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Thermoresponsive Gel Drug Delivery for Retina and Posterior Segment Disease

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Drug Delivery for the Retina and Posterior Segment Disease

Abstract

Significant melioration has been done in the optimization of drug delivery to target the tissues in the eye and gain maximum therapeutic efficacy with the drug doses within the organ. Thermoresponsive drug delivery systems propose immense prospective among their equivalents due to their flexibility in design, targeting ability and in situ temperature sensible phase transitions. The approach can be found advantageous for specific applications as it does not require organic solvents in formulation, copolymerization agents for gel formation or any externally applied stimuli for gelation. Thus, this chapter focuses on the emerging thermoresponsive gel technology for drug delivery to anterior and posterior segment of eye disease. This review examines the characteristics of this system including design, assessment and optimization and merits and limitations of thermoresponsive gels for ocular therapy. Future potential of the system for targeted and sustained drug delivery of drugs to ocular part is also presented.

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Authors and Affiliations

  1. ROFEL, Shri G.M. Bilakhia College of Pharmacy, Vapi, Gujarat, India

    Komal Parmar

  2. Nootan Pharmacy College, Faculty of Pharmacy, Sankalchand Patel University, Visnagar, Gujarat, India

    Jayvadan K. Patel

  3. Shenandoah University – ICPH Fairfax, Bernard J. Dunn School of Pharmacy, Fairfax, VA, USA

    Deepak Bhatia

  4. College of Pharmacy, University of South Florida, Tampa, FL, USA

    Yashwant V. Pathak

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  1. Komal Parmar
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  2. Jayvadan K. Patel
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Editors and Affiliations

  1. Faculty of Pharmacy, Sankalchand Patel University, Gujarat, India

    Jayvadan K. Patel

  2. College of Pharmacy, University of South Florida, Tampa, FL, USA

    Vijaykumar Sutariya

  3. School of Medicine, Faculty of Health, Deakin University, Victoria, Australia

    Jagat Rakesh Kanwar

  4. College of Pharmacy, University of South Florida, Tampa, FL, USA

    Yashwant V. Pathak

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Parmar, K., Patel, J.K., Bhatia, D., Pathak, Y.V. (2018). Thermoresponsive Gel Drug Delivery for Retina and Posterior Segment Disease. In: Patel, J., Sutariya, V., Kanwar, J., Pathak, Y. (eds) Drug Delivery for the Retina and Posterior Segment Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-95807-1_23

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