Abstract
Diabetes mellitus (DM)-associated hyperglycemia contributes to the initiation and progression of chronic microvascular (MIC) and macrovascular (MAC) complications. To carry out early identification of MIC, standardized and inexpensive tests are needed. Computerized nailfold video-capillaroscopy (CNVC) is a noninvasive tool to easily evaluate MIC at the level of the fingers and could be useful to detect the so-called ‘diabetic capillaropathy’. Aim: This was a prospective study using CNVC to examine the prevalence of capillaroscopic patterns in a cohort of type 1 (T1D) and type 2 (T2D) diabetic individuals, and to assess their relationship with the level of glycemic control (HbA1c) and DM-related complications. Results: Nailfold alterations were found to be more prevalent in diabetics, including tortuosity (p < 0.01), avascular zones (p < 0.01), ectasiae (p < 0.01) and capillary with bizarre shape (p < 0.01). At least two of these patterns were found with a higher prevalence in T1D and T2D individuals vs. controls (p < 0.01). Finally, a higher frequency of ‘capillary score’ equal to or higher than 2 points was found to be associated with worse glycemic control, and with the presence of diabetic retinopathy. Conclusions: These results confirm the presence of a ‘diabetic capillaropathy’, and nailfold capillary alterations appear to be related to the level of glycemic control and the existence of MIC, particularly when retinal damage is involved.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsAbbreviations
- ACR:
-
Albumin/creatinine ratio
- CKD:
-
Chronic kidney disease
- CNVC:
-
Computerized nailfold video-capillaroscopy
- CS:
-
Capillary score
- DM:
-
Diabetes mellitus
- eGFR:
-
Estimated glomerular filtration rate
- HbA1c:
-
Glycosylated hemoglobin
- MAC:
-
Macrovascular complications
- MIC:
-
Microvascular complications
- NPDR:
-
Not proliferative diabetic retinopathy
- PDR:
-
Proliferative diabetic retinopathy
- T1D:
-
Type 1 diabetes
- T2D:
-
Type 2 diabetes
References
International Diabetes Federation. IDF diabetes atlas (2015) IDF http://www.diabetesatlas.org/component/attachments/?task=download&id=116
Marcellusi A, Viti R, Sciattella P et al (2016) Economic aspects in the management of diabetes in Italy. BMJ Open Diabet Res Care 4(1):e000197. https://doi.org/10.1136/bmjdrc-2016-000197
Yau JWY, Rogers SL, Kawasaky R et al (2012) Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care 35(3):556–564
The Emerging Risk Factors Collaboration (2010) Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective study. Lancet 375(9733):2215–2222
Brun E, Nelson RG, Bennett PH et al (2003) Verona Diabetes Study. Diabetes duration and cause-specific mortality in the Verona Diabetes Study. Diabetes Care 23(8):1119–1123
Jackson G, Boon N, Eardley I et al (2010) Erectile dysfunction and coronary heart disease prediction: evidence-based guidance and consensus. Int J Clin Pract 64(7):848–857
American Diabetes Association Standard of Medical Care in Diabetes (2017) Diabet Care 40(Suppl 1):S1–S135
Tavakol ME, Fatemi A, Karbalaie A et al (2015) Nailfold capillaroscopy in rheumatic diseases: which parameters should be evaluated? Biomed Res Int. http://dx.doi.org/10.1155/2015/974530
Maggini M, Spila Alegiani S, Raschetti R et al (2003) Complicanze macroangiopatiche nei pazienti diabetici di tipo 2 afferenti ai Servizi di diabetologia Italiani. Ann Ist Super Sanita 39:165–171
Jellinger PS, Handelsman Y, Rosenblit PD, et al (2017) American Association of Clinical Endocrinologist and American College of Endocrinology guidelines for management of dyslipidemia and prevention of cardiovascular disease. Endocr Pract 23(Suppl 2):1–87
Brenner BM, Cooper ME, de Zeeuw D et al (2001) Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Med J Med 345:861–869
Pugliese G, Solini E, Bonora E et al (2014) Chronic kidney disease in type 2 diabetes: lessons from the renal insufficiency and cardiovascular events (RIACE) Italian Multicentre Study. Nutr Metab Cardiovasc Dis 24(8):815–822
Cicco G, Cicco S (2007) Hemorheological aspects in microvasculature of several pathologies. Adv Exp Med Biol 599:7–15
Barchetta I, Ricceri V, Vasile K et al (2011) High prevalence of capillary abnormalities in patients with diabetes and association with retinopathy. Diabet Med 28:1039–1044
Uyar S, Balkarli A, Erol MK et al (2016) Assessment of the relationship of diabetic retinopathy and nailfold capillaries in type 2 diabetics with a noninvasive method: nailfold videocapillaroscopy. J Diabet Res. https://dx.doi.org/10.1155/2016/7592402
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Lisco, G., Cicco, G., Cignarelli, A., Garruti, G., Laviola, L., Giorgino, F. (2018). Computerized Video-Capillaroscopy Alteration Related to Diabetes Mellitus and Its Complications. In: Thews, O., LaManna, J., Harrison, D. (eds) Oxygen Transport to Tissue XL. Advances in Experimental Medicine and Biology, vol 1072. Springer, Cham. https://doi.org/10.1007/978-3-319-91287-5_58
Download citation
DOI: https://doi.org/10.1007/978-3-319-91287-5_58
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-91285-1
Online ISBN: 978-3-319-91287-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)