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Transscleral Iontophoretic Drug Delivery for Treating Retinal Diseases

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Drug Delivery for the Retina and Posterior Segment Disease

Abstract

Drug delivery to the eye still is a challenge due to its intricate anatomical structure. Posterior segment delivery is much more challenging due to the acellular nature of the vitreous humor and the longer diffusion distance to the retina. Iontophoresis is a noninvasive technique that facilitates the movement of charged drug molecules into tissues by an electric field. Using iontophoresis, it is possible to achieve therapeutic concentrations faster by modulating the intensity and duration of the applied current. Transscleral iontophoretic delivery is gaining pace and is considered as an alternative for a safe and more effective treatment to retinal disorders. This chapter intends to highlight various aspects of iontophoresis, with a special emphasis on transscleral delivery of drugs and drug-loaded nanocarrier systems for treating disorders in the back of the eye. Finally, a section on toxic effects of iontophoresis to various ocular tissues is included.

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Authors and Affiliations

  1. College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Toledo, OH, USA

    Dherya Bahl, Rinda Devi Bachu, Pallabita Chowdhury & Sai H. S. Boddu

  2. Department of Pharmaceutical Sciences, The University of Texas at El Paso School of Pharmacy, El Paso, TX, USA

    Mrudula Chitti & Jwala Renukuntla

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  2. Rinda Devi Bachu
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  3. Mrudula Chitti
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  4. Pallabita Chowdhury
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  5. Jwala Renukuntla
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  6. Sai H. S. Boddu
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Corresponding author

Correspondence to Sai H. S. Boddu .

Editor information

Editors and Affiliations

  1. Faculty of Pharmacy, Sankalchand Patel University, Gujarat, India

    Jayvadan K. Patel

  2. College of Pharmacy, University of South Florida, Tampa, FL, USA

    Vijaykumar Sutariya

  3. School of Medicine, Faculty of Health, Deakin University, Victoria, Australia

    Jagat Rakesh Kanwar

  4. College of Pharmacy, University of South Florida, Tampa, FL, USA

    Yashwant V. Pathak

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Bahl, D., Bachu, R.D., Chitti, M., Chowdhury, P., Renukuntla, J., Boddu, S.H.S. (2018). Transscleral Iontophoretic Drug Delivery for Treating Retinal Diseases. In: Patel, J., Sutariya, V., Kanwar, J., Pathak, Y. (eds) Drug Delivery for the Retina and Posterior Segment Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-95807-1_14

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