Abstract
The integration of clinical, radiographic and pathology-based information has long been intrinsic to practice of Orthopaedic Oncology, making it paradigm of multidisciplinary medicine. Extension of this multifactorial approach can lead to better understanding of heterogeneous group of entities. Historically, pathologists have approached the study of bone tumors from imaging to gross to histological findings. However, a reversal of this norm emphasizing a detailed understanding of the histopathology and growth parameters of each entity can allow a better understanding of the macroscopic / gross appearance of the orthopaedic tumors which in turn leads to a better appreciation of the imaging features. The chapter emphasizes those tumors most unique to bone: cartilage, osseous, small cell, fibrous, vascular, notochord, adamantinoma and giant cell lesions.
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Czerniak B. Dorfman and Czerniak’s Bone Tumors. 2nd ed. Philadelphia: Saunders an imprint of Elsevier; 2016.
Raymond AK, Lazar AJ. Orthopedic Oncologic Surgical Specimen Management and Surgical Pathology. In: Lin PP, Patel S, editors. Bone Sarcoma. New York: Springer; 2013. p. 43–75.
Adler C-P. Bone diseases. Macroscopic, histological, and radiological diagnosis of structural changes in the skeleton. Berlin: Springer; 2000.
Bovée VMG, editor. Bone tumor pathology. Surgical pathology clinics. Clinics Review Articles. 2017;10(3):513–764.
Bullough PG. Atlas of orthopedic pathology: with clinical and radiologic correlations. Philadelphia: Lippincott Williams & Wilkins; 1992.
Dahlin DC. Bone tumors: general aspects and data on 6221 cases. 3rd ed. Springfield: Charles C Thomas; 1978.
Campanacci M, Bertoni F, Bacchini P. Bone and soft tissue tumors. New York: Springer-Verlag; 1990.
Fechner RE, Mills SE. AFIP Atlas of Tumor Pathology. Series 3. Washington, DC: American Registry of Pathology; 1993.
Fletcher CDM, Unni KK, Mertens F. In: Mertens F, editor. WHO classification of tumours of soft tissue and bone. 4th ed. Geneva: WHO Press; 2002.
Fletcher CDM, Bridge JA, Hogerndoorn PCW. In: Mertens F, editor. WHO classification of tumours of soft tissue and bone. 4th ed. Geneva: WHO Press; 2013.
Folpe AL, Inwards CY. Bone and soft tissue pathology. Foundations in diagnostic pathology. Philadelphia: Saunders Elsevier; 2010.
Huvos AG. Bone tumors: diagnosis, treatment, prognosis. 2nd ed. Philadelphia: W.B. Saunders; 1990.
Jaffe HL, Selin G. Tumors of bones and joints. Bull N Y Acad Med. 1951;27(3):165–74. PMID: 14812254.
Jaffe HL. Tumors and tumorous conditions of the bones and joints. Philadelphia: Lea & Febiger; 1972.
Klein MJ, Bonar SF, Freemont T, Vinh TN, Lopez-Ben R, Siegel HJ, Siegal GP. Atlas of nontumor pathology. Non-neoplastic diseases of bones and joints. Washington, DC: American Registry of Pathology; 2011.
Mirra JM, Picci P, Gold RH. Bone tumors. Clinical, radiologic, and pathologic correlations. Philadelphia: Lea & Febiger; 1998.
Nielsen GP, Rosenberg AE. Diagnostic pathology: bone. Philadelphia: Elsevier; 2017.
Spjut HJ, Fechner RE, Ackerman LV. Tumors of bone and cartilage. In: Hartmann WH, editor. Atlas of tumor pathology, series 2, fascicle 5, supplement. Washington, DC: Armed Forces Institute of Pathology; 1981.
Unni KK, Inwards CY, Bridge JA, Kindblom L-G, Wold LE. Tumors of the bones and joints, AFIP atlas of tumor pathology. Series 4. Washington, DC: American Registry of Pathology; 2005.
Unni KK, Inwards CY. Dahlin’s bone tumors. General aspects and data on 10,165 cases. 6th ed. Philadelphia: Lippincott, Williams, and Wilkins; 2010.
Wold LE, Adler C-P, Sim FH, Unni KK. Atlas of orthopedic pathology. 2nd ed. Philadelphia: Saunders-Elsevier; 2003.
Garcia RA, Inwards CY, Unni KK. Benign bone tumors—recent developments. Semin Diagn Pathol. 2011;28:73–85. PMID: 21675379.
Bovée JV, Hogendoorn PC, Wunder JS, et al. Cartilage tumours and bone development: molecular pathology and possible therapeutic targets. Nat Rev Cancer. 2010;10:481–8.
Hameetman L, Bovée JV, Taminiau AH, et al. Multiple osteochondromas: clinicopathological and genetic spectrum and suggestions for clinical management. Hered Cancer Clin Pract. 2004;2:161–73.
Hameetman L, Szuhai K, Yavas A, et al. The role of EXT1 in nonhereditary osteochondroma: identification of homozygous deletions. J Natl Cancer Inst. 2007;99:396–406.
Romeo S, Hogendoorn PCW, Dei Tos AP. Benign cartilaginous tumor of bone. From morphology to somatic and germ-line genetics. Adv Anat Pathol. 2009;16:307–15.
Unni KK, Inwards CY, editors. Dahlin’s bone tumors: general aspects and data on 10,165 cases. 6th ed. Philadelphia: Lippincott Williams & Wilkins Publishers; 2010.
Bell WC, Klein MJ, Pitt MJ, et al. Molecular pathology of chondroid neoplasms: part 1, benign lesions. Skeletal Radiol. 2006;35:805–13.
Bovée JV, van den Broek LJ, Cleton-Jansen AM, et al. Up-regulation of PTHrP and Bcl-2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma. Lab Investig. 2000;80:1925–34.
Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, Unni KK, Mertens F, editors. WHO classification of tumors of soft tissue and bone. Lyon: IARC Press; 2013.
Wicklund CL, Pauli RM, Johnston D, Hecht JT. Natural history study of hereditary multiple exostoses. Am J Med Genet. 1995;55(1):43–6.
Wuyts W, Schmale GA, Chansky HA, Raskind WH. Hereditary multiple osteochondromas. In: Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Fong CT, Mefford HC, Smith RJH, Stephens K, editors. Source GeneReviews® [Internet]. Seattle: University of Washington, Seattle; 1993–2016; 2000. Aug 03 [updated 2013 Nov 21].
Schmale GA, Conrad EU 3rd, Raskind WH. The natural history of hereditary multiple exostoses. J Bone Joint Surg Am. 1994;76(7):986–92.
Choi BB, Jee WH, Sunwoo HJ, Cho JH, Kim JY, Chun KA, Hong SJ, Chung HW, Sung MS, Lee YS, Chung YG. MR differentiation of low-grade chondrosarcoma from enchondroma. Clin Imaging. 2013;37(3):542–7.
Fletcher CDM, Unni KK, Mertens F, editors. Pathology and genetics: tumours of soft tissue and bone. Lyon: IARC Press; 2002.
Tallini G, Dorfman H, Brys P, Dal Cin P, de Wever I, Fletcher CD, Jonson K, Mandahl N, Mertens F, Miltelman F, Rosai J, Rydholm A, Samson I, Sciot R, van den Berghe H, Vanni R, Willén H. Correlation between clinicopathological features and karyotype in 100 cartilaginous and chordoid tumours. A report from the Chromosomes and Morphology (CHAMP) Collaborative Study Group. J Pathol. 2002;196:194–203.
Lichtenstein L, Hall JE. Periosteal chondroma; a distinctive benign cartilage tumor. J Bone Joint Surg Am. 1952;24 A(3):691–7.
Rabarin F, Laulan J, Saint Cast Y, Césari B, Fouque PA, Raimbeau G. Focal periosteal chondroma of the hand: a review of 24 cases. Orthop Traumatol Surg Res. 2014;100(6):617–20.
Boriani S, Bacchini P, Bertoni F, Campanacci M. Periosteal chondroma. A review of twenty cases. J Bone Joint Surg Am. 1983;65(2):205–12.
Nojima T, Unni KK, McLeod RA, Pritchard DJ. Periosteal chondroma and periosteal chondrosarcoma. Am J Surg Pathol. 1985;9(9):666–77.
Bauer TW, Dorfman HD, Latham JT Jr. Periosteal chondroma. A clinicopathologic study of 23 cases. Am J Surg Pathol. 1982;6(7):631–7.
deSantos LA, Spjut HJ. Periosteal chondroma: a radiographic spectrum. Skelet Radiol. 1981;6(1):15–20.
Nishio J, Arashiro Y, Mori S, Iwasaki H, Naito M. Periosteal chondroma of the distal tibia: computed tomography and magnetic resonance imaging characteristics and correlation with histological findings. Mol Clin Oncol. 2015;3(3):677–81. Epub 2015 Jan 22.
Varma DG, Kumar R, Carrasco CH, Guo SQ, Richli WR. MR imaging of periosteal chondroma. J Comput Assist Tomogr. 1991;15(6):1008–10.
Fletcher CDM, Bridge JA, Hogerndoorn PCW, Mertens F. In: Mertens F, editor. WHO classification of tumours of soft tissue and bone. 4th ed. Geneva: WHO Press; 2013.
Pansuriya TC, Kroon HM, Bovée JV. Enchondromatosis: insights on the different subtypes. Int J Clin Exp Pathol. 2010;3(6):557–69. Review.
Liu J, Hudkins PG, Swee RG, Unni KK. Bone sarcomas associated with Ollier’s disease. Cancer. 1987;59(7):1376–85.
Pansuriya TC, van Eijk R, d’Adamo P, van Ruler MA, Kuijjer ML, Oosting J, Cleton-Jansen AM, van Oosterwijk JG, Verbeke SL, Meijer D, van Wezel T, Nord KH, Sangiorgi L, Toker B, Liegl-Atzwanger B, San-Julian M, Sciot R, Limaye N, Kindblom LG, Daugaard S, Godfraind C, Boon LM, Vikkula M, Kurek KC, Szuhai K, French PJ, Bovée JV. Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome. Nat Genet. 2011;43(12):1256–61.
Amary MF, Damato S, Halai D, Eskandarpour M, Berisha F, Bonar F, McCarthy S, Fantin VR, Straley KS, Lobo S, Aston W, Green CL, Gale RE, Tirabosco R, Futreal A, Campbell P, Presneau N, Flanagan AM. Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2. Nat Genet. 2011;43(12):1262–5. https://doi.org/10.1038/ng.994.
Fanburg JC, Meis-Kindblom JM, Rosenberg AE. Multiple enchondromas associated with spindle-cell hemangioendotheliomas. An overlooked variant of Maffucci’s syndrome. Am J Surg Pathol. 1995;19(9):1029–38.
Pellegrini AE, Drake RD, Qualman SJ. Spindle cell hemangioendothelioma: a neoplasm associated with Maffucci’s syndrome. J Cutan Pathol. 1995;22(2):173–6.
Schaison F, Anract P, Coste F, Pinieux G, Forest M, Tomeno B. [Chondrosarcoma secondary to multiple cartilage diseases. Study of 29 clinical cases and review of the literature].Rev Chir Orthop Reparatrice Appar Mot. 1999;85(8):834–45.
Schwartz HS, Zimmerman NB, Simon MA, Wroble RR, Millar EA, Bonfiglio M. The malignant potential of enchondromatosis. J Bone Joint Surg Am. 1987;69(2):269–74.
Verdegaal SH, Bovée JV, Pansuriya TC, Grimer RJ, Ozger H, Jutte PC, San Julian M, Biau DJ, van der Geest IC, Leithner A, Streitbürger A, Klenke FM, Gouin FG, Campanacci DA, Marec-Berard P, Hogendoorn PC, Brand R, Taminiau AH. Incidence, predictive factors, and prognosis of chondrosarcoma in patients with Ollier disease and Maffucci syndrome: an international multicenter study of 161 patients. Oncologist. 2011;16(12):1771–9.
Lichtenstein L, Jaffe HL. Chondrosarcoma of bone. Am J Pathol. 1943;19(4):553–89.
Pritchard DJ, Lunke RJ, Taylor WF, Dahlin DC, Medley BE. Chondrosarcoma: a clinicopathologic and statistical analysis. Cancer. 1980;45(1):149–57.
Dahlin DC, Henderson ED. Chondrosarcoma, a surgical and pathological problem; review of 212 cases. J Bone Joint Surg Am. 1956;38-A(5):1025–38.
Evans HL, Ayala AG, Romsdahl MM. Prognostic factors in chondrosarcoma of bone. A clinicopathologic analysis with emphasis on histologic grading. Cancer. 1977;40(2):818–31.
Eefting D, Scharage YM, Geirnaerdt MJ, Le Cessie S, Taminiau AH, Bovée JV, Hogendoorn PC, EroBoNeT consortium. Assessment of interobserver variability and histologic parameters to improve reliability in classification and grading of central cartilaginous tumors. Am J Surg Pathol. 2009;33(1):50–7.
Wang W-L, Hilliard NJ, Deavers MT, Lewis VO, Raymond AK. Chondrosarcomas: skip metastasis. Lab Invest. 2009;89(Suppl 1):25A.
Björnsson J, McLeod RA, Unni KK, Ilstrup DM, Pritchard DJ. Primary chondrosarcoma of long bones and limb girdles. Cancer. 1998;83(10):2105–19.
Henderson ED, Dahlin DC. Chondrosarcoma of bone—a study of two hundred and eighty-eight cases. J Bone Joint Surg Am. 1963;45:1450–8. No abstract available.
Lichtenstein L. Tumors of periosteal origin. Cancer. 1955;8:1060–9.
Bertoni F, Boriani S, Laus M, Campanacci M. Periosteal chondrosarcoma and periosteal osteosarcoma: two distinct entities. J Bone Joint Surg Br. 1982;64:370–6.
Chaabane S, Bouaziz MC, Drissi C, Ladeeb MF. Periosteal chondrosarcoma. AJR Am J Roentgenol. 2009;192:1–6.
Matsumoto K, Hukuda S, Ishizawa M, Saruhashi Y, Okabe H, Asano Y. Parosteal (juxtacortical) chondrosarcoma of the humerus associated with regional lymph node metastasis. A case report. Clin Orthop Relat Res. 1993;290:168–73.
Papagelopoulos PJ, Galanis EC, Mavrogenis AF, Savvidou OD, Bond JR, Unni KK, Sim FH. Survivorship analysis in patients with periosteal chondrosarcoma. Clin Orthop Relat Res. 2006;448:199–207.
Schajowicz F. Juxtacortical chondrosarcoma. J Bone Joint Surg. 1977;59B:473–80.
Kumta SM, Griffith JF, Chow LT, Leung PC. Primary juxtacortical chondrosarcoma dedifferentiating after 20 years. Skeletal Radiol. 1998;27:569–73.
Vanel D, De Paolis M, Monti C, Mercuri M, Picci P. Radiological features of 24 periosteal chondrosarcomas. Skeletal Radiol. 2001;30:208–12.
Ahmed AR, Tan TS, Unni KK, Collins MS, Wenger DE, Sim FH. Secondary chondrosarcoma in osteochondroma: report of 107 patients. Clin Orthop Relat Res. 2003;411:193–206.
Garrison RC, Unni KK, McLeod RA, Pritchard DJ, Dahlin DC. Chondrosarcoma arising in osteochondroma. Cancer. 1982;49(9):1890–7.
Lichtenstein L, Bernstein D. Unusual benign and malignant chondroid tumors of bone. Cancer. 1959;12:1142–57.
Bertoni F, Picci P, Bacchini P. Mesenchymal chondrosarcoma of bone and soft tissues. Cancer. 1983;52:533–41. http://www.ncbi.nlm.nih.gov/pubmed/6861090
Cesari M, Bertoni F, Bacchini P, et al. Mesenchymal chondrosarcoma. An analysis of patients treated at single institution. Tumori. 2007;93:423–7. http://www.ncbi.nlm.nih.gov/pubmed/18038872
Huvos AG, Rosen G, Dabska M, et al. Mesenchymal chondrosarcoma: a clinicopathologic analysis of 35 patients with emphasis on treatment. Cancer. 1983;51:1230–7.
Xu J, Li D, Lu X, Tang S, Guo W. Mesenchymal chondrosarcoma of bone and soft tissue: a systematic review of 107 patients in the past 20 years. PLoS One. 2015;10(4):e0122216.
Nakashima Y, Unni KK, Shives TC, et al. Mesenchymal chondrosarcoma of bone and soft tissue: a review of 111 cases. Cancer. 1986;57:2444–53.
Swanson PE, Lillemoe TJ, Manivel JC, et al. Mesenchymal chondrosarcoma: an immunohistochemical study. Arch Pathol Lab Med. 1990;114:943–8.
Wehrli BM, Huang W, DeCrombrugghe B, Ayala AG, Czerniak B. Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors. Hum Pathol. 2003;34:263–9.
Lee AF, Hayes MM, Lebrun D, et al. FLI-1 distinguishes Ewing sarcoma from small cell osteosarcoma and mesenchymal chondrosarcoma. Appl Immunohistochem Mol Morphol. 2011;19:233–8.
Wang L, Motoi T, Khanin R, Olshen A, Mertens F, Bridge J, Dal Cin P, Antonescu CR, Singer S, Hameed M, Bovee JV, Hogendoorn PC, Socci N, Ladanyi M. Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data. Genes Chromosomes Cancer. 2012;51(2):127–39. https://doi.org/10.1002/gcc.20937.
Damato S, Alorjiani M, Bonar F, et al. IDH1 mutations are not found in cartilaginous tumours other than central and periosteal chondrosarcomas and enchondromas. Histopathology. 2012;60:363–5.
Frassica FJ, Unni KK, Beabout JW, Sim FH. Dedifferentiated chondrosarcoma: a report of the clinicopathological features and treatment of seventy-eight cases. J Bone Joint Surg. 1986;68A:1197–205.
Mirra JM, Marcove RC. Fibrosarcomatous dedifferentiation of primary and secondary chondrosarcoma. J Bone Joint Surg. 1974;56A:285–96.
Sanerkin NG, Woods CG. Fibrosarcomata and malignant fibrous histiocytomata arising in relation to enchondromata. J Bone Joint Surg. 1979;61B:366–72.
Dahlin DC, Beabout JW. Differentiation of low-grade chondrosarcomas. Cancer. 1971;28:461–6.
Staals EL, Bacchini P, Bertoni F. Dedifferentiated central chondrosarcoma. Cancer. 2006;106(12):2682–91.
Munk PL, Connell DG, Quenville NF. Dedifferentiated chondrosarcoma of bone with leiomyosarcomatous mesenchymal component: a case report. Can Assoc Radiol J. 1988;39:218–20.
Niezabitowski A, Edel G, Roessner A, Grundmann E, Timm C, Wuisman P. Rhabdomyosarcomatous component in dedifferentiated chondrosarcoma. Pathol Res Pract. 1987;182:275–82.
Okada K, Hasegawa T, Tateishi U, Endo M, Itoi E. Dedifferentiated chondrosarcoma with telangiectatic osteosarcoma-like features. J Clin Pathol. 2006;59:1200–2.
Estrada EG, Ayala AG, Lewis V, Czerniak B. Dedifferentiated chondrosarcoma with a noncartilaginous component mimicking a conventional giant cell tumor of bone. Ann Diagn Pathol. 2002;6:159–63.
Bierry G, Feydy A, Larousserie F, Pluot E, Guerini H, Campagna R, Dufau-Andreu C, Anract P, Babinet A, Dietemann JL, Chevrot A, Drapé JL. Dedifferentiated chondrosarcoma: radiologic-pathologic correlation. J Radiol. 2010;91(3 Pt 1):271–9.
Unni KK, Dahlin DC, Beabout JW, Sim FH. Chondrosarcoma: clear-cell variant—a report of 16 cases. J Bone Joint Surg. 1976;58A:676–83.
Bjornsson J, Unni KK, Dahlin DC, Beabout JW, Sim FH. Clear cell chondrosarcoma of bone: observations in 47 cases. Am J Surg Pathol. 1984;8:223–30.
Campanacci M, Bertoni F, Laus M. Clear cell chondrosarcoma. Ital J Orthop Traumatol. 1980;6(3):365–72.
van Oosterwijk JG, Meijer D, van Ruler MA, van den Akker BE, Oosting J, Krenács T, Picci P, Flanagan AM, Liegl-Atzwanger B, Leithner A, Athanasou N, Daugaard S, Hogendoorn PC, Bovée JV. Screening for potential targets for therapy in mesenchymal, clear cell, and dedifferentiated chondrosarcoma reveals Bcl-2 family members and TGFβ as potential targets. Am J Pathol. 2013;182(4):1347–56.
Wang LT, Liu TC. Clear cell chondrosarcoma of bone: a report of three cases with immunohistochemical and affinity histochemical observations. Pathol Res Pract. 1993;189:411–5.
Collins MS, Koyama T, Swee RG, Inward CY. Clear cell chondrosarcoma: radiographic, computed tomographic, and magnetic resonance findings in 34 patients with pathologic correlation. Skelet Radiol. 2003;32:687–94.
Codman EA. Epiphyseal chondromatous giant cell tumors of the upper end of the humerus. Surg Gynecol Obstet. 1931;52:543–8.
Dahlin DC, Ivins JC. Benign chondroblastoma: a study of 125 cases. Cancer. 1972;30:401–13.
Jaffe HL, Lichtenstein L. Benign chondroblastoma of bone: a reinterpretation of the so-called calcifying or chondromatous giant cell tumor. Am J Pathol. 1942;18(6):969–91.
Lin PP, Thenappan A, Deavers MT, Lewis VO, Yasko AW. Treatment and prognosis of chondroblastoma. Clin Orthop Relat Res. 2005;438:103–9.
Green P, Whittaker RP. Benign chondroblastoma: case report with pulmonary metastasis. J Bone Joint Surg. 1975;57A:418–20.
Mirra JM, Ulich TR, Eckardt JJ, Bhuta S. “Aggressive” chondroblastoma: light and ultramicroscropic findings after en bloc resection. Clin Orthop. 1983;178:276–84.
Dancer JY, Henry SP, Bondaruk J, Lee S, Ayala AG, de Crombrugghe B, Czerniak B. Expression of master regulatory genes controlling skeletal development in benign cartilage and bone forming tumors. Hum Pathol. 2010;41:1788–93.
Swarts SJ, Neff JR, Johansson SL, Nelson M, Bridge JA. Significance of abnormalities of chromosomes 5 and 8 in chondroblastoma. Clin Orthop Relat Res. 1998;349:189–93.
Brecher ME, Simon MA. Chondroblastoma: an immunohistochemical study. Hum Pathol. 1988;19:1043–7.
Konishi E, Nakashima Y, Iwasa Y, Nakao R, Yanagisawa A. Immunohistochemical analysis for Sox9 reveals the cartilaginous character of chondroblastoma and chondromyxoid fibroma of the bone. Hum Pathol. 2010;41:208–13.
Jaffe HL, Lichtenstein L. Chondromyxoid fibroma of bone: distinctive benign tumor likely to be mistaken especially for chondrosarcoma. Arch Pathol. 1948;45:541–51.
Dahlin DC. Chondromyxoid fibroma of bone, with emphasis on its morphological relationship to benign chondroblastoma. Cancer. 1956;9:195–203.
Kyriakos M. Soft tissue implantation of chondromyxoid fibroma. Am J Surg Pathol. 1979;3:363–72.
Rahimi A, Beabout JW, Ivins JC, Dahlin DC. Chondromyxoid fibroma: a clinicopathologic study of 76 cases. Cancer. 1972;30:726–36.
Söder S, Inwards C, Müller S, Kirchner T, Aigner T. Cell biology and matrix biochemistry of chondromyxoid fibroma. Am J Clin Pathol. 2001;116:271–7.
Wu CT, Inwards CY, O’Laughlin S, Bock MG, Geaubout JM, Unni KK. Chondromyxoid fibroma of bone: a clinicopathologic review of 278 cases. Hum Pathol. 1998;29:438–46.
Sim FH, Dahlin CD, Beabout JW. Osteoid-osteoma: diagnostic problems. J Bone Joint Surg Am. 1975;57(2):154–9.
Akhlaghpoor S, Ahari AA, Shabestari AA, Alinaghizadeh MR. Radiofrequency ablation of osteoid osteoma in atypical locations: a case series. Clin Orthop Relat Res. 2010;468:1963–70.
Baruffi MR, Volpon JB, Neto JB, Casartelli C. Osteoid osteomas with chromosome alterations involving 22q. Cancer Genet Cytogenet. 2001;124:127–31.
Mylona S, Patsoura S, Galani P, Karapostolakis G, Pomoni A, Thanos L. Osteoid osteomas in common and technically challenging locations treated with computed tomography- tomography-guided percutaneous radiofrequency ablation. Skelet Radiol. 2010;39:443–9.
Rosenthal DI. Radiofrequency treatment. Orthop Clin North Am. 2006;37:475–84.
Hasegawa T, Hirose T, Sakamoto R, Seki K, Ikata T, Hizawa K. Mechanism of pain in osteoid osteomas: an immunohistochemical study. Histopathology. 1993;22:487–91.
Mungo DV, Zhang X, O’Keefe RJ, Rosier RN, Puzas JE, Schwarz EM. COX-1 and COX-2 expression in osteoid osteomas. J Orthop Res. 2002;20:159–62.
Cantwell CP, Obyrne J, Eustace S. Current trends in treatment of osteoid osteoma with an emphasis on radiofrequency ablation. Eur Radiol. 2004;14:607–17.
Dahlin DC. Johnson EW Jr Giant osteoid osteoma. J Bone Joint Surg Am. 1954;36-A(3):559–72.
Jaffe H. Benign osteoblastoma. Bull Hosp Joint Dis. 1956;17(2):141–51.
Lichtenstein L. Benign osteoblastoma: a category of osteoid-and bone-forming tumors other than classical osteoid osteoma, which may be mistaken for giant-cell tumor or osteogenic sarcoma. Cancer. 1956;9(5):1044–52.
Bettelli G, Tigani D, Picci P. Recurring osteoblastoma initially presenting as a typical osteoid osteoma: report of two cases. Skelet Radiol. 1991;20:1–4.
Bruneau M, Polivka M, Cornelius JF, George B. Progression of an osteoid osteoma to an osteoblastoma. Case report. J Neurosurg Spine. 2005;3:238–41.
Chotel F, Franck F, Solla F, Dijoud F, Kohler R, Berard J, Abelin Genevois K. Osteoid osteoma transformation into osteoblastoma: fact or fiction? Orthop Traumatol Surg Res. 2012;98(6):S98–S104.
Bertoni F, Unni KK, McLeod RA, Dahlin DC. Osteosarcoma resembling osteoblastoma. Cancer. 1985;55(2):416–26.
Lucas DR, Unni KK, McLeod RA, O’Conner MI, Sim FH. Osteoblastoma: clinicopathologic study of 306 cases. Hum Pathol. 1994;25:117–34.
Lucas DR. Osteoblastoma. Arch Pathol Lab Med. 2010;134:1460–6.
Mirra JM, Kendrick RA, Kendrick RE. Pseudomalignant osteoblastoma versus arrested osteosarcoma: a case report. Cancer. 1976;37:2005–14.
Bertoni F, Unni KK, Lucas DR, McLeod RA. Osteoblastoma with cartilaginous matrix. An unusual morphologic presentation in 18 cases. Am J Surg Pathol. 1993;17(1):69–74.
McLeod RA, Dahlin DC, Beabout JW. The spectrum of osteoblastoma. Am J Roentgenol. 1976;126:321–35.
Berry M, Mankin H, Gebhardt M, Rosenberg A, Hornicek F. Osteoblastoma: a 30-yearstudy of 99 cases. J Surg Oncol. 2008;98:179–83.
Giannico G, Holt GE, Homlar KC, Johnson J, Pinnt J, Bridge JA. Osteoblastoma characterized by a three-way translocation: report of a case and review of the literature. Cancer Genet Cytogenet. 2009;195:168–71.
Coventry MB, Dahlin DC. Osteogenic sarcoma; a critical analysis of 430 cases. J Bone Joint Surg Am. 1957;39-A(4):741–57; discussion, 757–8.
Huvos AG. Clinicopathologic spectrum of osteogenic sarcoma. Recent observations. Pathol Annu. 1979;14 Pt 1:123–44.
Jaffe N, Frei E 3rd, Traggis D, Bishop Y. Adjuvant methotrexate and citrovorum-factor treatment of osteogenic sarcoma. N Engl J Med. 1974;291(19):994–7. No abstract available.
Dahlin DC, Unni KK. Osteosarcoma of bone and its important recognizable varieties. Am J Surg Pathol. 1977;1(1):61–72. Review.
Eilber F, Giuliano A, Eckardt J, Patterson K, Moseley S, Goodnight J. Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial. J Clin Oncol. 1987;5(1):21–6.
Klein MJ, Siegal GP. Osteosarcoma: anatomic and histologic variants. Am J Clin Pathol. 2006;125(4):555–81.
Link MP, Goorin AM, Miser AW, Green AA, Pratt CB, Belasco JB, Prichard J, Malpas JS, Baker AR, Kirpatrick JA, et al. The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity. N Engl J Med. 1986;314(25):1600–6.
Raymond AK, Chawala SP, Carrasco CH, Ayala AG, Fanning TV, Grice B, Armen T, Plager C, Papadopoulos NEJ, Edeiken J, Wallace S, Jaffe N, Murray JA, Benjamin RS. Osteosarcoma chemotherapy effect: a prognostic factor. Semin Diagn Pathol. 1987;4:212–36.
Taylor WF, Ivins JC, Dahlin DC, Edmonson JH, Pritchard DJ. Trends and variability in survival from osteosarcoma. Mayo Clin Proc. 1978;53(11):695–700.
Campanacci M, Bacci G, Bertoni F, Picci P, Minutillo A, Franceschi C. The treatment of osteosarcoma of the extremities: twenty year’s experience at the Istituto Ortopedico Rizzoli. Cancer. 1981;48(7):1569–81.
Rosen G, Murphy ML, Huvos AG, Gutierrez M, Marcove RC. Chemotherapy, en bloc resection, and prosthetic bone replacement in the treatment of osteogenic sarcoma. Cancer. 1976;37(1):1–11.
Bacci G, Ferrari S, Forni C, Mercuri M, Picci P, Bertoni F, Capanna R, Manfrini M, Donati D, Brach Del Prever A, Baldini N. The effect of intra-arterial versus intravenous cisplatinum in the neoadjuvant treatment of osteosarcoma of the limbs: the experience at the Rizzoli Institute. Chir Organi Mov. 1996;81(4):369–82. English, Italian.
Rosen G, Marcove RC, Caparros B, Nirenberg A, Kosloff C, Huvos AG. Primary osteogenic sarcoma: the rationale for preoperative chemotherapy and delayed surgery. Cancer. 1979;43(6):2163–77.
Rosen G, Caparros B, Groshen S, Nirenberg A, Cacavio A, Marcove RC, Lane JM, Huvos AG. Primary osteogenic sarcoma of the femur: a model for the use of preoperative chemotherapy in high risk malignant tumors. Cancer Investig. 1984;2:181–92.
Rosen G, Caparros B, Huvos AG, Kosloff C, Nirenberg A, Cacavio A, Marcove RC, Lane JM, Mehta B, Urban C. Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy. Cancer. 1982;49(6):1221–30.
Picci P, Bacci G, Campanacci M, Gasparini M, Pilotti S, Cerasoli S, Bertoni F, Guerra A, Capanna R, Albisinni U, Galletti S, Gherlinzoni F, Calderoni P, Sudanese A, Baldini N, Bernini M, Jaffe N. Histologic evaluation of necrosis in osteosarcoma induced by chemotherapy: regional mapping of viable and nonviable tumor. Cancer. 1985;56:1515–21.
Raymond AK, Ayala AG. Specimen management after osteosarcoma chemotherapy. In: Unni KK, editor. Bone tumors. New York: Churchill Livingstone; 1988.
Raymond AK, Ayala AG, Carrasco H, Jaffe N, Romsdahl MM, Martin RG, Murray JA, Benjamin R. Osteosarcoma preoperative chemotherapy: specimen management. Cancer Bulletin. 1990;42:317–31.
Raymond AK. Surface osteosarcoma. Clin Orthop Relat Res. 1991;270:140–8.
Raymond AK, Simms W, Ayala AG. Osteosarcoma: management following primary chemotherapy. Hematol Oncol Clin North Am. 1995;9:841–66.
Weatherby RP, Unni KK. Practical aspects of handling orthopedic specimens in the surgical pathology laboratory. Pathol Annu. 1982;17:1–31.
Cahan WG, Woodard HQ, Higinbotham NL, Stewart FW, Coley BL. Sarcoma arising in irradiated bone: report of eleven cases. Cancer. 1948;1:3–29.
Huvos AG, Woodard HQ, Cahan WG, Higinbotham NL, Stewart FW, Butler A, Bretsky SS. Postradiation osteogenic sarcoma of bone and soft tissues. A clinicopathologic study of 66 patients. Cancer. 1985;55(6):1244–55.
Inoue YZ, Frassica FJ, Sim FH, Unni KK, Petersen IA, McLeod RA. Clinicopathologic features and treatment of postirradiation sarcoma of bone and soft tissue. J Surg Oncol. 2000;75(1):42–50.
Lewis VO, Raymond K, Mirza AN, Lin P, Yasko AW. Outcome of postradiation osteosarcoma does not correlate with chemotherapy response. Clin Orthop Relat Res. 2006;450:60–6.
Sim FH, Cupps RE, Dahlin DC, Ivins JC. Postradiation sarcoma of bone. J Bone Joint Surg Am. 1972;54(7):1479–89.
Weatherby RP, Dahlin DC, Ivins JC. Postradiation sarcoma of bone: review of 78 Mayo Clinic cases. Mayo Clin Proc. 1981;56(5):294–306.
Deyrup AT, Montag AG, Inwards CY, Xu Z, Swee RG, Krishnan UK. Sarcomas arising in Paget disease of bone: a clinicopathologic analysis of 70 cases. Arch Pathol Lab Med. 2007;131(6):942–6.
McKenna RJ, Schwinn CP, Soong KY, Higinbotham NL. Osteogenic sarcoma arising in Paget’s disease. Cancer. 1964;17:42–66.
Mirabello L, Troisi RJ, Savage SA. Osteosarcoma incidence and survival rates from 1973 to 2004: data from the surveillance, epidemiology, and end results program. Cancer. 2009;115(7):1531–43. https://doi.org/10.1002/cncr.24121.
Porretta CA, Dahlin DC, Janes JM. Sarcoma in Paget’s disease of bone. J Bone Joint Surg Am. 1957;39-A(6):1314–29.
Seitz S, Priemel M, Zustin J, Beil FT, Semler J, Minne H, Schinke T, Amling M. Paget’s disease of bone: histologic analysis of 754 patients. J Bone Miner Res. 2009;24(1):62–9. https://doi.org/10.1359/jbmr.080907.
Hansen MF, Seton M, Merchant A. Osteosarcoma in Paget’s disease of bone. J Bone Miner Res. 2006;21 Suppl 2:P58–63. Review.
Greditzer HG 3rd, McLeod RA, Unni KK, Beabout JW. Bone sarcomas in Paget disease. Radiology. 1983;146(2):327–33.
Wick MR, Siegal GP, Unni KK, McLeod RA, Greditzer HG 3rd. Sarcomas of bone complicating osteitis deformans (Paget’s disease): fifty years’ experience. Am J Surg Pathol. 1981;5(1):47–59.
Hadjipavlou A, Lander P, Srolovitz H, Enker IP. Malignant transformation in Paget disease of bone. Cancer. 1992;70(12):2802–8.
Moore TE, King AR, Kathol MH, el-Khoury GY, Palmer R, Downey PR. Sarcoma in Paget disease of bone: clinical, radiologic, and pathologic features in 22 cases. AJR Am J Roentgenol. 1991;156(6):1199–203.
Haibach H, Farrell C, Dittrich FJ. Neoplasms arising in Paget’s disease of bone: a study of 82 cases. Am J Clin Pathol. 1985;83(5):594–600.
Jattiot F, Goupille P, Azais I, Roulot B, Alcalay M, Jeannou J, Bontoux D, Valat JP. Fourteen cases of sarcomatous degeneration in Paget’s disease. J Rheumatol. 1999;26(1):150–5.
Nellissery MJ, Padalecki SS, Brkanac Z, Singer FR, Roodman GD, Unni KK, Leach RJ, Hansen MF. Evidence for a novel osteosarcoma tumor-suppressor gene in the chromosome 18 region genetically linked with Paget disease of bone. Am J Hum Genet. 1998;63(3):817–24.
Bertoni F, Dallera P, Bacchini P, Marchetti C, Campobassi A. The Istituto Rizzoli-Beretta experience with osteosarcoma of the jaw. Cancer. 1991;68(7):1555–63.
Clark JL, Unni KK, Dahlin DC, Devine KD. Osteosarcoma of the jaw. Cancer. 1983;51(12):2311–6.
Bennett JH, Thomas G, Evans AW, Speight PM. Osteosarcoma of the jaws: a 30-year retrospective review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;90(3):323–32.
Doval DC, Kumar RV, Kannan V, Sabitha KS, Misra S, Vijay Kumar M, Hegde P, Bapsy PP, Mani K, Shenoy AM, Kumarswamy SV. Osteosarcoma of the jaw bones. Br J Oral Maxillofac Surg. 1997;35(5):357–62.
Garrington GE, Scofield HH, Cornyn J, Hooker SP. Osteosarcoma of the jaws. Analysis of 56 cases. Cancer. 1967;20(3):377–91. No abstract available.
Goepfert H, Raymond AK, Spires JR, Chawla SP, Wolf PF, Lee Y-Y, Batsakis JG. Osteosarcoma of the head and neck. Cancer Bulletin. 1990;42:347–54.
Guadagnolo BA, Zagars GK, Raymond AK, Benjamin RS, Sturgis EM. Osteosarcoma of the jaw/craniofacial region: outcomes after multimodality treatment. Cancer. 2009;115(14):3262–70. https://doi.org/10.1002/cncr.24297.
Demicco EG, Deshpande V, Nielsen GP, Kattapuram SV, Rosenberg AE. Well-differentiated osteosarcoma of the jaw bones: a clinicopathologic study of 15 cases. Am J Surg Pathol. 2010;34(11):1647–55.
Silverman G. Multiple osteosarcoma. Arch Pathol. 1936;21:88–95.
Mahoney JP, Spanier SS, Morris JL. Multifocal osteosarcoma: a case report with review of the literature. Cancer. 1979;44:1897–907.
Parham DM, Pratt CB, Parvey LS, Webber BL, Champion JC. Childhood multifocal osteosarcoma. Clinicopathologic and radiologic correlates. Cancer. 1985;55:2653–8.
Corradi D, Wenger DE, Bertoni F, Bacchini P, Bosio S, Goldoni M, Unni KK, Sim FH, Inwards CY. Multicentric osteosarcoma: clinicopathologic and radiographic study of 56 cases. Am J Clin Pathol. 2011;136(5):799–807.
Unni KK, Dahlin DC, McLeod RA, Pritchard DJ. Intraosseous well-differentiated osteosarcoma. Cancer. 1977;40:1337–47.
Campanacci M, Bertoni F, Capanna R, Cervellati C. Central osteosarcoma of low grade malignancy. Ital J Orthop Traurnatol. 1981;7:71–8.
Kurt AM, Unni KK, McLeod RA, Prichard DJ. Low-grade intraosseous osteosarcoma. Cancer. 1990;65(6):1418–28.
Okada K, Nishida J, Morita T, Kakizaki H, Ishikawa A, Hotta T. Low-grade intraosseous osteosarcoma in northern Japan: advantage of AgNOR and MIB-1 staining in differential diagnosis. Hum Pathol. 2000;31(6):633–9.
Xipell JM, Rush J. Case report. 340. Well- differentiated intraosseous osteosarcoma of the left femur. Skelet Radiol. 1985;14:312–6.
Yoshida A, Ushiku T, Motoi T, et al. Immunohistochemical analysis of MDM2 and CDK4 distinguishes low-grade osteosarcoma from benign mimics. Mod Pathol. 2010;23:1279–88.
Farr GH, Huvos AG, Marcove RC, Higinbotham NL, Foote FW Jr. Telangiectatic osteogenic sarcoma. A review of twenty-eight cases. Cancer. 1974;34(4):1150–8.
Matsuno T, Unni KK, McLeod RA, Dahlin DC. Telangiectatic osteogenic sarcoma. Cancer. 1976;38:2538–47.
Bacci G, Ferrari S, Ruggieri P, Biagini R, Fabbri N, Campanacci L, Bacchini P, Longhi A, Forni C, Bertoni F. Telangiectatic osteosarcoma of the extremity: neoadjuvant chemotherapy in 24 cases. Acta Orthop Scand. 2001;72:167–72.
Chawla SP, Benjamin RS. Effectiveness of chemotherapy in the management of metastatic telangiectatic osteosarcoma. Am J Clin Oncol. 1988;11:177–80.
Huvos AG, Rosen G, Bretsky SS, Butler A. Telangiectatic osteogenic sarcoma: a clinicopathologic study of 124 patients. Cancer. 1982;49:1679–89.
Larsson SE, Lorentzon R, Boquist L. Telangiectatic osteosarcoma. Acta Orthop Scand. 1978;49:589–94.
Weiss A, Khoury JD, Hoffer FA, Wu J, Billups CA, Heck RK, Quintana J, Poe D, Rao BN, Daw NC. Telangiectatic osteosarcoma: the St. Jude Children’s Research Hospital’s experience. Cancer. 2007;109:1627–37.
Rosen G, Huvos AG, Marcove R, Nirenberg A. Telangiectatic osteogenic sarcoma: improved survival with combination chemotherapy. Clin Orthop. 1986;207:164–73.
Murphey MD, wan Jaovisidha S, Temple HT, Gannon FH, Jelinek JS, Malawer MM. Telangiectatic osteosarcoma: radiologic-pathologic comparison. Radiology. 2003;229:545–53.
Sangle NA, Layfield LJ. Telangiectatic osteosarcoma. Arch Pathol Lab Med. 2012;136:572–6.
Sim FH, Unni KK, Beabout JW, Dahlin DC. Osteosarcoma with small cells simulating Ewing’s tumor. J Bone Joint Surg Am. 1979;61(2):207–15.
Righi A, Gambarotti M, Longo S, Benini S, Gamberi G, Cocchi S, Vanel D, Picci P, Bertoni F, Simoni A, Franchi A, Dei Tos AP. Small cell osteosarcoma: clinicopathologic, immunohistochemical, and molecular analysis of 36 cases. Am J Surg Pathol. 2015;39(5):691–9. https://doi.org/10.1097/PAS.0000000000000412.
Ayala AG, Ro JY, Raymond AK, Jaffe N, Chawla S, Carrasco H, Link M, Jimenez J. Small cell osteosarcoma. A clinicopathologic study of 27 cases. Cancer. 1989;64(10):2162–73.
Noguera R, Navarro S, Triche TJ. Translocation (11;22) in small cell osteosarcoma. Cancer Genet Cytogenet. 1990;45(1):121–4. No abstract available.
Edeiken J, Raymond AK, Ayala AG, Benjamin RS, Murray JA, Carrasco HC. Small cell osteosarcoma. Skelet Radiol. 1987;16(8):621–8. Review.
Bertoni F, Present D, Bacchini P, Pignatti G, Picci P, Campanacci M. The Istituto Rizzoli experience with small cell osteosarcoma. Cancer. 1989;64(12):2591–9. Review.
Dickersin GR, Rosenberg AE. The ultrastructure of small-cell osteosarcoma with a review of the light microscopy and differential diagnosis. Hum Pathol. 1991;22(3):267–75.
Martin SE, Dwyer A, Kissane JM, Costa J. Small-cell osteosarcoma. Cancer. 1982;50(5):990–6.
Geschickter CF, Copeland MM. Parosteal osteoma of bone: a new entity. Ann Surg. 1951;133:790–807.
Dwinnell LA, Dahlin DC, Ghormley RK. Parosteal (juxtacortical) osteogenic sarcoma. J Bone Joint Surg. 1954;36A:732–44.
Edeiken J, Farrell C, Ackerman LV, Spjut HJ. Parosteal sarcoma. Am J Roentgenol Radium Ther Nucl Med. 1971;111(3):579–83.
Kaste SC, Fuller CE, Saharia A, Neel MD, Rao BN, Daw NC. Pediatric surface osteosarcoma: clinical, pathologic, and radiologic features. Pediatr Blood Cancer. 2006;47(2):152–62.
Campanacci M, Picci P, Gherlinzoni F, Guerra A, Neff JR. Parosteal osteosarcoma. J Bone Joint Surg Br. 1984;66:313–21.
Picci P, Campanacci M, Bacci G, Capanna R, Ayala A. Medullary involvement in parosteal osteosarcoma. J Bone Joint Surg Am. 1987;69(1):131–6.
Campanacci M, Capanna R, Stilli S. Posterior hemiresection of the distal femur in parosteal osteosarcoma. Ital J Orthop Traumatol. 1982;8(1):23–8.
Laitinen M, Parry M, Albergo JI, Jeys L, Abudu A, Carter S, Sumathi V, Grimer R. The prognostic and therapeutic factors which influence the oncological outcome of parosteal osteosarcoma. Bone Joint J. 2015;97-B(12):1698–703.
Duhamel LA, Ye H, Halai D, Idowu BD, Presneau N, Tirabosco R, Flanagan AM. Frequency of Mouse Double Minute 2 (MDM2) and Mouse Double Minute 4 (MDM4) amplification in parosteal and conventional osteosarcoma subtypes. Histopathology. 2012;60(2):357–9.
Heidenblad M, Hallor KH, Staaf J, Jönsson G, Borg Å, Höglund M, Mertens F, Mandahl N. Genomic profiling of bone and soft tissue tumors with supernumerary ring chromosomes using tiling resolution bacterial artificial chromosome microarrays. Oncogene. 2006;25:7106–16.
Ahuja SC, Villacin AB, Smith J, Bullough PG, Huvos AG, Marcove RC. Juxtacortical (parosteal) osteogenic sarcoma: histological grading and prognosis. J Bone Joint Surg Am. 1977;59(5):632–47.
Stevens GM, Pugh DG, Dahlin DC. Roentgenographic recognition and differentiation of parosteal osteogenic sarcoma. Am J Roentgenol Radium Ther Nucl Med. 1957;78(1):1–12.
Bertoni F, Present D, Hudson T, Enneking WF. The meaning of radiolucencies in parosteal osteosarcoma. J Bone Joint Surg. 1985;67A:901–10.
Sheth DS, Yasko AW, Raymond AK, Ayala AG, Carrasco CH, Benjami RS, Jaffe N, Murray JA. Conventional and dedifferentiated parosteal osteosarcoma. Cancer. 1996;78(10):2136–45.
Lindell MM Jr, Shirkhoda A, Raymond AK, Murray JA, Harle TS. Parosteal osteosarcoma: radiologic-pathologic correlation with emphasis on CT. AJR Am J Roentgenol. 1987;148(2):323–8.
Wold LE, Unni KK, Beabout JW, Sim FH, Dahlin DC. Dedifferentiated parosteal osteosarcoma. J Bone Joint Surg Am. 1984;66(1):53–9.
Bertoni FI, Bacchini P, Staals EL, Davidovitz P. Dedifferentiated parosteal osteosarcoma: the experience of the Rizzoli institute. Cancer. 2005;103(11):2373–82.
Azura M, Vanel D, Alberghini M, Picci P, Staals E, Mercuri M. Parosteal osteosarcoma dedifferentiating into telangiectatic osteosarcoma: importance of lytic changes and fluid cavities at imaging. Skelet Radiol. 2009;38(7):685–90. https://doi.org/10.1007/s00256-009-0672-3. Epub 2009 Mar 7.
Cardona DM, Knapik JA, Reith JD. Dedifferentiated parosteal osteosarcoma with giant cell tumor component. Skelet Radiol. 2008;37(4):367–71. https://doi.org/10.1007/s00256-007-0440-1. Epub 2008 Feb 7.
Shuhaibar H, Friedman L. Dedifferentiated parosteal osteosarcoma with high-grade osteoclast-rich osteogenic sarcoma at presentation. Skelet Radiol. 1998;27(10):574–7. Review.
Dönmez FY, Tüzün U, Başaran C, Tunaci M, Bilgiç B, Acunaş G. MRI findings in parosteal osteosarcoma: correlation with histopathology. Diagn Interv Radiol. 2008;14(3):142–52.
Unni KK, Dahlin DC, Beabout JW. Periosteal osteogenic sarcoma. Cancer. 1976;37:2476–85.
Campanacci M, Giunti A. Periosteal osteosarcoma review of 41 cases, 22 with long-term follow-up. Ital J Orthop Traumatol. 1976;2:23–35.
Spjut HJ, Ayala AG, deSantos LA, et al. Periosteal osteosarcoma. In: Management of primary bone and soft tissue tumors. St. Louis: Mosby; 1977.
Grimer RJ, Bielack S, Flege S, Cannon SR, Foleras G, Andreeff I, Sokolov T, Taminiau A, Dominkus M, San-Julian M, Kollender Y, Gosheger G, European Musculo Skeletal Oncology Society. Periosteal osteosarcoma—a European review of outcome. Eur J Cancer. 2005;41:2806–11.
Ritts GD, Pritchard DJ, Unni KK, Beabout JW, Eckardt JJ. Periosteal osteosarcoma. Clin Orthop. 1987;219:299–307.
Cesari M, Albergini M, Vanel D, Palmerini E, Stalls EL, Longhi A, Abate M, Ferrari C, Balladelli A, Ferrari S. Periosteal osteosarcoma: a single-institution experience. Cancer. 2011;117(8):1731–5.
Rose PS, Dickey ID, Wenger DE, Unni KK, Sim FH. Periosteal osteosarcoma: long-term outcome and risk of late recurrence. Clin Orthop Relat Res. 2006;453:314–7.
Murphey MD, Jelinek JS, Temple HT, Flemming DJ, Gannon FH. Imaging of periosteal osteosarcoma: radiologic-pathologic comparison. Radiology. 2004;233:129–38.
Righi A, Gambarotti M, Benini S, Gamberi G, Cocchi S, Picci P, Bertoni F. MDM2 and CDK4 expression in periosteal osteosarcoma. Hum Pathol. 2015;46(4):549–53.
deSantos LA, Murray JA, Finklestein JB, Spjut HJ, Ayala AG. The radiographic spectrum of periosteal osteosarcoma. Radiology. 1978;127:123–9.
Wold LE, Unni KK, Raymond AK, Dahlin DC. High grade surface osteosarcoma. Lab Invest. 1983;48:94A. (abstract).
Wold LE, Unni KK, Beabout JW, Pritchard DJ. High grade surface osteosarcomas. Am J Surg Pathol. 1984;8:181–6.
Abe K, Kumagai K, Hayashi T, Kinoshita N, Shindo H, Uetani M, Ishida T. High-grade surface osteosarcoma of the hand. Skeletal Radiol. 2007;36(9):869–73.
Staals EL, Bacchini P, Bertoni F. High-grade surface osteosarcoma: a review of 25 cases from the Rizzoli Institute. Cancer. 2008;112(7):1592–9.
Okada K, Unni KK, Swee RG, Sim FH. High grade surface osteosarcoma: a clinicopathologic study of 46 cases. Cancer. 1999;85(5):1044–54.
Hoshi M, Matsumoto S, Manabe J, et al. Report of four cases with high-grade surface osteosarcoma. Jpn J Clin Oncol. 2006;36:180–4.
Sonneland PR, Unni KK. Case report 258: high-grade “surface” osteosarcoma arising from the femoral shaft. Skelet Radiol. 1984;11:77–80.
Vanel D, Picci P, De Paolis M, Mercuri M. Radiological study of 12 high-grade surface osteosarcomas. Skelet Radiol. 2001;30(12):667–71.
Lichtenstein L, Jaffe HL. Eosinophilic granuloma of bone: with report of a case. Am J Pathol. 1940;16(5):595–604.
Lichtenstein L. Histiocytosis X; integration of eosinophilic granuloma of bone, Letterer-Siwe disease, and Schüller-Christian disease as related manifestations of a single nosologic entity. AMA Arch Pathol. 1953;56(1):84–102.
Lieberman PH, Jones CR, Steinman RM, Erlandson RA, Smith J, Gee T, Huvos A, Garin-Chesa P, Filippa DA, Urmacher C, Gangi MD, Sperber M. Langerhans cell (eosinophilic) granulomatosis. A clinicopathologic study encompassing 50 years. Am J Surg Pathol. 1996;20(5):519–52.
Wester SM, Beabout JW, Unni KK, Dahlin DC. Langerhans’ cell granulomatosis (histiocytosis X) of bone in adults. Am J Surg Pathol. 1982;6(5):413–26.
Zeng K, Ohshima K, Liu Y, Zhang W, Wang L, Fan L, Li M, Li X, Wang Z, Guo S, Yan Q, Guo Y. BRAFV600E and MAP2K1 mutations in Langerhans cell histiocytosis occur predominantly in children. Hematol Oncol. 2017;35(4):845–51. https://doi.org/10.1002/hon.2344. Epub 2016 Sep 6.
Oberling C. Les reticulosarcomes et les reticuloendotheliosarcomes de la moelle osseuse (sarcomes d’Ewing). Bull Assoc Fr Cancer. 1928;17:259–96.
Boston HC, Dahlin DC, Ivans JC, Cupps RE. Malignant lymphoma (so-called reticulum cell sarcoma) of bone. Cancer. 1974;34(4):1131–7.
Dosoretz DE, Raymond AK, Murphy GF, Doppke KP, Schiller AL, Wang CC, Suit HD. Primary lymphoma of bone: the relationship of morphologic diversity to clinical behavior. Cancer. 1982;50(5):1009–14.
Ivins JC, Dahlin DC. Malignant lymphoma (reticulum sarcoma) of bone. Proc Staff Meet Mayo Clin. 1963;38:375–85. No abstract available.
Parker F, Jackson H. Primary reticulum cell sarcoma of bone. Surg Gynecol Obstet. 1939;68:45–53.
Heyning FH, Hogendoorn PC, Kramer MH, Hermans J, Kluin-Nelemans JC, Noordijk EM, Kluin PM. Primary non-Hodgkin’s lymphoma of bone: a clinicopathological investigation of 60 cases. Leukemia. 1999;13(12):2094–8.
Mertens F, Romeo S, Bovée JV, Tirabosco R, Athanasou N, Alberghini M, Hogendoorn PC, Dei Tos AP, Sciot R, Domanski HA, Aström K, Mandahl N, Debiec-Rychter M. Reclassification and subtyping of so-called malignant fibrous histiocytoma of bone: comparison with cytogenetic features. Clin Sarcoma Res. 2011;1(1):10.
Li X, Xu-Monette ZY, Yi S, Dabaja BS, Manyam GC, Westin J, Fowler N, Miranda RN, Zhang M, Ferry JA, Medeiros LJ, Harris NL, Young KH. Primary bone lymphoma exhibits a favorable prognosis and distinct gene expression signatures resembling diffuse large B-cell lymphoma derived from centrocytes in the germinal center. Am J Surg Pathol. 2017;41(10):1309–21.
Ewing J. The classic: diffuse endothelioma of bone. Proceedings of the New York Pathological Society. 1921;12:17. Clin Orthop Relat Res. 2006;450:25–7.
Ewing J. Diffuse endothelioma of bone. Proc NY Pathol Soc. 1921;21:17–24.
Fletcher CDM, Bridge JA, Hogerndoorn PCW. WHO classification of Tumours of soft tissue and bone. 4th ed. Geneva: Editors Fredrik Mertens. WHO Press; 2013.
Wilkins RM, Pritchard DJ, Burgert EO Jr, Unni KK. Ewing’s sarcoma of bone. Experience with 140 patients. Cancer. 1986;58(11):2551–5.
Bacci G, Longhi A, Barbieri E, Ferrari S, Mercuri M, Briccoli A, Versari M, Pignotti E, Picci P. Second malignancy in 597 patients with Ewing sarcoma of bone treated at a single institution with adjuvant and neoadjuvant chemotherapy between 1972 and 1999. J Pediatr Hematol Oncol. 2005;27(10):517–20.
Park YK, Chi SG, Park HR, Yang MH, Unni KK. Detection of t(11;22)(q24;q12) translocation of Ewing’s sarcoma in paraffin embedded tissue by nested reverse transcription-polymerase chain reaction. J Korean Med Sci. 1998;13(4):395–9.
Nascimento AG, Unii KK, Pritchard DJ, Cooper KL, Dahlin DC. A clinicopathologic study of 20 cases of large-cell (atypical) Ewing’s sarcoma of bone. Am J Surg Pathol. 1980;4(1):29–36.
Dahlin DC, Coventry MB, Scanlon PW. Ewing’s sarcoma. A critical analysis of 165 cases. J Bone Joint Surg Am. 1961;43-A:185–92.
Romeo S, Bovée JV, Kroon HM, Tirabosco R, Natali C, Zanatta L, Sciot R, Mertens F, Athanasou N, Alberghini M, Szuhai K, Hogendoorn PC, Dei Tos AP. Malignant fibrous histiocytoma and fibrosarcoma of bone: a re-assessment in the light of currently employed morphological, immunohistochemical and molecular approaches. Virchows Arch. 2012;461(5):561–70. https://doi.org/10.1007/s00428-012-1306-z. Epub 2012 Sep 22.
Inwards CY, Unni KK, Beabout JW, Sim FH. Desmoplastic fibroma of bone. Cancer. 1991;68(9):1978–83.
Jaffe HL. Tumors and tumorous conditions of the bones and joints. In: Lea&Febiger, editor. Tumors and tumorous conditions of the bones and joints. Philadelphia: Lea & Febiger; 1958.
Nedopil A, Raab P, Rudert M. Desmoplastic fibroma: a case report with three years of clinical and radiographic observation and review of the literature. Open Orthop J. 2013;8:40–6.
Hauben EI, Jundt G, Cleton-Jansen AM, Yavas A, Kroon HM, Van Marck E, Hogendoorn PC. Desmoplastic fibroma of bone: an immunohistochemical study including beta-catenin expression and mutational analysis for beta-catenin. Hum Pathol. 2005;36(9):1025–30.
Frick MA, Sundaram M, Unni KK, Inwards CY, Fabbri N, Trentani F, Baccini P, Bertoni F. Imaging findings in desmoplastic fibroma of bone: distinctive T2 characteristics. AJR Am J Roentgenol. 2005;184(6):1762–7.
Gebhardt MC, Campbell CJ, Schiller AL, Mankin HJ. Desmoplastic fibroma of bone. A report of eight cases and review of the literature. J Bone Joint Surg Am. 1985;67(5):732–47.
Papagelopoulos PJ, Galanis E, Frassica FJ, Sim FH, Larson DR, Wold LE. Primary fibrosarcoma of bone. Outcome after primary surgical treatment. Clin Orthop Relat Res. 2000;373:88–103.
Papagelopoulos PJ, Galanis EC, Trantafyllidis P, Boscainos PJ, Sim FH, Unni KK. Clinicopathologic features, diagnosis, and treatment of fibrosarcoma of bone. Am J Orthop (Belle Mead NJ). 2002;31(5):253–7. Review.
Bertoni F, Capanna R, Calderoni P, Patrizia B, Campanacci M. Primary central (medullary) fibrosarcoma of bone. Semin Diagn Pathol. 1984;1(3):185–98.
Jaffe HL, Lichtenstein L. Non-osteogenic fibroma of bone. Am J Pathol. 1942;28:205–21.
Campanacci M, Laus M, Boriani S. Multiple non-ossifying fibromata with extraskeletal anomalies: a new syndrome? J Bone Joint Surg Br. 1983;65:627–32.
Mirra JM, Gold RH, Rand F. Disseminated nonossifying fibromas in association with café-au-lait spots (Jaffe-Campanacci syndrome). Clin Orthop Relat Res. 1982;168:192–205.
Arata MA, Peterson HA, Dahlin DC. Pathological fractures through nonossifying fibromas: review of the Mayo Clinic experience. J Bone Joint Surg Am. 1981;63:980–8.
Mankin HJ, Trahan CA, Fondren G, Mankin CJ. Non-ossifying fibroma, fibrous cortical defect and Jaffe-Campanacci syndrome: a biologic and clinical review. Chir Organi Mov. 2009;93:1–7.
Betsy M, Kupersmith LM, Springfield DS. Metaphyseal fibrous defects. J Am Acad Orthop Surg. 2004;12:89–95.
Bhagwandeen SB. Malignant transformation of a non-osteogenic fibroma of bone. J Pathol Bacteriol. 1966;92:562–4; Glockenberg A, Sobel E, Noel JF. Nonossifying fibroma. Four cases and review of the literature. J Am Podiatr Med Assoc. 1977;87:66–9.
Nelson M, Perry D, Ginsburg G, Sanger WG, Neff JR, Bridge JA. Translocation (1;4)(p31;q34) in nonossifying fibroma. Cancer Genet Cytogenet. 2003;142:142–4.
Jee WH, Choe BY, Kang HS, Suh KJ, Ryu KN, Lee YS, Ok IY, Kim JM, Choi KH, Shinn KS. Nonossifying fibroma: characteristics at MR imaging with pathologic correlation. Radiology. 1998;209:197–202.
Ritschl P, Hajek PC, Pechmann U. Fibrous metaphyseal defects: magnetic resonance imaging appearances. Skeletal Radiol. 1989;18:253–9. PMID: 2781323.
Ponset IV, Friedman B. Evolution of metaphyseal fibrous defects. J Bone Joint Surg. 1949;31:582.
Moser RP Jr, Sweet DE, Haseman DB, et al. Multiple skeletal fibroxanthomas: radiologic-pathologic correlation of 72 cases. Skelet Radiol. 1987;16:353–9. PMID: 3629279.
Capanna R, Bertoni F, Bacchini P, Bacci G, Guerra A, Campanacci M. Malignant fibrous histiocytoma of bone. The experience at the Rizzoli Institute: report of 90 cases. Cancer. 1984;54(1):177–87.
Dahlin DC, Unni KK, Matsuno T. Malignant (fibrous) histiocytoma of bone-fact or fancy? Cancer. 1977;39(4):1508–16.
Feldman F, Norman D. Intra- and extraosseous malignant histiocytoma (malignant fibrous xanthoma). Radiology. 2013;1972:497–9.
Huvos AG, Heilweil M, Bretsky SS. The pathology of malignant fibrous histiocytoma of bone. A study of 130 patients. Am J Surg Pathol. 1985;9(12):853–71.
Papagelopoulos PJ, Galanis EC, Sim FH, Unni KK. Clinicopathologic features, diagnosis, and treatment of malignant fibrous histiocytoma of bone. Orthopedics. 2000;23(1):59–65; quiz 66–7.
Nooij MA, Whelan J, Bramwell VH, Taminiau AT, Cannon S, Hogendoorn PC, Pringle J, Uscinska BM, Weeden S, Kirkpatrick A, Glabbeke M, Craft AW, European Osteosarcoma Intergroup. Doxorubicin and cisplatin chemotherapy in high-grade spindle cell sarcomas of the bone, other than osteosarcoma or malignant fibrous histiocytoma: a European Osteosarcoma Intergroup Study. Eur J Cancer. 2005;41(2):225–30.
Bacci G, Ferrari S, Bertoni F, Mercuri M, Forni C, Sottili S, Gasbarrini A, Tienghi A, Cesari M, Campanacci M. Neoadjuvant chemotherapy for osseous malignant fibrous histiocytoma of the extremity: results in 18 cases and comparison with 112 contemporary osteosarcoma patients treated with the same chemotherapy regimen. J Chemother. 1997;9(4):293–9.
Lichtenstein L, Jaffe HL. Fibrous dysplasia of a bone: condition affecting one, several or many bones, graver cases of which may present abnormal pigmentation of skin, premature sexual development, hyperthyroidism or still other extraskeletal abnormalities. Arch Pathol. 1942;33:777.
Dorfman HD. New knowledge of fibro-osseous lesions of bone. Int J Surg Pathol. 2010;18(3 Suppl):62S–5S.
Lichtenstein L. Polyostotic fibrous dysplasia. Arch Surg. 1938;36:874–98.
DiCaprio MR, Enneking WF. Fibrous dysplasia. Pathophysiology, evaluation, and treatment. J Bone Joint Surg Am. 2005;87:1848–64.
Ruggieri P, Sim FH, Bond JR, Unni KK. Malignancies in fibrous dysplasia. Cancer. 1994;73:1411–24.
Morioka H, Kamata Y, Nishimoto K, Susa M, Kikuta K, Horiuchi K, Sasaki A, Kameyama K, Nakamura M, Matsumoto M. Fibrous dysplasia with massive cartilaginous differentiation (fibrocartilaginous dysplasia) in the proximal femur: a case report and review of the literature. Case Rep Oncol. 2016;9(1):126–33.
Dal Cin P, Sciot R, Brys P, et al. Recurrent chromosome aberrations in fibrous dysplasia of the bone: a report of the CHAMP study group. CHromosomes And MorPhology. Cancer Genet Cytogenet. 2000;122:30–2.
Campanacci M. Osteofibrous dysplasia of long bones a new clinical entity. Ital J Orthop Traumatol. 1976;2(2):221–37.
Park YK, Unni KK, McLeod RA, Pritchard DJ. Osteofibrous dysplasia: clinicopathologic study of 80 cases. Hum Pathol. 1993;24(12):1339–47.
Campbell CJ, Hawk T. A variant of fibrous dysplasia (osteofibrous dysplasia). J Bone Joint Surg Am. 1982;64(2):231–6.
Kempson RL. Ossifying fibroma of the long bones. A light and electron microscopic study. Arch Pathol. 1966;82(3):218–33.
Sweet DE, Vinh TN, Devaney K. Cortical osteofibrous dysplasia of long bone and its relationship to adamantinoma. A clinicopathologic study of 30 cases. Am J Surg Pathol. 1992;16(3):282–90.
Kamineni S, Briggs TW, Saifuddin A, Sandison A. Osteofibrous dysplasia of the ulna. J Bone Joint Surg Br. 2001;83(8):1178–80.
Most MJ, Sim FH, Inwards CY. Osteofibrous dysplasia and adamantinoma. J Am Acad Orthop Surg. 2010;18(6):358–66.
Nakashima Y, Yamamuro T, Fujiwara Y, Kotoura Y, Mori E, Hamashima Y. Osteofibrous dysplasia (ossifying fibroma of long bones). A study of 12 cases. Cancer. 1983;52(5):909–14.
Ishida T, Iijima T, Kikuchi F, Kitagamwa T, Imamura T, Machinami R. A clinicopathological and immunohistochemical study of osteofibrous dysplasia, differentiated adamantinoma, and adamantinoma of long bones. Skelet Radiol. 1992;21(8):493–502.
Jung JY, Jee WH, Hong SH, Kang HS, Chung HW, Ryu KN, Kim JY, Im SA, Park JM, Sung MS, Lee YS, Hong SJ, Jung CK, Chung YG. MR findings of the osteofibrous dysplasia. Korean J Radiol. 2014;15(1):114–22. https://doi.org/10.3348/kjr.2014.15.1.114.
Bridge JA, Dembinski A, DeBoer J, Travis J, Neff JR. Clonal chromosomal abnormalities in osteofibrous dysplasia. Implications for histopathogenesis and its relationship with adamantinoma. Cancer. 1994;73(6):1746–52.
Gleason BC, Liegl-Atzwanger B, Kozakewich HP, Connolly S, Gebhardt MC, Fletcher JA, Perez-Atayde AR. Osteofibrous dysplasia and adamantinoma in children and adolescents: a clinicopathologic reappraisal. Am J Surg Pathol. 2008;32(3):363–76. https://doi.org/10.1097/PAS.0b013e318150d53e.
Hazelbag HM, Taminiau AH, Fleuren GJ, Hogendoorn PC. Adamantinoma of the long bones. A clinicopathological study of thirty-two patients with emphasis on histological subtype, precursor lesion, and biological behavior. J Bone Joint Surg Am. 1994;76(10):1482–99.
Simoni P, Scarciolla L, Mutijima E, Zobel BB. Osteofibrous dysplasia: a case report and review of the literature. Radiol Case Rep. 2011;6:1–3.
Hazelbag HM, Hogendoorn PC. Adamantinoma of the long bones: an anatomo-clinical review and its relationship with osteofibrous dysplasia. Ann Pathol. 2001;21(6):499–511.
Ueda Y, Roessner A, Bosse A, Edel G, Böcker W, Wuisman P. Juvenile intracortical adamantinoma of the tibia with predominant osteofibrous dysplasia-like features. Pathol Res Pract. 1991;187(8):1039–43; discussion 1043–4.
Bridge JA, Swarts SJ, Buresh C, Nelson M, Degenhardt JM, Spanier S, Maale G, Meloni A, Lynch JC, Neff JR. Trisomies 8 and 20 characterize a subgroup of benign fibrous lesions arising in both soft tissue and bone. Am J Pathol. 1999;154(3):729–33.
Sakamoto A, Oda Y, Iwamoto Y, et al. A comparative study of fibrous dysplasia and osteofibrous dysplasia with regard to Gs-alpha mutation at the Arg201 codon: polymerase chain reaction-restriction fragment length polymorphism analysis of paraffin-embedded tissues. J Mol Diagn. 2000;2:67–72.
Springfield DS, Rosenberg AE, Mankin HJ, Mindell ER. Relationship between osteofibrous dysplasia and adamantinoma. Clin Orthop Relat Res. 1994;309:234–44.
Taylor RM, Kashima TG, Ferguson DJ, Szuhai K, Hogendoorn PC, Athanasou NA. Analysis of stromal cells in osteofibrous dysplasia and adamantinoma of long bones. Mod Pathol. 2012;25(1):56–64. https://doi.org/10.1038/modpathol.2011.141.
Nakahara H, Kunisada T, Noda T, Ozaki T. Minimally invasive plate osteosynthesis for osteofibrous dysplasia of the tibia: a case report. J Orthop Surg (Hong Kong). 2010;18(3):374–7.
Lee RS, Weitzel S, Eastwood DM, Monsell F, Pringle J, Cannon SR, Briggs TW. Osteofibrous dysplasia of the tibia. Is there a need for a radical surgical approach? J Bone Joint Surg Br. 2006;88(5):658–64.
Hahn SB, Kang ES, Jahng JS, Park BM, Choi JC. Ossifying fibroma. Yonsei Med J. 1991;32(4):347–55.
Ross JS, Masaryk TJ, Modic MT, Carter JR, Mapstone T, Dengel FH. Vertebral hemangiomas: MR imaging. Radiology. 1987;165(1):165–9.
Verbeke SLJ, Bovée JVMG. Review article: primary vascular tumors of bone: a spectrum of entities? Int J Clin Exp Pathol. 2011;4(6):541–51.
Matsumoto K, Ishizawa M, Okabe H, Taniguchi I. Hemangioma of bone arising in the ulna: imaging findings with emphasis on MR. Skelet Radiol. 2000;29(4):231–4.
Wold LE, Adler CP, Sim FH, Unni KK. Atlas of orthopedic pathology. 2nd ed. Philadelphia: Saunders; 2002.
Rosai J, Gold J, Landy R. The histiocytoid hemangiomas. A unifying concept embracing several previously described entities of skin, soft tissue, large vessels, bone, and heart. Hum Pathol. 1979;10(6):707–30.
Errani C, Zhang L, Panicek DM, Healey JH, Antonescu CR. Epithelioid hemangioma of bone and soft tissue: a reappraisal of a controversial entity. Clin Orthop Relat Res. 2012;470(5):1498–506.
Nielsen GP, Srivastava A, Kattapuram S, Deshpande V, O’Connell JX, Mangham CD, Rosenberg AE. Epithelioid hemangioma of bone revisited: a study of 50 cases. Am J Surg Pathol. 2009;33(2):270–7.
Verbeke SL, Bovée JV. Primary vascular tumors of bone: a spectrum of entities? Int J Clin Exp Pathol. 2011;4(6):541–51.
O’Connell JX, Kattapuram SV, Mankin HJ, Bhan AK, Rosenberg AE. Epithelioid hemangioma of bone. A tumor often mistaken for low-grade angiosarcoma or malignant hemangioendothelioma. Am J Surg Pathol. 1993;17(6):610–7.
Ling S, Rafii M, Klein M. Epithelioid hemangioma of bone. Skelet Radiol. 2001;30(4):226–9.
Kleer CG, Unni KK, McLeod RA. Epithelioid hemangioendothelioma of bone. Am J Surg Pathol. 1996;20(11):1301–11.
Gill R, O’Donnell RJ, Horvai A. Utility of immunohistochemistry for endothelial markers in distinguishing epithelioid hemangioendothelioma from carcinoma metastatic to bone. Arch Pathol Lab Med. 2009;133(6):967–72.
Kulkarni KR, Jambhekar NA. Epithelioid hemangioendothelioma of bone--a clinicopathologic and immunohistochemical study of 7 cases. Indian J Pathol Microbiol. 2003;46(4):600–4.
Errani C, Zhang L, Sung YS, Hajdu M, Singer S, Maki RG, Healey JH, Antonescu CR. A novel WWTR1-CAMTA1 gene fusion is a consistent abnormality in epithelioid hemangioendothelioma of different anatomic sites. Genes Chromosomes Cancer. 2011;50(8):644–53.
Davies JD, Rees GJ, Mera SL. Angiosarcoma in irradiated post-mastectomy chest wall. Histopathology. 1983;7(6):947–56.
Antonescu C. Malignant vascular tumors – an update. Mod Pathol. 2014;27 Suppl 1:S30–8.
Campanacci M, Boriani S, Giunti A. Hemangioendothelioma of bone: a study of 29 cases. Cancer. 1980;46(4):804–14.
O’Connell JX, Nielsen GP, Rosenberg AE. Epithelioid vascular tumors of bone: a review and proposal of a classification scheme. Adv Anat Pathol. 2001;8(2):74–82.
Mittal S, Goswami C, Kanoria N, Bhattacharya A. Post-irradiation angiosarcoma of bone. J Cancer Res Ther. 2007;3(2):96–9.
Nakanishi K, Yoshikawa H, Ueda T, Araki N, Tanaka H, Aozasa K, Nakamura H. Postradiation sarcomas of the pelvis after treatment for uterine cervical cancer: review of the CT and MR findings of five cases. Skelet Radiol. 2001;30(3):132–7.
Wold LE, Unni KK, Beabout JW, Ivins JC, Bruckman JE, Dahlin DC. Hemangioendothelial sarcoma of bone. Am J Surg Pathol. 1982;6(1):59–70.
Verbeke SL, Bertoni F, Bacchini P, Sciot R, Fletcher CD, Kroon HM, Hogendoorn PC, Bovée JV. Distinct histological features characterize primary angiosarcoma of bone. Histopathology. 2011;58(2):254–64.
Volpe R, Mazabraud A. Hemangioendothelioma (angiosarcoma) of bone: a distinct pathologic entity with an unpredictable course? Cancer. 1982;49(4):727–36.
Deshpande V, Rosenberg AE, O’Connell JX, Nielsen GP. Epithelioid angiosarcoma of the bone: a series of 10 cases. Am J Surg Pathol. 2003;27(6):709–16.
Miettinen M, Lindenmayer AE, Chaubal A. Endothelial cell markers CD31, CD34, and BNH9 antibody to H- and Y-antigens – evaluation of their specificity and sensitivity in the diagnosis of vascular tumors and comparison with von Willebrand factor. Mod Pathol. 1994;7(1):82–90.
Dunlap JB, Magenis RE, Davis C, Himoe E, Mansoor A. Cytogenetic analysis of a primary bone angiosarcoma. Cancer Genet Cytogenet. 2009;194(1):1–3.
Manner J, Radlwimmer B, Hohenberger P, Mössinger K, Küffer S, Sauer C, Belharazem D, Zettl A, Coindre JM, Hallermann C, Hartmann JT, Katenkamp D, Katenkamp K, Schöffski P, Sciot R, Wozniak A, Lichter P, Marx A, Ströbel P. MYC high level gene amplification is a distinctive feature of angiosarcomas after irradiation or chronic lymphedema. Am J Pathol. 2010;176(1):34–9.
Wenger DE, Wold LE. Malignant vascular lesions of bone: radiologic and pathologic features. Skelet Radiol. 2000;29(11):619–31. Review.
Palmerini E, Maki RG, Staals EL, Alberghini M, Antonescu CR, Ferrari C, Ruggieri P, Mavrogenis A, Bertoni F, Cesari M, Paioli A, Marchesi E, Picci P, Ferrari S. Primary angiosarcoma of bone: a retrospective analysis of 60 patients from 2 institutions. Am J Clin Oncol. 2014;37(6):528–34.
Evans HL, Raymond AK, Ayala AG. Vascular tumors of bone: a study of 17 cases other than ordinary hemangioma, with an evaluation of the relationship of hemangioendothelioma of bone to epithelioid hemangioma, epithelioid hemangioendothelioma, and high-grade angiosarcoma. Hum Pathol. 2003;34(7):680–9.
Mirra JM, Brien EW. Giant notochordal hamartoma of intraosseous origin: a newly reported benign entity to be distinguished from chordoma. Report of two cases. Skelet Radiol. 2001;30(12):698–709. Epub 2001 Oct 16. Review. Erratum in: Skeletal Radiol 2002 Apr;31(4):251.
Yamaguchi T, Suzuki S, Ishiiwa H, Ueda Y. Intraosseous benign notochordal cell tumours: overlooked precursors of classic chordomas? Histopathology. 2004;44(6):597–602.
Kyriakos M, Totty WG, Lenke LG. Giant vertebral notochordal rest: a lesion distinct from chordoma: discussion of an evolving concept. Am J Surg Pathol. 2003;27(3):396–406. Review.
Deshpande V, Nielsen GP, Rosenthal DI, Rosenberg AE. Intraosseous benign notochord cell tumors (BNCT): further evidence supporting a relationship to chordoma. Am J Surg Pathol. 2007;31:1573–7.
Nishiguchi T, Mochizuki K, Tsujio T, Nishita T, Inoue Y. Lumbar vertebral chordoma arising from an intraosseous benign notochordal cell tumour: radiological findings and histopathological description with a good clinical outcome. Br J Radiol. 2010;83:e49–53.
Yamaguchi T, Yamato M, Saotome K. First histologically confirmed case of a classic chordoma arising in a precursor benign notochordallesion: differential diagnosis of benign and malignant notochordallesions. Skelet Radiol. 2002;31:413–8.
Yamaguchi T, Suzuki S, Ishiiwa H, Shimizu K, Ueda Y. Benign notochordal cell tumors: a comparative histological study of benign notochordal cell tumors, classic chordomas, and notochordal vestiges of fetal intervertebral discs. Am J Surg Pathol. 2004;28(6):756–61.
Yamaguchi T, Watanabe-Ishiiwa H, Suzuki S, Igarashi Y, Ueda Y. Incipient chordoma: a report of two cases of early-stage chordoma arising from benign notochordal cell tumors. Mod Pathol. 2005;18:1005–10.
Kyriakos M. Benign notochordal lesions of the axial skeleton: a review and current appraisal. Skelet Radiol. 2011;40(9):1141–52. https://doi.org/10.1007/s00256-011-1167-6. Review.
Dahlin DC, MacCarty CS. Chordoma. Cancer. 1952;5(6):1170–8.
Dahlin DC, Unni KK. Chordoma. Arch Pathol Lab Med. 1994;118(6):596–7.
Heffelfinger MJ, Dahlin DC, MacCarty CS, Beabout JW. Chordomas and cartilaginous tumors at the skull base. Cancer. 1973;32(2):410–20.
Forsyth PA, Cascino TL, Shaw EG, Scheithauer BW, O’Fallon JR, Dozier JC, Piepgras DG. Intracranial chordomas: a clinicopathological and prognostic study of 51 cases. J Neurosurg. 1993;78(5):741–7.
Brooks JJ, Trojanowski JQ, LiVolsi VA. Chondroid chordoma: a low-grade chondrosarcoma and its differential diagnosis. Curr Top Pathol. 1989;80:165–81.
Brooks JJ, LiVolsi VA, Trojanowski JQ. Does chondroid chordoma exist? Acta Neuropathol. 1987;72(3):229–35.
Meis JM, Raymond AK, Evans HL, Charles RE, Giraldo AA. “Dedifferentiated” chordoma. A clinicopathologic and immunohistochemical study of three cases. Am J Surg Pathol. 1987;11(7):516–25.
Smith J, Reuter V, Demas B. Case report 576. Anaplastic sacrococcygeal chordoma (dedifferentiated chordoma). Skelet Radiol. 1989;18(7):561–4. No abstract available.
Frankl J, Grotepas C, Stea B, Lemole GM, Chiu A, Khan R. Chordoma dedifferentiation after proton beam therapy: a case report and review of the literature. J Med Case Rep. 2016;10(1):280. Review.
Fleming GF, Heimann PS, Stephens JK, Simon MA, Ferguson MK, Benjamin RS, Samuels BL. Dedifferentiated chordoma. Response to aggressive chemotherapy in two cases. Cancer. 1993;72(3):714–8. Review.
Zhou J, Sun J, Bai HX, Huang X, Zou Y, Tan X, Zhang Z, Tang X, Tao Y, Xiao B, Zhang PJ, Yang L. Prognostic factors in patients with spinal chordoma: an integrative analysis of 682 patients. Neurosurgery. 2017;81(5):812–23.
Chan AC, Tsang WY, Chan GP, Lam YL, Chan MK. Dedifferentiated chordoma with rhabdomyoblastic differentiation. Pathology. 2007;39(2):277–80. No abstract available.
Choi YJ, Kim TS. Malignant fibrous histiocytoma in chordoma – immunohistochemical evidence of transformation from chordoma to malignant fibrous histiocytoma. Yonsei Med J. 1994;35(2):239–43.
Chou WC, Hung YS, Lu CH, Yeh KY, Sheu S, Liaw CC. De novo dedifferentiated chordoma of the sacrum: a case report and review of the literature. Chang Gung Med J. 2009;32(3):330–5. Review.
Deepali J, Jain VK, Vassishta RK, Ranjan P, Kumar Y. Adamantinoma: a clinicopathological review and update. Diagn Pathol. 2008;3:8.
Baker PL, Dockerty MB, Coventry MB. Adamantinomas (so called) of long bones: review of literature and report of three new cases. J Bone Joint Surg. 1954;36A:704–20.
Weiss SW, Dorfman HD. Adamantinoma of long bone: an analysis of nine new cases with emphasis on metastasizing lesions and fibrous dysplasia–like changes. Hum Pathol. 1977;8:141–53.
Keeney GL, Unni KK, Beabout JW, Pritchard DJ. Adamantinoma of long bones. A clinicopathologic study of 85 cases. Cancer. 1989;64:730–7.
Huvos AG, Marcove RC. Adamantinoma of long bones. Clinicopathological study of fourteen cases with vascular origin suggested. J Bone Joint Surg Am. 1975;57(2):148–54.
Sarita-Reyes CD, Greco MA, Steiner GC. Mesenchymal-epithelial differentiation of adamantinoma of long bones: an immunohistochemical and ultrastructural study. Ultrastruct Pathol. 2012;36:23–30.
Benassi MS, Campanacci L, Gamberi G, Ferrari C, Picci P, Sangiorgi L, Campanacci M. Cytokeratin expression and distribution in adamantinoma of the long bones and osteofibrous dysplasia of tibia and fibula: an immunohistochemical study correlated to histogenesis. Histopathology. 1994;25:71–6.
Bridge JA, Fidler ME, Neff JR, Degenhardt J, Wang C, Dorfman HD, Baker KS, Seemayer TA. Adamantinoma-like Ewing’s sarcoma: genomic confirmation, phenotypic drift. Am J Surg Pathol. 1999;23(2):159–65.
Cohen DM, Dahlin DC, Pugh DG. Fibrous dysplasia associated with adamantinoma of the long bones. Cancer. 1962;15:515–21.
Eisenstein W, Pitcock JA. Adamantinoma of the tibia: an eccrine carcinoma. Arch Pathol Lab Med. 1984;108:246–50.
Hauben E, van den Broek, Van Marck E, Hogendoorn PC. Adamantinoma-like Ewing’s sarcoma and Ewing’s-like adamantinoma. The t(11;22), t(21;22) status. J Pathol. 2001;195(2):218–21.
Hazelbag HM, Laforga JB, Roels JH, Hogendoorn PC. Dedifferentiated adamantinoma with revertant mesenchymal phenotype. Am J Surg Pathol. 2003;27:1530–7.
Izquierdo FM, Ramos LR, Sanchez-Herraez S, Hernández T, de Alava E, Hazelbag HM. Dedifferentiated classic adamantinoma of the tibia: a report of a case with eventual complete revertant mesenchymal phenotype. Am J Surg Pathol. 2010;34:1388–92.
Kahn LB. Adamantinoma, osteofibrous dysplasia and differentiated adamantinoma. Skelet Radiol. 2003;32(5):245–58.
Kuruvilla G, Steiner GS. Osteofibrous dysplasia-like adamantinoma of bone: a report of five cases with immunohistochemical and ultrastructural studies. Hum Pathol. 1998;29(8):809–14.
Sung HW, Kuo DP, Shu WP, Chai YB, Liu CC, Li SM. Giant-cell tumor of bone: analysis of 208 cases in Chinese patients. J Bone Joint Surg. 1982;64A:755–61.
Bertoni F, Present D, Sudanese A, Baldini N, Bacchini P, Campanacci M. Giant-cell tumor of bone with pulmonary metastases: six case reports and a review of the literature. Clin Orthop. 1988;237:275–85.
Hoch B, Inwards C, Sundaram M, Rosenberg AE. Multicentric giant cell tumor of bone. Clinicopathologic analysis of thirty cases. J Bone Joint Surg Am. 2006;88:1998–2008.
Thomas D, Henshaw R, Skubitz K, Chawla S, Staddon A, Blay JY, Roudier M, Smith J, Ye Z, Sohn W, Dansey R, Jun S. Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study. Lancet Oncol. 2010;11:275–80.
Roux S, Amazit L, Meduri G, Guiochon-Mantel A, Milgrom E, Mariette X. RANK (receptor activator of nuclear factor kappa B) and RANK ligand are expressed in giant cell tumors of bone. Am J Clin Pathol. 2002;117:210–6.
Jaffe HL, Lichtenstein L, Portis RB. Giant cell tumor of bone: its pathologic appearance, grading, supposed variants and treatment. Arch Pathol. 1940;30:993–1031.
Jaffe HL. Aneurysmal bone cyst. Bull Hosp Joint Dis. 1950;11(1):3–13.
Kransdorf MJ, Sweet DE. Aneurysmal bone cyst: concept, controversy, clinical presentation, and imaging. AJR Am J Roentgenol. 1995;164(3):573–80. Review.
Martinez V, Sissons HA. Aneurysmal bone cyst. A review of 123 cases including primary lesions and those secondary to other bone pathology. Cancer. 1988;61(11):2291–304.
Mankin HJ, Hornicek FJ, Ortiz-Cruz E, Villafuerte J, Gebhardt MC. Aneurysmal bone cyst: a review of 150 patients. J Clin Oncol. 2005;23(27):6756–62. Review.
Vergel De Dios AM, Bond JR, Shives TC, McLeod RA, Unni KK. Aneurysmal bone cyst. A clinicopathologic study of 238 cases. Cancer. 1992;69(12):2921–31.
Dahlin DC, McLeod RA. Aneurysmal bone cyst and other nonneoplastic conditions. Skelet Radiol. 1982;8(4):243–50.
Gipple JR, Pritchard DJ, Unni KK. Solid aneurysmal bone cyst. Orthopedics. 1992;15(12):1433–6.
Mascard E, Gomez-Brouchet A, Lambot K. Bone cysts: unicameral and aneurysmal bone cyst. Orthop Traumatol Surg Res. 2015;101(1 Suppl):S119–27.
Jaffe HL. Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-osseous) dysplasia of the jaw bones. Oral Surg Oral Med Oral Pathol. 1953;6(1):159–75.
Lorenzo JC, Dorfman HD. Giant-cell reparative granuloma of short tubular bones of the hands and feet. Am J Surg Pathol. 1980;4(6):551–63.
Ilaslan H, Sundaram M, Unni KK. Solid variant of aneurysmal bone cysts in long tubular bones: giant cell reparative granuloma. AJR Am J Roentgenol. 2003;180(6):1681–7.
Bertoni F, Bacchini P, Capanna R, Ruggieri P, Biagini R, Ferruzzi A, Bettelli G, Picci P, Campanacci M. Solid variant of aneurysmal bone cyst. Cancer. 1993;71(3):729–34.
Agaram NP, LeLoarer FV, Zhang L, Hwang S, Athanasian EA, Hameed M, Antoescu CR. USP6 gene rearrangements occur preferentially in giant cell reparative granulomas of the hands and feet but not in gnathic location. Hum Pathol. 2014;45(6):1147–52.
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Raymond, A.K. (2020). Bone (Orthopedic Pathology). In: Moran, C.A., Kalhor, N., Weissferdt, A. (eds) Oncological Surgical Pathology . Springer, Cham. https://doi.org/10.1007/978-3-319-96681-6_3
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