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Neurology

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Part of the book series: Current Clinical Psychiatry ((CCPSY))

Abstract

Children and adults with autism spectrum disorder (ASD) commonly have associated neurological disorders including seizures and motor abnormalities. People with ASD are also susceptible to common neurological problems, such as headache, which may go undiagnosed due to limited communication skills. Increases in irritability, aggression, or self-injurious behavior that prompt office visits to the neurologist or other specialists are often signs of underlying medical problems in people who are nonverbal or have limited verbal skills.

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References

  1. Annus T, Wilson LR, Hong YT, Acosta-Cabronero J, Fryer TD, Cardenas-Blanco A, et al. The pattern of amyloid accumulation in the brains of adults with Down syndrome. Alzheimers Dement. 2016;12(5):538–45.

    Article  Google Scholar 

  2. Bolton PF, Carcani-Rathwell I, Hutton J, Goode S, Howlin P, Rutter M. Epilepsy in autism: features and correlates. Br J Psychiatry. 2011;198(4):289–94.

    Article  Google Scholar 

  3. Canitano R, Vivanti G. Tics and Tourette syndrome in autism spectrum disorders. Autism. 2007;11(1):19–28.

    Article  Google Scholar 

  4. Castro P, Zaman S, Holland A. Alzheimer’s disease in people with Down’s syndrome: the prospects for and the challenges of developing preventative treatments. J Neurol. 2017;264(4):804–13.

    Article  Google Scholar 

  5. Dekker AD, Fortea J, Blesa R, De Deyn PP. Cerebrospinal fluid biomarkers for Alzheimer’s disease in Down syndrome. Alzheimers Dement (Amst). 2017;8:1–10.

    Google Scholar 

  6. Doyle CA, McDougle CJ. Pharmacotherapy to control behavioral symptoms in children with autism. Expert Opin Pharmacother. 2012;13(11):1615–29.

    Article  CAS  Google Scholar 

  7. Grieco J, Pulsifer M, Seligsohn K, Skotko B, Schwartz A. Down syndrome: cognitive and behavioral functioning across the lifespan. Am J Med Genet C: Semin Med Genet. 2015;169(2):135–49.

    Article  Google Scholar 

  8. Jeste SS, Tuchman R. Autism spectrum disorder and epilepsy: two sides of the same coin? J Child Neurol. 2015;30(14):1963–71.

    Article  Google Scholar 

  9. Kanner L. Autistic disturbances of affective contact. Nerv Child. 1943;2:217–50.

    Google Scholar 

  10. Kanner L. Follow-up study of eleven autistic children originally reported in 1943. J Autism Child Schizophr. 1971;1(2):119–45.

    Article  CAS  Google Scholar 

  11. Kuske B, Wolff C, Gövert U, Müller SV. Early detection of dementia in people with an intellectual disability – A German pilot study. J Appl Res Intellect Disabil. 2017;30(Suppl 1):49–57. 28332285.

    Article  Google Scholar 

  12. Lautarescu BA, Holland AJ, Zaman SH. The early presentation of dementia in people with Down syndrome: a systematic review of longitudinal studies. Neuropsychol Rev. 2017;27(1):31–45.

    Article  Google Scholar 

  13. LeVine H, Spielmann HP, Matveev S, Cauvi FM, Murphy MP, Beckett TL, et al. Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan. Neurobiol Aging. 2017;54:163–9.

    Article  CAS  Google Scholar 

  14. Maltête D. Adult-onset stereotypical motor behaviors. Rev Neurol (Paris). 2016;172(8–9):477–82.

    Article  Google Scholar 

  15. Maski KP, Jeste SS, Spence SJ. Common neurological co-morbidities in autism spectrum disorders. Curr Opin Pediatr. 2011;23(6):609–15.

    Article  CAS  Google Scholar 

  16. Péter Z, Oliphant ME, Fernandez TV. Motor stereotypies: a pathophysiological review. Front Neurosci. 2017;11:171.

    Article  Google Scholar 

  17. Portelius E, Soininen H, Andreasson U, Zetterberg H, Persson R, Karlsson G, et al. Exploring Alzheimer molecular pathology in Down’s syndrome cerebrospinal fluid. Neurodegener Dis. 2014;14(2):98–106.

    Article  CAS  Google Scholar 

  18. Qadir AA, Obringer E, Hageman J, Marcuccilli C. Risk of second seizure in pediatric patients with idiopathic autism. J Child Neurol. 2017;32(10):876–9.

    Article  Google Scholar 

  19. Rafii MS, Lukic AS, Andrews RD, Brewer J, Rissman RA, Strother SC, et al. PET imaging of tau pathology and relationship to amyloid, longitudinal MRI, and cognitive change in Down syndrome: results from the Down Syndrome Biomarker Initiative (DSBI). J Alzheimers Dis. 2017;60(2):439–50.

    Article  CAS  Google Scholar 

  20. Ringman JM, Jankovic J. Occurrence of tics in Asperger’s syndrome and autistic disorder. J Child Neurol. 2000;15(6):394–400.

    Article  CAS  Google Scholar 

  21. Scott RC, Tuchman R. Epilepsy and autism spectrum disorders: relatively related. Neurology. 2016;87(2):130–1.

    Article  Google Scholar 

  22. Srivastava S, Sahin M. Autism spectrum disorder and epileptic encephalopathy: common causes, many questions. J Neurodev Disord. 2017;9:23.

    Article  Google Scholar 

  23. Trauner DA. Behavioral correlates of epileptiform abnormalities in autism. Epilepsy Behav. 2015;47:163–6.

    Article  Google Scholar 

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Correspondence to Ann Neumeyer .

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Mierau, S., Neumeyer, A. (2018). Neurology. In: Hazen, E., McDougle, C. (eds) The Massachusetts General Hospital Guide to Medical Care in Patients with Autism Spectrum Disorder. Current Clinical Psychiatry. Humana Press, Cham. https://doi.org/10.1007/978-3-319-94458-6_6

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  • DOI: https://doi.org/10.1007/978-3-319-94458-6_6

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  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-94456-2

  • Online ISBN: 978-3-319-94458-6

  • eBook Packages: MedicineMedicine (R0)

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