Abstract
There has been increased interest in the role that sex and gender have in the perception and experience of pain. The general finding is that women experience more pain when compared to men. The aim of this chapter will be to provide readers with an overview of the themes that have emerged and summarize what we currently understand about the nature of sex and gender differences in pain. Given the focus of this volume is on pain across the life course, a secondary aim will be to consider male-female differences across different ages, i.e., child, adult, and older adult groups. It will cover epidemiological, laboratory, and clinical studies and consider some of the reasons why there may be sex and gender differences in the experience of pain across the life span.
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References
Ahlsen, B., Bondevik, H., Mengshoel, A. M., & Solbraekke, K. N. (2014). (Un)doing gender in a rehabilitation context: A narrative analysis of gender and self in stories of chronic muscle pain. Disability and Rehabilitation, 36, 359–366.
Alabas, O. A., Tashani, O. A., & Johnson, M. I. (2012). Gender role expectations of pain mediate sex differences in cold pain responses in healthy Libyans. European Journal of Pain, 16, 300–311.
Almquist, Y. B., Ostberg, V., Rostila, M., Edling, C., & Rydgren, J. (2014). Friendship network characteristics and psychological well-being in late adolescence: Exploring differences by gender and gender composition. Scandinavian Journal of Public Health, 42, 146–154.
Altemus, M., Sarvaiya, N., & Epperson, C. N. (2014). Sex differences in anxiety and depression clinical perspectives. Frontiers in Neuroendocrinology, 35, 320–330.
Antonov, K. I., & Isacson, D. (1996). Use of analgesics in Sweden-the importance of sociodemographic factors, physical fitness, health and health-related factors, and working conditions. Social Science & Medicine, 42, 1473–1481.
Antonov, K. I., & Isacson, D. G. (1998). Prescription and nonprescription analgesic use in Sweden. The Annals of Pharmacotherapy, 32, 485–494.
Aslaksen, P. M., & Flaten, M. A. (2008). The roles of physiological and subjective stress in the effectiveness of a placebo on experimentally induced pain. Psychosomatic Medicine, 70, 811–818.
Aslaksen, P. M., Myrbakk, I. N., Hoifodt, R. S., & Flaten, M. A. (2007). The effect of experimenter gender on autonomic and subjective responses to pain stimuli. Pain, 129, 260–268.
Aslaksen, P. M., Bystad, M., Vambheim, S. M., & Flaten, M. A. (2011). Gender differences in placebo analgesia: Event-related potentials and emotional modulation. Psychosomatic Medicine, 73, 193–199.
Aubrun, F., Salvi, N., Coriat, P., & Riou, B. (2005). Sex- and age-related differences in morphine requirements for postoperative pain relief. Anesthesiology, 103, 156–160.
Averbuch, M., & Katzper, M. (2001). Gender and the placebo analgesic effect in acute pain. Clinical Pharmacology and Therapeutics, 70, 287–291.
Barrett, J. H., Brennan, P., Fiddler, M., & Silman, A. J. (1999). Does rheumatoid arthritis remit during pregnancy and relapse postpartum? Results from a nationwide study in the United Kingdom performed prospectively from late pregnancy. Arthritis and Rheumatism, 42, 1219–1227.
Bartley, E. J., King, C. D., Sibille, K. T., Cruz-Almeida, Y., Riley, J. L., Glover, T. L., et al. (2016). Enhanced pain sensitivity among individuals with symptomatic knee osteoarthritis: Potential sex differences in central sensitization. Arthritis Care & Research, 68, 472–480.
Beckham, J. C., Rice, J. R., Talton, S. L., Helms, M. J., & Young, L. D. (1994). Relationship of cognitive constructs to adjustment in rheumatoid arthritis patients. Cognitive Therapy and Research, 18, 479–496.
Bekker, M. H., & van Mens-Verhulst, J. (2007). Anxiety disorders: Sex differences in prevalence, degree, and background, but gender-neutral treatment. Gender Medicine, 4, S178–S193.
Belin, P., Fillion-Bilodeau, S., & Gosselin, F. (2008). The Montreal affective voices: A validated set of nonverbal affect bursts for research on auditory affective processing. Behavior Research Methods, 40, 531–539.
Berke, D. S., Reidy, D. E., Miller, J. D., & Zeichner, A. (2017). Take it like a man: Gender-rhreatened men’s experience of gender role discrepancy, emotion activation, and pain tolerance. Psychology of Men & Masculinity, 18, 62–69.
Berkley, K. J. (1997). Sex differences in pain. Behavioral and Brain Sciences, 20, 371–380.
Bernardes, S. F., Keogh, E., & Lima, M. L. (2008). Bridging the gap between pain and gender research: A selective literature review. European Journal of Pain, 12, 427–440.
Bernardes, S. F., Costa, M., & Carvalho, H. (2013). Engendering pain management practices: The role of physician sex on chronic low-back pain assessment and treatment prescriptions. The Journal of Pain, 14, 931–940.
Bernardes, S. F., Silva, S. A., Carvalho, H., Costa, M., & Pereira, S. (2014). Is it a (fe)male pain? Portuguese nurses’ and laypeople’s gendered representations of common pains. European Journal of Pain, 18, 530–539.
Bingefors, K., & Isacson, D. (2004). Epidemiology, co-morbidity, and impact on health-related quality of life of self-reported headache and musculoskeletal pain – A gender perspective. European Journal of Pain, 8(5), 435–450.
Birke, H., Kurita, G. P., Sjogren, P., Hojsted, J., Simonsen, M. K., Juel, K., et al. (2016). Chronic non-cancer pain and the epidemic prescription of opioids in the Danish population: Trends from 2000 to 2013. Acta Anaesthesiologica Scandinavica, 60, 623–633.
Blyth, F. M., March, L. M., Brnabic, A. J., Jorm, L. R., Williamson, M., & Cousins, M. J. (2001). Chronic pain in Australia: A prevalence study. Pain, 89, 127–134.
Boerner, K. E., Birnie, K. A., Caes, L., Schinkel, M., & Chambers, C. T. (2014). Sex differences in experimental pain among healthy children: A systematic review and meta-analysis. Pain, 155, 983–993.
Boerner, K. E., Chambers, C. T., McGrath, P. J., LoLordo, V., & Uher, R. (2017a). The effect of parental modeling on child pain responses: The role of parent and child sex. The Journal of Pain, 18, 702–715.
Boerner, K. E., Eccleston, C., Chambers, C. T., & Keogh, E. (2017b). Sex differences in the efficacy of psychological therapies for the management of chronic and recurrent pain in children and adolescents: A systematic review and meta-analysis. Pain, 158, 569–582.
Boyd, C. J., Esteban McCabe, S., & Teter, C. J. (2006). Medical and nonmedical use of prescription pain medication by youth in a Detroit-area public school district. Drug and Alcohol Dependence, 81, 37–45.
Breivik, H., Collett, B., Ventafridda, V., Cohen, R., & Gallacher, D. (2006). Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment. European Journal of Pain, 10, 287–333.
Bussey, K., & Bandura, A. (1999). Social cognitive theory of gender development and differentiation. Psychological Review, 106, 676–713.
Butcher, B. E., & Carmody, J. J. (2012). Sex differences in analgesic response to ibuprofen are influenced by expectancy: A randomized, crossover, balanced placebo-designed study. European Journal of Pain, 16, 1005–1013.
Chambers, C. T., Craig, K. D., & Bennett, S. M. (2002). The impact of maternal behavior on children’s pain experiences: An experimental analysis. Journal of Pediatric Psychology, 27, 293–301.
Chen, E. H., Shofer, F. S., Dean, A. J., Hollander, J. E., Baxt, W. G., Robey, J. L., et al. (2008). Gender disparity in analgesic treatment of emergency department patients with acute abdominal pain. Academic Emergency Medicine, 15, 414–418.
Chin, M. L., Fillingim, R. B., & Ness, T. J. (Eds.). (2013). Pain in women. Oxford: Oxford University Press.
Chong, G. S., Cogan, D., Randolph, P., & Racz, G. (2001). Chronic pain and self-efficacy: The effects of age, sex, and chronicity. Pain Practice, 1, 338–343.
Ciccone, G. K., & Holdcroft, A. (1999). Drugs and sex differences: A review of drugs relating to anaesthesia. British Journal of Anaesthesia, 82, 255–265.
Cicero, T. J., Wong, G., Tian, Y., Lynskey, M., Todorov, A., & Isenberg, K. (2009). Co-morbidity and utilization of medical services by pain patients receiving opioid medications: Data from an insurance claims database. Pain, 144, 20–27.
Clayton, J. A., & Tannenbaum, C. (2016). Reporting sex, gender, or both in clinical research? The Journal of the American Medical Association, 316, 1863–1864.
Cornally, N., & McCarthy, G. (2011). Chronic pain: The help-seeking behavior, attitudes, and beliefs of older adults living in the community. Pain Management Nursing, 12, 206–217.
Craft, R. M., Mogil, J. S., & Aloisi, A. M. (2004). Sex differences in pain and analgesia: The role of gonadal hormones. European Journal of Pain, 8, 397–411.
DALYs, G. B. D., & Collaborators, H. (2016). Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet, 388, 1603–1658.
de Kruijf, M., Stolk, L., Zillikens, M. C., de Rijke, Y. B., Bierma-Zeinstra, S. M. A., Hofman, A., et al. (2016). Lower sex hormone levels are associated with more chronic musculoskeletal pain in community-dwelling elderly women. Pain, 157, 1425–1431.
Deepmala, D., Franz, L., Aponte, C., Agrawal, M., & Jiang, W. (2013). Identification of provider characteristics influencing prescription of analgesics: A systematic literature review. Pain Practice, 13, 504–513.
Defrin, R., Shramm, L., & Eli, I. (2009). Gender role expectations of pain is associated with pain tolerance limit but not with pain threshold. Pain, 145, 230–236.
Dixon, K. E., Thorn, B. E., & Ward, L. C. (2004). An evaluation of sex differences in psychological and physiological responses to experimentally-induced pain: A path analytic description. Pain, 112, 188–196.
Docking, R. E., Fleming, J., Brayne, C., Zhao, J., Macfarlane, G. J., Jones, G. T., et al. (2015). The relationship between back pain and mortality in older adults varies with disability and gender: Results from the Cambridge City over-75s Cohort (CC75C) study. European Journal of Pain, 19, 466–472.
Doyle, H. H., & Murphy, A. Z. (2017). Sex differences in innate immunity and its impact on opioid pharmacology. Journal of Neuroscience Research, 95, 487–499.
Drossaers-Bakker, K. W., Zwinderman, A. H., van Zeben, D., Breedveld, F. C., & Hazes, J. M. (2002). Pregnancy and oral contraceptive use do not significantly influence outcome in long term rheumatoid arthritis. Annals of the Rheumatic Diseases, 61, 405–408.
Edwards, R. R., Augustson, E. M., & Fillingim, R. B. (2000). Sex-specific effects of pain-related anxiety on adjustment to chronic pain. The Clinical Journal of Pain, 16, 46–53.
Edwards, R. R., Doleys, D. M., Lowery, D., & Fillingim, R. B. (2003). Pain tolerance as a predictor of outcome following multidisciplinary treatment for chronic pain: Differential effects as a function of sex. Pain, 106, 419–426.
Edwards, R. R., Haythornthwaite, J. A., Sullivan, M. J., & Fillingim, R. B. (2004). Catastrophizing as a mediator of sex differences in pain: Differential effects for daily pain versus laboratory-induced pain. Pain, 111, 335–341.
Edwards, R., Eccleston, C., & Keogh, E. (2017). Observer influences on pain: An experimental series examining same-sex and opposite-sex friends, strangers, and romantic partners. Pain, 158, 846–855.
Egger, H. L., Costello, E. J., Erkanli, A., & Angold, A. (1999). Somatic complaints and psychopathology in children and adolescents: Stomach aches, musculoskeletal pains, and headaches. Journal of the American Academy of Child and Adolescent Psychiatry, 38, 852–860.
El Tumi, H., Johnson, M. I., Dantas, P. B. F., Maynard, M. J., & Tashani, O. A. (2017). Age-related changes in pain sensitivity in healthy humans: A systematic review with meta-analysis. European Journal of Pain, 21, 955–964.
Elklit, A., & Jones, A. (2006). The association between anxiety and chronic pain after whiplash injury: Gender-specific effects. The Clinical Journal of Pain, 22, 487–490.
El-Shormilisy, N., Strong, J., & Meredith, P. J. (2015). Associations between gender, coping patterns and functioning for individuals with chronic pain: A systematic review. Pain Research & Management, 20, 48–55.
Eriksen, J., Sjogren, P., Ekholm, O., & Rasmussen, N. K. (2004). Health care utilization among individuals reporting long-term pain: An epidemiological study based on Danish National Health Surveys. European Journal of Pain, 8, 517–523.
Evans, S., Tsao, J. C., Lu, Q., Myers, C., Suresh, J., & Zeltzer, L. K. (2008a). Parent-child pain relationships from a psychosocial perspective: A review of the literature. Journal of Pain Management, 1, 237–246.
Evans, S., Tsao, J. C., & Zeltzer, L. K. (2008b). Relationship of child perceptions of maternal pain to children’s laboratory and non-laboratory pain. Pain Research & Management, 13, 211–218.
Evans, S., Tsao, J. C., Lu, Q., Kim, S. C., Turk, N., Myers, C. D., et al. (2009). Sex differences in the relationship between maternal negative life events and children’s laboratory pain responsivity. Journal of Developmental and Behavioral Pediatrics, 30, 279–288.
Fanurik, D., Zeltzer, L. K., Roberts, M. C., & Blount, R. L. (1993). The relationship between children’s coping styles and psychological interventions for cold pressor pain. Pain, 53, 213–222.
Fayaz, A., Croft, P., Langford, R. M., Donaldson, L. J., & Jones, G. T. (2016). Prevalence of chronic pain in the UK: A systematic review and meta-analysis of population studies. BMJ Open, 6, e010364.
Fillingim, R. B. (2002). Sex differences in analgesic responses: Evidence from experimental pain models. European Journal of Anaesthesiology, 19, 16–24.
Fillingim, R. B. (2017). Individual differences in pain: Understanding the mosaic that makes pain personal. Pain, 158, S11–S18.
Fillingim, R. B., & Gear, R. W. (2004). Sex differences in opioid analgesia: Clinical and experimental findings. European Journal of Pain, 8, 413–425.
Fillingim, R. B., Edwards, R. R., & Powell, T. (1999). The relationship of sex and clinical pain to experimental pain responses. Pain, 83, 419–425.
Fillingim, R. B., Ness, T. J., Glover, T. L., Campbell, C. M., Price, D. D., & Staud, R. (2004). Experimental pain models reveal no sex differences in pentazocine analgesia in humans. Anesthesiology, 100, 1263–1270.
Fillingim, R. B., Ness, T. J., Glover, T. L., Campbell, C. M., Hastie, B. A., Price, D. D., et al. (2005). Morphine responses and experimental pain: Sex differences in side effects and cardiovascular responses but not analgesia. The Journal of Pain, 6, 116–124.
Fillingim, R. B., King, C. D., Ribeiro-Dasilva, M. C., Rahim-Williams, B., & Riley, J. L., III. (2009). Sex, gender, and pain: A review of recent clinical and experimental findings. The Journal of Pain, 10, 447–485.
Fischer, C. S., & Beresford, L. (2015). Changes in support networks in late middle age: The extension of gender and educational differences. The Journals of Gerontology. Series B. Psychological Sciences and Social Sciences, 70, 123–131.
Fowler-Kerry, S., & Lander, J. (1991). Assessment of sex differences in children’s and adolescents’ self-reported pain from venipuncture. Journal of Pediatric Psychology, 16, 783–793.
Gatchel, R. J., Peng, Y. B., Peters, M. L., Fuchs, P. N., & Turk, D. C. (2007). The biopsychosocial approach to chronic pain: Scientific advances and future directions. Psychological Bulletin, 133, 581–624.
Geisser, M. E., Robinson, M. E., Miller, Q. L., & Bade, S. M. (2003). Psychosocial factors and functional capacity evaluation among persons with chronic pain. Journal of Occupational Rehabilitation, 13, 259–276.
Ginsburg, G. S., & Drake, K. L. (2002). Anxiety sensitivity and panic attack symptomatology among low-income African-American adolescents. Journal of Anxiety Disorders, 16, 83–96.
Goodenough, B., Thomas, W., Champion, G. D., Perrott, D., Taplin, J. E., von Baeyer, C. L., et al. (1999). Unraveling age effects and sex differences in needle pain: Ratings of sensory intensity and unpleasantness of venipuncture pain by children and their parents. Pain, 80, 179–190.
Goubert, L., Vervoort, T., De Ruddere, L., & Crombez, G. (2012). The impact of parental gender, catastrophizing and situational threat upon parental behaviour to child pain: A vignette study. European Journal of Pain, 16, 1176–1184.
Green, C. A., & Pope, C. R. (1999). Gender, psychosocial factors and the use of medical services: A longitudinal analysis. Social Science & Medicine, 48, 1363–1372.
Greenspan, J. D., & Traub, R. J. (2013). Gender differences in pain and its relief. In S. McMahon, M. Koltzenburg, I. Tracey, & D. Turk (Eds.), Wall & Melzack’s Textbook of Pain (6th ed., pp. 221–231). Philadelphia: Saunders.
Greenspan, J. D., Craft, R. M., LeResche, L., Arendt-Nielsen, L., Berkley, K. J., Fillingim, R., et al. (2007). Studying sex and gender differences in pain and analgesia: A consensus report. Pain, 132(Suppl 1), S26–S45.
Grunau, R. V., & Craig, K. D. (1987). Pain expression in neonates – Facial action and cry. Pain, 28, 395–410.
Grunau, R. V., Johnston, C. C., & Craig, K. D. (1990). Neonatal facial and cry responses to invasive and non-invasive procedures. Pain, 42, 295–305.
Hall, J. A. (1978). Gender effects in decoding nonverbal cues. Psychological Bulletin, 85, 845–857.
Hall, J. A. (2006). Women’s and men’s nonverbal communication: Similarities, differences, stereotypes, and origins. In V. Manusov & M. L. Patterson (Eds.), The SAGE handbook of nonverbal communication (pp. 208–218). London: Sage Publishers.
Hampel, P., Graef, T., Krohn-Grimberghe, B., & Tlach, L. (2009). Effects of gender and cognitive-behavioral management of depressive symptoms on rehabilitation outcome among inpatient orthopedic patients with chronic low back pain: A 1 year longitudinal study. European Spine Journal, 18, 1867–1880.
Hargreave, M., Andersen, T. V., Nielsen, A., Munk, C., Liaw, K. L., & Kjaer, S. K. (2010). Factors associated with a continuous regular analgesic use-a population-based study of more than 45,000 Danish women and men 18–45 years of age. Pharmacoepidemiology and Drug Safety, 19, 65–74.
Hazes, J. M. (1991). Pregnancy and its effect on the risk of developing rheumatoid arthritis. Annals of the Rheumatic Diseases, 50, 71–72.
Hazes, J. M., Dijkmans, B. A., Vandenbroucke, J. P., de Vries, R. R., & Cats, A. (1990). Pregnancy and the risk of developing rheumatoid arthritis. Arthritis and Rheumatism, 33, 1770–1775.
Hechler, T., Blankenburg, M., Dobe, M., Kosfelder, J., Hubner, B., & Zernikow, B. (2010a). Effectiveness of a multimodal inpatient treatment for pediatric chronic pain: A comparison between children and adolescents. European Journal of Pain, 14(97), e91–e99.
Hechler, T., Kosfelder, J., Vocks, S., Monninger, T., Blankenburg, M., Dobe, M., et al. (2010b). Changes in pain-related coping strategies and their importance for treatment outcome following multimodal inpatient treatment: Does sex matter? The Journal of Pain, 11, 472–483.
Hechler, T., Vervoort, T., Hamann, M., Tietze, A. L., Vocks, S., Goubert, L., et al. (2011). Parental catastrophizing about their child’s chronic pain: Are mothers and fathers different? European Journal of Pain, 15.
Heitkemper, M. M., & Chang, L. (2009). Do fluctuations in ovarian hormones affect gastrointestinal symptoms in women with irritable bowel syndrome? Gender Medicine, 6, 152–167.
Henderson, E. M., Keogh, E., & Eccleston, C. (2014). Why go online when you have pain? A qualitative analysis of teenagers’ use of the Internet for pain management advice. Child Care Health and Development, 40, 572–579.
Hirsh, A. T., Alqudah, A. F., Stutts, L. A., & Robinson, M. E. (2008). Virtual human technology: Capturing sex, race, and age influences in individual pain decision policies. Pain, 140, 231–238.
Hodgins, M. J., & Lander, J. (1997). Children’s coping with venipuncture. Journal of Pain and Symptom Management, 13, 274–285.
Holdcroft, A. (2002). Sex differences and analgesics. European Journal of Anaesthesiology Supplement, 26, 1–2.
Holley, A. L., Wilson, A. C., & Palermo, T. M. (2017). Predictors of the transition from acute to persistent musculoskeletal pain in children and adolescents: A prospective study. Pain, 158(5), 794–801.
Hooten, W. M., Townsend, C. O., Bruce, B. K., Shi, Y., & Warner, D. O. (2009). Sex differences in characteristics of smokers with chronic pain undergoing multidisciplinary pain rehabilitation. Pain Medicine, 10, 1416–1425.
Huguet, A., Tougas, M. E., Hayden, J., McGrath, P. J., Chambers, C. T., Stinson, J. N., et al. (2016a). Systematic review of childhood and adolescent risk and prognostic factors for recurrent headaches. The Journal of Pain, 17, 855–873.
Huguet, A., Tougas, M. E., Hayden, J., McGrath, P. J., Stinson, J. N., & Chambers, C. T. (2016b). Systematic review with meta-analysis of childhood and adolescent risk and prognostic factors for musculoskeletal pain. Pain, 157, 2640–2656.
Iacovides, S., Avidon, I., & Baker, F. C. (2015). Does pain vary across the menstrual cycle? A review. European Journal of Pain, 19, 1389–1405.
Ip, H. Y., Abrishami, A., Peng, P. W., Wong, J., & Chung, F. (2009). Predictors of postoperative pain and analgesic consumption: A qualitative systematic review. Anesthesiology, 111, 657–677.
Isacson, D., & Bingefors, K. (2002). Epidemiology of analgesic use: A gender perspective. European Journal of Anaesthesiology, 19, 5–15.
Jackson, T., Iezzi, T., Gunderson, J., Nagasaka, T., & Fritch, A. (2002). Gender differences in pain perception: The mediating role of self-efficacy beliefs. Sex Roles, 47, 561–568.
Jensen, I., Nygren, A., Gamberale, F., Goldie, I., & Westerholm, P. (1994). Coping with long-term musculoskeletal pain and its consequences: Is gender a factor? Pain, 57, 167–172.
Jensen, I. B., Bergstrom, G., Ljungquist, T., Bodin, L., & Nygren, A. L. (2001). A randomized controlled component analysis of a behavioral medicine rehabilitation program for chronic spinal pain: Are the effects dependent on gender? Pain, 91, 65–78.
Johannes, C. B., Le, T. K., Zhou, X., Johnston, J. A., & Dworkin, R. H. (2010). The prevalence of chronic pain in United States adults: Results of an internet-based survey. The Journal of Pain, 11, 1230–1239.
Jones, A., & Zachariae, R. (2002). Gender, anxiety, and experimental pain sensitivity: An overview. Journal of the American Medical Women’s Association, 57, 91–94.
Jones, A., Spindler, H., Jorgensen, M. M., & Zachariae, R. (2002). The effect of situation-evoked anxiety and gender on pain report using the cold pressor test. Scandinavian Journal of Psychology, 43, 307–313.
Jones, A., Zachariae, R., & Arendt-Nielsen, L. (2003). Dispositional anxiety and the experience of pain: Gender-specific effects. European Journal of Pain, 7, 387–395.
Kaczynski, K. J., Claar, R. L., & Logan, D. E. (2009). Testing gender as a moderator of associations between psychosocial variables and functional disability in children and adolescents with chronic pain. Journal of Pediatric Psychology, 34, 738–748.
Kallai, I., Barke, A., & Voss, U. (2004). The effects of experimenter characteristics on pain reports in women and men. Pain, 112, 142–147.
Kaur, S., Stechuchak, K. M., Coffman, C. J., Allen, K. D., & Bastian, L. A. (2007). Gender differences in health care utilization among veterans with chronic pain. Journal of General Internal Medicine, 22, 228–233.
Keefe, F. J., Crisson, J., Urban, B. J., & Williams, D. A. (1990). Analyzing chronic low back pain: The relative contribution of pain coping strategies. Pain, 40, 293–301.
Keefe, F. J., Lefebvre, J. C., Egert, J. R., Affleck, G., Sullivan, M. J., & Caldwell, D. S. (2000). The relationship of gender to pain, pain behavior, and disability in osteoarthritis patients: The role of catastrophizing. Pain, 87, 325–334.
Kennedy, J., Roll, J. M., Schraudner, T., Murphy, S., & McPherson, S. (2014). Prevalence of persistent pain in the US adult population: New data from the 2010 National Health Interview Survey. The Journal of Pain, 15, 979–984.
Keogh, E. (2004). Investigating invariance in the factorial structure of the anxiety sensitivity index across adult men and women. Journal of Personality Assessment, 83, 153–160.
Keogh, E. (2013). Role of psychosocial factors and psychological interventions. In M. L. Chin, R. B. Fillingim, & T. J. Ness (Eds.), Pain in women (pp. 94–105). Oxford: Oxford University Press.
Keogh, E. (2014). Gender differences in the nonverbal communication of pain: A new direction for sex, gender, and pain research? Pain, 155, 1927–1931.
Keogh, E. (2015). Men, masculinity, and pain. Pain, 156(12), 2408–2412.
Keogh, E. (2018). Sex and gender as social-contextual factors in pain. In T. Vervoort, K. Karos, Z. Trost, & K. M. Prkachin (Eds.), Social and interpersonal dynamics in pain: We do not suffer alone. New York: Springer.
Keogh, E., & Birkby, J. (1999). The effect of anxiety sensitivity and gender on the experience of pain. Cognition & Emotion, 13, 813–829.
Keogh, E., & Denford, S. (2009). Sex differences in perceptions of pain coping strategy usage. European Journal of Pain, 13, 629–634.
Keogh, E., & Eccleston, C. (2006). Sex differences in adolescent chronic pain and pain-related coping. Pain, 123, 275–284.
Keogh, E., & Herdenfeldt, M. (2002). Gender, coping and the perception of pain. Pain, 97, 195–201.
Keogh, E., Hatton, K., & Ellery, D. (2000). Avoidance versus focused attention and the perception of pain: Differential effects for men and women. Pain, 85, 225–230.
Keogh, E., Hamid, R., Hamid, S., & Ellery, D. (2004). Investigating the effect of anxiety sensitivity, gender and negative interpretative bias on the perception of chest pain. Pain, 111, 209–217.
Keogh, E., Bond, F. W., Hanmer, R., & Tilston, J. (2005a). Comparing acceptance- and control-based coping instructions on the cold-pressor pain experiences of healthy men and women. European Journal of Pain, 9, 591–598.
Keogh, E., McCracken, L. M., & Eccleston, C. (2005b). Do men and women differ in their response to interdisciplinary chronic pain management? Pain, 114, 37–46.
Keogh, E., Barlow, C., Mounce, C., & Bond, F. W. (2006a). Assessing the relationship between cold pressor pain responses and dimensions of the anxiety sensitivity profile in healthy men and women. Cognitive Behavior Therapy, 35, 198–206.
Keogh, E., McCracken, L. M., & Eccleston, C. (2006b). Gender moderates the association between depression and disability in chronic pain patients. European Journal of Pain, 10, 413–422.
Khan, R. S., Ahmed, K., Blakeway, E., Skapinakis, P., Nihoyannopoulos, L., Macleod, K., et al. (2011). Catastrophizing: A predictive factor for postoperative pain. American Journal of Surgery, 201(1), 122–131.
King, S., Chambers, C. T., Huguet, A., MacNevin, R. C., McGrath, P. J., Parker, L., et al. (2011). The epidemiology of chronic pain in children and adolescents revisited: A systematic review. Pain, 152, 2729–2738.
Koopmans, G. T., & Lamers, L. M. (2007). Gender and health care utilization: The role of mental distress and help-seeking propensity. Social Science & Medicine, 64, 1216–1230.
Kreddig, N., & Hasenbring, M. I. (2017). Pain anxiety and fear of (re)injury in patients with chronic back pain: Sex as a moderator. Scandinavian Journal of Pain, 16, 105–111.
Krogstad, B. S., Jokstad, A., Dahl, B. L., & Vassend, O. (1996). The reporting of pain, somatic complaints, and anxiety in a group of patients with TMD before and 2 years after treatment: Sex differences. Journal of Orofacial Pain, 10, 263–269.
Krummenacher, P., Kossowsky, J., Schwarz, C., Brugger, P., Kelley, J. M., Meyer, A., et al. (2014). Expectancy-induced placebo analgesia in children and the role of magical thinking. The Journal of Pain, 15, 1282–1293.
Lackner, J. M., & Carosella, A. M. (1999). The relative influence of perceived pain control, anxiety, and functional self efficacy on spinal function among patients with chronic low back pain. Spine, 24, 2254–2260.
LaFrance, M., Hecht, M. A., & Paluck, E. L. (2003). The contingent smile: A meta-analysis of sex differences in smiling. Psychological Bulletin, 129, 305–334.
Larsson, C., Hansson, E. E., Sundquist, K., & Jakobsson, U. (2017). Chronic pain in older adults: Prevalence, incidence, and risk factors. Scandinavian Journal of Rheumatology, 46, 317–325.
Lautenbacher, S., Kunz, M., Strate, P., Nielsen, J., & Arendt-Nielsen, L. (2005). Age effects on pain thresholds, temporal summation and spatial summation of heat and pressure pain. Pain, 115, 410–418.
Lautenbacher, S., Peters, J. H., Heesen, M., Scheel, J., & Kunz, M. (2017). Age changes in pain perception: A systematic-review and meta-analysis of age effects on pain and tolerance thresholds. Neuroscience and Biobehavioral Reviews, 75, 104–113.
LeResche, L. (1999). Gender considerations in the epidemiology of chronic pain. In I. K. Crombie, P. R. Croft, S. J. Linton, L. LeResche, & M. Von Korff (Eds.), Epidemiology of pain (pp. 43–52). Seattle: IASP Press.
LeResche, L. (2013). Epidemiology of pain conditions with higher prevalence in women. In C. Chin, R. B. Fillingim, & T. J. Ness (Eds.), Pain in women (pp. 3–15). Oxford: Oxford University Press.
LeResche, L., Mancl, L., Sherman, J. J., Gandara, B., & Dworkin, S. F. (2003). Changes in temporomandibular pain and other symptoms across the menstrual cycle. Pain, 106, 253–261.
Leveille, S. G., Zhang, Y. Q., McMullen, W., Kelly-Hayes, M., & Felson, D. T. (2005). Sex differences in musculoskeletal pain in older adults. Pain, 116, 332–338.
Levine, F. M., & Desimone, L. L. (1991). The effects of experimenter gender on pain report in male and female subjects. Pain, 44, 69–72.
Lofgren, M., & Norrbrink, C. (2009). Pain relief in women with fibromyalgia: A cross-over study of superficial warmth stimulation and transcutaneous electrical nerve stimulation. Journal of Rehabilitation Medicine, 41, 557–562.
Logan, D. E., & Rose, J. B. (2004). Gender differences in post-operative pain and patient controlled analgesia use among adolescent surgical patients. Pain, 109, 481–487.
Lord, B., Cui, J., & Kelly, A. M. (2009). The impact of patient sex on paramedic pain management in the prehospital setting. The American Journal of Emergency Medicine, 27, 525–529.
Loyd, D. R., & Murphy, A. Z. (2014). The neuroanatomy of sexual dimorphism in opioid analgesia. Experimental Neurology, 259, 57–63.
Lu, Q., Tsao, J. C., Myers, C. D., Kim, S. C., & Zeltzer, L. K. (2007). Coping predictors of children’s laboratory-induced pain tolerance, intensity, and unpleasantness. The Journal of Pain, 8, 708–717.
Lund, I., Lundeberg, T., Kowalski, J., & Svensson, E. (2005). Gender differences in electrical pain threshold responses to transcutaneous electrical nerve stimulation (TENS). Neuroscience Letters, 375, 75–80.
Lynch, A. M., Kashikar-Zuck, S., Goldschneider, K. R., & Jones, B. A. (2007). Sex and age differences in coping styles among children with chronic pain. Journal of Pain and Symptom Management, 33, 208–216.
Mackenzie, C. S., Gekoski, W. L., & Knox, V. J. (2006). Age, gender, and the underutilization of mental health services: The influence of help-seeking attitudes. Aging & Mental Health, 10, 574–582.
Mahic, M., Fredheim, O. M., Borchgrevink, P. C., & Skurtveit, S. (2015). Use of prescribed opioids by children and adolescents: Differences between Denmark, Norway and Sweden. European Journal of Pain, 19, 1095–1100.
Martin, V. T. (2009). Ovarian hormones and pain response: A review of clinical and basic science studies. Gender Medicine, 6, 168–192.
Martin, V. T., & Behbehani, M. (2006). Ovarian hormones and migraine headache: Understanding mechanisms and pathogenesis – part I. Headache, 46, 3–23.
McCabe, S. E., Boyd, C. J., & Young, A. (2007). Medical and nonmedical use of prescription drugs among secondary school students. Journal of Adolescent Health, 40, 76–83.
McClelland, L. E., & McCubbin, J. A. (2008). Social influence and pain response in women and men. Journal of Behavioral Medicine, 31, 413–420.
McCracken, L. M., & Houle, T. (2000). Sex-specific and general roles of pain-related anxiety in adjustment to chronic pain: A reply to Edwards et al. The Clinical Journal of Pain, 16, 275–276.
McLean, C. P., & Anderson, E. R. (2009). Brave men and timid women? A review of the gender differences in fear and anxiety. Clinical Psychology Review, 29, 496–505.
Meints, S. M., Stout, M., Abplanalp, S., & Hirsh, A. T. (2017). Pain-related rumination, but not magnification or helplessness, mediates race and sex differences in experimental pain. The Journal of Pain, 18, 332–339.
Melchior, M., Poisbeau, P., Gaumond, I., & Marchand, S. (2016). Insights into the mechanisms and the emergence of sex-differences in pain. Neuroscience, 338, 63–80.
Merlijn, V. P., Hunfeld, J. A., van der Wouden, J. C., Hazebroek-Kampschreur, A. A., Koes, B. W., & Passchier, J. (2003). Psychosocial factors associated with chronic pain in adolescents. Pain, 101, 33–43.
Michael, G. E., Sporer, K. A., & Youngblood, G. M. (2007). Women are less likely than men to receive prehospital analgesia for isolated extremity injuries. American Journal of Emergency Medicine, 25, 901–906.
Mogil, J. S. (2012). Sex differences in pain and pain inhibition: Multiple explanations of a controversial phenomenon. Nature Reviews Neuroscience, 13, 859–866.
Moon, E. C., Chambers, C. T., Larochette, A. C., Hayton, K., Craig, K. D., & McGrath, P. J. (2008). Sex differences in parent and child pain ratings during an experimental child pain task. Pain Research & Management, 13, 225–230.
Moore, D. J., Eccleston, C., & Keogh, E. (2013). Does sex moderate the relationship between anxiety and pain? Psychology & Health, 28, 746–764.
Muehlenhard, C. L., & Peterson, Z. D. (2011). Distinguishing between sex and gender: History, urrent conceptualizations, and implications. Sex Roles, 64, 791–803.
Murphy, J. L., Phillips, K. M., & Rafie, S. (2016). Sex differences between Veterans participating in interdisciplinary chronic pain rehabilitation. Journal of Rehabilitation Research and Development, 53, 83–94.
Myers, C. D., Tsao, J. C., Glover, D. A., Kim, S. C., Turk, N., & Zeltzer, L. K. (2006). Sex, gender, and age: Contributions to laboratory pain responding in children and adolescents. The Journal of Pain, 7, 556–564.
Naugle, K. M., Cruz-Almeida, Y., Fillingim, R. B., Staud, R., & Riley, J. L., 3rd. (2017). Increased spatial dimensions of repetitive heat and cold stimuli in older women. Pain, 158, 973–979.
Niesters, M., Dahan, A., Kest, B., Zacny, J., Stijnen, T., Aarts, L., et al. (2010). Do sex differences exist in opioid analgesia? A systematic review and meta-analysis of human experimental and clinical studies. Pain, 151, 61–68.
Niesters, M., Dahan, A., Aarts, L., & Sarton, E. (2013). Sex differences in analgesic response: Clinical and experimental studies. In M. L. Chin, R. B. Fillingim, & T. J. Ness (Eds.), Pain in women (pp. 54–66). New York: Oxford University Press.
Paulose-Ram, R., Hirsh, R., Dillon, C., Losonczy, K., Cooper, M., & Ostchega, Y. (2003). Prescription and non-prescription analgesic use among the US adult population: Results from the third National Health and Nutrition Examination Survey (NHANES III). Pharmacoepidemiology and Drug Safety, 12, 315–326.
Paulson, M., Danielson, E., & Norberg, A. (1999). Nurses’ and physicians’ narratives about long-term non-malignant pain among men. Journal of Advanced Nursing, 30, 1097–1105.
Perquin, C. W., Hazebroek-Kampschreur, A. A., Hunfeld, J. A., Bohnen, A. M., van Suijlekom-Smit, L. W., Passchier, J., et al. (2000). Pain in children and adolescents: A common experience. Pain, 87, 51–58.
Petrini, L., Matthiesen, S. T., & Arendt-Nielsen, L. (2015). The effect of age and gender on pressure pain thresholds and suprathreshold stimuli. Perception, 44, 587–596.
Pickering, G., Jourdan, D., Eschalier, A., & Dubray, C. (2002). Impact of age, gender and cognitive functioning on pain perception. Gerontology, 48(2), 112–118.
Pieh, C., Altmeppen, J., Neumeier, S., Loew, T., Angerer, M., & Lahmann, C. (2012). Gender differences in outcomes of a multimodal pain management program. Pain, 153, 197–202.
Piira, T., Taplin, J. E., Goodenough, B., & von Baeyer, C. L. (2002). Cognitive-behavioural predictors of children’s tolerance of laboratory-induced pain: Implications for clinical assessment and future directions. Behavior Research & Therapy, 40, 571–584.
Piira, T., Champion, G. D., Bustos, T., Donnelly, N., & Lui, K. (2007). Factors associated with infant pain response following an immunization injection. Early Human Development, 83, 319–326.
Pleym, H., Spigset, O., Kharasch, E. D., & Dale, O. (2003). Gender differences in drug effects: Implications for anesthesiologists. Acta Anaesthesiologica Scandinavica, 47, 241–259.
Pokela, N., Bell, J. S., Lihavainen, K., Sulkava, R., & Hartikainen, S. (2010). Analgesic use among community dwelling people aged 75 years and older: A population based interview study. The American Journal of Geriatric Pharmacotherapy, 8, 233–244.
Popescu, A., LeResche, L., Truelove, E. L., & Drangsholt, M. T. (2010). Gender differences in pain modulation by diffuse noxious inhibitory controls: A systematic review. Pain, 150(2), 309–318.
Prkachin, K. M. (1992). The consistency of facial expressions of pain: A comparison across modalities. Pain, 51, 297–306.
Prkachin, K. M., & Solomon, P. E. (2009). The structure, reliability and validity of pain expression: Evidence from patients with shoulder pain. Pain, 139, 267–274.
Pud, D., Yarnitsky, D., Sprecher, E., Rogowski, Z., Adler, R., & Eisenberg, E. (2006). Can personality traits and gender predict the response to morphine? An experimental cold pain study. European Journal of Pain, 10, 103–112.
Rabbitts, J. A., Fisher, E., Rosenbloom, B. N., & Palermo, T. M. (2017). Prevalence and predictors of chronic postsurgical pain in children: A systematic review and meta-analysis. The Journal of Pain, 18, 605–614.
Racine, M. (in press). Chronic pain and suicide risk: A comprehensive review. Progress in Neuro-Psychopharmacology & Biological Psychiatry.
Racine, M., Tousignant-Laflamme, Y., Kloda, L. A., Dion, D., Dupuis, G., & Choiniere, M. (2012a). A systematic literature review of 10 years of research on sex/gender and experimental pain perception – Part 1: Are there really differences between women and men? Pain, 153, 602–618.
Racine, M., Tousignant-Laflamme, Y., Kloda, L. A., Dion, D., Dupuis, G., & Choiniere, M. (2012b). A systematic literature review of 10 years of research on sex/gender and pain perception – Part 2: Do biopsychosocial factors alter pain sensitivity differently in women and men? Pain, 153, 619–635.
Ramirez-Maestre, C., & Esteve, R. (2014). The role of sex/gender in the experience of pain: Resilience, fear, and acceptance as central variables in the adjustment of men and women with chronic pain. The Journal of Pain, 15, 608–618.
Rhudy, J. L., & Williams, A. E. (2005). Gender differences in pain: Do emotions play a role? Gender Medicine, 2, 208–226.
Ribeiro-Dasilva, M. C., Shinal, R. M., Glover, T., Williams, R. S., Staud, R., Riley, J. L., & Fillingim, R. B. (2011). Evaluation of menstrual cycle effects on morphine and pentazocine analgesia. Pain, 152, 614–622.
Riley, J. L., Robinson, M. E., Wise, E. A., Myers, C. D., & Fillingim, R. B. (1998). Sex differences in the perception of noxious experimental stimuli: A meta-analysis. Pain, 74, 181–187.
Riley, J. L., Robinson, M. E., Wise, E. A., & Price, D. D. (1999). A meta-analytic review of pain perception across the menstrual cycle. Pain, 81, 225–235.
Riley, J. L., Cruz-Almeida, Y., Glover, T. L., King, C. D., Goodin, B. R., Sibille, K. T., et al. (2014). Age and race effects on pain sensitivity and modulation among middle-aged and older adults. The Journal of Pain, 15, 272–282.
Robinson, M. E., & Wise, E. A. (2003). Gender bias in the observation of experimental pain. Pain, 104, 259–264.
Robinson, M. E., & Wise, E. A. (2004). Prior pain experience: Influence on the observation of experimental pain in men and women. The Journal of Pain, 5, 264–269.
Robinson, M. E., Riley, J. L., Myers, C. D., Papas, R. K., Wise, E. A., Waxenberg, L. B., et al. (2001). Gender role expectations of pain: Relationship to sex differences in pain. The Journal of Pain, 2, 251–257.
Robinson, M. E., Gagnon, C. M., Dannecker, E. A., Brown, J. L., Jump, R. L., & Price, D. D. (2003a). Sex differences in common pain events: Expectations and anchors. The Journal of Pain, 4, 40–45.
Robinson, M. E., Gagnon, C. M., Riley, J. L., & Price, D. D. (2003b). Altering gender role expectations: Effects on pain tolerance, pain threshold, and pain ratings. The Journal of Pain, 4, 284–288.
Robinson, M. E., George, S. Z., Dannecker, E. A., Jump, R. L., Hirsh, A. T., Gagnon, C. M., et al. (2004a). Sex differences in pain anchors revisited: Further investigation of “most intense” and common pain events. European Journal of Pain, 8, 299–305.
Robinson, M. E., Wise, E. A., Gagnon, C., Fillingim, R. B., & Price, D. D. (2004b). Influences of gender role and anxiety on sex differences in temporal summation of pain. The Journal of Pain, 5, 77–82.
Romano, J. M., Turner, J. A., Jensen, M. P., Friedman, L. S., Bulcroft, R. A., Hops, H., & Wright, S. F. (1995). Chronic pain patient-spouse behavioral interactions predict patient disability. Pain, 63, 353–360.
Rovner, G. S., Sunnerhagen, K. S., Bjorkdahl, A., Gerdle, B., Borsbo, B., Johansson, F., et al. (2017). Chronic pain and sex-differences; women accept and move, while men feel blue. Plos One, 12(4).
Schafer, G., Prkachin, K. M., Kaseweter, K. A., & Williams, A. C. D. (2016). Health care providers’ judgments in chronic pain: The influence of gender and trustworthiness. Pain, 157, 1618–1625.
Scheibe, S., & Carstensen, L. L. (2010). Emotional aging: Recent findings and future trends. The Journals of Gerontology Series B, 65B, 135–144.
Sharifzadeh, Y., Kao, M. C., Sturgeon, J. A., Rico, T. J., Mackey, S., & Darnall, B. D. (2017). Pain catastrophizing moderates relationships between pain intensity and opioid prescription nonlinear sex differences revealed using a learning health system. Anesthesiology, 127, 136–146.
Sherman, J. J., & LeResche, L. (2006). Does experimental pain response vary across the menstrual cycle? A methodological review. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, 291(2), R245–R256.
Sherman, J. J., LeResche, L., Mancl, L. A., Huggins, K., Sage, J. C., & Dworkin, S. F. (2005). Cyclic effects on experimental pain response in women with temporomandibular disorders. Journal of Orofacial Pain, 19, 133–143.
Simon, D., Craig, K. D., Gosselin, F., Belin, P., & Rainville, P. (2008). Recognition and discrimination of prototypical dynamic expressions of pain and emotions. Pain, 135, 55–64.
Sjogren, P., Ekholm, O., Peuckmann, V., & Gronbaek, M. (2009). Epidemiology of chronic pain in Denmark: An update. European Journal of Pain, 13, 287–292.
Skovbjerg, S., Jorgensen, T., Arendt-Nielsen, L., Ebstrup, J. F., Carstensen, T., & Graven-Nielsen, T. (2017). Conditioned pain modulation and pressure pain sensitivity in the adult Danish general population: The DanFunD study. The Journal of Pain, 18, 274–284.
Smith, S. J., Keefe, F. J., Caldwell, D. S., Romano, J., & Baucom, D. (2004). Gender differences in patient-spouse interactions: A sequential analysis of behavioral interactions in patients having osteoarthritic knee pain. Pain, 112, 183–187.
Smith, D., Wilkie, R., Uthman, O., Jordan, J. L., & McBeth, J. (2014). Chronic pain and mortality: A systematic review. Plos One, 9.
Sorge, R. E., & Totsch, S. K. (2017). Sex differences in pain. Journal of Neuroscience Research, 95, 1271–1281.
Stanford, E. A., Chambers, C. T., Biesanz, J. C., & Chen, E. (2008). The frequency, trajectories and predictors of adolescent recurrent pain: A population-based approach. Pain, 138, 11–21.
Stewart, W. F., Linet, M. S., Celentano, D. D., Van Natta, M., & Ziegler, D. (1991). Age- and sex-specific incidence rates of migraine with and without visual aura. American Journal of Epidemiology, 134, 1111–1120.
Stovner, L., Hagen, K., Jensen, R., Katsarava, Z., Lipton, R., Scher, A., et al. (2007). The global burden of headache: A documentation of headache prevalence and disability worldwide. Cephalalgia, 27, 193–210.
Strong, J., Ashton, R., & Chant, D. (1992). The measurement of attitudes towards and beliefs about pain. Pain, 48, 227–236.
Sullivan, M. J. L., Bishop, S. R., & Pivik, J. (1995). The Pain Catastrophizing Scale: Development and validation. Psychological Assessment, 7, 524–532.
Sullivan, M. J. L., Tripp, D. A., & Santor, D. (2000). Gender differences in pain and pain behavior: The role of catastrophizing. Cognitive Therapy and Research, 24, 121–134.
Swider, K., & Babel, P. (2013). The effect of the sex of a model on nocebo hyperalgesia induced by social observational learning. Pain, 154, 1312–1317.
Tamres, L. K., Janicki, D., & Helgeson, V. S. (2002). Sex differences in coping behavior: A meta-analytic review and an examination of relative coping. Personality and Social Psychology Review, 6, 2–30.
Thibodeau, M. A., Welch, P. G., Katz, J., & Asmundson, G. J. G. (2013). Pain-related anxiety influences pain perception differently in men and women: A quantitative sensory test across thermal pain modalities. Pain, 154, 419–426.
Thompson, T., Keogh, E., French, C. C., & Davis, R. (2008). Anxiety sensitivity and pain: Generalisability across noxious stimuli. Pain, 134, 187–196.
Tobin, D. D., Menon, M., Menon, M., Spatta, B. C., Hodges, E. V. E., & Perry, D. G. (2010). The intrapsychics of gender: A model of self-socialization. Psychological Review, 117, 601–622.
Tsang, A., Von Korff, M., Lee, S., Alonso, J., Karam, E., Angermeyer, M. C., et al. (2008). Common chronic pain conditions in developed and developing countries: Gender and age differences and co-morbidity with depression-anxiety disorders. The Journal of Pain, 9, 883–891.
Turunen, J. H., Mantyselka, P. T., Kumpusalo, E. A., & Ahonen, R. S. (2005). Frequent analgesic use at population level: Prevalence and patterns of use. Pain, 115, 374–381.
Unger, R. K. (1979). Toward a redefinition of sex and gender. American Psychologist, 34, 1085–1094.
Unruh, A. M., Ritchie, J., & Merskey, H. (1999). Does gender affect appraisal of pain and pain coping strategies? The Clinical Journal of Pain, 15, 31–40.
Vambheim, S. M., & Flaten, M. A. (2017). A systematic review of sex differences in the placebo and the nocebo effect. Journal of Pain Research, 10, 1831–1839.
Vambheim, S. M., & Oien, R. A. (2017). Sex differences in fear of pain: Item-level analysis of the Fear of Pain Questionnaire III. Journal of Pain Research, 10, 825–831.
Vervoort, T., Huguet, A., Verhoeven, K., & Goubert, L. (2011). Mothers’ and fathers’ responses to their child’s pain moderate the relationship between the child’s pain catastrophizing and disability. Pain, 152, 786–793.
Vetvik, K. G., & MacGregor, E. A. (2017). Sex differences in the epidemiology, clinical features, and pathophysiology of migraine. Lancet Neurology, 16, 76–87.
Vigil, J. M. (2009). A socio-relational framework of sex differences in the expression of emotion. The Behavioral and Brain Sciences, 32, 375–390.
Vigil, J. M., Rowell, L. N., Alcock, J., & Maestes, R. (2014). Laboratory personnel gender and cold pressor apparatus affect subjective pain reports. Pain Research & Management, 19, E13–E18.
Walsh, J., Eccleston, C., & Keogh, E. (2014). Pain communication through body posture: The development and validation of a stimulus set. Pain, 155, 2282–2290.
Walsh, J., Eccleston, C., & Keogh, E. (2017). Sex differences in the decoding of pain-related body postures. European Journal of Pain, 21, 1668–1677.
Wang, Y. Y., Hunt, K., Nazareth, I., Freemantle, N., & Petersen, I. (2013). Do men consult less than women? An analysis of routinely collected UK general practice data. BMJ Open, 3, e003320.
Wang, S., Eccleston, C., & Keogh, E. (2017). The role of spatial frequency information in the decoding of facial expressions of pain: A novel hybrid task. Pain, 158, 2233–2242.
Weir, R., Browne, G., Tunks, E., Gafni, A., & Roberts, J. (1996). Gender differences in psychosocial adjustment to chronic pain and expenditures for health care services used. The Clinical Journal of Pain, 12, 277–290.
Weisse, C. S., Sorum, P. C., Sanders, K. N., & Syat, B. L. (2001). Do gender and race affect decisions about pain management? Journal of General Internal Medicine, 16, 211–217.
Wilder-Smith, O. H. (2005). Opioid use in the elderly. European Journal of Pain, 9, 137–140.
Williams, R. E., Sampson, T. J., Kalilani, L., Wurzelmann, J. I., & Janning, S. W. (2008). Epidemiology of opioid pharmacy claims in the United States. Journal of Opioid Management, 4, 145–152.
Williams, A. C. D., Eccleston, C., & Morley, S. (2012). Psychological therapies for the management of chronic pain (excluding headache) in adults. Cochrane Database of Systematic Reviews, 11, CD007407.
Wilson, K. G., Heenan, A., Kowal, J., Henderson, P. R., McWilliams, L. A., & Castillo, D. (2017). Testing the interpersonal theory of suicide in chronic pain. Clinical Journal of Pain, 33(8), 699–706.
Wise, E. A., Price, D. D., Myers, C. D., Heft, M. W., & Robinson, M. E. (2002). Gender role expectations of pain: Relationship to experimental pain perception. Pain, 96, 335–342.
Wu, C. L., Rowlingson, A. J., Cohen, S. R., Michaels, R. K., Courpas, G. E., Joe, E. M., et al. (2006). Gender and post-dural puncture headache. Anesthesiology, 105, 613–618.
Wu, L. T., Pilowsky, D. J., & Patkar, A. A. (2008). Non-prescribed use of pain relievers among adolescents in the United States. Drug and Alcohol Dependence, 94, 1–11.
Yousaf, O., Grunfeld, E. A., & Hunter, M. S. (2015). A systematic review of the factors associated with delays in medical and psychological help-seeking amoung men. Health Psychology Review, 9, 264–276.
Zheng, H., Schnabel, A., Yahiaoui-Doktor, M., Meissner, W., Van Aken, H., Zahn, P., et al. (2017). Age and preoperative pain are major confounders for sex differences in postoperative pain outcome: A prospective database analysis. Plos One, 12(6), e0178659.
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Keogh, E. (2018). Sex and Gender Differences in Pain Across the Life Course. In: Moore, R. (eds) Handbook of Pain and Palliative Care. Springer, Cham. https://doi.org/10.1007/978-3-319-95369-4_18
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