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Utilisation of Tetraphenylethene-Derived Probes with Aggregation-Induced Emission Properties in Fluorescence Detection of Biothiols

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Principles and Applications of Aggregation-Induced Emission

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Abstract

Thiol-containing biomolecules (biothiols), including cysteine (Cys), homocysteine (Hcy), glutathione (GSH) and hydrogen sulphide (H2S), have crucial implications in human physiology and pathophysiology. They can be qualitatively and quantitatively analysed in the tissues of interest using sensitive and specific fluorescent probes, which may in turn reflect alternations in cellular activities and disease manifestations. In this regard, probes with aggregation-induced emission (AIE) properties are preferential owing to their enhanced emission in the aqueous environment present in biological systems. In this chapter, we review the recent progress in biothiol-specific probes that are derived from the well-documented tetraphenylethene (TPE) scaffold. In particular, we highlight their underlying reaction mechanisms with the target biothiol(s) and their applications in cell imaging where available.

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Authors and Affiliations

  1. Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia

    Mengjie Liu & Yuning Hong

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  1. Mengjie Liu
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  2. Yuning Hong
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Correspondence to Yuning Hong .

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Editors and Affiliations

  1. Institute for NanoScale Science and Technology, College of Science and Engineering, Flinders University, Adelaide, SA, Australia

    Youhong Tang

  2. State Key Laboratory of Luminescent Materials and Devices, Center for Aggregation-Induced Emission, South China University of Technology, Guangzhou, China

    Ben Zhong Tang

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Liu, M., Hong, Y. (2019). Utilisation of Tetraphenylethene-Derived Probes with Aggregation-Induced Emission Properties in Fluorescence Detection of Biothiols. In: Tang, Y., Tang, B. (eds) Principles and Applications of Aggregation-Induced Emission. Springer, Cham. https://doi.org/10.1007/978-3-319-99037-8_16

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