Abstract
Background and aim : Mucine-1 (MUC1) increases in primary lung disease; however, no data are available on pulmonary arterial hypertension (PAH). Our aim was to analyze MUC1 in PAH and a possible link with pulmonary artery pressure (PAPs), PaO2, PaCO2 and cell-mediated immunity. Methods : We studied nine PAH patients (four males and five females, aged 52 ± 21 years). The control groups were nine patients with pulmonary hypertensions due to lung disease (PPH; five males and four females, aged 63 ± 18 years) and 14 patients with left heart disease (HPH; four males and ten females, aged 73 ± 13 years). All underwent arterial gas analysis and echocardiography. A serum sample was collected to determine MUC1 and CD40L values on ELISA. Results: No differences were found for PAPs and CD40L. MUC1 resulted in comparable values between PAH and HPH but decreased when compared to PPH (16.46 ± 4.12 vs 116.6 ± 47.08 U/ml, p = 0.049). pO2 was higher in PAH (PAH 83.18 ± 1.77 vs PPH 62.75 ± 3.23 mmHg, p = 0.003; vs HPH 65.83 ± 6.94 mmHg, p = 0.036). pCO2 was lower compared to PPH (36.15 ± 2.19 vs 45.83 ± 3.00 mmHg, p = 0.026) but not compared to HPH. In PAH patients the MUC1 correlated with pO2 (r = −0.91), pCO2 (r = 0.80), PAPs (r = 0.82) and CD40L (r = 0.72) while it did not in PPH and HPH. Conclusions: These preliminary data show a possible mechanism of immune stimulation in PAH patients. This may imply an association between lung parenchyma, immunity and increase in vascular resistance. Additional studies are required to confirm these findings.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Galiè N et al (2016) 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J 37:67–119
Price LC et al (2012) Inflammation in pulmonary arterial hypertension. Chest 141:210–221
Santilli F, Basili S, Ferroni P, Davì G (2007) CD40/CD40L system and vascular disease. Intern Emerg Med 2:256–268
Allanore Y et al (2005) Increased plasma soluble CD40 ligand concentrations in systemic sclerosis and association with pulmonary arterial hypertension and digital ulcers. Ann Rheum Dis 64:481–483
Ishikawa N, Hattori N, Yokoyama A, Kohno N (2012) Utility of KL-6/MUC1 in the clinical management of interstitial lung diseases. Respir Investig 50:3–13
Dobrzanski MJ et al (2012) Immunotherapy with IL-10- and IFN-γ-producing CD4 effector cells modulate ‘natural’ and ‘inducible’ CD4 TReg cell subpopulation levels: observations in four cases of patients with ovarian cancer. Cancer Immunol Immunother 61:839–854
Xu L et al (2013) KL-6 regulated the expression of HGF, collagen and myofibroblast differentiation. Eur Rev Med Pharmacol Sci 17:3073–3077
May AE, Seizer P, Gawaz M (2008) Platelets: inflammatory firebugs of vascular walls. Arterioscler Thromb Vasc Biol 28:s5–s10
Ueland T et al (2005) Soluble CD40 ligand in acute and chronic heart failure. Eur Heart J 26:1101–1107
Damås JK et al (2004) Soluble CD40 ligand in pulmonary arterial hypertension: possible pathogenic role of the interaction between platelets and endothelial cells. Circulation 110:999–1005
Kawabe T, Matsushima M, Hashimoto N, Imaizumi K, Hasegawa Y (2011) CD40/CD40 ligand interactions in immune responses and pulmonary immunity. Nagoya J Med Sci 73:69–78
Lombardi V, Singh AK, Akbari O (2010) The role of costimulatory molecules in allergic disease and asthma. Int Arch Allergy Immunol 151:179–189
Cascio S, Finn OJ (2016) Intra-and extra-cellular events related to altered glycosylation of MUC1 promote chronic inflammation, tumor progression, invasion, and metastasis. Biomol Ther 6:1–16
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Cicco, S., Leone, P., Racanelli, V., Vacca, A. (2018). Mucine-1 Is Related to Cell-Mediated Immunoexpression and Blood Pressure in Pulmonary Artery in Pulmonary Arterial Hypertension (PAH): Preliminary Results. In: Thews, O., LaManna, J., Harrison, D. (eds) Oxygen Transport to Tissue XL. Advances in Experimental Medicine and Biology, vol 1072. Springer, Cham. https://doi.org/10.1007/978-3-319-91287-5_44
Download citation
DOI: https://doi.org/10.1007/978-3-319-91287-5_44
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-91285-1
Online ISBN: 978-3-319-91287-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)