on healing in periodontal fenestration defects in dogs. J Periodontol. 1993;64:878–82.
Choi SH, Kim CK, Cho KS, Huh JS, Sorensen RG, Wozney JM, Wikesjö UM. Effect of recombinant human bone morphogenetic protein-2/absorbable collagen sponge (rhBMP-2/ACS) on healing in 3-wall intrabony defects in dogs. J Periodontol. 2002;73:63–72.
Collins JG, Smith MA, Arnold RR, Offenbacher S. Effects of Escherichia coli and Porphyromonas gingivalis lipopolysaccharide on pregnancy outcome in the golden hamster. Infect Immun. 1994a;62:4652–5.
Collins JG, Windley 3rd HW, Arnold RR, Offenbacher S. Effects of a Porphyromonas gingivalis infection on inflammatory mediator response and pregnancy outcome in hamsters. Infect Immun. 1994b;62:4356–61.
Corrêa MG, Campos ML, Benatti BB, Marques MR, Casati MZ, Nociti Jr FH, Sallum EA. The impact of cigarette smoke inhalation on the outcome of enamel matrix derivative treatment in rats: histometric analysis. J Periodontol. 2010;81:1820–8.
Craig RG, Kallur SP, Inoue M, Rosenberg PA, LeGeros RZ. Effect of enamel matrix proteins on the periodontal connective tissue-material interface after wound healing. J Biomed Mater Res A. 2004;69:180–7.
Craig RG, Kamer AR, Kallur SP, Inoue M, Tarnow DP. Effects of periodontal cell grafts and enamel matrix proteins on the implant connective tissue interface: a pilot study in the minipig. J Oral Implantol. 2006;32:228–36.
Crawford JM, Taubman MA, Smith DJ. The natural history of periodontal bone loss in germfree and gnotobiotic rats infected with periodontopathic microorganisms. J Periodontal Res. 1978;13:316–25.
da Monteiro Silva AM, Newman HN, Oakley DA. Psychosocial factors in inflammatory periodontal diseases. A review. J Clin Periodontol. 1995;22:516–26.
da Silva Pereira SL, Sallum AW, Casati MZ. Comparison of bioabsorbable and non-resorbable membranes in the treatment of dehiscence-type defects: a histomorphometric study in dogs. J Periodontol. 2000;71:1306–14.
Danesh-Meyer MJ, Pack AR, McMillan MD. A comparison of 2 polytetrafluoroethylene membranes in guided tissue regeneration in sheep. J Periodontal Res. 1997;32(1 Pt 1):20–30.
de Aquino SG, Guimaraes MR, Stach-Machado DR, da Silva JA, Spolidorio LC, Rossa Jr C. Differential regulation of MMP-13 expression in two models of experimentally induced periodontal disease in rats. Arch Oral Biol. 2009;54:609–17.
DeCarlo AA, Huang Y, Collyer CA, Langley DB, Katz J. Feasibility of an HA2 domain-based periodontitis vaccine. Infect Immun. 2003;71:562–6.
Decker JF, Lee J, Cortella CA, Polimeni G, Rohrer MD, Wozney JM, Hall J, Susin C, Wikesjö UM. Evaluation of implants coated with recombinant human bone morphogenetic protein-2 and vacuum-dried using the critical-size supraalveolar peri-implant defect model in dogs. J Periodontol. 2010;81:1839–49.
DeLaurier A, Boyde A, Jackson B, Horton MA, Price JS. Identifying early osteoclastic resorptive lesions in feline teeth: a model for understanding the origin of multiple idiopathic root resorption. J Periodontal Res. 2009;44:248–57.
Di Paola R, Mazzon E, Muia’ C, Terrana D, Greco S, Britti D, Santori D, Oteri G, Cordasco G, Cuzzocrea S. 5-aminoisoquinolin-1(2H)-one, a water soluble poly (ADP-ribose) polymerase (PARP) inhibitor reduces the evolution of experimental periodontitis in rats. J Clin Periodontol. 2007;34:95–102.
Ding G, Liu Y, Wang W, Wei F, Liu D, Fan Z, An Y, Zhang C, Wang S. Allogeneic periodontal ligament stem cell therapy for periodontitis in swine. Stem Cells. 2010;28:1829–38.
Dogan A, Ozdemir A, Kubar A, Oygür T. Assessment of periodontal healing by seeding of fibroblast-like cells derived from regenerated periodontal ligament in artificial furcation defects in a dog: a pilot study. Tissue Eng. 2002;8:273–82.
Dogan A, Ozdemir A, Kubar A, Oygur T. Healing of artificial fenestration defects by seeding of fibroblast-like cells derived from regenerated periodontal ligament in a dog: a preliminary study. Tissue Eng. 2003;9:1189–96.
Donos N, Sculean A, Glavind L, Reich E, Karring T. Wound healing of degree III furcation involvements following guided tissue regeneration and/or Emdogain. A histologic study. J Clin Periodontol. 2003;30:1061–8.
Doxey DL, Cutler CW, Iacopino AM. Diabetes prevents periodontitis-induced increases in gingival platelet derived growth factor-B and interleukin 1-beta in a rat model. J Periodontol. 1998;69:113–9.
Dreyer WP, Basson NJ. Porphyromonas gingivalis as putative pathogen in ovine periodontitis. J Dent Assoc S Afr. 1992;47:513–6.
Duarte PM, Tezolin KR, Figueiredo LC, Feres M, Bastos MF. Microbial profile of ligature-induced periodontitis in rats. Arch Oral Biol. 2010;55:142–7.
Dumitrescu AL, Abd-El-Aleem S, Morales-Aza B, Donaldson LF. A model of periodontitis in the rat: effect of lipopolysaccharide on bone resorption, osteoclast activity, and local peptidergic innervation. J Clin Periodontol. 2004;31:596–603.
Duncan WJ, Persson GR, Sims TJ, Braham P, Pack ARC, Page RC. Ovine periodontitis as a potential model for periodontal studies. Cross-sectional analysis of clinical, microbiological, and serum immunological parameters. J Clin Periodontol. 2003;30:63–72.
Dyer BL, Caffesse RG, Nasjleti CE, Morrison EC. Guided tissue regeneration with dentin biomodification. J Periodontol. 1993;64:1052–60.
Ebersole JL, Kraig E, Bauman G, Spitznagel JK, Kolodrubetz D. Molecular approaches to leucotoxin as a virulence component in Actinobacillus actinomycetemcomitans. Arch Oral Biol. 1990;35(Suppl):69S–78.
Ebersole JL, Brunsvold M, Steffensen B, Wood R, Holt SC. Effects of immunization with Porphyromonas gingivalis and Prevotella intermedia on progression of ligature-induced periodontitis in the nonhuman primate Macaca fascicularis. Infect Immun. 1991;59:3351–9.
Ebersole JL, Cappelli D, Holt SC, Singer RE, Filloon T. Gingival crevicular fluid inflammatory mediators and bacteriology of gingivitis in nonhuman primates related to susceptibility to periodontitis. Oral Microbiol Immunol. 2000;15:19–26.
Ebersole JL, Cappelli D, Mathys EC, Steffen MJ, Singer RE, Montgomery M, Mott GE, Novak MJ. Periodontitis in humans and non-human primates: oral-systemic linkage inducing acute phase proteins. Ann Periodontol. 2002;7:102–11.
Ebersole JL, Steffen MJ, Holt SC, Kesavalu L, Chu L, Cappelli D. Systemic inflammatory responses in progressing periodontitis during pregnancy in a baboon model. Clin Exp Immunol. 2010;162:550–9.
Ekuni D, Firth JD, Putnins EE. Regulation of epithelial cell growth factor receptor protein and gene expression using a rat periodontitis model. J Periodontal Res. 2006;41:340–9.
Ekuni D, Tomofuji T, Tamaki N, Sanbe T, Azuma T, Yamanaka R, Yamamoto T, Watanabe T. Mechanical stimulation of gingiva reduces plasma 8-OHdG level in rat periodontitis. Arch Oral Biol. 2008;53:324–9.
Ekuni D, Tomofuji T, Sanbe T, Irie K, Azuma T, Maruyama T, Tamaki N, Murakami J, Kokeguchi S, Yamamoto T. Periodontitis-induced lipid peroxidation in rat descending aorta is involved in the initiation of atherosclerosis. J Periodontal Res. 2009;44:434–42.
Ekuni D, Tomofuji T, Irie K, Kasuyama K, Umakoshi M, Azuma T, Tamaki N, Sanbe T, Endo Y, Yamamoto T, Nishida T, Morita M. Effects of periodontitis on aortic insulin resistance in an obese rat model. Lab Invest. 2010;90:348–59.
Elharar F, Rodriguez HJ, Benque EP, Caffesse RG. Guided tissue regeneration with bioabsorbable and expanded polytetrafluoroethylenebarrier membranes in the treatment of naturally occurring periodontal defects in dogs. J Periodontol. 1998;69:1218–28.
Endo Y, Tomofuji T, Ekuni D, Irie K, Azuma T, Tamaki N, Yamamoto T, Morita M. Experimental periodontitis induces gene expression of proinflammatory cytokines in liver and white adipose tissues in obesity. J Periodontol. 2010;81:520–6.
Escartin Q, Lallam-Laroye C, Baroukh B, Morvan FO, Caruelle JP, Godeau G, Barritault D, Saffar JL. A new approach to treat tissue destruction in periodontitis with chemically modified dextran polymers. FASEB J. 2003;17:644–51.
Evans RT, Klausen B, Sojar HT, Bedi GS, Sfintescu C, Ramamurthy NS, Golub LM, Genco RJ. Immunization with Porphyromonas (Bacteroides) gingivalis fimbriae protects against periodontal destruction. Infect Immun. 1992;60:2926–35.
Faggion CM Jr, Listl S, Giannakopoulos NN. The methodological quality of systematic reviews of animal studies in dentistry. Vet J. 2012;192:140–7.
Faggion Jr CM, Schmitter M, Tu YK. Assessment of replication of research evidence from animals to humans in studies on peri-implantitis therapy. J Dent. 2009;37:737–47.
Faggion Jr CM, Chambrone L, Gondim V, Schmitter M, Tu YK. Comparison of the effects of treatment of peri-implant infection in animal and human studies: systematic review and meta-analysis. Clin Oral Implants Res. 2010;21:137–47.
Faggion Jr CM, Giannakopoulos NN, Listl S. Risk of bias of animal studies on regenerative procedures for periodontal and peri-implant bone defects – a systematic review. J Clin Periodontol. 2011;38:1154–60.
Felipe ME, Andrade PF, Novaes Jr AB, Grisi MF, Souza SL, Taba Jr M, Palioto DB. Potential of bioactive glass particles of different size ranges to affect bone formation in interproximal periodontal defects in dogs. J Periodontol. 2009;80:808–15.
Fernandes MI, Gaio EJ, Oppermann RV, Rados PV, Rosing CK. Comparison of histometric and morphometric analyses of bone height in ligature-induced periodontitis in rats. Braz Oral Res. 2007;21:216–21.
Fernandes LA, Martins TM, de Almeida JM, Nagata MJ, Theodoro LH, Garcia VG, Bosco AF. Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats. J Appl Oral Sci. 2010;18:635–40.
Fischer RG, Klinge B. Clinical and histiological evaluation of ligature-induced periodontitis in the domestic ferret. J Clin Periodontol. 1994;21:230–9.
Fischer RG, Edwardsson S, Klinge B. Oral microflora of the ferret at the gingival sulcus and mucosa membrane in relation to ligature-induced periodontitis. Oral Microbiol Immunol. 1994;9:40–9.
Fisher RG, Klinge B, Attsrom R. Normal histologic features of domestic ferret periodontium. Scand J Dent Res. 1993;101:357–62.
Frisken KW, Laws AJ, Tagg JR, Orr MB. Environmental influences on the progression of clinical and microbiological parameters of sheep periodontal disease. Res Vet Sci. 1989;46:147–52.
Fujishiro N, Anan H, Hamachi T, Maeda K. The role of macrophages in the periodontal regeneration using Emdogain® gel. J Periodontal Res. 2008;43:143–55.
Garant PR. An electron microscopic study of the periodontal tissues of germfree rats and rats monoinfected with Actinomyces naeslundii. J Periodontal Res. 1976a;15:3–79.
Garant PR. Light and electron microscopic observations of osteoclastic alveolar bone resorption in rats monoinfected with Actinomyces naeslundii. J Periodontol. 1976b;47:717–23.
Garlet GP, Cardoso CR, Silva TA, Ferreira BR, Avila-Campos MJ, Cunha FQ, Silva JS. Cytokine pattern determines the progression of experimental periodontal disease induced by Actinobacillus actinomycetemcomitans through the modulation of MMPs, RANKL, and their physiological inhibitors. Oral Microbiol Immunol. 2006;21:12–20.
Garlet GP, Cardoso CR, Mariano FS, Claudino M, de Assis GF, Campanelli AP, Ávila-Campos MJ, Silva JS. Regulatory T cells attenuate experimental periodontitis progression in mice. J Clin Periodontol. 2010;37:591–600.
Gašperšič R, Ŝtiblar-Martinčič D, Skalerič U. Influence of restraint stress on ligature-induced periodontitis in rats. Eur J Oral Sci. 2002;110:125–9.
Gavin JB. Ultrastructural features of chronic marginal gingivitis. J Periodontal Res. 1970;5:19–29.
Gemmell E, Bird PS, Ford PJ, Ashman RB, Gosling P, Hu Y, Seymour GJ. Modulation of the antibody response by Porphyromonas gingivalis and Fusobacterium nucleatum in a mouse model. Oral Microbiol Immunol. 2004;19:247–51.
Genco CA, Cutler CW, Kapczynski D, Maloney K, Arnold RR. A novel mouse model to study the virulence of and host response to Porphyromonas (Bacteroides) gingivalis. Infect Immun. 1991;59:1255–63.
Genco CA, Kapczynski DR, Cutler CW, Arko RJ, Arnold RR. Influence of immunization on Porphyromonas gingivalis colonization and invasion in the mouse chamber model. Infect Immun. 1992;60:1447–54.
Genco CA, Odusanya BM, Potempa J, Mikolajczyk-Pawlinska J, Travis J. A peptide domain on gingipain R which confers immunity against Porphyromonas gingivalis infection in mice. Infect Immun. 1998a;66:4108–14.
Genco CA, Van Dyke T, Amar S. Animal models for Porphyromonas gingivalis-mediated periodontal disease. Trends Microbiol. 1998b;6:444–9.
Germanier Y, Tosatti S, Broggini N, Textor M, Buser D. Enhanced bone apposition around biofunctionalized sandblasted and acid etched titanium implant surfaces. A histomorphometric study in miniature pigs. Clin Oral Implants Res. 2006;17:251–7.
Giannobile WV, Finkelman RD, Lynch SE. Comparison of canine and non-human primate animal models for periodontal regenerative therapy: Results following a single administration of PDGF/IGF-I. J Periodontol. 1994;65:1158–68.
Gibson 3rd FC, Genco CA. Prevention of Porphyromonas gingivalis-induced oral bone loss following immunization with gingipain R1. Infect Immun. 2001;69:7959–63.
Gibson 3rd FC, Hong C, Chou HH, Yumoto H, Chen J, Lien E, Wong J, Genco CA. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2004;109:2801–6.
Gineste L, Gineste M, Bluche L, et al. Histomorphometric comparison of three bioabsorbable GTR barrier membranes in the canine model. Int J Periodontics Restorative Dent. 2005a;25:61–71.
Gineste L, Gineste M, Bluche L, Guilhem A, Elefterion A, Frayssinet P, Duran D, Wang HL. Histomorphometric comparison of three bioabsorbable GTR barrier membranes in the canine model. Int J Periodontics Restorative Dent. 2005b;25:61–71.
Gitlin JM, Loftin CD. Cyclooxygenase-2 inhibition increases lipopolysaccharide-induced atherosclerosis in mice. Cardiovasc Res. 2009;81:400–7.
Garant PR, Cho MI. Histopathogenesis of spontaneous periodontal disease in conventional rats. II. Ultrastructural features of the inflamed subepithelial connective tissue. J Periodontal Res. 1979a;14(4):310–22.
Garant PR, Cho MI. Histopathogenesis of spontaneous periodontal disease in conventional rats. I. Histometric and histologic study. J Periodontal Res. 1979b;14(4):297–309.
Graves DT, Oskoui M, Volejnikova S, Naguib G, Cai S, Desta T, Kakouras A, Jiang Y. Tumor necrosis factor modulates fibroblast apoptosis, PMN recruitment, and osteoclast formation in response to P. gingivalis infection. J Dent Res. 2001;80:1875–9.
Graves DT, Naguib G, Lu H, Desta T, Amar S. Porphyromonas gingivalis fimbriae are pro-inflammatory but do not play a prominent role in the innate immune response to P. gingivalis. J Endotoxin Res. 2005a;11:13–8.
Graves DT, Naguib G, Lu H, Leone C, Hsue H, Krall E. Inflammation is more persistent in type 1 diabetic mice. J Dent Res. 2005b;84:324–8.
Graves DT, Fine D, Teng Y-T, Van Dyke TE, Hajishengallis G. The use of rodent models to investigate host-bacteria interactions related to periodontal diseases. J Clin Periodontol. 2008;35:89–105.
Graves DT, Kang J, Andriankaja O, Wada K, Rossa Jr C. Animal models to study host-bacteria interactions involved in periodontitis. Front Oral Biol. 2012;15:117–32.
Graziani F, Laurell L, Tonetti M, Gottlow J, Berglundh T. Periodontal wound healing following GTR therapy of dehiscence-type defects in the monkey: short-, medium- and long-term healing. J Clin Periodontol. 2005;32:905–14.
Guiha R, el Khodeiry S, Mota L, Caffesse R. Histological evaluation of healing and revascularization of the subepithelial connective tissue graft. J Periodontol. 2001;72:470–8.
Gaegauf-Zollinger R, Burckhardt JJ, Guggenheim B. Radiographic measurements of alveolar bone loss in the rat. Arch Oral Biol. 1982;27(8):651–8.
Hachicha M, Pouliot M, Petasis NA, Serhan CN. Lipoxin (LX)A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor 1alpha-initiated neutrophil responses and trafficking: regulators of a cytokine-chemokine axis. J Exp Med. 1999;189:1923–30.
Hackam DG, Redelmeier DA. Translation of research evidence from animals to humans. JAMA. 2006;296: 1731–2.
Hajishengallis G, Shakhatreh MA, Wang M, Liang S. Complement receptor 3 blockade promotes IL-12-mediated clearance of Porphyromonas gingivalis and negates its virulence in vivo. J Immunol. 2007;179: 2359–67.
Hayashi C, Gudino CV, Gibson FC 3rd, Genco CA. Review: Pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways. Mol Oral Microbiol. 2010;25(5):305-16.
Hammarström L, Heijl L, Gestrelius S. Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins. J Clin Periodontol. 1997;24:669–77.
Haney JM, Zimmerman GJ, Wikesjo UME. Periodontal repair in dogs: evaluation of the natural disease model. J Clin Periodontol. 1995;22:208–13.
Hanisch O, Sorensen RG, Kinoshita A, Spiekermann H, Wozney JM, Wikesjö UM. Effect of recombinant human bone morphogenetic protein-2 in dehiscence defects with non-submerged immediate implants: an experimental study in Cynomolgus monkeys. J Periodontol. 2003;74:648–57.
Hardham J, Reed M, Wong J, King K, Laurinat B, Sfintescu C, Evans RT. Evaluation of a monovalent companion animal periodontal disease vaccine in an experimental mouse periodontitis model. Vaccine. 2005;23:3148–56.
Harper DS, Mann PH, Regnier S. Measurement of dietary and dentifrice effects upon calculus accumulation rates in the domestic ferret. J Dent Res. 1990;69:447–50.
Hardt AB. Bisphosphonate effects on alveolar bone during rat molar drifting. J Dent Res. 1988;67:1430–3.
Hart GT, Shaffer DJ, Akilesh S, Brown AC, Moran L, Roopenian DC, Baker PJ. Quantitative gene expression profiling implicates genes for susceptibility and resistance to alveolar bone loss. Infect Immun. 2004;72:4471–9.
Hasturk H, Kantarci A, Ebrahimi N, Andry C, Holick M, Jones VL, Van Dyke TE. Topical H2 antagonist prevents periodontitis in a rabbit model. Infect Immun. 2006a;74:2402–14.
Hasturk H, Kantarci A, Ohira T, Arita M, Ebrahimi N, Chiang N, Petasis NA, Levy BD, Serhan CN, Van Dyke TE. RvE1 protects from local inflammation and osteoclast-mediated bone destruction in periodontitis. FASEB J. 2006b;20:401–3.
Hasturk H, Jones VL, Andry C, Kantarci A. 1-Tetradecanol complex reduces progression of Porphyromonas gingivalis-induced experimental periodontitis in rabbits. J Periodontol. 2007a;78:924–32.
Hasturk H, Kantarci A, Goguet-Surmenian E, Blackwood A, Andry C, Serhan CN, Van Dyke TE. Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo. J Immunol. 2007b;179:7021–9.
Hasturk H, Goguet-Surmenian E, Blackwood A, Andry C, Kantarci A. 1-Tetradecanol complex: therapeutic actions in experimental periodontitis. J Periodontol. 2009;80:1103–13.
Hasturk H, Kantarci A, Ghattas M, Schmidt M, Giordano RA, Ashman A, Diekwisch TG, Van Dyke T. The use of light/chemically-hardened poly-methyl-methacrylate, poly-hydroxyl-ethyl-methacrylate and calcium hydroxide graft material in combination with polyanhydride around implants in minipigs: part I: immediate stability and function. J Periodontol. 2011;82:1339–52.
Hasturk H, Kantarci A, Van Dyke TE. Paradigm shift in the pharmacological management of periodontal diseases. Front Oral Biol. 2012;15:160–76.
Hautamäki MP, Aho AJ, Alander P, Rekola J, Gunn J, Strandberg N, Vallittu PK. Repair of bone segment defects with surface porous fiber-reinforced polymethyl methacrylate (PMMA) composite prosthesis: histomorphometric incorporation model and characterization by SEM. Acta Orthop. 2008;79:555–64.
Hayashi C, Kinoshita A, Oda S, Mizutani K, Shirakata Y. Ishikawa Injectable calcium phosphate bone cement provides favorable space and a scaffold for periodontal regeneration in dogs. J Periodontol. 2006;77:940–6.
Heijl L, Wennstrom J, Lindhe J, Socransky SS. Periodontal disease in gnatobiotic rats. J Periodontal Res. 1980;15:405–19.
Hernández M, Gamonal J, Salo T, Tervahartiala T, Hukkanen M, Tjäderhane L, Sorsa T. Reduced expression of LIX/CXCL5 in Porphyromonas gingivalis-induced experimental periodontitis in matrix metalloproteinase-8 null mice. J Periodontal Res. 2011;46:58–66.
Hickey JS, O’Neal RB, Scheidt MJ, Strong SL, Turgeon D, Van Dyke TE. Microbiologic characterization of ligature-induced peri-implantitis in the microswine model. J Periodontol. 1991;62:548–53.
Hojo K, Tamura A, Mizoguchi C, Kato D, Ohshima T, Maeda N. Predominant bacteria recovered from a periodontitis site in a hamster model raised by silk-ligature with Porphyromonas gingivalis infection. Biosci Biotechnol Biochem. 2008;72:1348–51.
Holt SC, Ebersole J, Felton J, Brunsvold M, Kornman KS. Implantation of Bacteroides gingivalis in nonhuman primates initiates progression of periodontitis. Science. 1988;239(4835):55–7.
Holzhausen M, Rossa Júnior C, Marcantonio Júnior E, Nassar PO, Spolidório DM, Spolidório LC. Effect of selective cyclooxygenase-2 inhibition on the development of ligature-induced periodontitis in rats. J Periodontol. 2002;73:1030–6.
Holzhausen M, Garcia DF, Pepato MT, Marcantonio Jr E. The influence of short-term diabetes mellitus and insulin therapy on alveolar bone loss in rats. J Periodontal Res. 2004;39:188–93.
Hu SW, Huang CH, Huang HC, Lai YY, Lin YY. Transvascular dissemination of Porphyromonas gingivalis from a sequestered site is dependent upon activation of the kallikrein/kinin pathway. J Periodontal Res. 2006;41:200–7.
Huang KK, Shen C, Chiang CY, Hsieh YD, Fu E. Effects of bone morphogenetic protein-6 on periodontal wound healing in a fenestration defect of rats. J Periodontal Res. 2005;40:1–10.
Huang S, Lu F, Zhang Z, Yang X, Chen Y. The role of psychological stress induced hypoxia-inducible factor-1α in rat experimental periodontitis. J Periodontol. 2010;82:934–41.
Hyvärinen K, Tuomainen AM, Laitinen S, Bykov IL, Törmäkangas L, Lindros K, Käkelä R, Alfthan G, Salminen I, Jauhiainen M, Kovanen PT, Leinonen M, Saikku P, Pussinen PJ. Chlamydial and periodontal pathogens induce hepatic inflammation and fatty acid imbalance in apolipoprotein E-deficient mice. Infect Immun. 2009;77:3442–9.
Ijuhin N, Miyauchi M, Ito H, Takata T, Ogawa I, Nikai H. Enhanced collagen phagocytosis by rat molar periodontal fibroblasts after topical application of lipopolysaccharide – ultrastructural observations and morphometric analysis. J Periodontal Res. 1992;27:167–75.
Irokawa T, Ishida E, Fukuoka Y, Maita E, Yanagawa S. A study on the effects of continuous mechanical irritation to the periodontal tissues of germ-free and conventional rats (in Japanese). Nippon Shishubyo Gakkai Kaishi. 1977;19:333–40.
Irving JT, Socransky SS, Heeley JD. Histological changes in experimental periodontal disease in gnotobiotic rats and conventional hamsters. J Periodontal Res. 1974;9:73–80.
Irving JT, Newman MG, Socransky SS, Heely JD. Histological changes in experimental periodontal disease in rats mono-infected with a gram-negative organism. Arch Oral Biol. 1975a;20:219–20.
Irving JT, Heeley JD, Socransky SS. Cellular response to subgingival injection of bacterial products in the rat. J Periodontal Res. 1975b;10:324–31.
Irving JT, Socransky SS, Tanner AC. Histological changes in experimental periodontal disease in rats monoinfected with gram-negative organisms. J Periodontal Res. 1978;13:326–32.
Irving JT, Heeley JD, Amdur BH, Socransky SS. Pathological changes caused by the injection of lipids isolated from gram-positive organisms into the gingiva of rats. J Periodontal Res. 1979;14:160–6.
Ismaiel MO, Greenman J, Morgan K, Glover MG, Rees AS, Scully C. Periodontitis in sheep: a model for human periodontal disease. J Periodontol. 1989;60:279–84.
Iwatsuka H, Shino A, Suzuoki Z. General survey of diabetic features of yellow KK mice. Endocrinol Jpn. 1970;17:23–35.
Jain A, Batista Jr EL, Serhan C, Stahl GL, Van Dyke TE. Role for periodontitis in the progression of lipid deposition in an animal model. Infect Immun. 2003;71:6012–8.
Janssen U, Phillips AO, Floege J. Rodent models of nephropathy associated with type II diabetes. J Nephrol. 1999;12:159–72.
Jensen SS, Broggini N, Weibrich G, Hjôrting-Hansen E, Schenk R, Buser D. Bone regeneration in standardized bone defects with autografts or bone substitutes in combination with platelet concentrate: a histologic and histomorphometric study in the mandibles of minipigs. Int J Oral Maxillofac Implants. 2005;20:703–12.
Jensen S, Broggini N, Hjørting-Hansen E, Schenk R, Buser D. Bone healing and graft resorption of autograft, anorganic bovine bone and b-tricalcium phosphate. A histologic and histomorphometric study in the mandibles of mini-pigs. Clin Oral Implants Res. 2006;17:237–43.
Jogahara T, Oda S, Kawai T, Hanamura H, Koyasu K. Numerical variation of teeth in the wild house musk shrew Suncus murinus captured from Nagasaki, Japan. Arch Oral Biol. 2008;53:617–21.
Jones WA, O’Leary TJ. The effectiveness of in vivo root planing in removing bacterial endotoxin from the roots of periodontally involved teeth. J Periodontol. 1978;49:337–42.
Jordan HV, Keyes PH. Aerobic, gram-positive, filamentous bacteria as etiologic agents of experimental periodontal disease in hamsters. Arch Oral Biol. 1964;9:401–14.
Jordan HV, Keyes PH, Bellack S. Periodontal lesions in hamsters and gnotobiotic rats infected with actinomyces of human origin. J Periodontal Res. 1972;7:21–8.
Jovanovic SA, Hunt DR, Bernard GW, Spiekermann H, Wozney JM, Wikesjö UM. Bone reconstruction following implantation of rhBMP-2 and guided bone regeneration in canine alveolar ridge defects. Clin Oral Implants Res. 2007;18:224–30.
Jung UW, Chang YY, Um YJ, Kim CS, Cho KS, Choi SH. Interproximal periodontal defect model in dogs: a pilot study. Oral Dis. 2011;17:26–32.
Karimbux NY, Ramamurthy NS, Golub LM, Nishimura I. The expression of collagen I and XII mRNAs in Porphyromonas gingivalis-induced periodontitis in rats: the effect of doxycycline and chemically modified tetracycline. J Periodontol. 1998;69:34–40.
Kasiske BL, O’Donnell MP, Keane WF. The Zucker rat model of obesity, insulin resistance, hyperlipidemia, and renal injury. Hypertension. 1992;19 Suppl 1:I110–5.
Katz J, Ward DC, Michalek SM. Effect of host responses on the pathogenicity of strains of Porphyromonas gingivalis. Oral Microbiol Immunol. 1996;11:309–18.
Katz J, Black KP, Michalek SM. Host responses to recombinant hemagglutinin B of Porphyromonas gingivalis in an experimental rat model. Infect Immun. 1999;67:4352–9.
Kawai T, Eisen-Lev R, Seki M, Eastcott JW, Wilson ME, Taubman MA. Requirement of B7 costimulation for Th1-mediated inflammatory bone resorption in experimental periodontal disease. J Immunol. 2000;164:2102–9.
Kebschull M, Demmer RT, Papapanou PN. “Gum bug, leave my heart alone!” – epidemiologic and mechanistic evidence linking periodontal infections and atherosclerosis. J Dent Res. 2010;89:879–902.
Kesavalu L, Chandrasekar B, Ebersole JL. In vivo induction of proinflammatory cytokines in mouse tissue by Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol. 2002;17:177–80.
Kesavalu L, Sathishkumar S, Bakthavatchalu V, Matthews C, Dawson D, Steffen M, Ebersole JL. Rat model of polymicrobial infection, immunity, and alveolar bone resorption in periodontal disease. Infect Immun. 2007;75:1704–12.
Kiel RA, Kornman KS, Robertson PB. Clinical and microbiological effects of localized ligature-induced periodontitis on non-ligated sites in the cynomolgus monkey. J Periodontal Res. 1983;18:200–11.
Kilkenny C, Parsons N, Kadyszewski E, Festing MFW, Cuthill IC, et al. Survey of the quality of experimental design, statistical analysis and reporting of research using animals. PLoS One. 2009;4(11):e7824. doi:10.1371/journal.pone.0007824.
Kim CK, Kim HY, Chai JK, et al. Effect of a calcium sulfate implant with calcium sulfate barrier on periodontal healing in 3-wall intrabony defects in dogs. J Periodontol. 1998;69:982–8.
Kim HY, Kim CS, Jhon GJ, Moon IS, Choi SH, Cho KS, Chai JK, Kim CK. The effect of safflower seed extract on periodontal healing of 1-wall intrabony defects in beagle dogs. J Periodontol. 2002;73:1457–66.
Kim CS, Choi SH, Chai JK, et al. Periodontal repair in surgically created intrabony defects in dogs: influence of the number of bone walls on healing response. J Periodontol. 2004;75:229–35.
Kim CS, Choi SH, Cho KS, Chai JK, Wikesjo UM, Kim CK. Periodontal healing in one-wall intra-bony defects in dogs following implantation of autogenous bone or a coral-derived biomaterial. J Clin Periodontol. 2005;32:583–9.
Kim IY, Jung UW, Kim CS, Lee YK, Cho KS, Chai JK, Kim CK, Choi SH. Effects of a tetracycline blended polylactic and polyglycolic acid membrane on the healing of one-wall intrabony defects in beagle dogs. Biomed Mater. 2007;2:S106–10.
Kim TG, Wikesjö UM, Cho KS, Chai JK, Pippig SD, Siedler M, Kim CK. Periodontal wound healing⁄regeneration following implantation of recombinant human growth ⁄ differentiation factor-5 (rhGDF-5) in an absorbable collagen sponge carrier into one-wall intrabony defects in dogs: a dose-range study. J Clin Periodontol. 2009;36:589–97.
Kim CS, Um YJ, Chai JK, Cho KS, Moon IS, Choi SH, Jung UW, Lee DW, Kim CK. A canine model for histometric evaluation of periodontal regeneration. Periodontol 2000. 2011;56:209–26.
King GN, King N, Cruchley AT, Wozney JM, Hughes FJ. Recombinant human bone morphogenetic protein-2 promotes wound healing in rat periodontal fenestration defects. J Dent Res. 1997;76:1460–70.
King GN, King N, Hughes FJ. The effect of root surface demineralization on bone morphogenetic protein-2-induced healing of rat periodontal fenestration defects. J Periodontol. 1998;69:561–70.
Kirkham J, Robinson C, Spence JA. Effect of periodontal disease (“broken mouth”) on the distribution of matrix macromolecules in the sheep periodontium. Arch Oral Biol. 1991;36:257–63.
Kirkwood KL, Li F, Rogers JE, Otremba J, Coatney DD, Kreider JM, D’Silva NJ, Chakravarty S, Dugar S, Higgins LS, Protter AA, Medicherla S. A p38alpha selective mitogen-activated protein kinase inhibitor prevents periodontal bone loss. J Pharmacol Exp Ther. 2007;320:56–63.
Klausen B. Microbiological and immunological aspects of experimental periodontal disease in rats: a review article. J Periodontol. 1991;62:59–73.
Klausen B, Evans RT, Sfintescu C. Two complementary methods of assessing periodontal bone level in rats. Scand J Dent Res. 1989a;97:494–9.
Klausen B, Hougen HP, Fiehn NE. Increased periodontal bone loss in temporarily B lymphocyte-deficient rats. J Periodontal Res. 1989b;24:384–90.
Klepp M, Hinrichs JE, Eastlund T, Schaffer EM. Histologic evaluation of demineralized freeze-dried bone allografts in barrier membrane covered periodontal fenestration wounds and ectopic sites in dogs. J Clin Periodontol. 2004;31:534–44.
Koo KT, Polimeni G, Albandar JM, Wikesjö UM. Periodontal repair in dogs: analysis of histometric assessments in the supraalveolar periodontal defect model. J Periodontol. 2004a;75:1688–93.
Koo KT, Polimeni G, Albandar JM, Wikesjö UM. Periodontal repair in dogs: examiner reproducibility in the supraalveolar periodontal defect model. J Clin Periodontol. 2004b;31:439–42.
Koo KT, Polimeni G, Qahash M, Kim CK, Wikesjö UM. Periodontal repair in dogs: guided tissue regeneration enhances bone formation in sites implanted with a coral-derived calcium carbonate biomaterial. J Clin Periodontol. 2005;32(1):104–10.
Kornman KS, Holt SC, Roberston PB. The microbiology of ligature-induced periodontitis in the cynomolgus monkey. J Periodontal Res. 1981a;16:363–71.
Kornman KS, Siegrist B, Soskolne WA, Nuki K. The predominant cultivable subgingival flora of beagle dogs following ligature placement and metronidazole therapy. J Periodontal Res. 1981b;16:251–8.
Kornman KS, Manti F, Goldschneider I. Peripheral blood lymphocyte populations in ligature-induced periodontitis. J Periodontal Res. 1982;17:469–71.
Kostopoulos L, Karring T. Susceptibility of GTR-regenerated periodontal attachment to ligature-induced periodontitis. J Clin Periodontol. 2004;31:336–40.
Kozlovsky A, Tal H, Laufer BZ, Leshem R, Rohrer MD, Weinreb M, Artzi Z. Impact of implant overloading on the peri-implant bone in inflamed and non-inflamed peri-implant mucosa. Clin Oral Implants Res. 2007;18:601–10.
Kuhr A, Popa-Wagner A, Schmoll H, Schwahn C, Kocher T. Observations on experimental marginal periodontitis in rats. J Periodontal Res. 2004;39:101–6.
Kurtis B, Balos K, Oygür T. Effect of a collagen membrane enriched with fibronectin on guided tissue regeneration in dogs. Periodontal Clin Investig. 2002;24:11–9.
Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. J Pharmacol Pharmacother. 2010;1(2):94–9.
Lalla E, Lamster IB, Feit M, Huang L, Schmidt AM. A murine model of accelerated periodontal disease in diabetes. J Periodontal Res. 1998;33:387–99.
Lalla E, Lamster IB, Feit M, Huang L, Spessot A, Qu W, Kislinger T, Lu Y, Stern DM, Schmidt AM. Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice. J Clin Invest. 2000;105: 1117–24.
Lalla E, Lamster IB, Hofmann MA, Bucciarelli L, Jerud AP, Tucker S, Lu Y, Papapanou PN, Schmidt AM. Oral infection with a periodontal pathogen accelerates early atherosclerosis in apolipoprotein E-null mice. Arterioscler Thromb Vasc Biol. 2003;23:1405–11.
Lang H, Schüler N, Nolden R. Attachment formation following replantation of cultured cells into periodontal defects – a study in minipigs. J Dent Res. 1998;77:393–405.
Le Guehennec L, Goyenvalle E, Aguado E, Houchmand-Cuny M, Enkel B, Pilet P, Daculsi G, Layrolle P. Small-animal models for testing macroporous ceramic bone substitutes. J Biomed Mater Res B Appl Biomater. 2005;72:69–78.
Lee JY, Yi NN, Kim US, Choi JS, Kim SJ, Choi JI. Porphyromonas gingivalis heat shock protein vaccine reduces the alveolar bone loss induced by multiple periodontopathogenic bacteria. J Periodontal Res. 2006;41:10–4.
Lee J, Tran Q, Seeba G, Wikesjö UM, Susin C. The critical-size supraalveolar peri-implant defect model: reproducibility in histometric data acquisition of alveolar bone formation and osseointegration. J Clin Periodontol. 2009;36:1067–74.
Lekic P, Klausen B, Friis-Hasche E, Beloica D, Knezevic M, Hougen HP. Influence of age and immunization on development of gingivitis in rats. Acta Odontol Scand. 1989;47:233–8.
Lekovic V, Klokkevold PR, Kenney EB, Dimitrijelic B, Nedic M, Weinlaender M. Histologic evaluation of guided tissue regeneration using 4 barrier membranes: a comparative furcation study in dogs. J Periodontol. 1998;69:54–61.
Leone CW, Bokhadhoor H, Kuo D, Desta T, Yang J, Siqueira MF, Amar S, Graves DT. Immunization enhances inflammation and tissue destruction in response to Porphyromonas gingivalis. Infect Immun. 2006;74:2286–92.
Li CH, Amar S. Morphometric, histomorphometric, and microcomputed tomographic analysis of periodontal inflammatory lesions in a murine model. J Periodontol. 2007;78(6):1120–8.
Li L, Khansari A, Shapira L, Graves DT, Amar S. Contribution of interleukin-11 and prostaglandin(s) in lipopolysaccharide-induced bone resorption in vivo. Infect Immun. 2002a;70:3915–22.
Li L, Messas E, Batista Jr EL, Levine RA, Amar S. Porphyromonas gingivalis infection accelerates the progression of atherosclerosis in a heterozygous apolipoprotein E-deficient murine model. Circulation. 2002b;105(7):861–7.
Liang S, Hosur KB, Domon H, Hajishengallis G. Periodontal inflammation and bone loss in aged mice. J Periodontal Res. 2010;45:574–8.
Liao F, Li Z, Wang Y, Shi B, Gong Z, Cheng X. Porphyromonas gingivalis may play an important role in the pathogenesis of periodontitis-associated rheumatoid arthritis. Med Hypotheses. 2009;72:732–5.
Liberman DN, Pilau RM, Gaio EJ, Orlandini LF, Rösing CK. Low concentration alcohol intake may inhibit spontaneous alveolar bone loss in Wistar rats. Arch Oral Biol. 2011;56:109–13.
Lin D, Smith MA, Champagne C, Elter J, Beck J, Offenbacher S. Porphyromonas gingivalis infection during pregnancy increases maternal tumor necrosis factor alpha, suppresses maternal interleukin-10, and enhances fetal growth restriction and resorption in mice. Infect Immun. 2003;71:5156–62.
Lindhe J, Ericsson I. Effect of ligature placement and dental plaque on periodontal tissue breakdown in the dog. J Periodontol. 1978;49:343–50.
Lindhe J, Rylander H. Experimental gingivitis in young dogs. Scand J Dent Res. 1975;83:314–26.
Lindhe J, Hamp SE, Löe H. Plaque induced periodontal disease in beagle dogs. A 4-year clinical, roentgenographical and histometrical study. J Periodontal Res. 1975;10:243–55.
Lindhe J, Berglundh T, Ericsson I, Liljenberg B, Marinello CP. Experimental breakdown of periimplant and periodontal tissues. A study in the beagle dog. Clin Oral Implants Res. 1992;3:9–16.
Listgarten MA, Johnson D, Nowotny A, Tanner AC, Socransky SS. Histopathology of periodontal disease in gnotobiotic rats monoinfected with Eikenella corrodens. J Periodontal Res. 1978;13:134–48.
Listagarten MA, Johnson D, Nowotny A, Tanner AC, Socransky SS. Histopathology of periodontal disease in gnotobiotic rats monoinfected with Eikenella corrodens. J Periodontal Res. 1978;13(2):134-48.
Liu R, Bal HS, Desta T, Behl Y, Graves DT. Tumor necrosis factor-alpha mediates diabetes-enhanced apoptosis of matrix-producing cells and impairs diabetic healing. Am J Pathol. 2006;168:757–64.
Liu Y, Zheng Y, Ding G, et al. Periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine. Stem Cells. 2008;26:1065–73.
Liu PF, Haake SK, Gallo RL, Huang CM. A novel vaccine targeting Fusobacterium nucleatum against abscesses and halitosis. Vaccine. 2009;27:1589–95.
Liu PF, Shi W, Zhu W, Smith JW, Hsieh SL, Gallo RL, Huang CM. Vaccination targeting surface FomA of Fusobacterium nucleatum against bacterial co-aggregation: implication for treatment of periodontal infection and halitosis. Vaccine. 2010a;28(19):3496–505.
Liu Y-F, Wu L-A, Wang J, Wen L-Y, Wang X-J. Micro-computerized tomography analysis of alveolar bone loss in ligature- and nicotine-induced experimental periodontitis in rats. J Periodontal Res. 2010b;45:714–9.
Llavaneras A, Ramamurthy NS, Heikkila P, Teronen O, Salo T, Rifkin BR, Ryan ME, Golub LM, Sorsa T. A combination of a chemically modified doxycycline and a bisphosphonate synergistically inhibits endotoxin-induced periodontal breakdown in rats. J Periodontol. 2001;72:1069–77.
Lohinai Z, Benedek P, Feher E, Gyorfi A, Rosivall L, Fazekas A, Salzman AL, Szabo C. Protective effects of mercaptoethylguanidine, a selective inhibitor of inducible nitric oxide synthase, in ligature-induced periodontitis in the rat. Br J Pharmacol. 1998;123:353–60.
Ma JL, Pan JL, Tan BS, Cui FZ. Determination of critical size defect of minipig mandible. J Tissue Eng Regen Med. 2009;3:615–22.
Mahamed DA, Marleau A, Alnaeeli M, Singh B, Zhang X, Penninger JM, Teng YT. G(−) anaerobes-reactive CD4+ T-cells trigger RANKL-mediated enhanced alveolar bone loss in diabetic NOD mice. Diabetes. 2005;54:1477–86.
Mallison 3rd SM, Szakal AK, Ranney RR, Tew JG. Antibody synthesis specific for nonoral antigens in inflamed gingiva. Infect Immun. 1988;56:823–30.
Mallonee DH, Harvey CE, Venner M, Hammond BF. Bacteriology of periodontal disease in the cat. Arch Oral Biol. 1988;33:677–83.
Mann PH, Harper DS, Regnier S. Reduction of calculus accumulation in domestic ferrets with two dentifrices containing pyrophosphate. J Dent Res. 1990;69:451–3.
Manti F, Kornman K, Goldschneider I. Effects of an immunomodulating agent on peripheral blood lymphocytes and subgingival microflora in ligature-induced periodontitis. Infect Immun. 1984;45:172–9.
Martí A, Marcos A, Martínez JA. Obesity and immune function relationships. Obes Rev. 2001;2:131–40.
Matsson L, Attstrom R. Histologic characteristics of experimental gingivitis in the juvenile and adult beagle dog. J Clin Periodontol. 1979;6:334–50.
McCourtie J, Poxton IR, Brown R, Whittaker CR, Spence JA, Aitchison GU. A longitudinal study of the cultivable subgingival anaerobic bacteria isolated from sheep during the development of broken mouth periodontitis. J Med Microbiol. 1990;31:275–83.
Meng H, Xie H, Chen Z. Evaluation of ligature-induced periodontitis in minipig. Zhonghua Kou Qiang Yi Xue Za Zhi. 1996;31:333–6.
Mignini LE, Khan KS. Methodological quality of systematic reviews of animal studies: a survey of reviews of basic research. BMC Med Res Methodol. 2006;6:10.
Mikuls TR, Payne JB, Reinhardt RA, Thiele GM, Maziarz E, Cannella AC. Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis. Int Immunopharmacol. 2009;9:38–42.
Min DH, Kim MJ, Yun JH, Kim CS, Lee YK, Choi SH, Kim KN, Kim CK. Effect of calcium phosphate glass scaffold with chitosan membrane on the healing of alveolar bone in 1-wall intrabony defect in beagle dogs. Key Eng Mater. 2005;284–286:851–4.
Min C-K, Wikesjö UME, Park J-C, Chae G-J, Pippig SD, Bastone P, Kim C-S, Kim C-K. Wound healing/regeneration using recombinant human growth/ differentiation factor-5 in an injectable poly-lactide-co-glycolide-acid composite carrier and a one-wall intra-bony defect model in dogs. J Clin Peridontol. 2011;38:261–8.
Mitsuta T, Horiuchi H, Shinoda H. Effects of topical administration of clodronate on alveolar bone resorption in rats with experimental periodontitis. J Periodontol. 2002;73:479–86.
Miyauchi M, Takata T, Ito H, Ogawa I, Kudo Y, Takekoshi T, Nikai H. Distribution of macrophage lineage cells in rat gingival tissue after topical application of lipopolysaccharide: an immunohistochemical study using monoclonal antibodies: OX6, ED1 and ED2. J Periodontal Res. 1998;33:345–51.
Moher D, Schulz KF, Altman DG for the CONSORT Group. The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials. Lancet. 2011;357:1191–4.
Monjo M, Rubert M, Wohlfahrt JC, Rønold HJ, Ellingsen JE, Lyngstadaas SP. In vivo performance of absorbable collagen sponges with rosuvastatin in critical-size cortical bone defects. Acta Biomater. 2010;6:1405–12.
Moritz AJ, Cappelli D, Lantz MS, Holt SC, Ebersole JL. Immunization with Porphyromonas gingivalis cysteine protease: effects on experimental gingivitis and ligature-induced periodontitis in Macaca fascicularis. J Periodontol. 1998;69:686–97.
Nagini S. Of humans and hamsters: the hamster buccal pouch carcinogenesis model as a paradigm for oral oncogenesis and chemoprevention. Anticancer Agents Med Chem. 2009;9:843–52.
Nakajima K, Hamada N, Takahashi Y, Sasaguri K, Tsukinoki K, Umemoto T, Sato S. Restraint stress enhances alveolar bone loss in an experimental rat model. J Periodontal Res. 2006;41:527–34.
Naguib G, Al-Mashat H, Desta T, Graves DT. Diabetes prolongs the inflammatory response to a bacterial stimulus through cytokine dysregulation. J Invest Dermatol. 2004;123(1):87–92.
Nisengard R, Blann D, Zelonis L, McHenry K, Reynolds H, Zambon J. Effects of immunization with B. macacae on induced periodontitis–preliminary findings. Immunol Invest. 1989;18:225–37.
Nishimura M. Breeding of mice strains for diabetes mellitus. Exp Anim. 1969;18:147–57.
Nkenke E, Lehner B, Weinzierl K, et al. Bone contact, growth, and density around immediately loaded implants in the mandible of minipigs. Clin Oral Implants Res. 2003;14:312–21.
Nkenke E, Lehner B, Fenner M, et al. Immediate versus delayed loading of dental implants in the maxillae of minipigs: follow-up of implant stability and implant failures. Int J Oral Maxillofac Implants. 2005;20:39–47.
Nociti Jr FH, Nogueira-Filho GR, Primo MT, Machado MA, Tramontina VA, Barros SP, et al. The influence of nicotine on the bone loss rate in ligature-induced periodontitis. A histometric study in rats. J Periodontol. 2000;71:1460–4.
Nogueira-Filho GR, Froes Neto EB, Casati MZ, Reis SR, Tunes RS, Tunes UR. Nicotine effects on alveolar bone changes induced by occlusal trauma: a histometric study in rats. J Periodontol. 2004;75:348–52.
Nowotny A, Sanavi F. Induction of nonspecific tolerance to endotoxins reduces the alveolar bone resorption in ligature-treated rats. Infect Immun. 1983;39:873–8.
Núñez J, Caffesse R, Vignoletti F, Guerra F, San Roman F, Sanz M. Clinical and histological evaluation of an acellular dermal matrix allograft in combination with the coronally advanced flap in the treatment of Miller class I recession defects: an experimental study in the mini-pig. J Clin Periodontol. 2009;36:523–31.
Nuñez J, Sanz-Blasco S, Vignoletti F, Muñoz F, Caffesse RG, Sanz M, Villalobos C, Nuñez L. 17beta-estradiol promotes cementoblast proliferation and cementum formation in experimental periodontitis. J Periodontol. 2010;81:1064–74.
O’Brien-Simpson NM, Paolini RA, Reynolds EC. RgpA-Kgp peptide-based immunogens provide protection against Porphyromonas gingivalis challenge in a murine lesion model. Infect Immun. 2000;68:4055–63.
O’Brien-Simpson NM, Pathirana RD, Paolini RA, Chen YY, Veith PD, Tam V, Ally N, Pike RN, Reynolds EC. An immune response directed to proteinase and adhesion functional epitopes protects against Porphyromonas gingivalis-induced periodontal bone loss. J Immunol. 2005;175:3980–9.
Oates TW, Graves DT, Cochran DL. Clinical, radiographic and biochemical assessment of IL-1/TNF-alpha antagonist inhibition of bone loss in experimental periodontitis. J Clin Periodontol. 2002;29:137–43.
Ohnishi T, Bandow K, Kakimoto K, Machigashira M, Matsuyama T, Matsuguchi T. Oxidative stress causes alveolar bone loss in metabolic syndrome model mice with type 2 diabetes. J Periodontal Res. 2009;44:43–51.
Okada Y, Hamada N, Kim Y, Takahashi Y, Sasaguri K, Ozono S, Sato S. Blockade of sympathetic b-receptors inhibits Porphyromonas gingivalis-induced alveolar bone loss in an experimental rat periodontitis model. Arch Oral Biol. 2010;55:502–8.
Onodera H, Shibukawa Y, Sugito H, Ota M, Yamada S. Periodontal regeneration in intrabony defects after application of enamel matrix proteins with guided tissue regeneration: an experimental study in dogs. Biomed Res. 2005;26:69–77.
Oortgiesen DA, Meijer GJ, Bronckers AL, Walboomers XF, Jansen JA. Fenestration defects in the rabbit jaw: an inadequate model for studying periodontal regeneration. Tissue Eng Part C Methods. 2010;16: 133–40.
Oz HS, Ebersole JL. A novel murine model for chronic inflammatory alveolar bone loss. J Periodontal Res. 2010;45:94–9.
Oz HS, Chen T, Ebersole JL. A model for chronic mucosal inflammation in IBD and periodontitis. Dig Dis Sci. 2010;55:2194–202.
Oz HS, Puleo DA. Animal models for periodontal disease. J Biomed Biotechnol. 2011:754–857.
Ozmeric N, Bal B, Oygur T, Balos K. The effect of a collagen membrane in regenerative therapy of two-wall intrabony defects in dogs. Periodontal Clin Invest. 2000;22:22–30.
Papageorgiou A, Vouros I, Konstantinidis A. Treatment outcomes of ligature-induced recession in the dog model using guided tissue regeneration or coronally positioned flap procedures. J Int Acad Periodontol. 2009;11:177–87.
Park WY, Cho CS, Chai JK, Kim CK, Choi SH. The effects of bioactive glass on the periodontal healing of 1-wall intrabony defects in dogs. J Korean Acad Periodontol. 1998;28:145–60.
Park JS, Choi SH, Moon IS, Cho KS, Chai JK, Kim CK. Eight-week histological analysis on the effect of chitosan on surgically created one-wall intrabony defects in beagle dogs. J Clin Periodontol. 2003;30:443–53.
Park CH, Abramson ZR, Taba Jr M, Jin Q, Chang J, Kreider JM, Goldstein SA, Giannobile WV. Three-dimensional micro-computed tomographic imaging of alveolar bone in experimental bone loss or repair. J Periodontol. 2007;78:273–81.
Pathirana RD, O’Brien-Simpson NM, Brammar GC, Slakeski N, Reynolds EC. Kgp and RgpB, but not RgpA, are important for Porphyromonas gingivalis virulence in the murine periodontitis model. Infect Immun. 2007;75:1436–42.
Pellegrini G, Seol YJ, Gruber R, Giannobile WV. Pre-clinical models for oral and periodontal reconstructive therapies. J Dent Res. 2009;88:1065–76.
Perel P, Roberts I, Sena E, Wheble P, Briscoe C, Sandercock P, Macleod M, Mignini LE, Jayaram P, Khan KS. Comparison of treatment effects between animal experiments and clinical trials: systematic review. BMJ. 2007;334(7586):197.
Perlstein MI, Bissada NF. Influence of obesity and hypertension on the severity of periodontitis in rats. Oral Surg Oral Med Oral Pathol. 1977;43:707–19.
Persson GR. Immune responses and vaccination against periodontal infections. J Clin Periodontol. 2005;32 Suppl 6:39–53.
Persson GR, Engel D, Whitney C, Darveau R, Weinberg A, Brunsvold M, Page RC. Immunization against Porphyromonas gingivalis inhibits progression of experimental periodontitis in nonhuman primates. Infect Immun. 1994a;62:1026–31.
Persson GR, Engel LD, Whitney CW, Weinberg A, Moncla BJ, Darveau RP, Houston L, Braham P, Page RC. Macaca fascicularis as a model in which to assess the safety and efficacy of a vaccine for periodontitis. Oral Microbiol Immunol. 1994b;9:104–11.
Persson LG, Berglundh T, Sennerby L, Lindhe J. Reosseointegration after treatment of peri-implantitis at different implant surfaces. An experimental study in the dog. Clin Oral Implnts Res. 2001a;12:595–603.
Persson LG, Ericsson I, Berglundh T, Lindhe J. Osseintegration following treatment of peri-implantitis and replacement of implant components. An experimental study in the dog. J Clin Periodontol. 2001b;28:258–63.
Peruzzo DC, Benatti BB, Antunes IB, Andersen ML, Sallum EA, Casati MZ, et al. Chronic stress may modulate periodontal disease: a study in rats. J Periodontol. 2008;79:697–704.
Pieri F, Lucarelli E, Corinaldesi G, Fini M, Aldini NN, Giardino R, Donati D, Marchetti C. Effect of mesenchymal stem cells and platelet-rich plasma on the healing of standardized bone defects in the alveolar ridge: a comparative histomorphometric study in minipigs. J Oral Maxillofac Surg. 2009;67:265–72.
Pimentel SP, Sallum AW, Saldanha JB, Casati MZ, Nociti Jr FH, Sallum EA. Enamel matrix derivative versus guided tissue regeneration in the presence of nicotine: a histomorphometric study in dogs. J Clin Periodontol. 2006;33:900–7.
Polak D, Wilensky A, Shapira L, Halabi A, Goldstein D, Weiss EI, Houri-Haddad Y. Mouse model of experimental periodontitis induced by Porphyromonas gingivalis/Fusobacterium nucleatum infection: bone loss and host response. J Clin Periodontol. 2009;36:406–10.
Polak D, Wilensky A, Shapira L, Weiss EI, Houri-Haddad Y. Vaccination of mice with Porphyromonas gingivalis or Fusobacterium nucleatum modulates the inflammatory response, but fails to prevent experimental periodontitis. J Clin Periodontol. 2010;37:812–7.
Polimeni G, Albandar JM, Wikesjö UME. Prognostic factors for alveolar regeneration: osteogenic potential of resident bone. J Clin Periodontol. 2004a;31:840–4.
Polimeni G, Koo K-T, Qahash M, Xiropaidis AV, Albandar JM, Wikesjö UME. Prognostic factors for alveolar regeneration: bone formation at teeth and titanium implants. J Clin Periodontol. 2004b;31:927–32.
Polimeni G, Koo K-T, Qahash M, Xiropaidis AV, Albandar JM, Wikesjö UME. Prognostic factors for alveolar regeneration: effect of tissue occlusion on alveolar bone regeneration with guided tissue regeneration. J Clin Periodontol. 2004c;31:730–5.
Polimeni G, Koo K-T, Qahash M, Xiropaidis AV, Albandar JM, Wikesjö UME. Prognostic factors for alveolar regeneration: effect of a space-providing biomaterial on guided tissue regeneration. J Clin Periodontol. 2004d;31:725–9.
Polimeni G, Albandar JM, Wikesjö UME. Prognostic factors for alveolar regeneration: effect of space provision. J Clin Periodontol. 2005;32:951–4.
Polimeni G, Susin C, Wikesjö UME. Regenerative potential and healing dynamics of the periodontium: a critical-size supra-alveolar periodontal defect study. J Clin Periodontol. 2009;36:258–64.
Polimeni G, Xiropaidis AV, Wikesjö UM. Biology and principles of periodontal wound healing/regeneration. Periodontol 2000. 2006;41:30-47.
Pontes Andersen CC, Flyvbjerg A, Buschard K, Holmstrup P. Relationship between periodontitis and diabetes: lessons from rodent studies. J Periodontol. 2007;78:1264–75.
Pouliot M, Clish CB, Petasis NA, Van Dyke TE, Serhan CN. Lipoxin A(4) analogues inhibit leukocyte recruitment to Porphyromonas gingivalis: a role for cyclooxygenase-2 and lipoxins in periodontal disease. Biochemistry. 2000;39:4761–8.
Pound P, Ebrahim S, Sandercock P, Bracken MB, Roberts I, Reviewing Animal Trials Systematically (RATS) Group. Where is the evidence that animal research benefits humans? BMJ. 2004;328(7438):514–7.
Powell CA, Bannister SR, Mackey SA, Maller SC, McDonnell HT, Deas DE. Periodontal wound healing with and without platelet-rich plasma: histologic observations and assessment of flap tensile strength. J Periodontol. 2009;80:985–92.
Rajapakse PS, O’Brien-Simpson NM, Slakeski N, Hoffmann B, Reynolds EC. Immunization with the RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis protects against periodontal bone loss in the rat periodontitis model. Infect Immun. 2002;70:2480–6.
Romanowski AW, Squier CA, Lesch CA. Permeability of rodent junctional epithelium to exogenous protein. J Periodontal Res. 1988;23:81–6.
Ramamurthy NS, Rifkin BR, Greenwald RA, Xu JW, Liu Y, Turner G, Golub LM, Vernillo AT. Inhibition of matrix metalloproteinase-mediated periodontal bone loss in rats: a comparison of 6 chemically modified tetracyclines. J Periodontol. 2002a;73:726–34.
Ramamurthy NS, Xu JW, Bird J, Baxter A, Bhogal R, Wills R, Watson B, Owen D, Wolff M, Greenwald RA. Inhibition of alveolar bone loss by matrix metalloproteinase inhibitors in experimental periodontal disease. J Periodontal Res. 2002b;37:1–7.
Ramamurthy NS, Greenwald RA, Celiker MY, Shi EY. Experimental arthritis in rats induces biomarkers of periodontitis which are ameliorated by gene therapy with tissue inhibitor of matrix metalloproteinases. J Periodontol. 2005;76:229–33.
Reichart PA, Dürr UM, Triadan H, Vickendey G. Periodontal disease in the domestic cat. A histopathologic study. J Periodontal Res. 1984;19:67–75.
Repeke CE, Ferreira Jr SB, Claudino M, Silveira EM, de Assis GF, Avila-Campos MJ, Silva JS, Garlet GP. Evidences of the cooperative role of the chemokines CCL3, CCL4 and CCL5 and its receptors CCR1+ and CCR5+ in RANKL+ cell migration throughout experimental periodontitis in mice. Bone. 2010;46:1122–30.
Reymond F, Cimasoni G. Radiographic measurement of alveolar bone loss in the living rat. J Periodontol. 1997;68:141–4.
Rizzo AA, Mitchell CT. Chronic allergic inflammation induced by repeated deposition of antigen in rabbit gingival pockets. Periodontics. 1966;4:5–10.
Rogers JE, Li F, Coatney DD, Rossa C, Bronson P, Krieder JM, Giannobile WV, Kirkwood KL. Actinobacillus actinomycetemcomitans lipopolysaccharide-mediated experimental bone loss model for aggressive periodontitis. J Periodontol. 2007;78:550–8.
Roriz VM, Souza SL, Taba Jr M, Palioto DB, Grisi MF. Treatment of class III furcation defects with expanded polytetrafluoroethylene membrane associated or not with anorganic bone matrix/synthetic cell-binding peptide: a histologic and histomorphometric study in dogs. J Periodontol. 2006;77:490–7.
Ross BC, Czajkowski L, Vandenberg KL, Camuglia S, Woods J, Agius C, Paolini R, Reynolds E, Barr IG. Characterization of two outer membrane protein antigens of Porphyromonas gingivalis that are protective in a murine lesion model. Oral Microbiol Immunol. 2004;19:6–15.
Ryder MI. Histological and ultrastructural characteristics of the periodontal syndrome in the rice rat. I. General light microscopic observations and ultrastructural observations of initial inflammatory changes. J Periodontal Res. 1980;15:502–15.
Sallum EA, Pimentel SP, Saldanha JB, Nogueira-Filho GR, Casati MZ, Nociti FH, Sallum AW. Enamel matrix derivative and guided tissue regeneration in the treatment of dehiscence-type defects: a histomorphometric study in dogs. J Periodontol. 2004;75(10):1357–63.
Sallay K, Sanavi F, Ring I, Pham P, Behling UH, Nowotny A. Alveolar bone destruction in the immunosuppressed rat. J Periodontal Res. 1982;17(3):263–74.
Saito E, Saito A, Kawanami M. Favorable healing following space creation in rhBMP-2-induced periodontal regeneration of horizontal circumferential defects in dogs with experimental periodontitis. J Periodontol. 2003;74:1808–15.
Sakata J, Abe H, Ohazama A, et al. Effects of combined treatment with porous bovine inorganic bone grafts and bilayer porcine collagen membrane on refractory one-wall intrabony defects. Int J Periodontics Restorative Dent. 2006;26:161–9.
Sasaki H, Hou L, Belani A, Wang CY, Uchiyama T, Müller R, Stashenko P. IL-10, but not IL-4, suppresses infection-stimulated bone resorption in vivo. J Immunol. 2000;165:3626–30.
Sasaki H, Suzuki N, AlShwaimi E, Xu Y, Battaglino R, Morse L, Stashenko P. 18b-Glycyrrhetinic acid inhibits periodontitis via glucocorticoid-independent nuclear factor-jB inactivation in interleukin-10-deficient mice. J Periodontal Res. 2010;45:757–63.
Schenkein HA. Failure of Bacteroides gingivalis W83 to accumulate bound C3 following opsonization with serum. J Periodontal Res. 1989;24:20–7.
Schliephake H, Aleyt J. Mandibular onlay grafting using prefabricated bone grafts with primary implant placement: an experimental study in minipigs. Int J Oral Maxillofac Implants. 1998;13:384–93.
Schmitt JM, Buck DC, Joh SP, Lynch SE, Hollinger JO. Comparison of porous bone mineral and biologically active glass in critical-sized defects. J Periodontol. 1997;68:1043–53.
Schou S, Holmstrup P, Kornman KS. Non-human primates used in studies of periodontal disease pathogenesis: a review of the literature. J Periodontol. 1993;64:497–508.
Schou S, Holmstrup P, Stoltze K, Hjørting-Hansen E, Fiehn NE, Skovgaard LT. Probing around implants and teeth with healthy or inflamed peri-implant mucosa/gingiva. Clin Oral Implants Res. 2002;13:113–26.
Schulz KF, Altman DG, Moher D, The CONSORT Group. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ. 2010;340:c332.
Schwarz F, Herten M, Sager M, Bieling K, Sculean A, Becker J. Comparison of naturally occurring and ligature-induced periimplantitis bone defects in humans and dogs. Clin Oral Implants Res. 2007;18:161–70.
Sculean A, Karring T, Theilade J, Lioubavina N. The regenerative potential of oxytalan fibers: an experimental study in the monkey. J Clin Periodontol. 1997;24:932–6.
Sculean A, Donos N, Reich E, Karring T, Brecx M. Regeneration of oxytalan fibres in different types of periodontal defects: a histological study in monkeys. J Prriodontal Res. 1998;33:453–9.
Sculean A, Donos N, Brecx M, Karring T, Reich E. Healing of fenestration-type defects following treatment with guided tissue regeneration or enamel matrix proteins: an experimental study in monkeys. Clin Oral Investig. 2000a;4:50–6.
Sculean A, Donos N, Brecx M, Reich E, Karring T. Treatment of intrabony defects with guided tissue regeneration and enamel matrix-proteins: an experimental study in monkeys. J Clin Periodontol. 2000b;27:466–72.
Sculean A, Berakdar M, Pahl S, Windisch P, Brecx M, Reich E, Donos N. Patterns of cytokeratin expression in monkey and human periodontium following regenerative and conventional periodontal surgery. J Periodontal Res. 2001;36:260–8.
Sculean A, Nikolidakis D, Schwarz F. Regeneration of periodontal tissues: combinations of barrier membranes and grafting materials – biological foundation and preclinical evidence: a systematic review. J Clin Periodontol. 2008;35(8 Suppl):106–16.
Selvig KA, Wikesjö UM, Bogle GC, Finkelman RD. Impaired early bone formation in periodontal fenestration defects in dogs following application of insulin-like growth factor (II). Basic fibroblast growth factor and transforming growth factor beta 1. J Clin Periodontol. 1994;21:380–5.
Semenoff Segundo A, Semenoff TA, Borges AH, Pedro FL, Sakai VT. Methodological model of chronic stress associated with ligature-induced periodontitis in rats: a radiographic study. Braz Oral Res. 2010;24:455–9.
Serhan CN, Jain A, Marleau S, et al. Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators. J Immunol. 2003;171:6856–65.
Seto H, Toba Y, Takada Y, Kawakami H, Ohba H, Hama H, Horibe M, Nagata T. Milk basic protein increases alveolar bone formation in rat experimental periodontitis. J Periodontal Res. 2007;42:85–9.
Sharma A, Honma K, Evans RT, Hruby DE, Genco RJ. Oral immunization with recombinant Streptococcus gordonii expressing porphyromonas gingivalis FimA domains. Infect Immun. 2001;69:2928–34.
Sharma A, Inagaki S, Honma K, Sfintescu C, Baker PJ, Evans RT. Tannerella forsythia-induced alveolar bone loss in mice involves leucine-rich-repeat BspA protein. J Dent Res. 2005;84:462–7.
Shirakata Y, Oda S, Kinoshita A, Kikuchi S, Tsuchioka H, Ishikawa I. Histocompatible healing of periodontal defects after application of an injectable calcium phosphate bone cement. A preliminary study in dogs. J Periodontol. 2002;73:1043–53.
Shirakata Y, Yoshimoto T, Goto H, Yonamine Y, Kadomatsu H, Miyamoto M, Nakamura T, Hayashi C, Izumi Y. Favorable periodontal healing of 1-wall infrabony defects after application of calcium phosphate cement wall alone or in combination with enamel matrix derivative: a pilot study with canine mandibles. J Periodontol. 2007;78:889–98.
Shoji K, Horiuchi H, Shinoda H. Inhibitory effects of a bisphosphonate (risedronate) on experimental periodontitis in rats. J Periodontal Res. 1995;30:277–84.
Shoji K, Ohtsuka-Isoya M, Shimauchi H, Shinoda H. Effects of lactation on alveolar bone loss in experimental periodontitis. J Periodontol. 2007;78:152–6.
Siegrist B, Kornman KS. The effect of supragingival plaque control on the composition of the subgingival microbial flora in ligature-induced periodontitis in the monkey. J Dent Res. 1982;61:936–41.
Singh G, O’Neal RB, Brennan WA, Strong SL, Horner JA, Van Dyke TE. Surgical treatment of induced periimplantitis in the micro pig: clinical and histological analysis. J Periodontol. 1993;64:984–9.
Sluyter F, Breivik T, Cools A. Manipulations in maternal environment reverse periodontitis in genetically predisposed rats. Clin Diagn Lab Immunol. 2002;9:931–2.
Soames JV, Davies RM. Lymphocyte-macrophage and lymphocyte-lymphocyte associations in early gingivitis in beagle dogs. J Periodontal Res. 1980;15:341–4.
Socransky SS, Hubersak C, Propas D. Induction of periodontal destruction in gnotobiotic rats by a human oral strain of Actinomyces naeslundii. Arch Oral Biol. 1970;15:993–5.
Soletti AC, Gaio EJ, Rosing CK. Effect of neonatal clomipramine in the pathogenesis of ligature-induced periodontitis in Lewis rats. Acta Odontol Scand. 2009;67:94–8.
Song WS, Kim CS, Choi SH, Jhon GJ, Kim HY, Cho KS, Kim CK, Chai JK. The effects of a bioabsorbable barrier membrane containing safflower seed extracts on periodontal healing of 1-wall intrabony defects in beagle dogs. J Periodontol. 2005;76:22–33.
Stavropoulos A, Wikesjö UME. Influence of defect dimensions on periodontal wound healing/regeneration in intrabony defects following implantation of a bovine bone biomaterial and provisions for guided tissue regeneration: an experimental study in the dog. J Clin Periodontol. 2010;37:534–43.
Struillou X, Boutigny H, Soueidan A, Layrolle P. Experimental animal models in periodontology: a review. Open Dent J. 2010;4:37–47.
Suaid FF, Ribeiro FV, Rodrigues TL, Silvério KG, Carvalho MD, Nociti FH Jr, Casati MZ, Sallum EA. Autologous periodontal ligament cells in the treatment of class II furcation defects: a study in dogs. J Clin Periodontol. 2011;38:491–8.
Suzumura Y, Kameyama Y, Mizutani M, Kato M, Kondo K, Mabuchi R. Long junctional epithelium produced by application of bacterial protease in rats. J Periodontal Res. 1989;24:217–21.
Takahashi D, Odajima T, Morita M, Kawanami M, Kato H. Formation and resolution of ankylosis under application of recombinant human bone morphogenetic protein-2 (rhBMP-2) to class III furcation defects in cats. J Periodontal Res. 2005;40:299–305.
Takano M, Nishihara R, Sugano N, Matsumoto K, Yamada Y, Takane M, Fujisaki Y, Ito K. The effect of systemic anti-tumor necrosis factor-alpha treatment on Porphyromonas gingivalis infection in type 2 diabetic mice. Arch Oral Biol. 2010;55:379–84.
Takata T, Matsuura M, Murashima M, Miyauchi M, Nikai H. Periodontitis in the house musk shrew (Suncus murinus): a potential animal model for human periodontal disease. J Periodontol. 1999;70:195–200.
Tal H, Pitaru S, Moses O, Kozlovsky A. Collagen gel and membrane in guided tissue regeneration in periodontal fenestration defects in dogs. J Clin Periodontol. 1996;23:1–6.
Tal H, Artzi Z, Moses O, Nemcovsky C, Kozlovsky A. Guided periodontal regeneration using bilayered collagen membranes and bovine bone mineral in fenestration defects in the canine. Int J Periodontics Restorative Dent. 2005;25:509–18.
Teng YT, Nguyen H, Gao X, Kong YY, Gorczynski RM, Singh B, Ellen RP, Penninger JM. Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection. J Clin Invest. 2000;106(6):R59–67.
Teng YT, Nguyen H, Hassanloo A, Ellen RP, Hozumi N, Gorczynski RM. Periodontal immune responses of human lymphocytes in Actinobacillus actinomycetemcomitans-inoculated NOD/SCID mice engrafted with peripheral blood leukocytes of periodontitis patients. J Periodontal Res. 1999;34(1):54–61.
Teng YT. Mixed periodontal Th1-Th2 cytokine profile in Actinobacillus actinomycetemcomitans-specific osteoprotegerin ligand (or RANK-L)- mediated alveolar bone destruction in vivo. Infect Immun. 2002;70:5269–73.
Teng YT. The role of acquired immunity and periodontal disease progression. Crit Rev Oral Biol Med. 2003;14:237–52.
Teng YT, Hu W. Expression cloning of a periodontitis-associated apoptotic effector, cagE homologue, in Actinobacillus actinomycetemcomitans. Biochem Biophys Res Commun. 2003;303:1086–94.
Teng YT, Zhang X. Apoptotic activity and sub-cellular localization of a T4SS-associated CagE-homologue in Actinobacillus actinomycetemcomitans. Microb Pathog. 2005;38:125–32.
Teng YT, Mahamed D, Singh B. Gamma interferon positively modulates Actinobacillus actinomycetemcomitans-specific RANKL+ CD4+ Th-cell-mediated alveolar bone destruction in vivo. Infect Immun. 2005;73: 3453–61.
Thoma DS, Halg GA, Dard MM, Seibl R, Hammerle CH, Jung RE. Evaluation of a new biodegradable membrane to prevent gingival ingrowth into mandibular bone defects in minipigs. Clin Oral Implants Res. 2009;20:7–16.
Toker H, Ozan F, Ozer H, Ozdemir H, Eren K, Yeler H. A morphometric and histopathologic evaluation of the effects of propolis on alveolar bone loss in experimental periodontitis in rats. J Periodontol. 2008;79(6):1089–94.
Tomita S, Yamamoto S, Shibukawa Y, Kaneko T, Miyakoshi S, Shimono M, Yamada S. Application of 4-META/MMA-TBB resin for fixation of membrane to tooth in guided tissue regeneration in dog. Dent Mater J. 2010;29:690–6.
Tomofuji T, Ekuni D, Yamanaka R, Kusano H, Azuma T, Sanbe T, et al. Chronic administration of lipopolysaccharide and proteases induces periodontal inflammation and hepatic steatosis in rats. J Periodontol. 2007;78: 1999–2006.
Tomofuji T, Sanbe T, Ekuni D, Azuma T, Irie K, Maruyama T, Tamaki N, Yamamoto T. Oxidative damage of rat liver induced by ligature-induced periodontitis and chronic ethanol consumption. Arch Oral Biol. 2008;53:1113–8.
Tomofuji T, Ekuni D, Irie K, Azuma T, Endo Y, Tamaki N, Sanbe T, Murakami J, Yamamoto T, Morita M. Preventive effects of a cocoa-enriched diet on gingival oxidative stress in experimental periodontitis. J Periodontol. 2009a;80:1799–808.
Tomofuji T, Ekuni D, Sanbe T, Azuma T, Tamaki N, Irie K, Maruyama T, Yamamoto T, Watanabe T, Miyauchi M, Takata T. Effects of improvement in periodontal inflammation by toothbrushing on serum lipopolysaccharide concentration and liver injury in rats. Acta Odontol Scand. 2009b;67:1–6.
Tomofuji T, Ekuni D, Sanbe T, et al. Effects of improvement in periodontal inflammation by toothbrushing on serum lipopolysaccharide concentration and liver injury in rats. Acta Odontol Scand. 2009c;67:200–5.
Tomofuji T, Yamamoto T, Tamaki N, Ekuni D, Azuma T, Sanbe T, Irie K, Kasuyama K, Umakoshi M, Murakami J, Kokeguchi S, Morita M. Effects of obesity on gingival oxidative stress in a rat model. J Periodontol. 2009d;80:1324–9.
Tyrrell KL, Citron DM, Jenkins JR, Goldstein EJ. Periodontal bacteria in rabbit mandibular and maxillary abscesses. J Clin Microbiol. 2002;40:1044–7.
Vardar-Sengul S, Buduneli E, Turkoglu O, Buduneli N, Atilla G, Wahlgren J, Sorsa T, Baylas H. The effects of selective COX-2 inhibitor/celecoxib and omega-3 fatty acid on matrix metalloproteinases, TIMP-1, and laminin-5gamma2-chain immunolocalization in experimental periodontitis. J Periodontol. 2008;79: 1934–41.
Vastardis S, Yukna RA, Mayer ET, Atkinson BL. Periodontal regeneration with peptide-enhanced anorganic bone matrix in particulate and putty form in dogs. J Periodontol. 2005;76:1690–6.
Verma RK, Bhattacharyya I, Sevilla A, Lieberman I, Pola S, Nair M, Wallet SM, Aukhil I, Kesavalu L. Virulence of major periodontal pathogens and lack of humoral immune protection in a rat model of periodontal disease. Oral Dis. 2010;16:686–95.
Villaca JH, Novaes Jr AB, Souza SL, Taba Jr M, Molina GO, Carvalho TL. Bioactive glass efficacy in the periodontal healing of intrabony defects in monkeys. Braz Dent J. 2005;16:67–74.
Wang HL, Pappert TD, Castelli WA, Chiego Jr DJ, Shyr Y, Smith BA. The effect of platelet-derived growth factor on the cellular response of the periodontium: an autoradiographic study on dogs. J Periodontol. 1994;65:429–36.
Wang M, Shakhatreh MA, James D, Liang S, Nishiyama S, Yoshimura F, Demuth DR, Hajishengallis G. Fimbrial proteins of porphyromonas gingivalis mediate in vivo virulence and exploit TLR2 and complement receptor 3 to persist in macrophages. J Immunol. 2007a;179:2349–58.
Wang S, Liu Y, Fang D, Shi S. The miniature pig: a useful large animal model for dental and orofacial research. Oral Dis. 2007b;13:530–7.
Watanabe K, Petro BJ, Shlimon AE, Unterman TG. Effect of periodontitis on insulin resistance and the onset of type 2 diabetes mellitus in Zucker diabetic fatty rats. J Periodontol. 2008;79:1208–16.
Watanabe K, Iizuka T, Adeleke A, Pham L, Shlimon AE, Yasin M, Horvath P, Unterman TG. Involvement of toll-like receptor 4 in alveolar bone loss and glucose homeostasis in experimental periodontitis. J Periodontal Res. 2011;46(1):21–30.
Weinberg MA, Bral M. Laboratory animals models in periodontology. J Clin Priodontol. 1999;26:335-40.
Weng D, Hurzeler MB, Quinones CR, Pechstadt B, Mota L, Caffesse RG. Healing patterns in recession defects treated with ePTFE membranes and with free connective tissue grafts: a histologic and histometric study in the beagle dog. J Clin Periodontol. 1998;25:238–45.
Wikesjö UM, Nilvéus R. Periodontal repair in dogs: effect of wound stabilization on healing. J Periodontol. 1990;61:719–24.
Wikesjö UM, Selvig KA. Periodontal wound healing and regeneration. Periodontol 2000. 1999;19:21–39.
Wikesjö UM, Hagen K, Nielsen DD. Periodontal repair in dogs: effect of saliva contamination of the root surface. J Periodontol. 1990;61:559–63.
Wikesjö UM, Selvig KA, Zimmerman G, Nilvéus R. Periodontal repair in dogs: healing in experimentally created chronic periodontal defects. J Periodontol. 1991;62:258–63.
Wikesjo UME, Kean CJC, Zimmerman GJ. Periodontal repair in dogs: supraalveolar defect models for evaluation of safety and efficacy of periodontal reconstructive therapy. J Periodontol. 1994;65:1151–7.
Wikesjö UM, Xiropaidis AV, Thomson RC, Cook AD, Selvig KA, Hardwick WR. Periodontal repair in dogs: rhBMP-2 significantly enhances bone formation under provisions for guided tissue regeneration. J Clin Periodontol. 2003a;30:705–14.
Wikesjö UME, Lim WH, Thomson RC, Hardwick WR. Periodontal repair in dogs: gingival tissue occlusion, a critical requirement for GTR? J Clin Periodontol. 2003b;30:655–64.
Wikesjö UME, Susin C, Qahash M, Polimeni G, Leknes KN, Shanaman RH, Prasad HS, Rohrer MD, Hall J. The critical-size supraalveolar peri-implant defect model: characteristics and use. J Clin Periodontol. 2006;33:846–54.
Wilensky A, Polak D, Awawdi S, Halabi A, Shapira L, Houri-Haddad Y. Strain-dependent activation of the mouse immune response is correlated with Porphyromonas gingivalis-induced experimental periodontitis. J Clin Periodontol. 2009;36:915–21.
Wirthlin MR, Yeager JE, Hancock EB, Gaugler RW. The healing of gingival wounds in miniature swine. J Periodontol. 1980;51:318–27.
Wyss C, Guggenheim B. Effects of the association of conventional rats with Actinomyces viscosus Nyl and Bacteroides gingivalis W83. J Periodontal Res. 1984;19(6):574–7.
Wong DM, Tam V, Lam R, Walsh KA, Tatarczuch L, Pagel CN, Reynolds EC, O’Brien-Simpson NM, Mackie EJ, Pike RN. Protease-activated receptor 2 has pivotal roles in cellular mechanisms involved in experimental periodontitis. Infect Immun. 2010;78:629–38.
Yaffe A, Shoshan S. Re-attachment of periodontal ligament by collagen in experimentally-induced alveolar bone dehiscence in dogs. Arch Oral Biol. 1987;32:69–73.
Yamamoto S, Masuda H, Shibukawa Y, Yamada S. Combination of bovine-derived xenografts and enamel matrix derivative in the treatment of intrabony periodontal defects in dogs. Int J Periodontics Restorative Dent. 2007;27:471–9.
Yamamoto T, Tomofuji T, Tamaki N, Ekuni D, Azuma T, Sanbe T. Effects of topical application of lipopolysaccharide and proteases on hepatic injury induced by high-cholesterol diet in rats. J Periodontal Res. 2010;45:129–35.
Yamanaka A, Yasui K, Sonomura T, Uemura M. Development of heterodont dentition in house shrew (Suncus murinus). Eur J Oral Sci. 2007;115:433–40.
Yamazaki Y. Effects of destructive periodontitis, induced by diet, on the mechanical properties of the periodontal ligament of the mandibular first molar in golden hamsters. J Periodontal Res. 1992;27:149–58.
Yeo YJ, Jeon DW, Kim CS, Choi SH, Cho KS, Lee YK, Kim CK. Effects of chitosan nonwoven membrane on periodontal healing of surgically created one-wall intrabony defects in beagle dogs. J Biomed Mater Res B Appl Biomater. 2005;72:86–93.
Yu JJ, Ruddy MJ, Wong GC, Sfintescu C, Baker PJ, Smith JB, Evans RT, Gaffen SL. An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals. Blood. 2007;109:3794–802.
Yu G, Yu Y, Li YN, Shu R. Effect of periodontitis on susceptibility to atrial fibrillation in an animal model. J Electrocardiol. 2010;43(4):359-66.
Zechner W, Tangl S, Tepper G, et al. Influence of platelet-rich plasma on osseous healing of dental implants: a histologic and histomorphometric study in minipigs. Int J Oral Maxillofac Implants. 2003;18:15–22.
Zhang X, Teng YT. Interleukin-10 inhibits gram-negative-microbe-specific human receptor activator of NF-kappa B ligand-positive CD4+ −Th1-cell-associated alveolar bone loss in vivo. Infect Immun. 2006;74:4927–31.
Zhang MZ, Li CL, Jiang YT, et al. Porphyromonas gingivalis infection accelerates intimal thickening in iliac arteries in a balloon-injured rabbit model. J Periodontol. 2008;79:1192–9.
Zhao M, Jin Q, Berry JE, Nociti Jr FH, Giannobile WV, Somerman MJ. Cementoblast delivery for periodontal tissue engineering. J Periodontol. 2004;75:154–61.
Zhou Q, Desta T, Fenton M, Graves DT, Amar S. Cytokine profiling of macrophages exposed to Porphyromonas gingivalis, its lipopolysaccharide, or its FimA protein. Infect Immun. 2005;73:935–43.
Zubery Y, Dunstan CR, Story BM, Kesavalu L, Ebersole JL, Holt SC, Boyce BF. Bone resorption caused by three periodontal pathogens in vivo in mice is mediated in part by prostaglandin. Infect Immun. 1998;66:4158–62.
Zucker LM. Hereditary obesity in the rat associated with hyperlipemia. Ann N Y Acad Sci. 1965;131:447–58.
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Dumitrescu, A.L. (2012). Animal Models in Periodontal Research. In: Understanding Periodontal Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28923-1_21
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