Abstract
The life course epidemiological approach extends the WHO healthy ageing initiative by investigating how physical and mental capacities change across life; how they vary by birth cohort, socioeconomic position, gender, and ethnicity; and the extent to which experience and exposures earlier in life have long-term consequences for later life capacities, disability, and chronic diseases. This chapter summarises some of the social and biomedical factors from childhood that have long-term consequences for intrinsic capacities, and how a lower level and/or an accelerated decline in capacities during early and mid-adulthood can identify those at greatest risk of subsequent disability and disease. Promotion of healthy ageing requires preventive strategies that enhance capacities during growth and development, maintain them for as long as possible after maturity, and slow down their rate of decline.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
World Health Organization (2015) World report on ageing and health
Ben-Shlomo Y, Kuh D (2002) A life course approach to chronic disease epidemiology: conceptual models, empirical challenges and interdisciplinary perspectives. Int J Epidemiol 31(2):285–293
Kuh D, Ben-Shlomo Y (2004) A life course approach to chronic disease epidemiology, 2nd edn. Oxford University Press, Oxford
Ben-Shlomo Y, Cooper R, Kuh D (2016) The last two decades of life course epidemiology, and its relevance for research on ageing. Int J Epidemiol 45(4):973–988
Cooper R, Hardy R, Sayers A, Kuh D (2014) A life course approach to physical capability. In: Kuh D, Cooper R, Hardy R, Richards M, Ben-Shlomo Y (eds) A life course approach to healthy ageing, 1st edn. Oxford University Press, Oxford, pp 16–31
Gluckman PD, Hanson MA, Bateson P et al (2009) Towards a new developmental synthesis: adaptive developmental plasticity and human disease. Lancet 373(9675):1654–1657
Kuh D, Wong A, Shah I et al (2016) The MRC National Survey of Health and Development reaches age 70: maintaining participation at older ages in a birth cohort study. Eur J Epidemiol 31(11):1135–1147
Kuh D, Karunananthan S, Bergman H, Cooper R (2014) A life-course approach to healthy ageing: maintaining physical capability. Proc Nutr Soc 73(2):237–248
Lara J, Cooper R, Nissan J et al (2015) A proposed panel of biomarkers of healthy ageing. BMC Med 13:222
Dodds RM, Syddall HE, Cooper R et al (2014) Grip strength across the life course: normative data from twelve British studies. PLoS One 9(12):e113637
Dodds RM, Syddall HE, Cooper R, Kuh D, Cooper C, Sayer AA (2016) Global variation in grip strength: a systematic review and meta-analysis of normative data. Age Ageing 45(2):209–216
Davis D, Bendayan R, Muniz G, Hardy R, Richards M, Kuh D (2017) Decline in search speed and verbal memory over 26 years of midlife in a British birth cohort. Neuroepidemiology 49:121–128
Ferrucci L, Cooper R, Shardell M, Simonsick EM, Schrack JA, Kuh D (2016) Age-related change in mobility: perspectives from life course epidemiology and geroscience. J Gerontol A Biol Sci Med Sci 71(9):1184–1194
Case A, Deaton A (2015) Rising morbidity and mortality in midlife among white non-Hispanic Americans in the 21st century. Proc Natl Acad Sci U S A 112(49):15078–15083
Hiam L, Harrison D, McKee M, Dorling D (2018) Why is life expectancy in England and Wales ‘stalling’? J Epidemiol Community Health 72:404–408
Kuh D, Shah I, Richards M, Mishra G, Wadsworth M, Hardy R (2009) Do childhood cognitive ability or smoking behaviour explain the influence of lifetime socio-economic conditions on premature adult mortality in a British post war birth cohort? Soc Sci Med 68(9):1565–1573
Galobardes B, Lynch JW, Smith GD (2008) Is the association between childhood socioeconomic circumstances and cause-specific mortality established? Update of a systematic review. J Epidemiol Community Health 62(5):387–390
Calvin CM, Deary IJ, Fenton C et al (2011) Intelligence in youth and all-cause-mortality: systematic review with meta-analysis. Int J Epidemiol 40(3):626–644
Cooper R, Strand BH, Hardy R, Patel KV, Kuh D (2014) Physical capability in mid-life and survival over 13 years of follow-up: British birth cohort study. Br Med J 348:g2219
Cooper R, Kuh D, Hardy R (2010) Objectively measured physical capability levels and mortality: systematic review and meta-analysis. Br Med J 341:c4467
Davis D, Cooper R, Terrera GM, Hardy R, Richards M, Kuh D (2016) Verbal memory and search speed in early midlife are associated with mortality over 25 years’ follow-up, independently of health status and early life factors: a British birth cohort study. Int J Epidemiol 45(4):1216–1225
Birnie K, Cooper R, Martin RM et al (2011) Childhood socioeconomic position and objectively measured physical capability levels in adulthood: a systematic review and meta-analysis. PLoS One 6(1):e15564
Dodds R, Denison HJ, Ntani G et al (2012) Birth weight and muscle strength: a systematic review and meta-analysis. J Nutr Health Ageing 16(7):609–615
Cooper R, Richards M, Kuh D (2017) Childhood cognitive ability and age-related changes in physical capability from midlife: findings from a British Birth Cohort Study. Psychosom Med 79(7):785–791
Cooper R, Muniz-Terrera G, Kuh D (2016) Associations of behavioural risk factors and health status with changes in physical capability over 10 years of follow-up: the MRC National Survey of Health and Development. BMJ Open 6(4):e009962
World Health Organization (2010) Global recommendations on physical activity for health. WHO, Geneva
Anton SD, Woods AJ, Ashizawa T et al (2015) Successful aging: advancing the science of physical independence in older adults. Ageing Res Rev 24(Pt B):304–327
Leshner AI, Landis S, Stroud C, Downey A, Committee on Preventing Dementia and Cognitive Impairment (2017) Preventing cognitive decline and dementia. The National Academies Press, Washington, DC
Livingston G, Sommerlad A, Orgeta V et al (2017) Dementia prevention, intervention, and care. Lancet 390:2673–2734
Wills AK, Lawlor DA, Matthews FE et al (2011) Life course trajectories of systolic blood pressure using longitudinal data from eight UK cohorts. PLoS Med 8(6):e1000440
Hardy R, Lawlor DA, Kuh D (2015) A life course approach to cardiovascular aging. Future Cardiol 11(1):101–113
Lawlor DA, Hardy R (2014) Vascular and metabolic function across the life course. In: Kuh D, Cooper R, Hardy R, Richards M, Ben-Shlomo Y (eds) A life course approach to healthy ageing, 1st edn. Oxford University Press, Oxford, pp 146–161
Lange P, Celli B, Agusti A et al (2015) Lung-function trajectories leading to chronic obstructive pulmonary disease. N Engl J Med 373(2):111–122
Colley JRT, Douglas JWB, Reid DD (1973) Respiratory disease in young adults; influence of early childhood lower respiratory tract illness, social class, air pollution, and smoking. Br Med J 3:195–198
Allinson JP, Hardy R, Donaldson GC, Shaheen SO, Kuh D, Wedzicha JA (2017) Combined impact of smoking and early life exposures on adult lung function trajectories. Am J Respir Crit Care Med 196:1021–1030
Allinson JP, Hardy R, Donaldson GC, Shaheen SO, Kuh D, Wedzicha JA (2016) The presence of chronic mucus hypersecretion across adult life in relation to chronic obstructive pulmonary disease development. Am J Respir Crit Care Med 193(6):662–672
Whincup PH, Kaye SJ, Owen CG et al (2008) Birth weight and risk of type 2 diabetes: a systematic review. JAMA 300(24):2886–2897
Galobardes B, Smith GD, Lynch JW (2006) Systematic review of the influence of childhood socioeconomic circumstances on risk for cardiovascular disease in adulthood. Ann Epidemiol 16(2):91–104
Hardy R, Kuh D, Langenberg C, Wadsworth M (2003) Birthweight, childhood social class, and change in adult blood pressure in the 1946 British birth cohort. Lancet 362:1178–1183
Ghosh AK, Hardy RJ, Francis DP et al (2014) Midlife blood pressure change and left ventricular mass and remodelling in older age in the 1946 British birth cohort studydagger. Eur Heart J 35:3287–3295
Allen NB, Siddique J, Wilkins JT et al (2014) Blood pressure trajectories in early adulthood and subclinical atherosclerosis in middle age. JAMA 311(5):490–497
Ghosh AK, Hughes AD, Francis D et al (2016) Midlife blood pressure predicts future diastolic dysfunction independently of blood pressure. Heart 102:1380–1387
Hardy R, Cooper R, Sayer AA et al (2013) Body mass index, muscle strength and physical performance in older adults from eight cohort studies: the HALCyon programme. PLoS One 8(2):e56483
Singh-Manoux A, Dugravot A, Shipley M et al (2017) Obesity trajectories and risk of dementia: 28 years of follow-up in the Whitehall II Study. Alzheimers Dement 14:178–186
Senese LC, Almeida ND, Fath AK, Smith BT, Loucks EB (2009) Associations between childhood socioeconomic position and adulthood obesity. Epidemiol Rev 31:21–51
Bann D, Cooper R, Wills AK, Adams J, Kuh D (2014) Socioeconomic position across life and body composition in early old age: findings from a British birth cohort study. J Epidemiol Community Health 68(6):516–523
Bann D, Johnson W, Li L, Kuh D, Hardy R (2017) Socioeconomic inequalities in body mass index across adulthood: coordinated analyses of individual participant data from three British birth cohort studies initiated in 1946, 1958 and 1970. PLoS Med 14(1):e1002214
Johnson W, Li L, Kuh D, Hardy R (2015) How has the age-related process of overweight or obesity development changed over time? Co-ordinated analyses in five United Kingdom birth cohorts. PLoS Med 12(5):e1001828
Bann D, Johnson W, Kuh D, Hardy R (2018) Socioeconomic inequalities in childhood and adolescent body-mass index, weight, and height from 1953 to 2015: an analysis of four longitudinal, observational, British birth cohort studies. Lancet Public Health 3(4):e194–e203
Acknowledgements
Thanks to Dr. Rachel Cooper, Professor Rebecca Hardy, Professor Marcus Richards, and Professor Yoav Ben-Shlomo for their helpful comments on an earlier draft of this chapter.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Kuh, D. (2019). A Life Course Approach to Healthy Ageing. In: Michel, JP. (eds) Prevention of Chronic Diseases and Age-Related Disability. Practical Issues in Geriatrics. Springer, Cham. https://doi.org/10.1007/978-3-319-96529-1_1
Download citation
DOI: https://doi.org/10.1007/978-3-319-96529-1_1
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-96528-4
Online ISBN: 978-3-319-96529-1
eBook Packages: MedicineMedicine (R0)