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Leukotriene-C4 synthase

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Book cover Class 4–6 Lyases, Isomerases, Ligases

Part of the book series: Springer Handbook of Enzymes ((HDBKENZYMES,volume S7))

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References

  1. Sala, A.; Garcia, M.; Zarini, S.; Rossi, J.C.; Folco, G.; Durand, T.: 14,15-dehydroleukotriene A4: a specific substrate for leukotriene C4 synthase. Biochem. J., 328, 225–229 (1997)

    CAS  PubMed  Google Scholar 

  2. Penrose, J.F.: LTC4 synthase: Enzymology, biochemistry, and molecular characterization. Clin. Rev. Allergy Immunol., 17, 133–152 (1999)

    Article  CAS  PubMed  Google Scholar 

  3. Penrose, J.F.; Austen, K.F.: The biochemical, molecular, and genomic aspects of leukotriene C4 synthase. Proc. Assoc. Am. Phys., 111, 537–546 (1999)

    Article  CAS  PubMed  Google Scholar 

  4. Hevko, J.M.; Murphy, R.C.: Formation of murine macrophage-derived 5-oxo-7-glutathionyl-8,11,14-eicosatrienoic acid (FOG7) is catalyzed by leukotriene C4 synthase. J. Biol. Chem., 277, 7037–7043 (2002)

    Article  CAS  PubMed  Google Scholar 

  5. Sjostrom, M.; Jakobsson, P.-J.; Juremalm, M.; Ahmed, A.; Nilsson, G.; Macchia, L.; Haeggstrom, J.Z.: Human mast cells express two leukotriene C4 synthase isoenzymes and the CysLT1 receptor. Biochim. Biophys. Acta, 1583, 53–62 (2002)

    CAS  PubMed  Google Scholar 

  6. Gupta, N.; Gresser, M.J.; Ford-Hutchinson, A.W.: Kinetic mechanism of glutathione conjugation to leukotriene A4 by leukotriene C4 synthase. Biochim. Biophys. Acta, 1391, 157–168 (1998)

    CAS  PubMed  Google Scholar 

  7. Söderström, M.; Hammarström, S.; Mannervik, B.: Leukotriene C synthase in mouse mastocytoma cells. An enzyme distinct from cytosolic and microsomal glutathione transferases. Biochem. J., 250, 713–718 (1988)

    PubMed  Google Scholar 

  8. Christmas, P.; Weber, B.M.; McKee, M.; Brown, D.; Soberman, R.J.: Membrane localization and topology of leukotriene C4 synthase. J. Biol. Chem., 277, 28902–28908 (2002)

    Article  CAS  PubMed  Google Scholar 

  9. Nicholson, D.W.; Ali, A.; Vaillancourt, J.P.; Calaycay, J.R.; Mumford, R.A.; Zamboni, R.J.; Ford-Hutchinson, A.W.: Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits. Proc. Natl. Acad. Sci. USA, 90, 2015–2019 (1993)

    Article  CAS  PubMed  Google Scholar 

  10. Nicholson, D.W.; Ali, A.; Klemba, M.W.; Munday, N.A.; Zamboni, R.J.; Ford-Hutchinson, A.W.: Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells. J. Biol. Chem., 267, 17849–17857 (1992)

    CAS  PubMed  Google Scholar 

  11. Abe, M.; Hugli, T.E.: Characterization of leukotriene C4 synthetase in mouse peritoneal exudate cells. Biochim. Biophys. Acta, 959, 386–398 (1988)

    CAS  PubMed  Google Scholar 

  12. Soederstroem, M.; Morgenstern, R.; Hammarstroem, S.: Protein-protein interaction affinity chromatography of leukotriene C4 synthase. Protein Expr. Purif., 6, 352–356 (1995)

    Article  CAS  Google Scholar 

  13. Izumi, T.; Honda, Z.; Ohishi, N.; Kitamura, S.; Tsuchida, S.; Sato, K.; Shimizu, T.; Seyama, Y.: Solubilization and partial purification of leukotriene C4 synthase from guinea-pig lung: a microsomal enzyme with high specificity towards 5,6-epoxide leukotriene A4. Biochim. Biophys. Acta, 959, 305–315 (1988)

    CAS  PubMed  Google Scholar 

  14. Goppelt-Struebe, M.: Two step purification of human and murine leukotriene C4 synthase. Biochim. Biophys. Acta, 1256, 257–261 (1995)

    PubMed  Google Scholar 

  15. Söderström, M.; Mannervik, B.; Garkov, V.; Hammarström, S.: On the nature of leukotriene C4 synthase in human platelets. Arch. Biochem. Biophys., 294, 70–74 (1992)

    Article  PubMed  Google Scholar 

  16. Lam, B.K.; Frank Austen, K.: Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes. Prostaglandins Other Lipid Mediat., 68–69, 511–520 (2002)

    Article  PubMed  Google Scholar 

  17. Yoshimoto, T.; Soberman, R.J.; Lewis, R.A.; Austen, K.F.: Isolation and characterization of leukotriene C4 synthetase of rat basophilic leukemia cells. Proc. Natl. Acad. Sci. USA, 82, 8399–8403 (1985)

    Article  CAS  PubMed  Google Scholar 

  18. Tornhamre, S.; Sjolinder, M.; Lindberg, A.; Ericsson, I.; Nasman-Glaser, B.; Griffiths, W.J.; Lindgren, J.A.: Demonstration of leukotriene-C4 synthase in platelets and species distribution of the enzyme activity. Eur. J. Biochem., 251, 227–235 (1998)

    Article  CAS  PubMed  Google Scholar 

  19. Wu, C.: Conversion of leukotrienes A4 to C4 in cell-free systems. Biochem. Biophys. Res. Commun., 134, 85–92 (1986)

    Article  CAS  PubMed  Google Scholar 

  20. Penrose, J.F.; Gagnon, L.; Goppelt-Struebe, M.; Myers, P.; Lam, B.K.; Jack, R.M.; Austen, K.F.; Soberman, R.J.: Purification of human leukotriene C4 synthase. Proc. Natl. Acad. Sci. USA, 89, 11603–11606 (1992)

    Article  CAS  PubMed  Google Scholar 

  21. Nicholson, D.W.; Klemba, M.W.; Rasper, D.M.; Metters, K.M.; Zamboni, R.J.: Purification of human leukotriene C4 synthase from dimethylsulfoxide-differentiated U937 cells. Eur. J. Biochem., 209, 725–734 (1992)

    Article  CAS  PubMed  Google Scholar 

  22. Soberman, R.J.; Yoshimoto, T.: Leukotriene C4 synthase from rat basophilic leukemia cell microsomes. Methods Enzymol., 163, 353–357 (1988)

    Article  CAS  PubMed  Google Scholar 

  23. Soberman, R.J.: Purification and properties of leukotriene C4 synthase from guinea pig lung microsomes. Methods Enzymol., 187, 335–337 (1990)

    Article  CAS  PubMed  Google Scholar 

  24. Söderström, M.; Mannervik, B.; Mammarström, S.: Leukotriene C4 synthase: characterization in mouse mastocytoma cells. Methods Enzymol., 187, 306–312 (1990)

    Article  PubMed  Google Scholar 

  25. Lam, B.K.; Penrose, J.F.; Rokach, J.; Xu, K.; Baldasaro, M.H.; Austen, K.F.: Molecular cloning, expression and characterization of mouse leukotriene C4 synthase. Eur. J. Biochem., 238, 606–612 (1996)

    Article  CAS  PubMed  Google Scholar 

  26. Bach, M.K.; Brashler, J.R.; Morton, D.R.: Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase. Arch. Biochem. Biophys., 230, 455–465 (1984)

    Article  CAS  PubMed  Google Scholar 

  27. Petric, R.; Nicholson, D.W.; Ford-Hutchinson, A.W.: Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis. Biochim. Biophys. Acta, 1254, 207–215 (1995)

    PubMed  Google Scholar 

  28. Schroder, O.; Sjostrom, M.; Qiu, H.; Stein, J.; Jakobsson, P.-J.; Haeggstrom, J.Z.: Molecular and catalytic properties of three rat leukotriene C4 synthase homologs. Biochem. Biophys. Res. Commun., 312, 271–276 (2003)

    Article  CAS  PubMed  Google Scholar 

  29. Svartz, J.; Blomgran, R.; Hammarstrom, S.; Soderstrom, M.: Leukotriene C4 synthase homo-oligomers detected in living cells by bioluminescence resonance energy transfer. Biochim. Biophys. Acta, 1633, 90–95 (2003)

    CAS  PubMed  Google Scholar 

  30. Schroder, O.; Sjostrom, M.; Qiu, H.; Jakobsson, P.J.; Haeggstrom, J.Z.: Microsomal glutathione S-transferases: selective up-regulation of leukotriene C4 synthase during lipopolysaccharide-induced pyresis. Cell. Mol. Life Sci., 62, 87–94 (2005)

    Article  CAS  PubMed  Google Scholar 

  31. Yoshikawa, K.; Matsui, E.; Kaneko, H.; Fukao, T.; Inoue, R.; Teramoto, T.; Shinoda, S.; Fukutomi, O.; Aoki, M.; Kasahara, K.; Kondo, N.: A novel single-nucleotide substitution, Glu 4 Lys, in the leukotriene C4 synthase gene associated with allergic diseases. Int. J. Mol. Med., 16, 827–831 (2005)

    CAS  PubMed  Google Scholar 

  32. Zaitsu, M.; Hamasaki, Y.; Matsuo, M.; Ichimaru, T.; Fujita, I.; Ishii, E.: Leukotriene synthesis is increased by transcriptional up-regulation of 5-lipoxygenase, leukotriene A4 hydrolase, and leukotriene C4 synthase in asthmatic children. J. Asthma, 40, 147–154 (2003)

    Article  CAS  PubMed  Google Scholar 

  33. Abe, M.; Shibata, K.; Urata, H.; Sakata, N.; Katsuragi, T.: Induction of leukotriene C4 synthase after the differentiation of rat basophilic leukemia cells with retinoic acid and a low dose of actinomycin D and its suppression with methylprednisolone. J. Cell. Physiol., 196, 154–164 (2003)

    Article  CAS  PubMed  Google Scholar 

  34. Mansour, M.; Tornhamre, S.: Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone. J. Enzyme Inhib. Med. Chem., 19, 431–436 (2004)

    Article  CAS  PubMed  Google Scholar 

  35. Shimada, A.; Satoh, M.; Chiba, Y.; Saitoh, Y.; Kawamura, N.; Keino, H.; Hosokawa, M.; Shimizu, T.: Highly selective localization of leukotriene C4 synthase in hypothalamic and extrahypothalamic vasopressin systems of mouse brain. Neuroscience, 131, 683–689 (2005)

    Article  CAS  PubMed  Google Scholar 

  36. Mandal, A.K.; Skoch, J.; Bacskai, B.J.; Hyman, B.T.; Christmas, P.; Miller, D.; Yamin, T.-t.D.; Xu, S.; Wisniewski, D.; Evans, J.F.; Soberman, R.J.: The membrane organization of leukotriene synthesis. Proc. Natl. Acad. Sci. USA, 101, 6587–6592 (2004)

    Article  CAS  PubMed  Google Scholar 

  37. Lam, B.K.: Leukotriene C4 synthase. Prostaglandins Leukot. Essent. Fatty Acids, 69, 111–116 (2003)

    Article  CAS  Google Scholar 

  38. Schmidt-Krey, I.; Kanaoka, Y.; Mills, D.J.; Irikura, D.; Haase, W.; Lam, B.K.; Austen, K.F.; Kuehlbrandt, W.: Human leukotriene C4 synthase at 4.5.ANG. resolution in projection. Structure, 12, 2009–2014 (2004)

    Article  CAS  PubMed  Google Scholar 

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  1. Bioinformatics & Systems Biology, Technical University Braunschweig, Langer Kamp 19b, 38106, Braunschweig, Germany

    Dietmar Schomburg , Ida Schomburg  & Antje Chang ,  & 

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(2010). Leukotriene-C4 synthase. In: Schomburg, D., Schomburg, I., Chang, A. (eds) Class 4–6 Lyases, Isomerases, Ligases. Springer Handbook of Enzymes, vol S7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85707-5_83

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