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Pulmonary Matrikines: Origin, Function, and Contribution to Fibrotic and Non-fibrotic Lung Disease

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Fibrosis in Disease

Part of the book series: Molecular and Translational Medicine ((MOLEMED))

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Abstract

The extracellular matrix (ECM) of the lung is an acellular compartment that maintains organ structure and regulates the behavior of cells. Once thought to be a static structure, the lung ECM is now recognized to be highly dynamic, undergoing frequent degradation and resynthesis of its core components. However, excessive degradation of the ECM can have disastrous consequences, not only compromising organ structure but also leading to the release of potent bioactive substances called matrikines, which can impart deleterious effects on tissues. Although the field of lung matrikine biology is still in its infancy, a growing body of evidence supports the concept that these biological factors control a wide range of pathological processes, including many of those that contribute to the onset and progression of respiratory disorders like pulmonary fibrosis and chronic obstructive pulmonary disease. In this chapter, we will discuss the major matrikines identified in the mouse and human lung. We will also review the mechanisms leading to their production, discuss their putative role in the pathobiology of several respiratory disorders, and propose how targeting these molecules could be used in treating these diseases.

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Authors and Affiliations

  1. Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, USA

    Gautam George & Ross Summer

  2. Division of Pulmonary, Allergy and Critical Care Medicine, Jane and Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, PA, USA

    Gautam George & Ross Summer

  3. Department of Pathology, Thomas Jefferson University, Philadelphia, PA, USA

    Janice Walker

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  1. Gautam George
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  2. Janice Walker
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  3. Ross Summer
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Correspondence to Ross Summer .

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Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Krannert Institute of Cardiology, Indiana University School of Medicine, Indiana Center for Musculoskeletal Health, Indianapolis, IN, USA

    Monte S. Willis

  2. Department of Health Promotion and Development, McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Nursing, Pittsburgh, PA, USA

    Cecelia C. Yates

  3. Department of Pharmacology and Department of Pathology and Lab Medicine, McAllister Heart Institute, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Jonathan C. Schisler

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George, G., Walker, J., Summer, R. (2019). Pulmonary Matrikines: Origin, Function, and Contribution to Fibrotic and Non-fibrotic Lung Disease. In: Willis, M., Yates, C., Schisler, J. (eds) Fibrosis in Disease . Molecular and Translational Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-98143-7_5

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  • DOI: https://doi.org/10.1007/978-3-319-98143-7_5

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