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Ablative Techniques for Painful Metastasis (Radiofrequency ablation, Microwave ablation, Cryoablation, Chemical ablation, and HIFU)

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Essentials of Interventional Cancer Pain Management

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Abstract

Cancer pain remains a common devastating and debilitating problem that negatively impacts cancer patients’ quality of life. Multiple methods have been developed for palliative cancer pain control. In this chapter, the most common ablative techniques that are being implemented for treatment of intractable pain secondary to cancer will be described, and their applications will be elucidated.

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References

  1. Valeberg BT, Miaskowski C, Hanestad BR, Bjordal K, Moum T, Rustoen T. Prevalence rates for and predictors of self-reported adherence of oncology outpatients with analgesic medications. Clin J Pain. 2008;24(7):627–36.

    Article  PubMed  Google Scholar 

  2. Fitzgibbon D. Interventional procedures for cancer pain management: selecting the right procedure at the right time. J Support Oncol. 2010;8(2):60–1.

    PubMed  Google Scholar 

  3. Wu JS, Wong R, Johnston M, Bezjak A, Whelan T. Meta-analysis of dose-fractionation radiotherapy trials for the palliation of painful bone metastases. Int J Radiat Oncol Biol Phys. 2003;55(3):594–605.

    Article  PubMed  Google Scholar 

  4. Patel IJ, Pirasteh A, Passalacqua MA, Robbin MR, Hsu DP, Buethe J, et al. Palliative procedures for the interventional oncologist. AJR Am J Roentgenol. 2013;201(4):726–35.

    Article  PubMed  Google Scholar 

  5. Bhaskar AK. Interventional management of cancer pain. Curr Opin Support Palliat Care. 2012;6(1):1–9.

    Article  PubMed  Google Scholar 

  6. McCullough HK, Bain RM, Clark HP, Requarth JA. The radiologist as a palliative care subspecialist: providing symptom relief when cure is not possible. AJR Am J Roentgenol. 2011;196(2):462–7.

    Article  PubMed  Google Scholar 

  7. Foster RC, Stavas JM. Bone and soft tissue ablation. Semin Interv Radiol. 2014;31(2):167–79.

    Article  Google Scholar 

  8. Thacker PG, Callstrom MR, Curry TB, Mandrekar JN, Atwell TD, Goetz MP, et al. Palliation of painful metastatic disease involving bone with imaging-guided treatment: comparison of patients’ immediate response to radiofrequency ablation and cryoablation. AJR Am J Roentgenol. 2011;197(2):510–5.

    Article  PubMed  Google Scholar 

  9. Requarth J. Image-guided palliative care procedures. Surg Clin North Am. 2011;91(2):367–402. i35

    Article  PubMed  Google Scholar 

  10. Dupuy DE, Liu D, Hartfeil D, Hanna L, Blume JD, Ahrar K, et al. Percutaneous radiofrequency ablation of painful osseous metastases: a multicenter American College of Radiology Imaging Network trial. Cancer. 2010;116(4):989–97.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Bang HJ, Littrup PJ, Currier BP, Goodrich DJ, Aoun HD, Klein LC, et al. Percutaneous cryoablation of metastatic lesions from non-small-cell lung carcinoma: initial survival, local control, and cost observations. J Vasc Interv Radiol. 2012;23(6):761–9.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Nazario J, Hernandez J, Tam AL. Thermal ablation of painful bone metastases. Tech Vasc Interv Radiol. 2011;14(3):150–9.

    Article  PubMed  Google Scholar 

  13. Dupuy DE, Hong R, Oliver B, Goldberg SN. Radiofrequency ablation of spinal tumors: temperature distribution in the spinal canal. AJR Am J Roentgenol. 2000;175(5):1263–6.

    Article  CAS  PubMed  Google Scholar 

  14. Nahum Goldberg S, Dupuy DE. Image-guided radiofrequency tumor ablation: challenges and opportunities--part I. J Vasc Interv Radiol. 2001;12(9):1021–32.

    Article  CAS  PubMed  Google Scholar 

  15. Simon CJ, Dupuy DE. Percutaneous minimally invasive therapies in the treatment of bone tumors: thermal ablation. Semin Musculoskelet Radiol. 2006;10(2):137–44.

    Article  PubMed  Google Scholar 

  16. Dupuy DE, Goldberg SN. Image-guided radiofrequency tumor ablation: challenges and opportunities--part II. J Vasc Interv Radiol. 2001;12(10):1135–48.

    Article  CAS  PubMed  Google Scholar 

  17. Patterson EJ, Scudamore CH, Owen DA, Nagy AG, Buczkowski AK. Radiofrequency ablation of porcine liver in vivo: effects of blood flow and treatment time on lesion size. Ann Surg. 1998;227(4):559–65.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Goldberg SN, Hahn PF, Tanabe KK, Mueller PR, Schima W, Athanasoulis CA, et al. Percutaneous radiofrequency tissue ablation: does perfusion-mediated tissue cooling limit coagulation necrosis? J Vasc Interv Radiol. 1998;9(1 Pt 1):101–11.

    Article  CAS  PubMed  Google Scholar 

  19. Lu DS, Raman SS, Vodopich DJ, Wang M, Sayre J, Lassman C. Effect of vessel size on creation of hepatic radiofrequency lesions in pigs: assessment of the “heat sink” effect. AJR Am J Roentgenol. 2002;178(1):47–51.

    Article  PubMed  Google Scholar 

  20. Rhim H, Goldberg SN, Dodd GD 3rd, Solbiati L, Lim HK, Tonolini M, et al. Essential techniques for successful radio-frequency thermal ablation of malignant hepatic tumors. Radiographics. 2001;21 Spec No:S17–35; discussion S6–9.

    Article  PubMed  Google Scholar 

  21. Goldberg SN, Solbiati L, Halpern EF, Gazelle GS. Variables affecting proper system grounding for radiofrequency ablation in an animal model. J Vasc Interv Radiol. 2000;11(8):1069–75.

    Article  CAS  PubMed  Google Scholar 

  22. Woertler K, Vestring T, Boettner F, Winkelmann W, Heindel W, Lindner N. Osteoid osteoma: CT-guided percutaneous radiofrequency ablation and follow-up in 47 patients. J Vasc Interv Radiol. 2001;12(6):717–22.

    Article  CAS  PubMed  Google Scholar 

  23. Thanos L, Mylona S, Kalioras V, Pomoni M, Batakis N. Palliation of painful perineal metastasis treated with radiofrequency thermal ablation. Cardiovasc Intervent Radiol. 2005;28(3):381–3.

    Article  CAS  PubMed  Google Scholar 

  24. Sanou R, Bazin C, Krakowski I, Boccaccini H, Mathias J, Beot S, et al. Radiofrequency ablation for palliation of soft tissue tumor pain. J Radiol. 2010;91(3 Pt 1):281–6.

    Article  CAS  PubMed  Google Scholar 

  25. Rosenthal DI, Alexander A, Rosenberg AE, Springfield D. Ablation of osteoid osteomas with a percutaneously placed electrode: a new procedure. Radiology. 1992;183(1):29–35.

    Article  CAS  PubMed  Google Scholar 

  26. Goetz MP, Callstrom MR, Charboneau JW, Farrell MA, Maus TP, Welch TJ, et al. Percutaneous image-guided radiofrequency ablation of painful metastases involving bone: a multicenter study. J Clin Oncol Off J Am Soc Clin Oncol. 2004;22(2):300–6.

    Article  Google Scholar 

  27. Guenette JP, Lopez MJ, Kim E, Dupuy DE. Solitary painful osseous metastases: correlation of imaging features with pain palliation after radiofrequency ablation—a multicenter American college of Radiology Imaging Network study. Radiology. 2013;268(3):907–15.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Callstrom MR, Charboneau JW, Goetz MP, Rubin J, Wong GY, Sloan JA, et al. Painful metastases involving bone: feasibility of percutaneous CT- and US-guided radio-frequency ablation. Radiology. 2002;224(1):87–97.

    Article  PubMed  Google Scholar 

  29. Thanos L, Mylona S, Galani P, Tzavoulis D, Kalioras V, Tanteles S, et al. Radiofrequency ablation of osseous metastases for the palliation of pain. Skelet Radiol. 2008;37(3):189–94.

    Article  CAS  Google Scholar 

  30. Carrafiello G, Lagana D, Pellegrino C, Fontana F, Mangini M, Nicotera P, et al. Percutaneous imaging-guided ablation therapies in the treatment of symptomatic bone metastases: preliminary experience. Radiol Med. 2009;114(4):608–25.

    Article  CAS  PubMed  Google Scholar 

  31. Clarencon F, Jean B, Pham HP, Cormier E, Bensimon G, Rose M, et al. Value of percutaneous radiofrequency ablation with or without percutaneous vertebroplasty for pain relief and functional recovery in painful bone metastases. Skelet Radiol. 2013;42(1):25–36.

    Article  Google Scholar 

  32. Pusceddu C, Sotgia B, Fele RM, Melis L. Treatment of bone metastases with microwave thermal ablation. J Vasc Interv Radiol. 2013;24(2):229–35.

    Article  PubMed  Google Scholar 

  33. Kastler A, Alnassan H, Pereira PL, Alemann G, Barbe DA, Aubry S, et al. Analgesic effects of microwave ablation of bone and soft tissue tumors under local anesthesia. Pain Med (Malden Mass). 2013;14(12):1873–81.

    Article  Google Scholar 

  34. Callstrom MR, Atwell TD, Charboneau JW, Farrell MA, Goetz MP, Rubin J, et al. Painful metastases involving bone: percutaneous image-guided cryoablation—prospective trial interim analysis. Radiology. 2006;241(2):572–80.

    Article  PubMed  Google Scholar 

  35. Masala S, Schillaci O, Bartolucci AD, Calabria F, Mammucari M, Simonetti G. Metabolic and clinical assessment of efficacy of cryoablation therapy on skeletal masses by 18F-FDG positron emission tomography/computed tomography (PET/CT) and visual analogue scale (VAS): initial experience. Skelet Radiol. 2011;40(2):159–65.

    Article  Google Scholar 

  36. Callstrom MR, Dupuy DE, Solomon SB, Beres RA, Littrup PJ, Davis KW, et al. Percutaneous image-guided cryoablation of painful metastases involving bone: multicenter trial. Cancer. 2013;119(5):1033–41.

    Article  PubMed  Google Scholar 

  37. Prologo JD, Passalacqua M, Patel I, Bohnert N, Corn DJ. Image-guided cryoablation for the treatment of painful musculoskeletal metastatic disease: a single-center experience. Skelet Radiol. 2014;43(11):1551–9.

    Article  Google Scholar 

  38. Gangi A, Kastler B, Klinkert A, Dietemann JL. Injection of alcohol into bone metastases under CT guidance. J Comput Assist Tomogr. 1994;18(6):932–5.

    Article  CAS  PubMed  Google Scholar 

  39. Catane R, Beck A, Inbar Y, Rabin T, Shabshin N, Hengst S, et al. MR-guided focused ultrasound surgery (MRgFUS) for the palliation of pain in patients with bone metastases--preliminary clinical experience. Ann Oncol. 2007;18(1):163–7.

    Article  CAS  PubMed  Google Scholar 

  40. Liberman B, Gianfelice D, Inbar Y, Beck A, Rabin T, Shabshin N, et al. Pain palliation in patients with bone metastases using MR-guided focused ultrasound surgery: a multicenter study. Ann Surg Oncol. 2009;16(1):140–6.

    Article  PubMed  Google Scholar 

  41. Napoli A, Anzidei M, Marincola BC, Brachetti G, Noce V, Boni F, et al. MR imaging-guided focused ultrasound for treatment of bone metastasis. Radiographics. 2013;33(6):1555–68.

    Article  PubMed  Google Scholar 

  42. Simon CJ, Dupuy DE, Mayo-Smith WW. Microwave ablation: principles and applications. Radiographics. 2005;25(Suppl 1):S69–83.

    Article  PubMed  Google Scholar 

  43. Skinner MG, Iizuka MN, Kolios MC, Sherar MD. A theoretical comparison of energy sources—microwave, ultrasound and laser—for interstitial thermal therapy. Phys Med Biol. 1998;43(12):3535–47.

    Article  CAS  PubMed  Google Scholar 

  44. Yu J, Liang P, Yu X, Liu F, Chen L, Wang Y. A comparison of microwave ablation and bipolar radiofrequency ablation both with an internally cooled probe: results in ex vivo and in vivo porcine livers. Eur J Radiol. 2011;79(1):124–30.

    Article  PubMed  Google Scholar 

  45. Izzo F. Other thermal ablation techniques: microwave and interstitial laser ablation of liver tumors. Ann Surg Oncol. 2003;10(5):491–7.

    Article  PubMed  Google Scholar 

  46. Wright AS, Lee FT Jr, Mahvi DM. Hepatic microwave ablation with multiple antennae results in synergistically larger zones of coagulation necrosis. Ann Surg Oncol. 2003;10(3):275–83.

    Article  PubMed  Google Scholar 

  47. Wright AS, Sampson LA, Warner TF, Mahvi DM, Lee FT Jr. Radiofrequency versus microwave ablation in a hepatic porcine model. Radiology. 2005;236(1):132–9.

    Article  PubMed  Google Scholar 

  48. Brace CL. Microwave tissue ablation: biophysics, technology, and applications. Crit Rev Biomed Eng. 2010;38(1):65–78.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Hoffmann NE, Bischof JC. The cryobiology of cryosurgical injury. Urology. 2002;60(2 Suppl 1):40–9.

    Article  PubMed  Google Scholar 

  50. Rubinsky B. Cryosurgery. Annu Rev Biomed Eng. 2000;2:157–87.

    Article  CAS  PubMed  Google Scholar 

  51. Rubinsky B, Lee CY, Bastacky J, Onik G. The process of freezing and the mechanism of damage during hepatic cryosurgery. Cryobiology. 1990;27(1):85–97.

    Article  CAS  PubMed  Google Scholar 

  52. Silverman SG, Tuncali K, Adams DF, Nawfel RD, Zou KH, Judy PF. CT fluoroscopy-guided abdominal interventions: techniques, results, and radiation exposure. Radiology. 1999;212(3):673–81.

    Article  CAS  PubMed  Google Scholar 

  53. Tacke J, Speetzen R, Heschel I, Hunter DW, Rau G, Gunther RW. Imaging of interstitial cryotherapy--an in vitro comparison of ultrasound, computed tomography, and magnetic resonance imaging. Cryobiology. 1999;38(3):250–9.

    Article  CAS  PubMed  Google Scholar 

  54. Weber SM, Lee FT Jr, Warner TF, Chosy SG, Mahvi DM. Hepatic cryoablation: US monitoring of extent of necrosis in normal pig liver. Radiology. 1998;207(1):73–7.

    Article  CAS  PubMed  Google Scholar 

  55. Farrell MA, Charboneau JW, Callstrom MR, Reading CC, Engen DE, Blute ML. Paranephric water instillation: a technique to prevent bowel injury during percutaneous renal radiofrequency ablation. AJR Am J Roentgenol. 2003;181(5):1315–7.

    Article  CAS  PubMed  Google Scholar 

  56. Rosenthal D, Callstrom MR. Critical review and state of the art in interventional oncology: benign and metastatic disease involving bone. Radiology. 2012;262(3):765–80.

    Article  PubMed  Google Scholar 

  57. Yarmohammadi H, Nakamoto DA, Azar N, Hayek SM, Haaga JR. Percutaneous computed tomography guided cryoablation of the celiac plexus as an alternative treatment for intractable pain caused by pancreatic cancer. J Cancer Res Ther. 2011;7(4):481–3.

    Article  PubMed  Google Scholar 

  58. Fanucci E, Manenti G, Ursone A, Fusco N, Mylonakou I, D’Urso S, et al. Role of interventional radiology in pudendal neuralgia: a description of techniques and review of the literature. Radiol Med. 2009;114(3):425–36.

    Article  CAS  PubMed  Google Scholar 

  59. Xiao YY, Tian JL, Li JK, Yang L, Zhang JS. CT-guided percutaneous chemical ablation of adrenal neoplasms. AJR Am J Roentgenol. 2008;190(1):105–10.

    Article  PubMed  Google Scholar 

  60. Fry WJ, Barnard JW, Fry FJ, Brennan JF. Ultrasonically produced localized selective lesions in the central nervous system. Am J Phys Med. 1955;34(3):413–23.

    CAS  PubMed  Google Scholar 

  61. Stewart EA, Rabinovici J, Tempany CM, Inbar Y, Regan L, Gostout B, et al. Clinical outcomes of focused ultrasound surgery for the treatment of uterine fibroids. Fertil Steril. 2006;85(1):22–9.

    Article  PubMed  Google Scholar 

  62. Gianfelice D, Khiat A, Boulanger Y, Amara M, Belblidia A. Feasibility of magnetic resonance imaging-guided focused ultrasound surgery as an adjunct to tamoxifen therapy in high-risk surgical patients with breast carcinoma. J Vasc Interv Radiol. 2003;14(10):1275–82.

    Article  PubMed  Google Scholar 

  63. Chen W, Zhu H, Zhang L, Li K, Su H, Jin C, et al. Primary bone malignancy: effective treatment with high-intensity focused ultrasound ablation. Radiology. 2010;255(3):967–78.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Hooman Yarmohammadi

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  1. Hooman Yarmohammadi
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Correspondence to Hooman Yarmohammadi .

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Editors and Affiliations

  1. Department of Anesthesiology and Critical Care, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Amitabh Gulati

  2. Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Vinay Puttanniah

  3. Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA

    Brian M. Bruel

  4. Midwest Neuroscience Institute, Center for the Relief of Pain, Kansas City, MO, USA

    William S. Rosenberg

  5. Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Joseph C. Hung

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Yarmohammadi, H. (2019). Ablative Techniques for Painful Metastasis (Radiofrequency ablation, Microwave ablation, Cryoablation, Chemical ablation, and HIFU). In: Gulati, A., Puttanniah, V., Bruel, B., Rosenberg, W., Hung, J. (eds) Essentials of Interventional Cancer Pain Management. Springer, Cham. https://doi.org/10.1007/978-3-319-99684-4_35

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  • DOI: https://doi.org/10.1007/978-3-319-99684-4_35

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