Skip to main content

Threonine synthase

  • Chapter
  • 131 Accesses

Part of the book series: Springer Handbook of Enzymes ((HDBKENZYMES,volume S7))

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Flavin, M.; Slaughter, C.: Purification and properties of threonine synthetase of Neurospora. J. Biol. Chem., 235, 1103–1108 (1960)

    CAS  PubMed  Google Scholar 

  2. Skarstedt, M.T.; Greer, S.B.: Threonine synthetase of Bacillus subtilis. The nature of an associated dehydratase activity. J. Biol. Chem., 248, 1032–1044 (1973)

    CAS  PubMed  Google Scholar 

  3. Schildkraut, I.; Greer, S.: Threonine synthetase-catalyzed conversion of phosphohomoserine to α-ketobutyrate in Bacillus subtilis. J. Bacteriol., 115, 777–785 (1973)

    CAS  PubMed  Google Scholar 

  4. Madison, J.T.; Thompson, J.F.: Threonine synthetase from higher plants: stimulation by S-adenosylmethionine and inhibition by cysteine. Biochem. Biophys. Res. Commun., 71, 684–691 (1976)

    Article  CAS  PubMed  Google Scholar 

  5. Thoen, A.; Rognes, S.E.; Aarnes, H.: Biosynthesis of threonine from homoserine in pea seedlings. II. Threonine synthase. Plant Sci. Lett., 13, 113–119 (1978)

    Article  CAS  Google Scholar 

  6. Parsot, C.; Cossart, P.; Saint-Girons, I.; Cohen, G.N.: Nucleotide sequence of thrC and of the transcription termination region of the threonine operon in Escherichia coli K12. Nucleic Acids Res., 11, 7331–7345 (1983)

    Article  CAS  PubMed  Google Scholar 

  7. Giovanelli, J.; Veluthambi, K.; Thompson, G.A.; Mudd, S.H.; Datko, A.H.: Threonine synthase of Lemna paucicostata Hegelm. 6746. Plant Physiol., 76, 285–292 (1984)

    Article  CAS  PubMed  Google Scholar 

  8. Shames, S.L.; Ash, D.E.; Wedler, F.C.; Villafranca, J.J.: Interaction of aspartate and aspartate-derived antimetabolites with the enzymes of the threonine biosynthetic pathway of Escherichia coli. J. Biol. Chem., 259, 15331–15339 (1984)

    CAS  PubMed  Google Scholar 

  9. Parsot, C.: Evolution of biosynthetic pathways: a common ancestor for threonine synthase, threonine dehydratase and d-serine dehydratase. EMBO J., 5, 3013–3019 (1986)

    CAS  PubMed  Google Scholar 

  10. Giovanelli, J.; Mudd, S.H.; Datko, A.H.; Thompson, G.A.: Effects of orthophosphate and adenosine 5′-phosphate on threonine synthase and cystathionine g-synthase of Lemna paucicostata Hegelm. 6746. Plant Physiol., 81, 577–583 (1986)

    Article  CAS  PubMed  Google Scholar 

  11. Parsot, C.: A common origin for enzymes involved in the terminal step of the threonine and tryptophan biosynthetic pathways. Proc. Natl. Acad. Sci. USA, 84, 5207–5210 (1987)

    Article  CAS  PubMed  Google Scholar 

  12. Curien, G.; Dumas, R.; Ravanel, S.; Douce, R.: Characterization of an Arabidopsis thaliana cDNA encoding an S-adenosylmethionine-sensitive threonine synthase. Threonine synthase from higher plants. FEBS Lett., 390, 85–90 (1996)

    Article  CAS  PubMed  Google Scholar 

  13. Malumbres, M.; Mateos, L.M.; Lumbreras, M.A.; Guerrero, C.; Martin, J.F.: Analysis and expression of the thrC gene of Brevibacterium lactofermentum and characterization of the encoded threonine synthase. Appl. Environ. Microbiol., 60, 2209–2219 (1994)

    CAS  PubMed  Google Scholar 

  14. Laber, B.; Maurer, W.; Hanke, C.; Graefe, S.; Ehlert, S.; Messerschmidt, A.; Clausen, T.: Characterization of recombinant Arabidopsis thaliana threonine synthase. Eur. J. Biochem., 263, 212–221 (1999)

    Article  CAS  PubMed  Google Scholar 

  15. Greenberg, J.M.; Thompson, J.F.; Madison, J.T.: Homoserine kinase and threonine synthase in methionine-overproducing soybean tissue cultures. Plant Cell Rep., 7, 477–480 (1988)

    Article  CAS  Google Scholar 

  16. Farrington, G.K.; Kumar, A.; Shames, S.L.; Ewaskiewicz, J.I.; Ash, D.A.; Wedler, F.C.: Threonine synthase of Escherichia coli: inhibition by classical and slow-binding analogues of homoserine phosphate. Arch. Biochem. Biophys., 307, 165–174 (1993)

    Article  CAS  PubMed  Google Scholar 

  17. Laber, B.; Gerbling, K.P.; Harde, C.; Neff, K.H.; Nordhoff, E.; Pohlenz, H.D.: Mechanisms of interaction of Escherichia coli threonine synthase with substrates and inhibitors. Biochemistry, 33, 3413–3423 (1994)

    Article  CAS  PubMed  Google Scholar 

  18. Curien, G.; Job, D.; Douce, R.; Dumas, R.: Allosteric activation of Arabidopsis threonine synthase by S-adenosylmethionine. Biochemistry, 37, 13212–13221 (1998)

    Article  CAS  PubMed  Google Scholar 

  19. Muhitch, M.J.: Effects of expressing E. coli threonine synthase in tobacco (Nicotiana tabacum L.) suspension culture cells on free amino acid levels, aspartate pathway enzyme activities and uptake of aspartate into the cells. Plant Physiol., 150, 16–22 (1997)

    CAS  Google Scholar 

  20. Thomazeau, K.; Curien, G.; Thompson, A.; Dumas, R.; Biou, V.: MAD on threonine synthase: the phasing power of oxidized selenomethionine. Acta Crystallogr. Sect. D, 57, 1337–1340 (2001)

    Article  CAS  Google Scholar 

  21. Curien, G.; Ravanel, S.; Dumas, R.: A kinetic model of the branch-point between the methionine and threonine biosynthesis pathways in Arabidopsis thaliana. Eur. J. Biochem., 270, 4615–4627 (2003)

    Article  CAS  PubMed  Google Scholar 

  22. Garrido-Franco, M.; Ehlert, S.; Messerschmidt, A.; Marinkovic, S.; Huber, R.; Laber, B.; Bourenkov, G.P.; Clausen, T.: Structure and function of threonine synthase from yeast. J. Biol. Chem., 277, 12396–12405 (2002)

    Article  CAS  PubMed  Google Scholar 

  23. Omi, R.; Goto, M.; Miyahara, I.; Mizuguchi, H.; Hayashi, H.; Kagamiyama, H.; Hirotsu, K.: Crystal structures of threonine synthase from Thermus thermophilus HB8: conformational change, substrate recognition, and mechanism. J. Biol. Chem., 278, 46035–46045 (2003)

    Article  CAS  PubMed  Google Scholar 

  24. Thomazeau, K.; Curien, G.; Dumas, R.; Biou, V.: Crystal structure of threonine synthase from Arabidopsis thaliana. Protein Sci., 10, 638–648 (2001)

    Article  CAS  PubMed  Google Scholar 

  25. Lee, M.; Martin, M.N.; Hudson, A.O.; Lee, J.; Muhitch, M.J.; Leustek, T.: Methionine and threonine synthesis are limited by homoserine availability and not the activity of homoserine kinase in Arabidopsis thaliana. Plant J., 41, 685–696 (2005)

    Article  CAS  PubMed  Google Scholar 

  26. Mas-Droux, C.; Biou, V.; Dumas, R.: Allosteric threonine synthase. Reorganization of the pyridoxal phosphate site upon asymmetric activation through S-adenosylmethionine binding to a novel site. J. Biol. Chem., 281, 5188–5196 (2006)

    Article  CAS  PubMed  Google Scholar 

  27. Avraham, T.; Amir, R.: The expression level of threonine synthase and cystathionine-γ-synthase is influenced by the level of both threonine and methionine in Arabidopsis plants. Transgenic Res., 14, 299–311 (2005)

    Article  CAS  PubMed  Google Scholar 

Download references

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

(2010). Threonine synthase. In: Schomburg, D., Schomburg, I., Chang, A. (eds) Class 4–6 Lyases, Isomerases, Ligases. Springer Handbook of Enzymes, vol S7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85707-5_45

Download citation

Publish with us

Policies and ethics