Abstract
The behavior of particles in bulk dictates their behavior. The forces of interaction between particles influence their flow and dispersion and the ease with which they can be suspended in any medium. These interactions are in the form of electrostatic and capillary forces that are reciprocally but not linearly related, mechanical interlocking arising from surface asperities and bulk van der Waals forces.
Pharmaceutical inhalation aerosols are a clear example of the way interparticulate forces influence particle behavior and illustrate the considerations that need to be given to these forces.
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References
Hickey A. Summary of common approaches to pharmaceutical aerosol administration. In: Hickey A, editor. Pharmaceutical inhalation aerosol technology. 2nd ed. New York: Marcel Dekker; 2004. p. 385–421.
Hickey A. Pharmaceutical inhalation aerosol powder dispersion – an unbalancing act. Am Pharm Rev. 2003;6:106–10.
Rietema K. The dynamics of fine powders. New York: Elsevier Science Publishing; 1991.
Wuethen T, Roeder S, Brand P, Mullinger B, Scheuch G. In vitro testing of two formoterol dry powder inhalers at different flow rates. J Aerosol Med. 2002;15(3):297–303.
Hickey A, Concessio N, VanOort M, Platz R. Factors influencing the dispersion of dry powders as aerosols. Pharm Technol. 1994;18:58–64.
ICRP Task Group on Lung Dynamics. Deposition and retention models for internal dosimetry of the human respiratory tract. Health Phys. 1966;12:173–207.
Edwards D, Hanes J, Caponetti G, Hrkach J, Ben-Jebria A, Eskew M, et al. Large porous particles for pulmonary drug delivery. Science. 1997;276:1868–71.
Hirst P, Pitcairn G, Weers J, Tarara T, Clark A, Dellamary L, et al. In vivo lung depostion of hollow porous particles from a pressurized metered dose inhaler. Pharm Res. 2002;9(10):258–64.
Fults K, Miller I, Hickey A. Effect of particle morphology on emitted dose of fatty acid-treated disodium cromoglycate powder aerosols. Pharm Dev Technol. 1997;2(1):67–79.
Hickey A, Martonen T. Behavior of hygroscopic pharmaceutical aerosols and the influence of hydrophobic additives. Pharm Res. 1993;10:1–7.
Hickey A, Ganderton D. Pharmaceutical process engineering. 2nd ed: Informa Healthcare USA; 2010.
Crowder T, Hickey A. The physics of powder flow applied to pharmaceutical solids. Pharm Technol. 2000;24(2):50–8.
Barrow J. Size, life and landscape. The artful universe the cosmic source of human creativity. New York: Little, Brown and Company; 1995. p. 48–113.
Autumn K. Adhesive force of a single gecko foot-hair. Nature. 2000;405:681–5.
Autumn K. Evidence of van der Waals adhesion in gecko setae. Proc Natl Acad Sci. 2002;99(19):12252–6.
Jaeger H. The physics of granular materials. Phys Today. 1996;49(4):32–8.
Israelachvilli J. Intermolecular and surface forces. 2nd ed. New York: Academic; 1992.
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© 2018 American Association of Pharmaceutical Scientists
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Hickey, A.J., Giovagnoli, S. (2018). Fundamentals of Particle Interactions. In: Pharmaceutical Powder and Particles. AAPS Introductions in the Pharmaceutical Sciences. Springer, Cham. https://doi.org/10.1007/978-3-319-91220-2_7
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DOI: https://doi.org/10.1007/978-3-319-91220-2_7
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