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Evidence-Based Psoriasis pp 73–92Cite as

Biologics

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Part of the book series: Updates in Clinical Dermatology ((UCD))

Abstract

Biologic medications used in the treatment of psoriasis are antibodies or proteins that target specific components of the immune system. Biologics have revolutionized the treatment of psoriasis due to their overall high efficacy and excellent safety. Currently, seven biologic agents are approved by the US Food and Drug Administration (FDA) for the treatment of psoriasis vulgaris: adalimumab, brodalumab, etanercept, infliximab, ixekizumab, secukinumab, and ustekinumab. To date, these various biologics target the action of three inflammatory cytokines including TNF-alpha, IL-12/23 p40, and IL-17. Newer biologics in development are aimed at additional molecular targets including IL-23 p19, TBK1, IKK1ε, RORγt, and the combination of IL-17/TNF-α . This chapter focuses on biologics currently approved by the US FDA for treatment of psoriasis vulgaris.

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  1. Department of Dermatology, UCSF Psoriasis Center, University of California San Francisco, San Francisco, CA, USA

    Sahil Sekhon, Caleb Jeon & Wilson Liao

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  1. Sahil Sekhon
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  2. Caleb Jeon
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  3. Wilson Liao
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Correspondence to Wilson Liao .

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Editors and Affiliations

  1. Department of Dermatology UCSF Psoriasis Center, University of California, San Francisco, California, USA

    Tina Bhutani

  2. Department of Dermatology UCSF Psoriasis Center, University of California, San Francisco, California, USA

    Wilson Liao

  3. Department of Dermatology Psoriasis and Skin Treatment Center, University of California, San Francisco, California, USA

    Mio Nakamura

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Sekhon, S., Jeon, C., Liao, W. (2018). Biologics. In: Bhutani, T., Liao, W., Nakamura, M. (eds) Evidence-Based Psoriasis. Updates in Clinical Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-90107-7_5

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  • DOI: https://doi.org/10.1007/978-3-319-90107-7_5

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-90106-0

  • Online ISBN: 978-3-319-90107-7

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