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Modeling Synaptic Plasticity in Hippocampus: A Calcium-Based Approach

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Hippocampal Microcircuits

Part of the book series: Springer Series in Computational Neuroscience ((NEUROSCI))

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Abstract

Multiple stimulation protocols using firing rate and spike-timing correlations have been found to be effective in changing synaptic efficacy by inducing long-term potentiation or depression. In many of those protocols, increases in postsynaptic calcium concentration have been shown to play a crucial role. To which extent the plasticity outcome can be explained by the dynamics of the postsynaptic calcium alone remains unclear. Here, we discuss a minimal calcium-based model of a synapse in which potentiation and depression mechanisms are triggered by calcium. We illustrate that this model gives rise to a large diversity of spike timing-dependent plasticity curves, most of which have been observed experimentally in different systems. It accounts quantitatively for plasticity outcomes evoked by protocols involving patterns with variable spike timing and firing rate in hippocampus and neocortex. Furthermore, we use the model to predict memory decay times and plasticity in the presence of uncorrelated Poisson firing. The calcium model provides a mechanistic understanding of how various stimulation protocols provoke specific synaptic changes through the dynamics of calcium concentration and thresholds implementing in simplified fashion protein signaling cascades, leading to long-term potentiation and long-term depression.

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Authors and Affiliations

  1. Laboratoire de Physiologie Cérébrale – UMR 8118, CNRS, Université Paris Descartes, Paris Cedex 06, France

    Michael Graupner

  2. Departments of Neurobiology and Physics, Duke University, Durham, NC, USA

    Nicolas Brunel

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  1. Michael Graupner
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  2. Nicolas Brunel
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Correspondence to Michael Graupner .

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Editors and Affiliations

  1. School of Computer Science, University of Lincoln, Lincoln, UK

    Vassilis Cutsuridis

  2. School of Natural Sciences, Department of Computing Science and Mathematics, University of Stirling, Stirling, UK

    Bruce P. Graham

  3. Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK

    Stuart Cobb

  4. Institute for Integrative Neuroanatomy, Charité – Universitätsmedizin Berlin, Berlin, Germany

    Imre Vida

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Graupner, M., Brunel, N. (2018). Modeling Synaptic Plasticity in Hippocampus: A Calcium-Based Approach. In: Cutsuridis, V., Graham, B., Cobb, S., Vida, I. (eds) Hippocampal Microcircuits. Springer Series in Computational Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-319-99103-0_17

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