Abstract
Most of the lesions included in this chapter are frequently encountered in breast pathology and easy to diagnose. Some of them, however, may mimic radiologically, clinically, and pathologically an invasive carcinoma (the so-called pseudoinfiltrative lesions of the breast). Especially in these cases, the experience of the pathologist together with ancillary studies allow a correct diagnosis, while management requires a breast tumor board approach. Also, some of these lesions increase the risk of developing a malignancy, and closer follow-up should be considered in these patients.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Moinfar F. Essentials of diagnostic breast pathology. New York, NY: Springer; 2007. p. 16.
Hutter RVP. Consensus meeting: is “fibrocystic disease” of the breast precancerous? Arch Pathol Lab Med. 1986;110:171–3.
Stolnicu S, Mocan S, Radulescu D, Podeanu MD. Diagnosticul morfologic al leziunilor mamare. Lanham, MD: University Press; 2005.
Leis HP Jr. Fibrocystic disease of the breast. J Med Assoc Alabama. 1962;32:97–104.
Tavassoli FA, Purcell CA, Bratthauer GL, Man Y-G. Androgen receptor expression along with loss of bcl-2, ER and PR expression in benign and malignant apocrine lesions of the breast: implications for therapy. Breast J. 1996;4:261–9.
Tavassoli FA, Eusebi V. Tumors of the mammary gland. AFIP Atlas of tumor pathology, series 4. Washington, DC: American Registry of Pathology; 2009.
Dupont WD, Page DL. Risk factors for breast cancer in women with proliferative disease. N Engl J Med. 1985;312:146–51.
Semb C. Pathologico-anatomical and clinical investigations of fibroadenomatosis cystica mammae and its relation to the other pathological conditions in mamma, especially cancer. Acta Chir Scand. 1928;64:1–484.
Anderson TJ, Battersby S. Radial scars and complex sclerosing lesions. Histopathology. 1994;24:296–7.
Hilson JB, Schnitt SJ, Collins LC. Phenotypic alterations in myoepithelial cells associated with benign sclerosing lesions of the breast. Am J Surg Pathol. 2010;34(6):896–900.
Lakhani SR, Schnitt SJ, Tan PH, van de Vijver MJ. WHO classification of tumors of the breast. IARC: Lyon; 2012.
Jacobs TW, Byrne C, Colditz G, Connolly JL, Schnitt SJ. Radial scar in benign breast-biopsy specimens and the risk of breast cancer. N Engl J Med. 1999;340(6):430–6.
Sanders ME, Page DL, Simpson JF, Schuyler PA, Dale Plummer W, Dupont WD. Interdependence of radial scar and proliferative disease with respect to invasive breast carcinoma risk in patients with benign breast biopsies. Cancer. 2006;106(7):1453–61.
Resetkova E, Edelweiss M, Albarracin CT, Yang WT. Management of radial sclerosing lesions of the breast diagnosed using percutaneous vacuum-assisted core needle biopsy: recommendations for excision based on seven years of experience at a single institution. Breast Cancer Res Treat. 2011;127(2):335–43.
Bianchi S, Giannotti E, Vanzi E, Marziali M, Abdulcadir D, Boeri C, et al. Radial scar without associated atypical epithelial proliferation on image-guided 14-gauge needle core biopsy: analysis of 49 cases from a single—center and review of the literature. Breast. 2012;21(2):159–64.
Ferreira AI, Borges S, Sousa A, Ribeiro C, Mesquita A, Martins PC, et al. Radial scar of the breast: is it possible to avoid surgery? Eur J Surg Oncol. 2017;43(7):1265–72.
Carter DJ, Rosen PP. Atypical apocrine metaplasia in sclerosing lesions of the breast. A study of 51 patients. Mod Pathol. 1991;4:1–5.
Rosen PP. Rosen’s breast pathology. 3rd ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2009.
Tavassoli FA, Norris HJ. Microglandular adenosis of the breast. A clinicopathologic study of 11 cases with ultrastructural observations. Am J Surg Pathol. 1983;7(8):731–7.
Clement PB, Azzopardi JG. Microglamdular adenosis of the breast—a lesion simulating tubular racinoma. Histopathology. 1983;7(2):169–80.
Rosen PP. Microglandular adenosis. A benign lesion simulating invasive mammary carcinoma. Am J Surg Pathol. 1983;7(2):137–44.
Geyer FC, Lacroix-Triki M, Colombo PE, Patani N, Gauthier A, Natrajan R, et al. Molecular evidence in support of the neoplastic and precursor nature of microglandular adenosis. Histopathology. 2012;60:E115–30.
Khalifeh IM, Albarracin C, Diaz LK, Symmans FW, Edgerton ME, Hwang RF, et al. Clinical, histopathologic and immunohistochemical features of mucroglandular adenosis and transition into in situ and invasive carcinoma. Am J Surg Pathol. 2008;32(2):544–52.
Shin SJ, Rosen PP. Pregnancy-like (pseudolactational) hyperplasia: a primary diagnosis in mammographically detected lesions of the breast and its relationship to cystic hypersecretory hyperplasia. Am J Surg Pathol. 2000;24:1670–4.
Tavassoli FA. Pathology of the breast. 2nd ed. Appleton and Lange: Stamford, CT; 1999.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Stolnicu, S. (2018). Benign Lesions (Proliferations) and Tumors of the Breast. In: Stolnicu, S., Alvarado-Cabrero, I. (eds) Practical Atlas of Breast Pathology . Springer, Cham. https://doi.org/10.1007/978-3-319-93257-6_7
Download citation
DOI: https://doi.org/10.1007/978-3-319-93257-6_7
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-93256-9
Online ISBN: 978-3-319-93257-6
eBook Packages: MedicineMedicine (R0)