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Humoral Primary Immunodeficiencies pp 1–20Cite as

The B-Side of the Immune Response

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Part of the book series: Rare Diseases of the Immune System ((RDIS))

Abstract

B lymphocytes have long been, and still are, known to play a crucial role in orchestrating the humoral immune responses. This concept arises from their ability to take advantage of interactions with the other immune cells to become antibody-producing plasma cells or memory B cells. This chapter focuses on the mechanisms by which B cells encounter, manage, and present antigens to T cells, to finally integrate both humoral and cellular immune responses. The intrinsic ability of B cells to actively interact with the other immune cells makes them the leading units of the immune system.

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Acknowledgments

The CTB lab is supported by grants from AIRC (IG 2014-15220), Telethon-Italy (Grant GGP1102) and ITT-Regione Toscana. The MMDE lab is supported by grants from the University of Florence and the Italian Ministry of Health.

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Authors and Affiliations

  1. Department of Life Sciences, University of Siena, Siena, Italy

    Laura Patrussi, Nagaja Capitani & Cosima T. Baldari

  2. Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

    Nagaja Capitani & Mario Milco D’Elios

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  1. Laura Patrussi
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  2. Nagaja Capitani
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  3. Mario Milco D’Elios
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  4. Cosima T. Baldari
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Correspondence to Laura Patrussi or Nagaja Capitani .

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Editors and Affiliations

  1. Careggi Hospital, Department of Clinical and Experimental Medicine, University of Florence, Firenze, Italy

    Mario Milco D'Elios

  2. University Medical Centre Freiburg, Department of Rheumatology and Clinical Immunology and Center for Chronic Immunodeficiency, Freiburg, Germany

    Marta Rizzi

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Patrussi, L., Capitani, N., D’Elios, M.M., Baldari, C.T. (2019). The B-Side of the Immune Response. In: D'Elios, M., Rizzi, M. (eds) Humoral Primary Immunodeficiencies. Rare Diseases of the Immune System. Springer, Cham. https://doi.org/10.1007/978-3-319-91785-6_1

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