Abstract
Primary central nervous system lymphomas (PCNLs) and histiocytic tumors are neoplasms that correspond to their nodal or systemic counterparts but lack an apparent systemic manifestation at presentation. The most common “typical” types include diffuse large B cell lymphoma and Langerhans cell histiocytosis, respectively, being the many other subtypes considerably rarer in the CNS. Given the usually deep-seated nature of these tumors and the fact that PCNSL is not considered a surgical disease, surgery is often restricted to stereotactic biopsy. Because misdiagnosis of lymphoma is one of the most common errors in frozen section evaluation, smears are recommended for the intraoperative procedure. In this chapter, the cytomorphologic features and differential diagnosis of lymphomas and histiocytic tumors arising in the CNS are discussed.
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Lacruz, C.R., Saénz de Santamaría, J., Bardales, R.H. (2018). Lymphomas and Histiocytic Tumors. In: Central Nervous System Intraoperative Cytopathology. Essentials in Cytopathology, vol 13. Springer, Cham. https://doi.org/10.1007/978-3-319-98491-9_16
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DOI: https://doi.org/10.1007/978-3-319-98491-9_16
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