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Iodine Requirements in Pregnancy

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Part of the book series: Nutrition and Health ((NH))

Abstract

Iodine is an essential micronutrient required for thyroid hormone production. Thyroid hormone is critically important for growth and development, especially in utero and in early childhood. Pregnant women have increased iodine requirements of 220–250 μg/day. Maternal iodine deficiency during pregnancy can have adverse obstetrical effects such as miscarriage, prematurity, and stillbirth, as well as adverse effects on offspring development including low birth weight and head circumference, and lower intelligence quotient (IQ). Worldwide, universal salt iodization is the mainstay of iodine deficiency disorder elimination efforts. Maternal iodine supplementation prior to conception or in early gestation is beneficial to prevent the adverse effects of iodine deficiency, especially in severely iodine-deficient areas. Meta-analyses of studies of maternal iodine supplementation in moderately to severely iodine-deficient areas have shown benefits for child development and cognitive function, although more research is warranted. Maternal iodine excess in pregnancy can also adversely affect maternal and offspring thyroid function. The United States is considered generally iodine sufficient, but pregnant women in the USA have been mildly iodine deficient in recent years. To prevent adverse effects of iodine deficiency, women are currently advised to take supplements containing 150 μg iodine/day preconception, during pregnancy, and during lactation.

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References

  1. Lazarus JH. The importance of iodine in public health. Environ Geochem Health. 2015;37(4):605–18.

    CAS  PubMed  Google Scholar 

  2. Zimmermann MB. Iodine deficiency. Endocr Rev. 2009;30(4):376–408.

    CAS  PubMed  Google Scholar 

  3. Leung AM, Pearce EN, Braverman LE. Iodine nutrition in pregnancy and lactation. Endocrinol Metab Clin N Am. 2011;40(4):765–77.

    CAS  Google Scholar 

  4. Yarrington C, Pearce EN. Iodine and pregnancy. J Thyroid Res. 2011;2011:934104.

    PubMed  PubMed Central  Google Scholar 

  5. Syed S. Iodine and the “near” eradication of cretinism. Pediatrics. 2015;135(4):594–6.

    PubMed  Google Scholar 

  6. Zimmermann MB. The role of iodine in human growth and development. Semin Cell Dev Biol. 2011;22(6):645–52.

    CAS  PubMed  Google Scholar 

  7. Leung AM, Braverman LE, Pearce EN. History of U.S. iodine fortification and supplementation. Nutrients. 2012;4(11):1740–6.

    PubMed  PubMed Central  Google Scholar 

  8. Maberly GF, Haxton DP, van der Haar F. Iodine deficiency: consequences and progress toward elimination. Food Nutr Bull. 2003;24(4 Suppl):S91–8.

    PubMed  Google Scholar 

  9. Shepard TH. Onset of function in the human fetal thyroid: biochemical and radioautographic studies from organ culture. J Clin Endocrinol Metab. 1967;27(7):945–58.

    CAS  PubMed  Google Scholar 

  10. Burrow GN, Fisher DA, Larsen PR. Maternal and fetal thyroid function. N Engl J Med. 1994;331(16):1072–8.

    CAS  PubMed  Google Scholar 

  11. WHO, UNICEF, ICCIDD. Assessment of iodine deficiency disorders and monitoring their elimination: a guide for programme managers. 3rd ed. [Internet]. 2007. Available from: http://whqlibdoc.who.int/publications/2007/9789241595827_eng.pdf.

  12. Institute of Medicine (US) Panel on Micronutrients. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc [Internet]. Washington (DC): National Academies Press (US); 2001. [cited 2015 Feb 1]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK222310/.

  13. Andersen SL, Sørensen LK, Krejbjerg A, Møller M, Laurberg P. Challenges in the evaluation of urinary iodine status in pregnancy: the importance of iodine supplement intake and time of sampling. Eur Thyroid J. 2014;3(3):179–88.

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Andersen SL, Sørensen LK, Krejbjerg A, Møller M, Klitbo DM, Nøhr SB, et al. Iodine status in Danish pregnant and breastfeeding women including studies of some challenges in urinary iodine status evaluation. J Trace Elem Med Biol. 2015;31:285–9.

    CAS  PubMed  Google Scholar 

  15. Amouzegar A, Azizi F. Variations of urinary iodine during the first trimester of pregnancy in an iodine-replete area. Comparison with non-pregnant women. Horm Athens Greece. 2013;12(1):111–8.

    Google Scholar 

  16. Li C, Peng S, Zhang X, Xie X, Wang D, Mao J, et al. The urine iodine to creatinine as an optimal index of iodine during pregnancy in an iodine adequate area in China. J Clin Endocrinol Metab. 2016;101(3):1290–8.

    CAS  PubMed  Google Scholar 

  17. Soldin OP. Controversies in urinary iodine determinations. Clin Biochem. 2002;35(8):575–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Perrine CG, Cogswell ME, Swanson CA, Sullivan KM, Chen T-C, Carriquiry AL, et al. Comparison of population iodine estimates from 24-hour urine and timed-spot urine samples. Thyroid. 2013;24(4):748–57.

    Google Scholar 

  19. Andersen S, Karmisholt J, Pedersen KM, Laurberg P. Reliability of studies of iodine intake and recommendations for number of samples in groups and in individuals. Br J Nutr. 2008;99(4):813–8.

    CAS  PubMed  Google Scholar 

  20. Laurberg P, Andersen S, Bjarnadóttir RI, Carlé A, Hreidarsson A, Knudsen N, et al. Evaluating iodine deficiency in pregnant women and young infants-complex physiology with a risk of misinterpretation. Public Health Nutr. 2007;10(12A):1547–52. Discussion 1553.

    CAS  PubMed  Google Scholar 

  21. Ma ZF, Skeaff SA. Thyroglobulin as a biomarker of iodine deficiency: a review. Thyroid. 2014;24(8):1195–209.

    CAS  PubMed  PubMed Central  Google Scholar 

  22. Krejbjerg A, Bjergved L, Bülow Pedersen I, Carlé A, Knudsen N, Perrild H, et al. Serum thyroglobulin as a biomarker of iodine deficiency in adult populations. Clin Endocrinol. 2016;85(3):475–82.

    CAS  Google Scholar 

  23. Moreno-Reyes R, Glinoer D, Van Oyen H, Vandevijvere S. High prevalence of thyroid disorders in pregnant women in a mildly iodine-deficient country: a population-based study. J Clin Endocrinol Metab. 2013;98(9):3694–701.

    CAS  PubMed  Google Scholar 

  24. Costeira MJ, Oliveira P, Ares S, de Escobar GM, Palha JA. Iodine status of pregnant women and their progeny in the Minho Region of Portugal. Thyroid. 2009;19(2):157–63.

    CAS  PubMed  Google Scholar 

  25. Costeira MJ, Oliveira P, Ares S, Roque S, de Escobar GM, Palha JA. Parameters of thyroid function throughout and after pregnancy in an iodine-deficient population. Thyroid. 2010;20(9):995–1001.

    PubMed  Google Scholar 

  26. Moleti M, Lo Presti VP, Mattina F, Mancuso A, De Vivo A, Giorgianni G, et al. Gestational thyroid function abnormalities in conditions of mild iodine deficiency: early screening versus continuous monitoring of maternal thyroid status. Eur J Endocrinol. 2009;160(4):611–7.

    CAS  PubMed  Google Scholar 

  27. Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R, et al. Guidelines of the American thyroid association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011;21(10):1081–125.

    PubMed  PubMed Central  Google Scholar 

  28. Amouzegar A, Khazan M, Hedayati M, Azizi F. An assessment of the iodine status and the correlation between iodine nutrition and thyroid function during pregnancy in an iodine sufficient area. Eur J Clin Nutr. 2014;68(3):397–400.

    CAS  PubMed  Google Scholar 

  29. Brucker-Davis F, Ferrari P, Gal J, Berthier F, Fenichel P, Hieronimus S. Iodine status has no impact on thyroid function in early healthy pregnancy. J Thyroid Res. 2012;2012:168764.

    CAS  PubMed  PubMed Central  Google Scholar 

  30. Abuye C, Berhane Y. The goitre rate, its association with reproductive failure, and the knowledge of iodine deficiency disorders (IDD) among women in Ethiopia: cross-section community based study. BMC Public Health. 2007;7:316.

    PubMed  PubMed Central  Google Scholar 

  31. Jiskra J, Fait T, Bílek R, Krátký J, Bartáková J, Lukáš J, et al. Mild iodine deficiency in women after spontaneous abortions living in an iodine-sufficient area of Czech Republic: prevalence and impact on reproductive health. Clin Endocrinol. 2014;80(3):452–8.

    CAS  Google Scholar 

  32. Charoenratana C, Leelapat P, Traisrisilp K, Tongsong T. Maternal iodine insufficiency and adverse pregnancy outcomes. Matern Child Nutr. 2016;12(4):680–7.

    PubMed  Google Scholar 

  33. Rydbeck F, Rahman A, Grandér M, Ekström E-C, Vahter M, Kippler M. Maternal urinary iodine concentration up to 1.0 mg/L is positively associated with birth weight, length, and head circumference of male offspring. J Nutr. 2014;144(9):1438–44.

    CAS  PubMed  Google Scholar 

  34. Olivares JL, Olivi GI, Verdasco C, Ortiz VA, Mayer MA, Cresto JC. Low iodine intake during pregnancy relationship to placental development and head circumference in newborn. Endocrinol Nutr. 2012;59(5):326–30.

    PubMed  Google Scholar 

  35. Pearce EN. Effects of iodine deficiency in pregnancy. J Trace Elem Med Biol. 2012;26(2–3):131–3.

    CAS  PubMed  Google Scholar 

  36. Glinoer D. The importance of iodine nutrition during pregnancy. Public Health Nutr. 2007;10(12A):1542–6.

    PubMed  Google Scholar 

  37. Howdeshell KL. A model of the development of the brain as a construct of the thyroid system. Environ Health Perspect. 2002;110(Suppl 3):337–48.

    CAS  PubMed  PubMed Central  Google Scholar 

  38. De Escobar GM, Obregón MJ, del Rey FE. Iodine deficiency and brain development in the first half of pregnancy. Public Health Nutr. 2007;10(12A):1554–70.

    PubMed  Google Scholar 

  39. Berbel P, Navarro D, Román GC. An evo-devo approach to thyroid hormones in cerebral and cerebellar cortical development: etiological implications for autism. Front Endocrinol. 2014;5:146.

    Google Scholar 

  40. Wei W, Wang Y, Wang Y, Dong J, Min H, Song B, et al. Developmental hypothyroxinaemia induced by maternal mild iodine deficiency delays hippocampal axonal growth in the rat offspring. J Neuroendocrinol. 2013;25(9):852–62.

    CAS  PubMed  Google Scholar 

  41. Gilbert ME, Hedge JM, Valentín-Blasini L, Blount BC, Kannan K, Tietge J, et al. An animal model of marginal iodine deficiency during development: the thyroid axis and neurodevelopmental outcome. Toxicol Sci. 2013;132(1):177–95.

    CAS  PubMed  Google Scholar 

  42. Bougma K, Aboud FE, Harding KB, Marquis GS. Iodine and mental development of children 5 years old and under: a systematic review and meta-analysis. Nutrients. 2013;5(4):1384–416.

    CAS  PubMed  PubMed Central  Google Scholar 

  43. Qian M, Wang D, Watkins WE, Gebski V, Yan YQ, Li M, et al. The effects of iodine on intelligence in children: a meta-analysis of studies conducted in China. Asia Pac J Clin Nutr. 2005;14(1):32–42.

    CAS  PubMed  Google Scholar 

  44. Bath SC, Steer CD, Golding J, Emmett P, Rayman MP. Effect of inadequate iodine status in UK pregnant women on cognitive outcomes in their children: results from the Avon Longitudinal Study of Parents and Children (ALSPAC). Lancet. 2013;382(9889):331–7.

    CAS  PubMed  Google Scholar 

  45. Hynes KL, Otahal P, Hay I, Burgess JR. Mild iodine deficiency during pregnancy is associated with reduced educational outcomes in the offspring: 9-year follow-up of the gestational iodine cohort. J Clin Endocrinol Metab. 2013;98(5):1954–62.

    CAS  PubMed  Google Scholar 

  46. van Mil NH, Tiemeier H, Bongers-Schokking JJ, Ghassabian A, Hofman A, Hooijkaas H, et al. Low urinary iodine excretion during early pregnancy is associated with alterations in executive functioning in children. J Nutr. 2012;142(12):2167–74.

    PubMed  Google Scholar 

  47. Costeira MJ, Oliveira P, Santos NC, Ares S, Saenz-Rico B, de Escobar GM, et al. Psychomotor development of children from an iodine-deficient region. J Pediatr. 2011;159(3):447–53.

    PubMed  Google Scholar 

  48. Moleti M, Trimarchi F, Tortorella G, Candia Longo A, Giorgianni G, Sturniolo G, et al. Effects of maternal iodine nutrition and thyroid status on cognitive development in offspring: a pilot study. Thyroid. 2016;26(2):296–305.

    CAS  PubMed  Google Scholar 

  49. Ghassabian A, Steenweg-de Graaff J, Peeters RP, Ross HA, Jaddoe VW, Hofman A, et al. Maternal urinary iodine concentration in pregnancy and children’s cognition: results from a population-based birth cohort in an iodine-sufficient area. BMJ Open. 2014;4(6):e005520.

    PubMed  PubMed Central  Google Scholar 

  50. Zhang L, Zhai X, Liu Y, Li J, Shan Z, Teng W. Treatment with iodine in pregnant rats with marginal iodine deficiency improves cell migration in the developing brain of the progeny. Mol Neurobiol. 2016;53(4):2212–21.

    CAS  PubMed  Google Scholar 

  51. Pharoah PO, Buttfield IH, Hetzel BS. Neurological damage to the fetus resulting from severe iodine deficiency during pregnancy. Lancet. 1971;1(7694):308–10.

    CAS  PubMed  Google Scholar 

  52. Zimmermann MB. Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: a review. Am J Clin Nutr. 2009;89(2):668S–72S.

    CAS  PubMed  Google Scholar 

  53. Berbel P, Mestre JL, Santamaría A, Palazón I, Franco A, Graells M, et al. Delayed neurobehavioral development in children born to pregnant women with mild hypothyroxinemia during the first month of gestation: the importance of early iodine supplementation. Thyroid. 2009;19(5):511–9.

    CAS  PubMed  Google Scholar 

  54. Moleti M, Lo Presti VP, Campolo MC, Mattina F, Galletti M, Mandolfino M, et al. Iodine prophylaxis using iodized salt and risk of maternal thyroid failure in conditions of mild iodine deficiency. J Clin Endocrinol Metab. 2008;93(7):2616–21.

    CAS  PubMed  Google Scholar 

  55. O’Donnell KJ, Rakeman MA, Zhi-Hong D, Xue-Yi C, Mei ZY, DeLong N, et al. Effects of iodine supplementation during pregnancy on child growth and development at school age. Dev Med Child Neurol. 2002;44(2):76–81.

    PubMed  Google Scholar 

  56. Velasco I, Carreira M, Santiago P, Muela JA, García-Fuentes E, Sánchez-Muñoz B, et al. Effect of iodine prophylaxis during pregnancy on neurocognitive development of children during the first two years of life. J Clin Endocrinol Metab. 2009;94(9):3234–41.

    CAS  PubMed  Google Scholar 

  57. Santiago P, Velasco I, Muela JA, Sánchez B, Martínez J, Rodriguez A, et al. Infant neurocognitive development is independent of the use of iodised salt or iodine supplements given during pregnancy. Br J Nutr. 2013;110(05):831–9.

    CAS  PubMed  Google Scholar 

  58. Rebagliato M, Murcia M, Espada M, Alvarez-Pedrerol M, Bolúmar F, Vioque J, et al. Iodine intake and maternal thyroid function during pregnancy. Epidemiology. 2010;21(1):62–9.

    PubMed  Google Scholar 

  59. Moleti M, Di Bella B, Giorgianni G, Mancuso A, De Vivo A, Alibrandi A, et al. Maternal thyroid function in different conditions of iodine nutrition in pregnant women exposed to mild-moderate iodine deficiency: an observational study. Clin Endocrinol. 2011;74(6):762–8.

    CAS  Google Scholar 

  60. Murcia M, Rebagliato M, Iñiguez C, Lopez-Espinosa M-J, Estarlich M, Plaza B, et al. Effect of iodine supplementation during pregnancy on infant neurodevelopment at 1 year of age. Am J Epidemiol. 2011;173(7):804–12.

    PubMed  Google Scholar 

  61. Rebagliato M, Murcia M, Alvarez-Pedrerol M, Espada M, Fernández-Somoano A, Lertxundi N, et al. Iodine supplementation during pregnancy and infant neuropsychological development. INMA Mother and Child Cohort Study. Am J Epidemiol. 2013;177(9):944–53.

    PubMed  Google Scholar 

  62. Zhou SJ, Skeaff SA, Ryan P, Doyle LW, Anderson PJ, Kornman L, et al. The effect of iodine supplementation in pregnancy on early childhood neurodevelopment and clinical outcomes: results of an aborted randomised placebo-controlled trial. Trials. 2015;16:563.

    PubMed  PubMed Central  Google Scholar 

  63. Zimmermann MB. The effects of iodine deficiency in pregnancy and infancy. Paediatr Perinat Epidemiol. 2012;26(Suppl 1):108–17.

    PubMed  Google Scholar 

  64. Zhou SJ, Anderson AJ, Gibson RA, Makrides M. Effect of iodine supplementation in pregnancy on child development and other clinical outcomes: a systematic review of randomized controlled trials. Am J Clin Nutr. 2013;98(5):1241–54.

    CAS  PubMed  Google Scholar 

  65. Taylor PN, Okosieme OE, Dayan CM, Lazarus JH. Therapy of endocrine disease: impact of iodine supplementation in mild-to-moderate iodine deficiency: systematic review and meta-analysis. Eur J Endocrinol. 2014;170(1):R1–R15.

    CAS  PubMed  Google Scholar 

  66. Wolff J, Chaikoff IL. Plasma inorganic iodide as a homeostatic regulator of thyroid function. J Biol Chem. 1948;174(2):555–64.

    CAS  PubMed  Google Scholar 

  67. Wolff J, Chaikoff IL. The temporary nature of the inhibitory action of excess iodine on organic iodine synthesis in the normal thyroid. Endocrinology. 1949;45(5):504–13.

    CAS  PubMed  Google Scholar 

  68. Eng PH, Cardona GR, Fang SL, Previti M, Alex S, Carrasco N, et al. Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein. Endocrinology. 1999;140(8):3404–10.

    CAS  PubMed  Google Scholar 

  69. Leung AM, Braverman LE. Iodine-induced thyroid dysfunction. Curr Opin Endocrinol Diabetes Obes. 2012;19(5):414–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  70. Theodoropoulos T, Braverman LE, Vagenakis AG. Iodide-induced hypothyroidism: a potential hazard during perinatal life. Science. 1979;205(4405):502–3.

    CAS  PubMed  Google Scholar 

  71. Atwell TD, Lteif AN, Brown DL, McCann M, Townsend JE, Leroy AJ. Neonatal thyroid function after administration of IV iodinated contrast agent to 21 pregnant patients. AJR Am J Roentgenol. 2008;191(1):268–71.

    PubMed  Google Scholar 

  72. Fuse Y, Ohashi T, Yamaguchi S, Yamaguchi M, Shishiba Y, Irie M. Iodine status of pregnant and postpartum Japanese women: effect of iodine intake on maternal and neonatal thyroid function in an iodine-sufficient area. J Clin Endocrinol Metab. 2011;96(12):3846–54.

    CAS  PubMed  Google Scholar 

  73. Du Q, Zhu H, Yao L. Thyroid function: comparison of women in late pregnancy with control women of reproductive age in regions of dietary iodine excess. Asia Pac J Public Health. 2013;25(4 Suppl):36S–42S.

    PubMed  Google Scholar 

  74. Sang Z, Wei W, Zhao N, Zhang G, Chen W, Liu H, et al. Thyroid dysfunction during late gestation is associated with excessive iodine intake in pregnant women. J Clin Endocrinol Metab. 2012;97(8):E1363–9.

    CAS  PubMed  Google Scholar 

  75. Connelly KJ, Boston BA, Pearce EN, Sesser D, Snyder D, Braverman LE, et al. Congenital hypothyroidism caused by excess prenatal maternal iodine ingestion. J Pediatr. 2012;161(4):760–2.

    PubMed  PubMed Central  Google Scholar 

  76. Emder PJ, Jack MM. Iodine-induced neonatal hypothyroidism secondary to maternal seaweed consumption: a common practice in some Asian cultures to promote breast milk supply. J Paediatr Child Health. 2011;47(10):750–2.

    PubMed  Google Scholar 

  77. Serreau R, Polack M, Leger J, Vuillard E, Thurninger O, Chemouny S, et al. Fetal thyroid goiter after massive iodine exposure. Prenat Diagn. 2004;24(9):751–3.

    CAS  PubMed  Google Scholar 

  78. Orito Y, Oku H, Kubota S, Amino N, Shimogaki K, Hata M, et al. Thyroid function in early pregnancy in Japanese healthy women: relation to urinary iodine excretion, emesis, and fetal and child development. J Clin Endocrinol Metab. 2009;94(5):1683–8.

    CAS  PubMed  Google Scholar 

  79. Chen W, Sang Z, Tan L, Zhang S, Dong F, Chu Z, et al. Neonatal thyroid function born to mothers living with long-term excessive iodine intake from drinking water. Clin Endocrinol. 2015;83(3):399–404.

    CAS  Google Scholar 

  80. Medici M, Ghassabian A, Visser W, de Muinck Keizer-Schrama SMPF, Jaddoe VWV, Visser WE, et al. Women with high early pregnancy urinary iodine levels have an increased risk of hyperthyroid newborns: the population-based Generation R Study. Clin Endocrinol. 2014;80(4):598–606.

    CAS  Google Scholar 

  81. Shi X, Han C, Li C, Mao J, Wang W, Xie X, et al. Optimal and safe upper limits of iodine intake for early pregnancy in iodine-sufficient regions: a cross-sectional study of 7,190 pregnant women in China. J Clin Endocrinol Metab. 2015;100(4):1630–8.

    CAS  PubMed  Google Scholar 

  82. Pearce EN, Andersson M, Zimmermann MB. Global iodine nutrition: where do we stand in 2013? Thyroid. 2013;23(5):523–8.

    CAS  PubMed  Google Scholar 

  83. Zimmermann MB, Gizak M, Abbott K, Andersson M, Lazarus JH. Iodine deficiency in pregnant women in Europe. Lancet Diabetes Endocrinol. 2015;3(9):672–4.

    PubMed  Google Scholar 

  84. Caldwell KL, Pan Y, Mortensen ME, Makhmudov A, Merrill L, Moye J. Iodine status in pregnant women in the National Children’s Study and in U.S. women (15-44 years), National Health and Nutrition Examination Survey 2005–2010. Thyroid. 2013;23(8):927–37.

    CAS  PubMed  PubMed Central  Google Scholar 

  85. Caldwell KL, Miller GA, Wang RY, Jain RB, Jones RL. Iodine status of the U.S. population, National Health and Nutrition Examination Survey 2003-2004. Thyroid. 2008;18(11):1207–14.

    CAS  PubMed  Google Scholar 

  86. Caldwell KL, Makhmudov A, Ely E, Jones RL, Wang RY. Iodine status of the U.S. population, National Health and Nutrition Examination Survey, 2005–2006 and 2007–2008. Thyroid. 2011;21(4):419–27.

    PubMed  Google Scholar 

  87. Pearce EN, Bazrafshan HR, He X, Pino S, Braverman LE. Dietary iodine in pregnant women from the Boston, Massachusetts area. Thyroid. 2004;14(4):327–8.

    PubMed  Google Scholar 

  88. Stagnaro-Green A, Dogo-Isonaige E, Pearce EN, Spencer C, Gaba ND. Marginal iodine status and high rate of subclinical hypothyroidism in Washington DC women planning conception. Thyroid. 2015;25(10):1151–4.

    CAS  PubMed  Google Scholar 

  89. Untoro J, Mangasaryan N, de Benoist B, Darnton-Hill I. Reaching optimal iodine nutrition in pregnant and lactating women and young children: programmatic recommendations. Public Health Nutr. 2007;10(12A):1527–9.

    PubMed  Google Scholar 

  90. WHO Secretariat, Andersson M, de Benoist B, Delange F, Zupan J. Prevention and control of iodine deficiency in pregnant and lactating women and in children less than 2-years-old: conclusions and recommendations of the Technical Consultation. Public Health Nutr. 2007;10(12A):1606–11.

    Google Scholar 

  91. Public Health Committee of the American Thyroid Association, Becker DV, Braverman LE, Delange F, Dunn JT, Franklyn JA, et al. Iodine supplementation for pregnancy and lactation-United States and Canada: recommendations of the American Thyroid Association. Thyroid. 2006;16(10):949–51.

    Google Scholar 

  92. Lazarus J, Brown RS, Daumerie C, Hubalewska-Dydejczyk A, Negro R, Vaidya B. 2014 European Thyroid Association guidelines for the management of subclinical hypothyroidism in pregnancy and in children. Eur Thyroid J. 2014;3(2):76–94.

    CAS  PubMed  PubMed Central  Google Scholar 

  93. De Groot L, Abalovich M, Alexander EK, Amino N, Barbour L, Cobin RH, et al. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2012;97(8):2543–65.

    PubMed  Google Scholar 

  94. Council on Environmental Health, Rogan WJ, Paulson JA, Baum C, Brock-Utne AC, Brumberg HL, et al. Iodine deficiency, pollutant chemicals, and the thyroid: new information on an old problem. Pediatrics. 2014;133(6):1163–6.

    Google Scholar 

  95. Obican SG, Jahnke GD, Soldin OP, Scialli AR. Teratology Public Affairs Committee position paper: iodine deficiency in pregnancy. Birth Defects Res A Clin Mol Teratol. 2012;94(9):677–82.

    CAS  PubMed  PubMed Central  Google Scholar 

  96. Zimmermann M, Delange F. Iodine supplementation of pregnant women in Europe: a review and recommendations. Eur J Clin Nutr. 2004;58(7):979–84.

    CAS  PubMed  Google Scholar 

  97. Gahche JJ, Bailey RL, Mirel LB, Dwyer JT. The prevalence of using iodine-containing supplements is low among reproductive-age women, NHANES 1999-2006. J Nutr. 2013;143(6):872–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  98. Leung AM, Pearce EN, Braverman LE. Iodine content of prenatal multivitamins in the United States. N Engl J Med. 2009;360(9):939–40.

    CAS  PubMed  Google Scholar 

  99. Council for Responsible Nutrition. Recommended guidelines: iodine quantity in multivitamin/mineral supplements for pregnancy and lactation [Internet]. 2015 [cited 2016 May 4]. Available from: http://www.crnusa.org/pdfs/CRNRecommendedGuidelinesIodine_Final.pdf.

  100. Murray CW, Egan SK, Kim H, Beru N, Bolger PM. US Food and Drug Administration’s Total Diet Study: dietary intake of perchlorate and iodine. J Expo Sci Environ Epidemiol. 2008;18(6):571–80.

    CAS  PubMed  Google Scholar 

  101. Pearce EN. National trends in iodine nutrition: is everyone getting enough? Thyroid. 2007;17(9):823–7.

    CAS  PubMed  Google Scholar 

  102. Pearce EN, Pino S, He X, Bazrafshan HR, Lee SL, Braverman LE. Sources of dietary iodine: bread, cows’ milk, and infant formula in the Boston area. J Clin Endocrinol Metab. 2004;89(7):3421–4.

    CAS  PubMed  Google Scholar 

  103. Alvarez-Pedrerol M, Ribas-Fitó N, García-Esteban R, Rodriguez À, Soriano D, Guxens M, et al. Iodine sources and iodine levels in pregnant women from an area without known iodine deficiency. Clin Endocrinol. 2010;72(1):81–6.

    CAS  Google Scholar 

  104. Mian C, Vitaliano P, Pozza D, Barollo S, Pitton M, Callegari G, et al. Iodine status in pregnancy: role of dietary habits and geographical origin. Clin Endocrinol. 2009;70(5):776–80.

    CAS  Google Scholar 

  105. Swanson CA, Zimmermann MB, Skeaff S, Pearce EN, Dwyer JT, Trumbo PR, et al. Summary of an NIH workshop to identify research needs to improve the monitoring of iodine status in the United States and to inform the DRI. J Nutr. 2012;142(6):1175S–85S.

    CAS  PubMed  PubMed Central  Google Scholar 

  106. Teas J, Pino S, Critchley A, Braverman LE. Variability of iodine content in common commercially available edible seaweeds. Thyroid. 2004;14(10):836–41.

    CAS  Google Scholar 

  107. Maalouf J, Barron J, Gunn JP, Yuan K, Perrine CG, Cogswell ME. Iodized salt sales in the United States. Nutrients. 2015;7(3):1691–5.

    CAS  PubMed  PubMed Central  Google Scholar 

  108. Lee SY, Leung AM, He X, Braverman LE, Pearce EN. Iodine content in fast foods: comparison between two fast-food chains in the United States. Endocr Pract. 2010;16(6):1071–2.

    PubMed  Google Scholar 

  109. Kuriti M, Pearce EN, Braverman LE, He X, Leung AM. Iodine content of U.S. weight-loss food. Endocr Pract. 2014;20(3):232–5.

    PubMed  PubMed Central  Google Scholar 

  110. Leung AM, Lamar A, He X, Braverman LE, Pearce EN. Iodine status and thyroid function of Boston-area vegetarians and vegans. J Clin Endocrinol Metab. 2011;96(8):E1303–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  111. Kristensen NB, Madsen ML, Hansen TH, Allin KH, Hoppe C, Fagt S, et al. Intake of macro- and micronutrients in Danish vegans. Nutr J. 2015;14:115.

    PubMed  PubMed Central  Google Scholar 

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Lee, S.Y., Pearce, E.N. (2018). Iodine Requirements in Pregnancy. In: Lammi-Keefe, C., Couch, S., Kirwan, J. (eds) Handbook of Nutrition and Pregnancy. Nutrition and Health. Humana Press, Cham. https://doi.org/10.1007/978-3-319-90988-2_3

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