Skip to main content
SpringerLink
Log in

Genitourinary Cancer Pain Syndromes

  • Chapter
  • First Online:
Essentials of Interventional Cancer Pain Management

  • 1559 Accesses

Abstract

Genitourinary and gynecological malignancies include bladder, prostate, renal cell, uterine, ovarian, cervical, and testicular cancers. These all present differently and symptoms vary among patients. It is estimated that at least 70% of patients have pain syndromes associated with their pathology [Office for National Statistics Cancer statistics registrations: registrations of cancer diagnosed in 2002 England, Series MB1 no. 33. Office for National Statistics, London, 2005]. While pain may be the result of the disease process itself, it may also be the consequence of therapies used when treating malignancies. Furthermore, patients may have pain from sites primarily involved or from distant metastases. The following chapter discusses potential pain syndromes a cancer patient may face and how techniques and paradigms in pain management strategies can improve the patient’s pain symptoms.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Office for National Statistics Cancer statistics registrations: registrations of cancer diagnosed in 2002 England. Series MB1 no. 33. London: Office for National Statistics, 2005.

    Google Scholar 

  2. Siegel R, et al. Cancer statistics, 2014. CA Cancer J Clin. 2014;64(1):9–29.

    Article  Google Scholar 

  3. Ali M, et al. Anatomy of the pelvic plexus and innervation of the prostate gland. Clin Anat. 2004;17(2):123–9.

    Article  CAS  Google Scholar 

  4. Eman A, Serbülent G, Gürcü ME. Pain management in prostate cancer. Open J Urol. 2012;2(3):164.

    Article  Google Scholar 

  5. Bader P, et al. Prostate cancer pain management: EAU guidelines on pain management. World J Urol. 2012;30(5):677–86.

    Article  Google Scholar 

  6. Autio KA, et al. Prevalence of pain and analgesic use in men with metastatic prostate cancer using a patient-reported outcome measure. J Oncol Pract. 2013;9(5):223–9.

    Article  Google Scholar 

  7. Khosla A, Adeyefa O, Nasir S. Successful treatment of radiation-induced proctitis pain by blockade of the ganglion impar in an elderly patient with prostate cancer: a case report. Pain Med. 2013;14:662–6. https://doi.org/10.1111/pme.12065.

    Article  PubMed  Google Scholar 

  8. Gulati A, Khelemsky Y, Loh J, Puttanniah V, Malhotra V, Cubert K. The use of lumbar sympathetic blockade at L4 for management of malignancy-related bladder spasms. Pain Physician. 2011;14(3):305–10.

    PubMed  Google Scholar 

  9. Portenoy RK, et al. Pain in ovarian cancer patients. Prevalence, characteristics, and associated symptoms. Cancer. 1994;74(3):907–15.

    Article  CAS  Google Scholar 

  10. Noronha AF, Mello de Figueiredo E, Rossi de Figueiredo Franco TM, Cândido EB, Silva-Filho AL. Treatments for invasive carcinoma of the cervix: what are their impacts on the pelvic floor functions? Int Braz J Urol. 2013;39(1):46–54.

    Article  Google Scholar 

  11. Coleman RE. Metastatic bone disease: clinical features, pathophysiology and treatment strategies. Cancer Treat Rev. 2001;27(3):165–76.

    Article  CAS  Google Scholar 

  12. Serafini AN. Therapy of metastatic bone pain. J Nucl Med. 2001;42(6):895–906.

    CAS  PubMed  Google Scholar 

  13. Buga S, Sarria JE. The management of pain in metastatic bone disease. Cancer Control. 2012;19(2):154–66.

    Article  CAS  Google Scholar 

  14. Birthi P, Sloan P. Interventional treatment of refractory cancer pain. Cancer J. 2013;19(5):390–6.

    Article  CAS  Google Scholar 

  15. Hutson N, Hung JC, Puttanniah V, Lis E, Laufer I, Gulati A. Interventional pain management for sacroiliac tumors in the oncologic population: a case series and paradigm approach. Pain Med. 2017;18(5):959–68.

    PubMed  Google Scholar 

  16. Brejt N, et al. Pelvic radiculopathies, lumbosacral plexopathies, and neuropathies in oncologic disease: a multidisciplinary approach to a diagnostic challenge. Cancer Imaging. 2013;13(4):591.

    Article  Google Scholar 

  17. Amr YM, Makharita MY. Neurolytic sympathectomy in the management of cancer pain – time effect: a prospective, randomized multicenter study. J Pain Symptom Manag. 2014;48(5):944–56.

    Article  Google Scholar 

  18. Woo JH, Park HS, Kim SC, Kim YH. The effect of lumbar sympathetic ganglion block on gynecologic cancer-related lymphedema. Pain Physician. 2013;16(4):345–52.

    PubMed  Google Scholar 

  19. de Oliveira R, dos Reis MP, Prado WA. The effects of early or late neurolytic sympathetic plexus block on the management of abdominal or pelvic cancer pain. Pain. 2004;110(1):400–8.

    Article  Google Scholar 

  20. Ahmed DG, Mohamad MF, Mohamed SA-E. Superior hypogastric plexus combined with ganglion impar neurolytic blocks for pelvic and/or perineal cancer pain relief. Pain Physician. 2015;18(1):E49–56.

    PubMed  Google Scholar 

  21. Stogicza A, et al. Inferior hypogastric plexus block affects sacral nerves and the superior hypogastric plexus. ISRN Anesthesiology. 2012;2012:1–5.

    Article  Google Scholar 

  22. Saito T, Den S, Tanuma K, Tanuma Y, Carney E, Carlsson C. Anatomical bases for paravertebral anesthetic block: fluid communication between the thoracic and lumbar paravertebral regions. Surg Radiol Anat. 1999;21(6):359–63.

    Article  CAS  Google Scholar 

  23. Mishra S, Bhatnagar S, Rana SP, Khurana D, Thulkar S. Efficacy of the anterior ultrasound-guided superior hypogastric plexus neurolysis in pelvic cancer pain in advanced gynecological cancer patients. Pain Med. 2013;14(6):837–42.

    Article  Google Scholar 

  24. Eker HE, Cok OY, Kocum A, Acil M, Turkoz A. Transsacrococcygeal approach to ganglion impar for pelvic cancer pain: a report of 3 cases. Reg Anesth Pain Med. 2008;33(4):381–2.

    PubMed  Google Scholar 

  25. Elahi, et al. Pudendal entrapment neuropathy: a rare complication of pelvic radiation therapy. Pain Physician. 2013;16:E793–7.

    PubMed  Google Scholar 

  26. Prologo JD, et al. Percutaneous CT-guided cryoablation for the treatment of refractory pudendal neurologia. Skelet Radiol. 2015;44:709–14.

    Article  Google Scholar 

  27. Candido K, Stevens RA. Intrathecal neurolytic blocks for the relief of cancer pain. Best Pract Res Clin Anaesthesiol. 2003;17(3):407–28. Becker R, Sure U, Bertalanffy H. Punctate midline myelotomy a new approach in the management of visceral pain. Acta Neurochir 1999;141(8): 881–883.

    Google Scholar 

  28. Becker R1, Gatscher S, Sure U, Bertalanffy H. The punctate midline myelotomy concept for visceral cancer pain control-case report and review of the literature. Acta Neurochir Suppl. 2002;79:77–8.

    Google Scholar 

  29. Nauta HJW, et al. Punctate midline myelotomy for the relief of visceral cancer pain. J Neurosurg Spine. 2000;92(2):125–30.

    Article  CAS  Google Scholar 

  30. Flagg II, Artemus, McGreevy K, Williams K. Spinal cord stimulation in the treatment of cancer-related pain:“back to the origins”. Curr Pain Headache Rep. 2012;16(4):343–9.

    Article  Google Scholar 

  31. Cameron T. Safety and efficacy of spinal cord stimulation for the treatment of chronic pain: a 20-year literature review. J Neurosurg Spine. 2004;100(3):254–67.

    Article  Google Scholar 

  32. Baranidharan G, Simpson KH, Dhandapani K. Spinal cord stimulation for visceral pain – a novel approach. Neuromodulation. 2014;17(8):753–8.

    Article  Google Scholar 

  33. Deer TR, et al. Comprehensive consensus based guidelines on intrathecal drug delivery systems in the treatment of pain caused by cancer pain. Pain Physician. 2011;14(3):E283–312.

    PubMed  Google Scholar 

  34. Bruel BM, Burton AW. Intrathecal therapy for cancer-related pain. Pain Med. 2016;17(12):2404–21.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Anesthesiology, New York-Presbyterian Hospital/Weill Cornell Medicine, New York, NY, USA

    Ilan Margulis

  2. Department of Anesthesiology and Critical Care, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Amitabh Gulati

Authors
  1. Ilan Margulis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Amitabh Gulati
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Anesthesiology and Critical Care, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Amitabh Gulati

  2. Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Vinay Puttanniah

  3. Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA

    Brian M. Bruel

  4. Midwest Neuroscience Institute, Center for the Relief of Pain, Kansas City, MO, USA

    William S. Rosenberg

  5. Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Joseph C. Hung

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Margulis, I., Gulati, A. (2019). Genitourinary Cancer Pain Syndromes. In: Gulati, A., Puttanniah, V., Bruel, B., Rosenberg, W., Hung, J. (eds) Essentials of Interventional Cancer Pain Management. Springer, Cham. https://doi.org/10.1007/978-3-319-99684-4_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-99684-4_12

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-99682-0

  • Online ISBN: 978-3-319-99684-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation