Skip to main content

How “Dara” You!

  • Chapter
  • First Online:
Immunohematology and Transfusion Medicine

Abstract

A 73-year-old man with immunoglobulin (Ig)G kappa multiple myeloma is referred for outpatient transfusion due to severe anemia with hemoglobin (Hgb) of 6.6 g/dL. The patient has a history of red blood cell (RBC) transfusion at your hospital 2 years ago at which time the antibody screen was negative. An ethylenediaminetetraacetic acid (EDTA) anticoagulant sample is submitted to the blood bank for type and screen along with a request for two units of irradiated RBCs.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Chapuy CI, Nicholson RT, Aquad MD, Chapuy B, Laubach JP, Richardson PG, et al. Resolving the daratumumab interference with blood compatibility testing. Transfusion. 2015;55(6 Pt 2):1545–54.

    Article  CAS  Google Scholar 

  2. DARZALEX® Prescribing Information. Janssen Biotech, Inc., Horsesham, PA; 2017.

    Google Scholar 

  3. Nedelcu E, Hall C, Stoner A, Eichbaum Q, Meena-Leist C. Interference of anti-CD47 therapy with blood bank testing. Transfusion. 2017;57(Suppl S3):148A.

    Google Scholar 

  4. Sher T, Fenton B, Akhtar A, Gertz MA. First report of safety and efficacy of daratumumab in two cases of advanced immunoglobulin light chain amyloidosis. Blood. 2016;128:1987–9.

    Article  CAS  Google Scholar 

  5. Bride KL, Vincent TL, Im S-Y, Aplenc R, Barrett DM, Carroll WL, et al. Preclinical efficacy of daratumumab in T-cell acute lymphoblastic leukemia (T-ALL). Blood. 2018;131:995–9.

    Article  CAS  Google Scholar 

  6. Chari A, Arinsburg SA, Jagannath S, Satta T, Treadwell I, Catemero D, et al. Blood transfusion management and transfusion-related outcomes in daratumumab-treated patients with relapsed or refractory multiple myeloma. Clin Lymphoma Myeloma Leuk. 2018;18(1):44–51. http://www.clinical-lymphoma-myeloma-leukemia.com/article/S2152-2650(17)30111-8/fulltext. Accessed 6 Jan 2018

    Article  Google Scholar 

Recommended Reading

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Friedman, M.T., West, K.A., Bizargity, P., Annen, K., Jhang, J.S. (2018). How “Dara” You!. In: Immunohematology and Transfusion Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-90960-8_34

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-90960-8_34

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-90959-2

  • Online ISBN: 978-3-319-90960-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics