Zusammenfassung
Die Gruppe der Hodgkin Lymphome hat eine lange und für das heutige Verständnis der malignen Lymphome paradigmatische Geschichte. Die in der neuen WHO Klassifikation bestätigten Entitäten und Varianten des klassischen Hodgkin Lymphoms und des nodulären Lymphozyten-prädominanten Hodgkin Lymphoms sind morphologisch, immunhistochemisch, molekulargenetisch und klinisch definiert und von morphologisch ähnlichen Befunden großzelliger und auch EBV-assoziierter Non-Hodgkin Lymphome abzugrenzen. Dieses wichtige und komplizierte Kapitel ist hier umfassend und unter Berücksichtigung neuer pathogenetischer und funktioneller Befunde dargestellt und erlaubt so für Pathologen und Kliniker eine moderne und relevante Diagnostik.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Literatur
Achten R, Verhoef G, Vanuytsel L, De Wolf-Peeters C (2002) Histiocyte-rich, T-cell-rich B-cell lymphoma: a distinct diffuse large B-cell lymphoma subtype showing characteristic morphologic and immunophenotypic features. Histopathology 40:31–45
Agostinelli C, Sabattini E, Gjorret JO, Righi S, Rossi M, Mancini M et al (2010) Characterization of a new monoclonal antibody against PAX5/BASP in 1525 paraffin-embedded human and animal tissue samples. Appl Immunohistochem Mol Morphol 18:561–572
Al-Mansour M, Connors JM, Gascoyne RD, Skinnider B, Savage KJ (2010) Transformation to aggressive lymphoma in nodular lymphocyte-predominant Hodgkin’s lymphoma. J Clin Oncol 28:793–799
Alavaikko MJ, Blanco G, Aine R, Lehtinen T, Fellbaum C, Taskinen PJ et al (1994) Follicular dendritic cells have prognostic relevance in Hodgkin’s disease. Am J Clin Pathol 101:761–767
Anagnostopoulos I, Hansmann ML, Franssila K, Harris M, Harris NL, Jaffe ES et al (2000) European Task Force on Lymphoma project on lymphocyte predominance Hodgkin disease: histologic and immunohistologic analysis of submitted cases reveals 2 types of Hodgkin disease with a nodular growth pattern and abundant lymphocytes. Blood 96:1889–1899
Ansell SM, Lesokhin AM, Borrello I, Halwani A, Scott EC, Gutierrez M et al (2015) PD-1 blockade with nivolumab in relapsed or refractory Hodgkin’s lymphoma. N Engl J Med 372:311–319
Audouin J, Diebold J, Pallesen G Frequent expression of Epstein-Barr virus latent membrane protein-1 in tumour cells of Hodgkin’s disease in HIV-positive patients. J Pathol 167:381–384
Biasoli I, Stamatoullas A, Meignin V, Delmer A, Reman O, Morschhauser F et al (2010) Nodular, lymphocyte-predominant Hodgkin lymphoma: a long-term study and analysis of transformation to diffuse large B-cell lymphoma in a cohort of 164 patients from the Adult Lymphoma Study Group. Cancer 116:631–639
Braeuninger A, Küppers R, Strickler JG, Wacker HH, Rajewsky K, Hansmann ML (1997) Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells. Proc Natl Acad Sci Usa 94:9337–9342
Brauninger A, Spieker T, Willenbrock K, Gaulard P, Wacker HH, Rajewsky K et al (2001) Survival and clonal expansion of mutating „forbidden“ (immunoglobulin receptor-deficient) Epstein-Barr virus-infected B cells in angioimmunoblastic Tcell lymphoma. J Exp Med 194:927–940
Brune V, Tiacci E, Pfeil I, Doring C, Eckerle S, van Noesel CJ et al (2008) Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis. J Exp Med 205:2251–2268
Bryant AJ, Newman JH (2013) Alcohol intolerance associated with Hodgkin lymphoma. CMAJ 185:E353
Cabannes E, Khan G, Aillet F, Jarrett RF, Hay RT (1999) Mutations in the IkBa gene in Hodgkin’s disease suggest a tumour suppressor role for IkBa. Oncogene 18:3063–30670
Döring C, Hansmann ML, Agostinelli C, Piccaluga PP, Facchetti F, Pileri S et al (2014) A novel immunohistochemical classifier to distinguish Hodgkin lymphoma from ALK anaplastic large cell lymphoma. Mod Pathol 27:1345–1354
Dutton A, Reynolds GM, Dawson CW, Young LS, Murray PG (2005) Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin’s lymphoma cells through a mechanism involving Akt kinase and mTOR. J Pathol 205:498–506
Eberle FC, Song JY, Xi L, Raffeld M, Harris NL, Wilson WH et al (2012) Nodal involvement by cutaneous CD30-positive T-cell lymphoma mimicking classical Hodgkin lymphoma. Am J Surg Pathol 36:716–725
Eichenauer DA, Engert A (2014) Antibodies and antibody-drug conjugates in the treatment of Hodgkin lymphoma. Eur J Haematol 93:1–8
Fan Z, Natkunam Y, Bair E, Tibshirani R, Warnke RA (2003) Characterization of variant patterns of nodular lymphocyte predominant hodgkin lymphoma with immunohistologic and clinical correlation. Am J Surg Pathol 27:1346–1356
Federico M, Rudiger T, Bellei M, Nathwani BN, Luminari S, Coiffier B et al (2013) Clinicopathologic characteristics of angioimmunoblastic T-cell lymphoma: analysis of the international peripheral T-cell lymphoma project. J Clin Oncol 31:240–246
Ferry JA, Zukerberg LR, Harris NL (1992) Florid progressive transformation of germinal centers. A syndrome affecting young men, without early progression to nodular lymphocyte predominance Hodgkin’s disease. Am J Surg Pathol 16:252–258
Hansmann ML, Fellbaum C, Hui PK, Moubayed P (1990) Progressive transformation of germinal centers with and without association to Hodgkin’s disease. Am J Clin Pathol 93:219–226
Hansmann ML, Stein H, Dallenbach F, Fellbaum C (1991) Diffuse lymphocyte-predominant Hodgkin’s disease (diffuse paragranuloma). A variant of the B-cell-derived nodular type. Am J Pathol 138:29–36
Hansmann ML, Stein H, Fellbaum C, Hui PK, Parwaresch MR, Lennert K (1989) Nodular paragranuloma can transform into high-grade malignant lymphoma of B type. Hum Pathol 120:1169–1175
Hartmann S, Doring C, Jakobus C, Rengstl B, Newrzela S, Tousseyn T et al (2013) Nodular lymphocyte predominant hodgkin lymphoma and T cell/histiocyte rich large B cell lymphoma – endpoints of a spectrum of one disease? PLoS ONE 8:e78812
Hartmann S, Eichenauer DA, Plutschow A, Mottok A, Bob R, Koch K et al (2013) The prognostic impact of variant histology in nodular lymphocyte-predominant Hodgkin lymphoma: a report from the German Hodgkin Study Group (GHSG). Blood 122:4246–4252
Hartmann S, Jakobus C, Rengstl B, Doring C, Newrzela S, Brodt HR et al (2013) Spindle-shaped CD163+ rosetting macrophages replace CD4+ T-cells in HIV-related classical Hodgkin lymphoma. Mod Pathol 26:648–657
Hartmann S, Martin-Subero JI, Gesk S, Husken J, Giefing M, Nagel I et al (2008) Detection of genomic imbalances in microdissected Hodgkin and Reed-Sternberg cells of classical Hodgkin’s lymphoma by array-based comparative genomic hybridization. Haematologica 93:1318–1326
Hartmann S, Martin-Subero JI, Gesk S, Hüsken J, Giefing M, Nagel I et al (2008) Detection of genomic imbalances in microdissected Hodgkin and Reed-Sternberg cells of classical Hodgkin’s lymphoma by array-based comparative genomic hybridization. Haematologica 93:1318–1326
Hartmann S, Schuhmacher B, Rausch T, Fuller L, Doring C, Weniger M et al (2016) Highly recurrent mutations of SGK1, DUSP2 and JUNB in nodular lymphocyte predominant Hodgkin lymphoma. Leukemia 30:844–853
Hartmann S, Winkelmann R, Metcalf RA, Treetipsatit J, Warnke RA, Natkunam Y et al (2015) Immunoarchitectural patterns of progressive transformation of germinal centers with and without nodular lymphocyte-predominant Hodgkin lymphoma. Hum Pathol 46:1655–1661
Hartmann SD (2015) C, Vucic E, Chan FC, Ennishi D, Tousseyn T, de Wolf-Peeters C, Perner S, Wlodarska I, Steidl C. Gascoyne RD, Hansmann ML (Array comparative genomic hybridization reveals similarities between nodular lymphocyte predominant Hodgkin lymphoma and T cell/histiocyte rich large B cell lymphoma. Br J Haematol 169: 415–422)
Hodgkin T (1832) On some morbid appearances of the absorbent glands and spleen. Med Chir Trans 17:68–114
Hu S, Young KH, Konoplev SN, Medeiros LJ (2012) Follicular T-cell lymphoma: a member of an emerging family of follicular helper T-cell derived T-cell lymphomas. Hum Pathol 43:1789–1798
Huppmann AR, Nicolae A, Slack GW, Pittaluga S, Davies-Hill T, Ferry JA et al. (2014) EBV may be expressed in the LP cells of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) in both children and adults. Am J Surg Pathol 38: 316–324
Jackson H Jr, Parker F Jr (1946) Hodgkin’s disease; clinical diagnosis. N Engl J Med 234:37–41
Jackson H Jr, Parker F Jr (1946) Hodgkin’s disease; treatment and prognosis. N Engl J Med 234:103–110
Joos S, Küpper M, Ohl S, von Bonin F, Mechtersheimer G, Bentz M et al (2000) Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30+ Hodgkin cells. Cancer Res 60:549–552
Joos S, Menz CK, Wrobel G, Siebert R, Gesk S, Ohl S et al (2002) Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2. Blood 99:1381–1387
Jundt F, Anagnostopoulos I, Förster R, Mathas S, Stein H, Dörken B (2001) Activated Notch 1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma. Blood 99:3398–3403
Jungnickel B, Staratschek-Jox A, Bräuninger A, Spieker T, Wolf J, Diehl V et al (2000) Clonal deleterious mutations in the IkBa gene in the malignant cells in Hodgkin’s lymphoma. J Exp Med 191:395–402
Kanzler H, Hansmann ML, Kapp U, Wolf J, Diehl V, Rajewsky K et al (1996) Sternberg cells of a Hodgkin’s lymphoma patient. Molecular single cell analysis demonstrates the derivation of a peripheral blood-derived cell line (L1236) from the Hodgkin, Bd. 87. Reed, , S 3429–3436
Kanzler H, Küppers R, Hansmann ML, Rajewsky K (1996) Hodgkin and Reed-Sternberg cells in Hodgkin’s disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. J Exp Med 184:1495–1505
Kanzler H, Küppers R, Hansmann ML, Rajewsky K (1996) Hodgkin and Reed-Sternberg cells in Hodgkin’s disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. J Exp Med 184:1495–1505
Kanzler H, Kuppers R, Helmes S, Wacker HH, Chott A, Hansmann ML et al (2000) Hodgkin and Reed-Sternberg-like cells in B-cell chronic lymphocytic leukemia represent the outgrowth of single germinal-center B-cell-derived clones: potential precursors of Hodgkin and Reed-Sternberg cells in Hodgkin’s disease. Blood 95:1023–1031
Kreher S, Bouhlel MA, Cauchy P, Lamprecht B, Li S, Grau M et al (2014) Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma. Proc Natl Acad Sci U S A 111:E4513–4522
Küppers R (2003) B cells under influence: transformation of B cells by Epstein-Barr virus. Nat Rev Immunol 3:801–812
Küppers R, Dührsen U, Hansmann ML (2014) Pathogenesis, diagnosis, and treatment of composite lymphomas. Lancet Oncol 15:e435–446
Küppers R, Engert A, Hansmann ML (2012) Hodgkin lymphoma. J Clin Invest 122:3439–3447
Küppers R, Rajewsky K, Zhao M, Simons G, Laumann R, Fischer R et al (1994) Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. Proc Natl Acad Sci Usa 91:10962–10966
Küppers R, Zhao M, Hansmann ML, Rajewsky K (1993) Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. Embo J 12:4955–4967
Lamprecht B, Walter K, Kreher S, Kumar R, Hummel M, Lenze D et al (2010) Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma. Nat Med 16:571–579
Liu Y, Razak AFR, Terpstra M, Chan FC, Saber A, Nijland M et al (2014) The mutational landscape of Hodgkin lymphoma cell lines determined by whole-exome sequencing. Leukemia 28:2248–2251
Lukes RJ, Butler JJ (1966) The pathology and nomenclature of Hodgkin’s disease. Cancer Res 26:1063–1083
Ma Y, Visser L, Roelofsen H, de Vries M, Diepstra A, van Imhoff G et al (2008) Proteomics analysis of Hodgkin lymphoma: identification of new players involved in the cross-talk between HRS cells and infiltrating lymphocytes. Blood 111:2339–2346
Mader A, Bruderlein S, Wegener S, Melzner I, Popov S, Muller-Hermelink HK et al (2007) U-HO1, a new cell line derived from a primary refractory classical Hodgkin lymphoma. Cytogenet Genome Res 119:204–210
Mao Z, Quintanilla-Martinez L, Raffeld M, Richter M, Krugmann J, Burek C et al (2007) IgVH mutational status and clonality analysis of Richter’s transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolution. Am J Surg Pathol 31:1605–1614
Martin-Subero JI, Klapper W, Sotnikova A, Callet-Bauchu E, Harder L, Bastard C et al (2006) Chromosomal breakpoints affecting immunoglobulin loci are recurrent in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma. Cancer Res 66:10332–10338
Mathas S, Hinz M, Anagnostopoulos I, Krappmann D, Lietz A, Jundt F et al (2002) Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B. Embo J 21:4104–4113
Moroch J, Copie-Bergman C, de Leval L, Plonquet A, Martin-Garcia N, Delfau-Larue MH et al (2012) Follicular peripheral T-cell lymphoma expands the spectrum of classical Hodgkin lymphoma mimics. Am J Surg Pathol 36:1636–1646
Mottok A, Renne C, Willenbrock K, Hansmann ML, Brauninger A (2007) Somatic hypermutation of SOCS1 in lymphocyte-predominant Hodgkin lymphoma is accompanied by high JAK2 expression and activation of STAT6. Blood 110:3387–3390
Nagel S, Burek C, Venturini L, Scherr M, Quentmeier H, Meyer C et al (2007) Comprehensive analysis of homeobox genes in Hodgkin lymphoma cell lines identifies dysregulated expression of HOXB9 mediated via ERK5 signaling and BMI1. Blood 109:3015–3023
Nam-Cha SH, Montes-Moreno S, Salcedo MT, Sanjuan J, Garcia JF, Piris MA (2009) Lymphocyte-rich classical Hodgkin’s lymphoma: distinctive tumor and microenvironment markers. Mod Pathol 22:1006–1015
Nam-Cha SH, Roncador G, Sanchez-Verde L, Montes-Moreno S, Acevedo A, Dominguez-Franjo P et al (2008) PD-1, a follicular T-cell marker useful for recognizing nodular lymphocyte-predominant Hodgkin lymphoma. Am J Surg Pathol 32:1252–1257
Nathwani B, Vornanen M, Winkelmann R, Kansal R, Döring C, Hartmann S et al (2013) Intranodular clusters of activated cells with T follicular helper (TFH) phenotype in nodular lymphocyte predominant Hodgkin lymphoma: a pilot study of 32 cases from Finland. Hum Pathol 44:1737–1746
Nicolae A, Pittaluga S, Venkataraman G, Vijnovich-Baron A, Xi L, Raffeld M et al (2013) Peripheral T-cell lymphomas of follicular T-helper cell derivation with Hodgkin/Reed-Sternberg cells of B-cell lineage: both EBV-positive and EBV-negative variants exist. Am J Surg Pathol 37:816–826
Prakash S, Fountaine T, Raffeld M, Jaffe ES, Pittaluga S (2006) IgD positive L&H cells identify a unique subset of nodular lymphocyte predominant Hodgkin lymphoma. Am J Surg Pathol 30:585–592
Quintanilla-Martinez L, Fend F, Moguel LR, Spilove L, Beaty MW, Kingma DW et al (1999) Peripheral T-cell lymphoma with Reed-Sternberg-like cells of B-cell phenotype and genotype associated with Epstein-Barr virus infection. Am J Surg Pathol 23:1233–1240
Reed D (1902) On the pathological changes in Hodgkin’s disease with special reference to its relation to tuberculosis. John Hopkins Hosp Rep 10:133–193
Reichel J, Chadburn A, Rubinstein PG, Giulino-Roth L, Tam W, Liu Y et al (2015) Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells. Blood 125:1061–1072
Rengstl B, Newrzela S, Heinrich T, Weiser C, Thalheimer FB, Schmid F et al (2013) Re-fusion of small mononucleated Hodgkin cells leads to giant multinucleated Reed-Sternberg cells in Hodgkin lymphoma. Proc Natl Acad Sci U S A 110:20729–20734
Renné C, Martin-Subero JI, Hansmann ML, Siebert R (2005) Molecular cytogenetic analyses of immunoglobulin loci in nodular lymphocyte predominant Hodgkin’s lymphoma reveal a recurrent IGH-BCL6 juxtaposition. J Mol Diagn 7:352–356
Renné C, Willenbrock K, Küppers R, Hansmann ML, Bräuninger A (2005) Autocrine- and paracrine-activated receptor tyrosine kinases in classic Hodgkin lymphoma. Blood 105:4051–4059
Roca B, Simon E (1998) Hodgkin’s disease presenting with hypercalcaemia of unknown origin. Ir Med J 91:102
Rudiger T, Ichinohasama R, Ott MM, Muller-Deubert S, Miura I, Ott G et al (2000) Peripheral T-cell lymphoma with distinct perifollicular growth pattern: a distinct subtype of T-cell lymphoma? Am J Surg Pathol 24:117–122
Schaadt M, Diehl V, Stein H, Fonatsch C, Kirchner HH (1980) Two neoplastic cell lines with unique features derived from Hodgkin’s disease. Int J Cancer 26:723–731
Schmid C, Sargent C, Isaacson PG (1991) L and H cells of nodular lymphocyte predominant Hodgkin’s disease show immunoglobulin light-chain restriction. Am J Pathol 139:1281–1289
Schmidt A, Schmitz R, Giefing M, Martin-Subero JI, Gesk S, Vater I et al (2010) Rare occurrence of biallelic CYLD gene mutations in classical Hodgkin lymphoma. Genes Chromosomes Cancer 49:803–809
Schmitz R, Hansmann ML, Bohle V, Martin-Subero JI, Hartmann S, Mechtersheimer G et al. (2009) TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma. J Exp Med 206: 981–989
Schmitz R, Stanelle J, Hansmann ML, Kuppers R (2009) Pathogenesis of classical and lymphocyte-predominant Hodgkin lymphoma. Annu Rev Pathol 4:151–174
Schneider M, Schneider S, Zuhlke-Jenisch R, Klapper W, Sundstrom C, Hartmann S et al (2015) Alterations of the CD58 gene in classical Hodgkin lymphoma. Genes Chromosomes Cancer 54:638–645
Schwering I, Bräuninger A, Klein U, Jungnickel B, Tinguely M, Diehl V et al (2003) Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Blood 101:1505–1512
Slack GW, Ferry JA, Hasserjian RP, Sohani AR, Longtine JA, Harris NL et al (2009) Lymphocyte depleted Hodgkin lymphoma: an evaluation with immunophenotyping and genetic analysis. Leuk Lymphoma 50:937–943
Stanelle J, Doring C, Hansmann ML, Kuppers R (2010) Mechanisms of aberrant GATA3 expression in classical Hodgkin lymphoma and its consequences for the cytokine profile of Hodgkin and Reed/Sternberg cells. Blood 116:4202–4211
Steidl C, Connors JM, Gascoyne RD (2011) Molecular pathogenesis of Hodgkin’s lymphoma: increasing evidence of the importance of the microenvironment. J Clin Oncol 29:1812–1826
Steidl C, Diepstra A, Lee T, Chan FC, Farinha P, Tan K et al (2012) Gene expression profiling of microdissected Hodgkin Reed Sternberg cells correlates with treatment outcome in classical Hodgkin lymphoma. Blood 120:3530–3540
Steidl C, Lee T, Shah SP, Farinha P, Han G, Nayar T et al (2010) Tumor-associated macrophages and survival in classic Hodgkin’s lymphoma. N Engl J Med 362:875–885
Steidl C, Shah SP, Woolcock BW, Rui L, Kawahara M, Farinha P et al (2011) MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers. Nature 471:377–381
Stein H, Mason DY, Gerdes J, O’Connor N, Wainscoat J, Pallesen G et al (1985) The expression of the Hodgkin’s disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood 66:848–858
Sternberg C (1898) Über eine eigenartige unter dem Bilde der Pseudoleukämie verlaufende Tuberkolose des lymphatischen Apparates. Z Heilkd 19:21–90
Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R et al (2016) The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood 127:2375–2390
Swerdlow SH, International Agency for Research on Cancer, World Health Organization (2008) WHO classification of tumours of haematopoietic and lymphoid tissues. 4th edn. International Agency for Research on Cancer: Lyon, France, pp 317–334
Tedoldi S, Mottok A, Ying J, Paterson JC, Cui Y, Facchetti F et al (2007) Selective loss of B-cell phenotype in lymphocyte predominant Hodgkin lymphoma. J Pathol 213:429–440
Thirumala S, Esposito M, Fuchs A (2000) An unusual variant of composite lymphoma: a short case report and review of the literature. Arch Pathol Lab Med 124:1376–1378
Vandenberghe P, Wlodarska I, Tousseyn T, Dehaspe L, Dierickx D, Verheecke M et al (2015) Non-invasive detection of genomic imbalances in Hodgkin/Reed-Sternberg cells in early and advanced stage Hodgkin’s lymphoma by sequencing of circulating cell-free DNA: a technical proof-of-principle study. Lancet Haematol 2:e55–65
von Wasielewski R, Seth S, Franklin J, Fischer R, Hubner K, Hansmann ML et al (2000) Tissue eosinophilia correlates strongly with poor prognosis in nodular sclerosing Hodgkin’s disease, allowing for known prognostic factors. Blood 95:1207–1213
Weniger MA, Melzner I, Menz CK, Wegener S, Bucur AJ, Dorsch K et al (2006) Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation. Oncogene 25:2679–2684
Willenbrock K, Ichinohasama R, Kadin ME, Miura I, Terui T, Meguro K et al (2002) T-cell variant of classical Hodgkin’s lymphoma with nodal and cutaneous manifestations demonstrated by single-cell polymerase chain reaction. Lab Invest 82:1103–1109
Wlodarska I, Nooyen P, Maes B, Martin-Subero JI, Siebert R, Pauwels P et al (2003) Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin lymphoma. Blood 101:706–710
Wood KM, Roff M, Hay RT (1998) Defective IkBa in Hodgkin cell lines with constitutively active NF-kB. Oncogene 16:2131–2139
Wurster KD, Hummel F, Richter J, Giefing M, Hartmann S, Hansmann ML et al (2016) Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma. Leukemia 31:602–613
Xie L, Ushmorov A, Leithauser F, Guan H, Steidl C, Farbinger J et al (2012) FOXO1 is a tumor suppressor in classical Hodgkin lymphoma. Blood 119:3503–3511
Zheng B, Fiumara P, Li YV, Georgakis G, Snell V, Younes M et al (2003) MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival. Blood 102:1019–1027
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature
About this chapter
Cite this chapter
Hartmann, S., Hansmann, ML. (2019). Hodgkin-Lymphome. In: Müller-Hermelink, H., Kreipe, H. (eds) Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85184-4_24
Download citation
DOI: https://doi.org/10.1007/978-3-540-85184-4_24
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-85183-7
Online ISBN: 978-3-540-85184-4
eBook Packages: Medicine (German Language)