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Biologic Solutions for Articular Cartilage Healing

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Intraarticular Fractures

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Abstract

Post-traumatic articular defects are debilitating conditions. The biomechanical, metabolic, and biological changes due to injury accelerate the wear of articular cartilage, eventually leading to osteoarthritis (OA).

Treatment goals of articular fractures involve accurate fragment reduction and stable fixation, in order to restore native anatomy. However, direct mechanical injury to articular cartilage and the injury-related inflammatory response, as well as concurrent joint injuries, frequently lead to progressive degeneration of the articular surface and ultimately OA.

Proper intra-articular fracture treatment should consider all factors, which may contribute to the development of OA. Once joint congruity, stability, and alignment are restored, different strategies can be applied in order to address the residual articular cartilage lesion. Besides conventional reconstructive strategies, innovative biologic and tissue-engineered ones have been made available more recently, increasing the possibilities of intervention and showing promising results. However, only limited evidence is yet available, and further studies are necessary to prove their effectiveness for these novel forms of articular cartilage lesion management.

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Author information

Authors and Affiliations

  1. Clinica Ortopedica e Traumatologica 2, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

    F. Perdisa, L. Andriolo & R. De Filippis

  2. Knee Joint Reconstruction Center—3rd Orthopaedic Division, Humanitas Clinical Institute, Milan, Italy

    E. Kon

  3. Department of Biomedical Sciences, Humanitas University, Milan, Italy

    E. Kon

  4. Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

    G. Filardo

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  1. F. Perdisa
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  2. L. Andriolo
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  3. R. De Filippis
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  4. E. Kon
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  5. G. Filardo
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Editor information

Editors and Affiliations

  1. Department of Orthopedics and Traumatology, T.C. Ufuk University, Ankara, Turkey

    Mahmut Nedim Doral

  2. Department of Orthopaedics, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden

    Jón Karlsson

  3. Kosair Charities College of Health and Natural Sciences, Spalding University, Louisville, KY, USA

    John Nyland

  4. Helfentalweg 1A, Landeskrankenhaus Feldkirch Abt. Unfallchirurgie, Innsbruck, Austria

    Karl Peter Benedetto

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Perdisa, F., Andriolo, L., De Filippis, R., Kon, E., Filardo, G. (2019). Biologic Solutions for Articular Cartilage Healing. In: Doral, M., Karlsson, J., Nyland, J., Benedetto, K. (eds) Intraarticular Fractures. Springer, Cham. https://doi.org/10.1007/978-3-319-97602-0_5

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  • DOI: https://doi.org/10.1007/978-3-319-97602-0_5

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  • Online ISBN: 978-3-319-97602-0

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