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Liver Assist Systems for Bridging to Transplantation: Devices and Concepts

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Critical Care for Potential Liver Transplant Candidates

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Abstract

Liver transplantation continues to be the gold standard for the treatment of patients with acute liver failure, chronic liver diseases, and in the early stages of hepatocellular carcinoma. However, the success of liver transplantation is increasingly limited by the lack of suitable donor organs. Liver support systems have been developed in order to solve this issue by providing temporary support for the failing liver, thereby either helping to bridge the time until a suitable liver graft becomes available, or giving the patient’s liver a chance to regenerate. We here discuss the conceptual background of the devices and practices currently in use and under development for liver assist: I. artificial und bioartificial liver support devices, II. hepatocyte transplantation, and III. the bioengineered liver. Liver support devices and hepatocyte transplantation have already been clinically evaluated. Yet, the bioengineered liver is still a challenge although also a goal for the near future. Not all the systems described are ready to apply in clinical routines.

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Authors and Affiliations

  1. Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Experimental Surgery and Regenerative Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany

    Nathanael Raschzok, Karl Herbert Hillebrandt & Igor M. Sauer

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  1. Nathanael Raschzok
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  2. Karl Herbert Hillebrandt
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  3. Igor M. Sauer
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Correspondence to Nathanael Raschzok .

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Editors and Affiliations

  1. Anesthesiology and Perioperative Medicine, Penn State Hershey Medical Center, Hershey, PA, USA

    Dmitri Bezinover

  2. General, Visceral and Transplant Surgery, University of Duisburg-Essen, Essen, Germany

    Fuat Saner

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Raschzok, N., Hillebrandt, K.H., Sauer, I.M. (2019). Liver Assist Systems for Bridging to Transplantation: Devices and Concepts. In: Bezinover, D., Saner, F. (eds) Critical Care for Potential Liver Transplant Candidates. Springer, Cham. https://doi.org/10.1007/978-3-319-92934-7_13

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