Skip to main content

Congenital Hepatic Cysts

  • Chapter
  • First Online:
Neonatal Surgery

Abstract

Congenital hepatic cysts are rare but with an increasing prevalence due to antenatal ultrasonography. Cysts which arise solely from within the liver parenchyma can be divided into four categories: simple hepatic cysts, mesenchymal hamartomas, ciliated hepatic foregut cysts, and intrahepatic choledochal malformations. Distinguishing between these categories can be difficult, and diagnosis should be deferred until after birth. Whilst the majority of simple hepatic cysts can be managed conservatively, both mesenchymal hamartomas and ciliated hepatic foregut cysts should be excised.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Foley PT, Sithasanan N, McEwing R, et al. Enteric duplications presenting as antenatally detected abdominal cysts: is delayed resection appropriate? J Pediatr Surg. 2003;38:1810–3.

    Article  CAS  Google Scholar 

  2. Todani T, Watanabe Y, Narusue M, et al. Congenital bile duct cysts: classification, operative procedures, and review of thirty-seven cases including cancer arising from choledochal cyst. Am J Surg. 1977;134:263–9.

    Article  CAS  Google Scholar 

  3. Dabbas N, Davenport M. Congenital choledochal malformation: not just a problem for children. Ann R Coll Surg Engl. 2009;91:100–5.

    Article  Google Scholar 

  4. Michel W, Albig M, Waldschmidt J, et al. Prenatal ultrasound diagnosis of a cystic abdominal tumor – liver cyst and it’s differential diagnosis. Z Geburtshilfe Perinatol. 1986;190:172–4.

    CAS  PubMed  Google Scholar 

  5. Macken MB, Wright JR Jr, Lau H, et al. Prenatal sonographic detection of congenital hepatic cyst in third trimester after normal second- trimester sonographic examination. J Clin Ultrasound. 2000;28:307–10.

    Article  CAS  Google Scholar 

  6. Ishak KG, Sharp HL. Developmental abnormalities and liver dis eases in childhood. In: MacSween NM, Anthony PP, Scheurer PJ, editors. Pathology of the liver. 3rd ed. Edinburgh: Churchill Livingstone; 1994. p. 83–122.

    Google Scholar 

  7. Chung WM. Antenatal detection of hepatic cyst. J Clin Ultrasound. 1986;14:217–9.

    Article  CAS  Google Scholar 

  8. Schramm T, Schmolz A, Gloning KP, Brusis E, Permanetter W. Sonographic diagnosis of fetal liver cysts. Geburtshilfe Frauenheilkd. 1987;47:124–7.

    Article  CAS  Google Scholar 

  9. Ruiz J, Jimenez L, Cuenca M, et al. Solitary hepatic cyst. Presentation of a case diagnosed in neonatal period. Cir Pediatr. 1992;5:228–30.

    Google Scholar 

  10. Alcacay M, Dan U, Kessler A, Graif M, Shalev E. Prenatal ultrasonic diagnosis of hepatic cyst. J Pediatr Surg. 1991;6:146–7.

    Google Scholar 

  11. Tsao L, Jeanty P. Liver cyst. The Fetus. 1993;3:75164–6.

    Google Scholar 

  12. Avni EF, Rypens F, Donner C, Cuvelliez P, Rodesch F. Hepatic cysts and hyperechogenicities: perinatal assessment and unifying theory on their origin. Pediatr Radiol. 1994;24:569–72.

    Article  CAS  Google Scholar 

  13. Ito M, Yoshimura K, Toyoda N, Tanaka H. Aspiration of giant hepatic cyst in the fetus in utero. Fetal Diagn Ther. 1997;12:221–5.

    Article  CAS  Google Scholar 

  14. Arzt W, Stock M, Yaman C. Prenatal diagnosis and therapy of a fetal hepatic cyst in the 2nd trimester. Geburtshilfe Frauenheilkd. 1998;58:129–31.

    Article  Google Scholar 

  15. Shankar SR, Parelkar SV, Das SA, Mathure AB. An antenatally- diagnosed solitary, non-parasitic hepatic cyst with duodenal obstruction. Pediatr Surg Int. 2000;16:214–5.

    Article  CAS  Google Scholar 

  16. Hackmon-Ram R, Wiznitzer A, Gohar J, Mazor M. Prenatal diagnosis of a fetal abdominal cyst. Eur J Obstet Gynecol Reprod Biol. 2000;91:79–82.

    Article  CAS  Google Scholar 

  17. Ropp E, Alviedo N, Kent A. Solitary septated simple liver cyst in a newborn infant. ACG Case Rep J. 2015;2:255–7.

    Article  Google Scholar 

  18. Charlesworth P, Ade-Ajayi N, Davenport M. Natural history and long-term follow-up of antenatally detected liver cysts. J Pediatr Surg. 2007;42:494–9.

    Article  Google Scholar 

  19. Tabrizan P, Midulla P. Laparoscopic excision of a large hepatic cyst. JSLS. 2010;14:272–4.

    Article  Google Scholar 

  20. Banbury J, Conlon K, Ghossein R, et al. Squamous cell carcinoma within a solitary nonparasitic hepatic cyst. J Surg Oncol. 1994;57:210–2.

    Article  CAS  Google Scholar 

  21. Weimann A, Klempnauer J, Gebel M. Squamous cell carcinoma of the liver originating from a solitary non-parasitic cyst: case report and review of the literature. HPB Surg. 1996;10:45–9.

    Article  CAS  Google Scholar 

  22. Sanchez H, Gagner M, Rossi RL, et al. Surgical management of nonparasitic cystic liver disease. Am J Surg. 1991;161:113–9.

    Article  CAS  Google Scholar 

  23. Foucar E, Williamson RA, Yiu-Chiu V, et al. Mesenchymal hamartoma of the liver identified by foetal sonography. AJR Am J Roentgenol. 1983;140:970–2.

    Article  CAS  Google Scholar 

  24. Hirata G, Matsunaga M, Medearis A, et al. Ultrasonographic diagnosis of a fetal abdominal mass: a case of a mesenchymal liver hamartoma and a review of the literature. Prenat Diagn. 1990;10:507–12.

    Article  CAS  Google Scholar 

  25. Bartho S, Schulz HJ, Bollmann R, et al. Prenatally diagnosed mesenchymal hamartoma of the liver. Zentralblatt fur Pathologie. 1992;138:141–4.

    CAS  PubMed  Google Scholar 

  26. Hansen G, Ragavendra N. Atypical mesenchymal hamartoma of the liver: prenatal sonographic diagnosis. AJR Am J Roentgenol. 1992;158:921–2.

    Article  CAS  Google Scholar 

  27. Mason B, Hodges W, Goodman J. Antenatal sonographic detection of a rare solid hepatic mesenchymal hamartoma. J Matern Fetal Med. 1992;1:134–6.

    Article  Google Scholar 

  28. Bessho T, Kubota K, Komori S, et al. Prenatally detected hepatic hamartoma: another cause of non-immune hydrops. Prenat Diagn. 1996;16:337–41.

    Article  CAS  Google Scholar 

  29. Bejvan S, Winter T, Shields L, et al. Prenatal evaluation of mesenchymal hamartoma of the liver: gray scale and power Doppler sonographic imaging. J Ultrasound Med. 1997;16:227–9.

    Article  CAS  Google Scholar 

  30. Tovbin J, Segal M, Tavori I, et al. Hepatic mesenchymal hamartoma: a pediatric tumor that may be diagnosed prenatally. Ultrasound Obstet Gynecol. 1997;10:63–5.

    Article  CAS  Google Scholar 

  31. Littlewood Teele R, Pease PW, Rowley RS. Malrotation in newborns following antenatal diagnosis of intra-abdominal cyst. Pediatr Radiol. 1998;28:717–21.

    Article  CAS  Google Scholar 

  32. Dickinson JE, Knowles S, Phillips JM. Prenatal diagnosis of hepatic mesenchymal hamartoma. Prenatal Diag. 1999;19:81–4.

    Article  CAS  Google Scholar 

  33. Kitano Y, Ruchelli E, Weiner S, et al. Hepatic mesenchymal hamartoma associated with mesenchymal stem villous hyperplasia of the placenta. Fetal Diagn Ther. 2000;15:134–8.

    Article  CAS  Google Scholar 

  34. Garcia-de-la-Torre JP, Sotelo-Rodriguez MT, Santos-Briz A, et al. Mesenchymal hamartoma of the liver in Beckwith–Wiedemann syndrome: the first reported case. Pediatr Pathol Mol Med. 2000;19:455–60.

    Article  Google Scholar 

  35. Kamata S, Nose K, Sawai T, et al. Fetal mesenchymal hamartoma of the liver: report of a case. J Pediatr Surg. 2003;38:639–41.

    Article  Google Scholar 

  36. Tsao K, Hirose S, Sydorak R, et al. Fetal therapy for giant hepatic cysts. J Pediatr Surg. 2002;37:31–4.

    Article  Google Scholar 

  37. Mittermayer C, Bettelheim D, Horcher E, et al. Prenatal sonographic detection of a giant multiseptate hepatic cyst in the third trimester. Ultrasound Obstet Gynecol. 2002;20:97–8.

    Article  CAS  Google Scholar 

  38. Carta M, Maresi E, Giuffre M, et al. Congenital hepatic mesenchymal hamartoma associated with mesenchymal stem villous hyperplasia of the placenta: case report. J Pediatr Surg. 2005;40:37–9.

    Article  Google Scholar 

  39. Laberge JM, Patenaude Y, Desilets V, et al. Large hepatic mesenchymal hamartoma leading to mid-trimester fetal demise. Fetal Diagn Ther. 2005;20:141–5.

    Article  Google Scholar 

  40. Cignini P, Coco C, Giorlandino M, et al. Fetal hepatic mesenchymal hamartoma: a case report. J Prenat Med. 2007;1:45–6.

    PubMed  PubMed Central  Google Scholar 

  41. Cornette J, Festen S, van den Hoonaard TL, et al. Mesenchymal hamartoma of the liver: a benign tumor with deceptive prognosis in the perinatal period. Case report and review of the literature. Fetal Diagn Ther. 2009;25(2):196–202.

    Article  CAS  Google Scholar 

  42. Kodandapani S, Pai MV, Kumar V, et al. Prenatal diagnosis of congenital mesenchymal hamartoma of liver: a case report. Case Rep Obstet Gynaecol. 2011;2011:932583.

    Google Scholar 

  43. Ruhland B, Schroer A, Gembruch U, et al. Prenatal imaging and postnatal pathologic work-up in a case of fetal hepatic hamartoma and placental mesenchymal dysplasia. Ultrasound Obstet Gynecol. 2011;38(3):360–2.

    Article  CAS  Google Scholar 

  44. Douik F, Blel A, Ben Jamaa N, et al. Fetal hepatic mesenchymal hamartoma. A case report. Rare Dis Orphan Drugs. 2016;3:48–50.

    Google Scholar 

  45. Leung J, Coakley F, Hricak H, et al. Prenatal MR imaging of congenital diaphragmatic hernia. J Roentgenol. 2000;174:1607–12.

    Article  CAS  Google Scholar 

  46. Chang HJ, Jin SY, Park C, et al. Mesenchymal hamartomas of the liver: comparison of clinicopathologic features between cystic and solid forms. J Korean Med Sci. 2006;21:63–8.

    Article  Google Scholar 

  47. Hart I. Fetal and neonatal hepatic tumors. J Pediatr Surg. 2007;42:1797–803.

    Article  Google Scholar 

  48. Wheeler DA, Edmonson HA. Ciliated hepatic foregut cyst. Am J Surg Pathol. 1984;8:467–70.

    Article  CAS  Google Scholar 

  49. Stringer MD, Jones MO, Woodley H, et al. Ciliated hepatic foregut cyst. J Pediatr Surg. 2006;41:1180–3.

    Article  Google Scholar 

  50. Betalli P, Gobbi D, Talenti E, et al. Ciliated hepatic foregut cyst: from antenatal diagnosis to surgery. Pediatr Radiol. 2008;38:230–2.

    Article  Google Scholar 

  51. Guerin F, Hadhri R, Fabre M, et al. Prenatal and postnatal ciliated hepatic foregut cysts in infants. J Pediatr Surg. 2010;45:9–14.

    Article  Google Scholar 

  52. Khoddami M, Aghdam MK, Alvandimanesh A. Ciliated hepatic foregut cyst: two case reports in children and a review of the literature. Case Rep Med. 2013;2013:72017.

    Article  Google Scholar 

  53. Furlanetto A, Dei Tos AP. Squamous cell carcinoma arising in a ciliated hepatic foregut cyst. Arch Pathol Lab Med. 1999;123:1115–7.

    Google Scholar 

  54. Bishop K, Perrino C, Ruzinova M, et al. Ciliated hepatic foregut cyst: a report of 6 cases and a review of the English literature. Diagnostic Pathol. 2015;10:81. https://doi.org/10.1186/s13000-015-0321-1.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mark Davenport .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Allan, M., Davenport, M. (2019). Congenital Hepatic Cysts. In: Lima, M., Reinberg, O. (eds) Neonatal Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-93534-8_29

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-93534-8_29

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-93532-4

  • Online ISBN: 978-3-319-93534-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics