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Difficult Decisions in Endocrine Surgery pp 69–78Cite as

Operative Management Versus Observation for Thyroid Nodules Larger than 4 cm with Benign Cytology

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Part of the book series: Difficult Decisions in Surgery: An Evidence-Based Approach ((DDSURGERY))

Abstract

Workup of thyroid nodules usually involves a multi-disciplinary approach, including fine needle aspiration (FNA) biopsy. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) was devised to stratify patients into tiers with increasing risk for cancer, based on features identified on FNA. A number of studies have attempted to correlate thyroid nodule size with intrinsic risk of malignancy, as well as with false negative rates (nodules with a benign diagnosis on cytology but a malignant diagnosis on final surgical pathology following resection). The aims of this chapter are (1) to review studies that have evaluated the false negative rate of thyroid nodules based on size, (2) to summarize, analyze, and grade the published data, and (3) to make recommendations for treatment of large thyroid nodules.

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Authors and Affiliations

  1. The University of Chicago, Department of Pathology, Chicago, IL, USA

    Nicole A. Cipriani

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  1. Nicole A. Cipriani
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Correspondence to Nicole A. Cipriani .

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Editors and Affiliations

  1. Department of Surgery and MacLean Center for Clinical Medical Ethics, The University of Chicago, Chicago, IL, USA

    Peter Angelos

  2. Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA

    Raymon H. Grogan

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Cipriani, N.A. (2018). Operative Management Versus Observation for Thyroid Nodules Larger than 4 cm with Benign Cytology. In: Angelos, P., Grogan, R. (eds) Difficult Decisions in Endocrine Surgery. Difficult Decisions in Surgery: An Evidence-Based Approach. Springer, Cham. https://doi.org/10.1007/978-3-319-92860-9_7

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  • DOI: https://doi.org/10.1007/978-3-319-92860-9_7

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  • Print ISBN: 978-3-319-92858-6

  • Online ISBN: 978-3-319-92860-9

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