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Hematopoietic Lesions of the Breast

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Practical Atlas of Breast Pathology

Abstract

The diagnosis of primary breast lymphoma (PBL) is limited to patients without evidence of systemic lymphoma or leukemia at the time that the breast lesion is detected. Clinically, the disease should involve only the breast or the breast and ipsilateral lymph nodes. PBL is a rare clinical entity that accounts for less than 1% of all patients with non-Hodgkin lymphoma (NHL) and approximately 1.7% of all patients with extra lymph node NHL.

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References

  1. Aviv A, Tadmor T, Polliack A. Primary diffuse large B-cell lymphoma of the breast: looking at pathogenesis, clinical issues and therapeutic options. Ann Oncol. 2013;24:2236–44.

    Article  CAS  PubMed  Google Scholar 

  2. Cheah CY, Campbell B, Seymour J. Primary breast lymphoma. Cancer Treat Rev. 2014;40:900–8.

    Article  PubMed  Google Scholar 

  3. Lin YC, Tsai CH, Wu JS, Huang CS, Kuo SH, Lin CW, et al. Clinicopathologic features and treatment outcome of non-Hodgkin lymphoma of the breast. A review of 42 primary and second cases in Taiwanese patients. Leuk Lymphoma. 2009;50:918–24.

    Article  CAS  PubMed  Google Scholar 

  4. Yhim HY, Kang HJ, Choi YH, Kim SJ, Kim WS, Chae YS, et al. Clinical outcomes and prognostic factors in patients with breast diffuse large B-cell lymphoma; Consortium for improving Survival of Lymphoma study. BMC Cancer. 2010;10:321.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Wiseman C, Liao KT. Primary lymphoma of the breast. Cancer. 1972;29:1705–12.

    Article  CAS  PubMed  Google Scholar 

  6. Hugh J, Jackson F, Hanson J, Poppema S. Primary breast lymphoma. An immunohistologic study of 20 new cases. Cancer. 1990;66:2602–11.

    Article  CAS  PubMed  Google Scholar 

  7. Talwakar SS, Miranda RN, Valbuena JR, Routbort MJ, Martin AW, Medeiros LJ. Lymphomas involving the breast: a study of 106 cases comparing localized and disseminated neoplasms. Am J Surg Pathol. 2008;32:1299–309.

    Article  Google Scholar 

  8. Nicholson BT, Bhatti RM, Glassman L. Extranodal lymphoma of the breast. Radiol Clin N Am. 2016;54:711–26.

    Article  PubMed  Google Scholar 

  9. Lyons J, Myles T, Pohlman B, Macklis RM, Crowe J, Crownover RL. Treatment and prognosis of primary breast lymphoma. A review of 13 cases. Am J Clin Pathol. 2000;23:334–6.

    CAS  Google Scholar 

  10. Yoshida S, Nakamura N, Sasaki Y, Yoshida S, Yasuda M, Sagara H, et al. Primary breast diffuse large B-cell lymphoma shows a non-germinal center B-cell phenotype. Mod Pathol. 2005;18:398–405.

    Article  CAS  PubMed  Google Scholar 

  11. Hoffman J, Ohgami RS. Hematolymphoid lesions of the breast. Semin Diagn Pathol. 2017;34:462–9.

    Article  Google Scholar 

  12. Lakhani SR, Ellis IO, Schnitt S, Tan PH, van de Vijver MJ. World Health Organization classification of tumors of the breast. 4th ed. Lyon: IARC Press; 2012.

    Google Scholar 

  13. Koganti SB, Lozada A, Curras E, Shah A. Marginal zone lymphoma of the breast. A diminished role for surgery. Int J Surg Case Rep. 2016;25:4–6.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Martinelli G, Ryan G, Seymour JF, Nassi L, Steffanoni S, Alietti A, et al. Primary follicular and marginal-zone lymphoma of the breast: clinical features, prognostic factors and outcome: a study by the International Extranodal Lymphoma Study Group. Ann Oncol. 2009;20(12):1993–9.

    Article  CAS  PubMed  Google Scholar 

  15. Cohen MS, Petryk M, Varma M, Kozuch PS, Ames ED, Grossbard ML. Non-Hodgkin lymphoma of mucosa-associated lymphoid tissue. Oncologist. 2006;11:1100–17.

    Article  CAS  PubMed  Google Scholar 

  16. Bacon CM, Du M-Q, Dogan A. Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologist. J Clin Pathol. 2007;60:361–72.

    Article  CAS  PubMed  Google Scholar 

  17. Cabras MG, Amichetti M, Nagliati M, Orrù P, Mamusa AM, Angelucci E. Primary non-Hodgkin’s lymphoma of the breast: a report of 11 cases. Haematologica. 2004;89:1527–8.

    PubMed  Google Scholar 

  18. Ogawa T, Mizutani M, Yabana T, Miyahara S, Murabayashi K. A case of Burkitt’s lymphoma involving both breasts. Breast Cancer. 2005;12:234–7.

    Article  PubMed  Google Scholar 

  19. Mawson AR, Majumdar S. Malaria, Epstein-Barr virus infection and the pathogenesis of Burkitt’s lymphoma. Int J Cancer. 2017;141:1849–55.

    Article  CAS  PubMed  Google Scholar 

  20. Faenza M, Ronchi A, Santoriello A, Rubino C, Pieretti G, Guastafierro A, et al. What’s new on primary Hodgkin’s lymphoma of the breast. A case report and review of the literature. Int J Surg Case Rep. 2017;38:149–53.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Schouten JT, Weese JL, Carbone PP. Lymphoma of the breast. Ann Surg. 1981;194:749–53.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Ariad S, Lewis D, Cohen R, Bezwoda WR. Breast lymphoma. A clinical and pathological review and 10-year treatment results. S Afr Med J. 1995;85:85–9.

    PubMed  CAS  Google Scholar 

  23. Ergül N, Güner SI, Sağer S, Huq GE, Ciftçi H, Cermik TF. Bilateral breast involvement of Hodgkin lymphoma revealed by FDG PET/CT. Med Oncol. 2012;29:1105–8.

    Article  PubMed  Google Scholar 

  24. Wong WW, Schild SE, Halyard MY, Schomberg PJ. Primary non-Hodgkin lymphoma of the breast: the Mayo Clinic experience. J Surg Oncol. 2002;80:19–25.

    Article  PubMed  Google Scholar 

  25. de Jong D, Vasmel WL, de Boer JP, Verhave G, Barbé E, Casparie MK, et al. Anaplastic large-cell lymphoma in women with breast implants. JAMA. 2008;300:2030–5.

    Article  PubMed  Google Scholar 

  26. Erhan Y, Veral A, Kara E, Ozdemir N, Kapkac M, Ozdedeli E. A clinicopathologic study of a rare clinical entity mimicking breast carcinoma: idiopathic granulomatous mastitis. Breast. 2000;9:52–6.

    Article  CAS  PubMed  Google Scholar 

  27. Ely KA, Tse G, Simpson JF, Clarfeld R, Page DL. Diabetic Mastopathy: A Clinicopathologic Review. Am J Clin Pathol. 2000;113:541–5.

    Article  CAS  PubMed  Google Scholar 

  28. Dialani V, Mani K, Johnson NB. Chronic lymphocytic leukemia involving the breast parenchyma, mimicker of invasive breast cancer: differentiation on Breast MRI. Case Rep Med. 2013;18:1–5.

    Article  Google Scholar 

  29. Green I, Dorfman RF, Rosai J. Breast involvement by extranodal disease: report of seven cases. Am J Surg Pathol. 1997;21:664–8.

    Article  CAS  PubMed  Google Scholar 

  30. Picón-Coronel G, Palmerín-Bucio ME, Méndez-Pérez V, Alvarado-Cabrero I. Mammary gland Rosai Dorfman disease. A case report and literature review. Gac Med Mex. 2010;146:212–5.

    PubMed  Google Scholar 

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Alvarado-Cabrero, I. (2018). Hematopoietic Lesions of the Breast. In: Stolnicu, S., Alvarado-Cabrero, I. (eds) Practical Atlas of Breast Pathology . Springer, Cham. https://doi.org/10.1007/978-3-319-93257-6_16

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  • DOI: https://doi.org/10.1007/978-3-319-93257-6_16

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-93256-9

  • Online ISBN: 978-3-319-93257-6

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