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Cerebrospinal Fluid Disorders pp 31–45Cite as

Iron and Hydrocephalus

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Abstract

The role of iron in hemorrhagic injury and the development of hydrocephalus is a hot topic in current stroke research. It is clear that iron overload is directly related to hydrocephalus, and efforts to specifically address iron in animal models and in in vitro experiments have been met with some success. Due to its ability to engage in dangerous Fenton reactions with oxygenated species like hydrogen peroxide, iron can create free radicals and reactive oxygen species capable of causing significant damage to the brain. The mechanism by which these reactions influence hydrocephalus is less well understood. Current hypotheses implicate damage to the ependymal surface and possibly motile cilia in the dysfunction of CSF dynamics. However, additional pathways may exist. Identifying mechanisms of iron-mediated ventriculomegaly is an important goal of hydrocephalus research and is one that holds significant promise with respect to our ability to improve treatment for patients suffering from hydrocephalus.

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Authors and Affiliations

  1. University of Michigan, Department of Neurosurgery, Ann Arbor, MI, USA

    Thomas Garton

  2. Washington Univeristy in St. Louis, Department of Neurosurgery, St. Louis, MO, USA

    Jennifer M. Strahle

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Correspondence to Jennifer M. Strahle .

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  1. Department of Neurological Surgery, Washington University School of Medicine, St. Louis Children’s Hospital, St. Louis, MO, USA

    David D. Limbrick Jr.

  2. Nationwide Children’s Hospital, Department of Neurosurgery, The Ohio State University College of Medicine, Columbus, OH, USA

    Jeffrey R. Leonard

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Garton, T., Strahle, J.M. (2019). Iron and Hydrocephalus. In: Limbrick Jr., D., Leonard, J. (eds) Cerebrospinal Fluid Disorders . Springer, Cham. https://doi.org/10.1007/978-3-319-97928-1_2

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