-
Proteolytic processing and degradation plays an important role in modulating the generation and bioactivity of neuroendocrine peptide mediators, a class of key molecules in cutaneous biology.
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Accordingly, the cellular localization and expression, and the molecular biology and structural properties of selected intracellular prohormone convertases and ectopically expressed zinc-binding metalloendoproteases are discussed.
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A special reference will be made to the physiologic and pathophysiologic significance of these endopeptidases in cutaneous immunobiology.
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Because of the number of pathologically relevant changes in inflammation and tumor progression that can be directly attributed to neprilysin and angiotensin-converting enzyme, a particular focus will be on the role of these enzymes in modulating innate and adaptive immune responses in the skin.
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Keywords
- Angiotensin Converting Enzyme
- Alopecia Areata
- Dipeptidyl Peptidase
- Neutral Endopeptidase
- Transporter Associate With Antigen Presentation
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Abbreviations
- ACE :
-
Angiotensin-converting enzyme
- ACTH :
-
Adrenocorticotropin
- Ag :
-
Antigen
- Ang :
-
Angiotensin
- BK :
-
Bradykinin
- CGRP :
-
Calcitonin gene-related peptide
- CTCL :
-
Cutaneous T-cell lymphomas
- DC :
-
Dendritic cell(s)
- DPIV :
-
Dipeptidyl peptidase IV
- EAE :
-
Experimental autoimmune encephalomyelitis
- ECE :
-
Endothelin-converting enzyme
- EC :
-
Endothelial cells
- END :
-
Endorphin
- MC x :
-
Melanocortin receptor
- MHC :
-
Major histocompatibility complex
- MSH :
-
Melanocytestimulating hormone
- NEP :
-
Neprilysin
- PACAP :
-
Pituitary adenylate-cyclase-activating polypeptide
- PC :
-
Prohormone convertase
- POMC :
-
Proopiomelanocortin
- SP :
-
Substance P
- TC :
-
T-cell(s)
- T H :
-
helper T-cells
- T eff :
-
Effector T-cells
- VIP :
-
Vasoactive intestinal peptide
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Scholzen, T.E. (2009). The Role of Neuropeptide Endopeptidases in Cutaneous Immunity. In: Granstein, R.D., Luger, T.A. (eds) Neuroimmunology of the Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-35989-0_8
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