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Role of Adenosine Receptors in Clinical Biophysics Based on Pulsed Electromagnetic Fields

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The Adenosine Receptors

Part of the book series: The Receptors ((REC,volume 34))

Abstract

Clinical biophysics studies the effects of physical agents such as the low frequency low energy pulsed electromagnetic fields (PEMFs) utilized for the treatment of different human pathologies. Much research activity has focused on the mechanisms of interaction and the metabolic pathways involved between PEMFs and the A1, A2A, A2B, and A3 adenosine receptors (ARs). In particular, PEMF exposure mediates a significant upregulation of A2A and A3ARs expressed in various cells and tissues present in both the peripheral and central nervous system involving primarily a significant reduction in some of the most interesting pro-inflammatory cytokines. Of interest is that PEMFs through the increase of ARs enhance the working efficiency of adenosine, producing a more physiological effect than the use of drugs without the side effects, desensitization, and receptor downregulation often related to the use of agonists. This observation suggests the hypothesis that PEMFs may be an interesting approach as a noninvasive treatment with a low impact on daily life mediating a significant increase on the effect of the endogenous modulator. In this chapter, the role of ARs and PEMFs and their relevance in various inflammatory diseases in both peripheral or in central nervous system disorders will be reported.

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  1. Department of Medical Sciences, University of Ferrara, Ferrara, Italy

    Katia Varani, Fabrizio Vincenzi & Pier Andrea Borea

  2. Igea, Biophysic Laboratories, Carpi, Italy

    Matteo Cadossi, Stefania Setti & Ruggero Cadossi

Authors
  1. Katia Varani
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  2. Fabrizio Vincenzi
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  3. Matteo Cadossi
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  4. Stefania Setti
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  5. Pier Andrea Borea
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  6. Ruggero Cadossi
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Corresponding author

Correspondence to Katia Varani .

Editor information

Editors and Affiliations

  1. Department of Medical Sciences, University of Ferrara, Ferrara, Italy

    Pier Andrea Borea

  2. Department of Medical Sciences, University of Ferrara, Ferrara, Italy

    Katia Varani

  3. Department of Medical Sciences, University of Ferrara, Ferrara, Italy

    Stefania Gessi

  4. Department of Medical Sciences, University of Ferrara, Ferrara, Italy

    Stefania Merighi

  5. Department of Medical Sciences, University of Ferrara, Ferrara, Italy

    Fabrizio Vincenzi

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Varani, K., Vincenzi, F., Cadossi, M., Setti, S., Borea, P.A., Cadossi, R. (2018). Role of Adenosine Receptors in Clinical Biophysics Based on Pulsed Electromagnetic Fields. In: Borea, P., Varani, K., Gessi, S., Merighi, S., Vincenzi, F. (eds) The Adenosine Receptors. The Receptors, vol 34. Humana Press, Cham. https://doi.org/10.1007/978-3-319-90808-3_24

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