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Biophysical Analysis of miRNA-Dependent Gene Regulation

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Systems Biology

Part of the book series: RNA Technologies ((RNATECHN))

Abstract

microRNAs (miRNAs) are short (∼22 nucleotides long) RNAs that are encoded in the genome of species ranging from viruses to man. Together with proteins of the Argonaute family, they form RNA-induced silencing complexes, which bind target mRNAs, reducing their stability and translation rate. A miRNA typically has hundreds of evolutionarily conserved binding sites across the transcriptome, and frequently, a given mRNA carries binding sites for multiple miRNAs. In this chapter we discuss behaviors that miRNA-containing regulatory networks can exhibit, with specific examples from various experimental systems.

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Author information

Authors and Affiliations

  1. Institut de Génétique et Biologie Moléculaire et Cellulaire, Illkirch, France

    Andrea Riba

  2. Dipartimento di Fisica, Torino, Italy

    Matteo Osella & Michele Caselle

  3. Biozentrum, University of Basel, Basel, Switzerland

    Mihaela Zavolan

Authors
  1. Andrea Riba
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  2. Matteo Osella
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  3. Michele Caselle
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  4. Mihaela Zavolan
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Corresponding authors

Correspondence to Andrea Riba or Mihaela Zavolan .

Editor information

Editors and Affiliations

  1. Max Delbrück Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, Berlin-Buch, Berlin, Germany

    Nikolaus Rajewsky

  2. Nanobiomedical Center, Adam Mickiewicz University, Poznań, Poland

    Stefan Jurga

  3. Polish Academy of Sciences, Institute of Bioorganic Chemistry, Poznań, Poland

    Jan Barciszewski

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Riba, A., Osella, M., Caselle, M., Zavolan, M. (2018). Biophysical Analysis of miRNA-Dependent Gene Regulation. In: Rajewsky, N., Jurga, S., Barciszewski, J. (eds) Systems Biology. RNA Technologies. Springer, Cham. https://doi.org/10.1007/978-3-319-92967-5_13

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