Abstract
Distinguishing glaucomatous from non-glaucomatous optic neuropathies based on optical coherence tomography (OCT) can be challenging as test results of both pathologies may show similar loss patterns. The differential diagnosis between glaucomatous and non-glaucomatous optic neuropathies is important as misdiagnosis in such cases may result in unnecessary glaucoma treatment in patients who previously suffered from various optic nerve disorders such as anterior ischemic optic neuropathy, optic neuritis or traumatic optic neuropathy. In addition, the differential diagnosis is crucial so that treatable lesions such as compressive lesions of the visual pathways, which can have life treatening consequences, are detected in a timely manner. Subtle differences in pattern of the RNFL damage, absence of significant cupping, presence of optic nerve pallor, visual field test results and other clinical findings may be helpful in differential diagnosis. This chapter summarizes the key points for differentiating glaucomatous and non-glaucomatous optic neuropathies and presents OCT test results of sample cases for some of the common non-glaucomatous optic neuropathies.
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References
Dias DT, Ushida M, Battistella R, Dorairaj S, Prata TS. Neurophthalmological conditions mimicking glaucomatous optic neuropathy: analysis of the most common causes of misdiagnosis. BMC Ophthalmol. 2017;17:2–5.
Rosdahl JA, Asrani S. Glaucoma masqueraders: diagnosis by spectral domain optical coherence tomography. Saudi J Ophthalmol. 2012;26(4):433–40.
Paquet C, Boissonnot M, Roger F, Dighiero P, Gil R, Hugon JDP, Gil R, Hugon J. Abnormal retinal thickness in patients with mild cognitive impairment and Alzheimer’s disease. Neurosci Lett. 2007;420:97–9.
Moschos MM, Tagaris G, Markopoulos I, Margetis I, Tsapakis S, Kanakis M, Koutsandrea C. Morphologic changes and functional retinal impairment in patients with Parkinson disease without visual loss. Eur J Ophthalmol. 2011;21:24–9.
Inzelberg R, Ramirez JA, Nisipeanu P, Ophir A. Retinal nerve fiber layer thinning in Parkinson disease. Vis Res. 2004;44:2793–7.
Miller RN, Arnold AC. Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischemic optic neuropathy. Eye. 2015;29:65–79.
Gerling J, Meyer JH, Kommerell G. Visual field defects in optic neuritis and anterior ischemic optic neuropathy: distinctive features. Graefes Arch Clin Exp Ophthalmol. 1998;236(3):188–92.
Danesh-Meyer HV, Savino PJ, Sergott RC. The prevalence of cupping in end-stage arteritic and nonarteritic anterior ischemic optic neuropathy. Ophthalmology. 2001;108:593–8.
Bock M, Brandt AU, Dörr J, Kraft H, Weinges-Evers N, Gaede G, Pfueller CF, Herges K, Radbruch H, Ohlraun S, Bellmann-Strobl J, Kuchenbecker J, Zipp F, Paul F. Patterns of retinal nerve fiber layer loss in multiple sclerosis patients with or without optic neuritis and glaucoma patients. Clin Neurol Neurosurg. 2010;112:647–52.
Pueyo V, Ara JR, Almarcegui C, Martin J, Güerri N, García E, Pablo LE, Honrubia FM, Fernandez FJ. Sub-clinical atrophy of the retinal nerve fibre layer in multiple sclerosis. Acta Ophthalmol. 2010;88:748–52.
Talman LS, Bisker ER, Sackel DJ, Long DA Jr, Galetta KM, Ratchford JN, Lile DJ, Farrell SK, Loguidice MJ, Remington G, Conger A, Frohman TC, Jacobs DA, Markowitz CE, Cutter GR, Ying GS, Dai Y, Maguire MG, Galetta SL, Frohman EM, Calabresi PA, Balcer LJ. Longitudinal study of vision and retinal nerve fiber layer thickness in multiple sclerosis. Ann Neurol. 2010;67:749–60.
Nakamura M, Nakazawa T, Doi H, Hariya T, Omodaka K, Misu T, Takahashi T, Fujihara K, Nishida K. Early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with neuromyelitis optica. Graefes Arch Clin Exp Ophthalmal. 2010;248:1777–85.
Ratchford JN, Quigg ME, Conger A, Frohman T, Frohman E, Balcer LJ, Calabresi PA, Kerr DA. Optical coherence tomography helps differentiate neuromyelitis optica and MS optic neuropathies. Neurology. 2009;73:302–8.
Trobe JD, Glaser JS, Cassady J, Herschler J, Anderson DR. Non-glaucomatous excavation of the optic disc. Arch Ophthalmol. 1980;98:1046–50.
Greenfield DS. Glaucomatous versus non-glaucomatous optic disc cupping: clinical differentiation. Semin Ophthalmol. 1999;14:95–108.
Costa-Cunha LV, Cunha LP, Malta RF, Monteiro ML. Comparison of Fourier-domain and time-domain optical coherence tomography in the detection of band atrophy of the optic nerve. Am J Ophthalmol. 2009;147:56–63.
Monteiro ML, Cunha LP, Costa-Cunha LV, Maia OO Jr, Oyamada MK. Relationship between optical coherence tomography, pattern electroretinogram and automated perimetry in eyes with temporal hemianopia from chiasmal compression. Invest Ophthalmol Vis Sci. 2009;50:3535–41.
Goto K, Miki A, Yamashita T, Araki S, Takizawa G, Nakagawa M, Ieki Y, Kiryu J. Sectoral analysis of the retinal nerve fiber layer thinning and its association with visual field loss in homonymous hemianopia caused by post-geniculate lesions using spectral-domain optical coherence tomography. Graefes Arch Clin Exp Ophthalmol. 2016;254:745–56.
Cunha LP, Costa-Cunha LV, Malta RF, Monteiro ML. Comparison between retinal nerve fiber layer and macular thickness measured with OCT detecting progressive axonal loss following traumatic optic neuropathy. Arq Bras Oftalmol. 2009;72:622–5.
Medeiros FA, Moura FC, Vessani RM, Susanna R Jr. Axonal loss after traumatic optic neuropathy documented by optical coherence tomography. Am J Ophthalmol. 2003;135:406–8.
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Akman, A., Gür Güngör, S. (2018). Optical Coherence Tomography in Non-Glaucomatous Optic Neuropathies. In: Akman, A., Bayer, A., Nouri-Mahdavi, K. (eds) Optical Coherence Tomography in Glaucoma. Springer, Cham. https://doi.org/10.1007/978-3-319-94905-5_9
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