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Primary Cutaneous T-Cell Lymphomas: Mycosis Fungoides and Sezary Syndrome

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T-Cell and NK-Cell Lymphomas

Part of the book series: Cancer Treatment and Research ((CTAR,volume 176))

Abstract

Mycosis fungoides and Sézary syndrome are the most common subtypes of all primary cutaneous lymphomas and represent complex diseases that require a multidisciplinary assessment by dermatologists, oncologists, and pathologists. Staging and work-up are critical to guarantee an optimal treatment plan that includes skin-directed and/or systemic regimens depending on the clinical stage, tumor burden, drug-related side effect profile, and patient comorbidities. However, there is no cure and patients frequently relapse, requiring repeated treatment courses for disease control. The study of the tumor microenvironment and molecular mechanisms of these rare neoplasms may assist in the development of new immune therapies providing promising treatment approaches tailored for patients with relapse/refractory disease.

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Author information

Authors and Affiliations

  1. Division of Dermatology, City of Hope, 1500 E. Duarte Road, Duarte, CA, 91010, USA

    Christiane Querfeld

  2. Department of Hematology/Hematopoietic Cell Transplantation, Duarte, USA

    Christiane Querfeld, Jasmine Zain & Steven T. Rosen

  3. Department of Pathology, Duarte, USA

    Christiane Querfeld

  4. Toni Stephenson Lymphoma Center, City of Hope National Medical Center, Duarte, CA, USA

    Christiane Querfeld, Jasmine Zain & Steven T. Rosen

Authors
  1. Christiane Querfeld
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  2. Jasmine Zain
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  3. Steven T. Rosen
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Correspondence to Christiane Querfeld .

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Editors and Affiliations

  1. Division of Dermatology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA

    Christiane Querfeld

  2. Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA

    Jasmine Zain

  3. Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA

    Steven T. Rosen

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Querfeld, C., Zain, J., Rosen, S.T. (2019). Primary Cutaneous T-Cell Lymphomas: Mycosis Fungoides and Sezary Syndrome. In: Querfeld, C., Zain, J., Rosen, S. (eds) T-Cell and NK-Cell Lymphomas. Cancer Treatment and Research, vol 176. Springer, Cham. https://doi.org/10.1007/978-3-319-99716-2_11

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  • DOI: https://doi.org/10.1007/978-3-319-99716-2_11

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