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Collecting Duct Carcinoma

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Rare Kidney Tumors

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Abstract

Collecting duct carcinoma (CDC) of the kidney is a rare variant of renal cell carcinoma (RCC) with an extremely poor prognosis as most cases are metastatic at the time of diagnosis. RCC is a clinically, histologically and genetically heterogeneous group of tumours. The different subtypes of RCC are classified according to the cells of origin in the different parts of the nephron. Conventional (clear cell) RCC and papillary RCC show alterations linked to the proximal tubules, while chromophobe RCC and CDC are presumed to originate from the collecting duct epithelium (intercalated cells and principal cells of the collecting ducts, respectively). The collecting ducts in the kidney are also known as the Bellini’s ducts, named after the Italian physician Lorenzo Bellini (1643–1704) who described these tubes for the first time (ref: https://www.britannica.com/biography/Lorenzo-Bellini). This explains why CDC is also known as Bellini duct carcinoma. Of all renal neoplasms, CDC is the most aggressive with no established treatment guidelines [1, 2].

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Authors and Affiliations

  1. Department of Urology, University Hospitals, KU Leuven, Leuven, Belgium

    Hendrik Van Poppel, Maarten Albersen & Steven Joniau

  2. Department of Pathology, University Hospitals, KU Leuven, Leuven, Belgium

    Evelyne Lerut

  3. Department of Radiology, University Hospitals, KU Leuven, Leuven, Belgium

    Raymond Oyen

  4. Department of Genetics, University Hospitals, KU Leuven, Leuven, Belgium

    Maria Debiec-Rychter

  5. Department of Medical Oncology, University Hospitals, KU Leuven, Leuven, Belgium

    Herlinde Dumez

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  1. Department of Hematology and Oncology, Strasbourg University Hospital, Hopital Civil, Strasbourg, France

    Gabriel G. Malouf

  2. Department of Genitourinary Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Nizar M. Tannir

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Van Poppel, H. et al. (2019). Collecting Duct Carcinoma. In: Malouf, G., Tannir, N. (eds) Rare Kidney Tumors. Springer, Cham. https://doi.org/10.1007/978-3-319-96989-3_7

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