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Modeling Schizophrenia with Human Stem Cells

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Stem Cell Genetics for Biomedical Research

Abstract

The complexity of psychiatric disorders is a challenge still to overcome, and schizophrenia has been the most prevalent yet little understood. Several studies have used knowledge from postmortem brain tissue and other models, to address difficult questions regarding diagnostic and treatment. An improvement in the translational capacity of molecular profiling studies of psychiatric disorders was achieved with the development of human-induced pluripotent stem cells (iPSCs), through provision of human neuronal-like tissue. The finding that iPSCs can recapitulate the phenotype of the donor also affords the possibility of using this approach to study both the disease and control states in a given medical area.

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Acknowledgments

JMN, VMSC, GSZ, and DMS are supported by the São Paulo Research Foundation (FAPESP) grants 14/21035-0, 16/07332-7, 16/04912-2, 13/08711-3, and 14/10068-4.

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Authors and Affiliations

  1. Lab of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil

    Juliana Minardi Nascimento, Veronica M. Saia-Cereda, Giuliana S. Zuccoli, Danielle Gouvêa-Junqueira & Daniel Martins-de-Souza

  2. D’Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil

    Juliana Minardi Nascimento

  3. Instituto Nacional de Biomarcadores em Neuropsiquiatria (INBION) Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, São Paulo, Brazil

    Daniel Martins-de-Souza

  4. UNICAMP’s Neurobiology Center, Campinas, Brazil

    Daniel Martins-de-Souza

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  1. Juliana Minardi Nascimento
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  3. Giuliana S. Zuccoli
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Correspondence to Juliana Minardi Nascimento .

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  1. Duran i Reynals Hospital, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain

    Raul Delgado-Morales

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Minardi Nascimento, J., Saia-Cereda, V.M., Zuccoli, G.S., Gouvêa-Junqueira, D., Martins-de-Souza, D. (2018). Modeling Schizophrenia with Human Stem Cells. In: Delgado-Morales, R. (eds) Stem Cell Genetics for Biomedical Research. Springer, Cham. https://doi.org/10.1007/978-3-319-90695-9_2

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