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Current and Future Perspectives on Sperm RNAs

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Abstract

The presence of RNA in sperm was originally thought to be a controversial topic as transcription was absent in the mature mammalian sperm. With the recent development of RNA-seq and advanced molecular techniques, an unexpectedly rich and complex repertoire of RNAs has been identified in the mature sperm. Although a vast majority of RNAs packed in sperm are known to be remnants of spermatogenic process, some studies using animal model have proved that some RNAs are deliberately packed in sperm. Recent evidence suggests that some sperm RNAs are linked to transgenerational inheritance of paternal traits, in a non-Mendelian fashion, and some RNAs may have potential roles during early embryonic development. In this chapter, we summarize the different types of RNAs identified in sperm and their functional significance, clinical potential, and role in transgenerational inheritance.

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  1. Department of Surgery, Andrology and IVF Laboratories, University of Utah, Salt Lake City, UT, USA

    Luke Simon PhD & Douglas T. Carrell PhD, HCLD

  2. Department of Human Genetics, University of Utah, Salt Lake City, UT, USA

    Douglas T. Carrell PhD, HCLD

Authors
  1. Luke Simon PhD
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  2. Douglas T. Carrell PhD, HCLD
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Correspondence to Douglas T. Carrell PhD, HCLD .

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Editors and Affiliations

  1. Division of Andrology, University of Utah School of Medicine, Salt Lake City, Utah, USA

    Douglas T. Carrell

  2. Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Boston, Massachusetts, USA

    Catherine Racowsky

  3. Department of Urology, Weill Cornell Medical College, New York, New York, USA

    Peter N. Schlegel

  4. NICHD, National Institutes of Health, Bethesda, Maryland, USA

    Alan H. DeCherney

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Simon, L., Carrell, D.T. (2018). Current and Future Perspectives on Sperm RNAs. In: Carrell, D., Racowsky, C., Schlegel, P., DeCherney, A. (eds) Emerging Topics in Reproduction. Springer, Cham. https://doi.org/10.1007/978-3-319-90823-6_3

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  • DOI: https://doi.org/10.1007/978-3-319-90823-6_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-90822-9

  • Online ISBN: 978-3-319-90823-6

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