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Advanced Nuclear and Related Techniques for Metallomics and Nanometallomics

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Metallomics

Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 1055))

Abstract

Metallomics, focusing on the global and systematic understanding of the metal uptake, trafficking, role, and excretion in biological systems, has attracted more and more attention. Metal-related nanomaterials, including metallic and metal-containing nanomaterials, have unique properties compared to their macroscale counterparts and therefore require special attention. The absorption, distribution, metabolism, excretion (ADME) behavior of metal-related nanomaterials in the biological systems is influenced by their physicochemical properties, the exposure route, and the microenvironment of the deposition site. Nanomaterials not only may interact directly or indirectly with genes, proteins, and other molecules to bring genotoxicity, immunotoxicity, DNA damage, and cytotoxicity but may also stimulate the immune responses, circumvent tumor resistance, and inhibit tumor metastasis. Because of their advantages of absolute quantification, high sensitivity, excellent accuracy and precision, low matrix effects, and nondestructiveness, nuclear and related analytical techniques have been playing important roles in the study of metallomics and nanometallomics. In this chapter, we present a comprehensive overview of nuclear and related analytical techniques applied to the quantification of metallome and nanometallome, the biodistribution, bioaccumulation, and transformation of metallome and nanometallome in vivo, and the structural analysis. Besides, metallomics and nanometallomics need to cooperate with other -omics, like genomics, proteomics, and metabolomics, to obtain the knowledge of underlying mechanisms and therefore to improve the application performance and to reduce the potential risk of metallome and nanometallome.

Part of this chapter was reproduced from (1) Li Y-F, Gao YX, Chai ZF, Chen CY. Nanometallomics: An emerging field studying the biological effects of metal-related nanomaterials. Metallomics, 2014, 6(2): 220–232; and adapted from (2) Li Y-F, Chen CY, Qu Y, Gao YX, Li B, Zhao YL and Chai ZF. Metallomics, elementomics and the analytical techniques. Pure Appl. Chem., 2008, 80(12): 2577–2594.

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Abbreviations

ADME:

Absorption, distribution, metabolism, and excretion

ASE:

Accelerated solvent extraction

CAE:

Capillary array electrophoresis

CD:

Dichroism spectroscopy

CE:

Capillary electrophoresis

CEC:

Capillary electrochromatography

CGE:

Capillary gel electrophoresis

CNT:

Carbon nanotubes

CT-SPECT:

Computed tomography coregistered with single-photon emission computerized Tomography

CZE:

Capillary zone electrophoresis

EC:

Electrochromatography

EDX:

Energy dispersive X-ray fluorescence

ESI-MS:

Electrospray ionization mass spectrometer

EXAFS:

Extended X-ray absorption fine structure

GC:

Gas chromatography

GE:

Gel electrophoresis

HPLC:

High-performance liquid chromatography

ICP-AES:

Inductively coupled plasma atomic emission spectrometry

ICP-MS:

Inductively coupled plasma mass spectrometry

LA:

Laser ablation

MALDI-TOF-MS:

Matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy

MECC:

Micelle electrokinetic capillary chromatography

MEKC:

Micelle electrokinetic capillary electrophoresis

MMP:

Matrix metalloproteinases

MW:

Multiwalled

NAA:

Neutron activation analysis

nanoXRF:

XRF mapping with the nano-sized spatial resolution

NATs:

Advanced nuclear analytical techniques

NMR:

Nuclear magnetic resonance spectroscopy

NPs:

Nanoparticles

PAHs:

Polycyclic aromatic hydrocarbons

PCBs:

Polychlorinated biphenyls

PDDAC:

Poly(diallydimethylammonium chloride)

PEI:

Polyethyleneimine

PET:

Positron emission tomography

PIXE:

Proton-inducted X-ray emission spectrometry

PLE:

Pressurized liquid extraction

POPs:

Persistent Organic Pollutants

QDs:

Quantum dots

RES:

Reticuloendothelial systems

ROS:

Reactive oxygen species

SANS:

Small angle neutron scattering

SAXS:

Small angle X-ray scattering

SCND:

Single crystal neutron diffraction spectroscopy

SEM:

Scanning electron microscopy

SFE:

Supercritical fluid extraction

SIMS:

Secondary ion mass spectroscopy

SPE:

Solid-phase extraction

SPECT:

Single-photon emission computed tomography

SPME:

Solid-phase microextraction

SR:

Synchrotron radiation

SR-μXRF:

Synchrotron radiation-based microbeam X-ray fluorescence analysis

SW:

Single-walled

SWE:

Subcritical water extraction

TEM:

Transmission electron microscopy

WDX:

Wavelength dispersive x-ray fluorescence

XAS:

X-ray absorption spectroscopy

XRD:

X-ray diffraction

XRF:

X-ray fluorescence analysis

μ-XRF:

Microbeam X-ray fluorescence analysis

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Acknowledgments

Y-F Li gratefully acknowledges the support of K. C. Wong Education Foundation, Hong Kong, and the CAS Youth Innovation Association, Chinese Academy of Sciences. This work was supported by the National Natural Science Foundation of China (11205168, 11405196, and U1432241) and the Ministry of Science and Technology of China (2011CB933401, 2012CB934003, and 2016YFA0201600). We thank staffs at Beijing Synchrotron Radiation Facility (BSRF) and Shanghai Synchrotron Radiation Facility (SSRF), who provided us beam time and technical assistance.

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  1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, and Laboratory for Metallomic and Nanometallomics, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China

    Yu-Feng Li, Jiating Zhao, Yuxi Gao & Zhifang Chai

  2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China

    Chunying Chen

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    Marco Aurélio Zezzi Arruda

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Li, YF., Zhao, J., Gao, Y., Chen, C., Chai, Z. (2018). Advanced Nuclear and Related Techniques for Metallomics and Nanometallomics. In: Arruda, M. (eds) Metallomics. Advances in Experimental Medicine and Biology(), vol 1055. Springer, Cham. https://doi.org/10.1007/978-3-319-90143-5_9

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