Keywords

  1. 1.

    Transferred as dissolved CO2 , carbonic acid , bicarbonate ion (predominant form), carbonate ion , and carbaminohemoglobin

  2. 2.

    CO2 is 20× more diffusible than O2 and readily crosses the placenta

  3. 3.

    Only dissolved CO2 crosses the placenta. Carbonic anhydrase in RBCs convert bicarbonate ion to CO2.

  4. 4.

    CO2 transfer is augmented by the Haldane effect (higher affinity for CO2 in maternal deoxyhemoglobin than fetal oxyhemoglobin)