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Using Peptidomics to Identify Extracellular Matrix-Derived Peptides as Novel Therapeutics for Cardiac Disease

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Fibrosis in Disease

Part of the book series: Molecular and Translational Medicine ((MOLEMED))

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Abstract

Peptidomics involves the analysis of endogenous peptides from biological samples; this analysis can be used both to catalog peptides present at a time point and to compare peptide levels across samples. During cardiac injury, there is extensive extracellular matrix (ECM) protein turnover as ECM is degraded to clear damaged/necrotic cells and de novo ECM is synthesized during myocardial regeneration and remodeling. These processes generate numerous endogenous peptides that are often biologically active and can be used as biomarkers, cellular modulators, and even as tools to assess response to therapy. The analysis of the cardiac or systemic ECM peptidome is important for a complete understanding of myocardial remodeling and is an exciting avenue to identify novel mechanisms to limit adverse cardiac remodeling and progression to heart failure.

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Acknowledgments

This work was supported by the American Heart Association 14SDG18860050; by the National Institute of Health HL075360, HL129823, HL051971, GM114833, GM115428, and GM104357; and by the Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development Award 5I01BX000505.

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Authors and Affiliations

  1. Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USA

    Lisandra E. de Castro Brás

  2. Mississippi Center for Heart Research, Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA

    Merry L. Lindsey

  3. Research Service, G.V. (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, MS, USA

    Merry L. Lindsey

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  1. Lisandra E. de Castro Brás
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  2. Merry L. Lindsey
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Correspondence to Lisandra E. de Castro Brás .

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Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Krannert Institute of Cardiology, Indiana University School of Medicine, Indiana Center for Musculoskeletal Health, Indianapolis, IN, USA

    Monte S. Willis

  2. Department of Health Promotion and Development, McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Nursing, Pittsburgh, PA, USA

    Cecelia C. Yates

  3. Department of Pharmacology and Department of Pathology and Lab Medicine, McAllister Heart Institute, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Jonathan C. Schisler

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de Castro Brás, L.E., Lindsey, M.L. (2019). Using Peptidomics to Identify Extracellular Matrix-Derived Peptides as Novel Therapeutics for Cardiac Disease. In: Willis, M., Yates, C., Schisler, J. (eds) Fibrosis in Disease . Molecular and Translational Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-98143-7_13

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  • DOI: https://doi.org/10.1007/978-3-319-98143-7_13

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