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Fat and Fibrosis

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Fibrostenotic Inflammatory Bowel Disease

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Abstract

Wrapping of the mesenteric fat (creeping fat) represents a characteristic feature of Crohn’s disease (CD). As a powerful producer of fatty acids, cytokines and adipokines, creeping fat plays an important role in regulation of immunity and inflammation. Increasing evidence points towards a link between creeping fat and intestinal inflammation in CD. Early data from macroscopic findings showed a significant relationship between creeping fat and connective tissue changes including fibrosis and muscular hypertrophy. Emerging mechanistic data indicate a link between creeping fat and intestinal fibrosis in CD. Data on fibrosis in other organs could provide clues to address the mechanistic role of distinct components of creeping fat in the pathogenesis of intestinal fibrosis. Future studies will provide essential new information and could lead to novel therapeutic agents for the prevention or treatment of IBD-associated fibrosis.

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Author information

Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

    Ren Mao

  2. Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA

    Ren Mao

  3. Department of Pathobiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA

    Ren Mao

  4. Department of Surgery, Graduate Entry Medical School, University Hospital Limerick, 4i Centre, University of Limerick, Limerick, Ireland

    J. Calvin Coffey

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  1. Ren Mao
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  2. J. Calvin Coffey
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Editors and Affiliations

  1. Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic Foundation, Cleveland, OH, USA

    Florian Rieder

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Mao, R., Calvin Coffey, J. (2018). Fat and Fibrosis. In: Rieder, F. (eds) Fibrostenotic Inflammatory Bowel Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-90578-5_7

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  • DOI: https://doi.org/10.1007/978-3-319-90578-5_7

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-90577-8

  • Online ISBN: 978-3-319-90578-5

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