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Double Face of eHsp70 in Front of Different Situations

Multiple Role of eHsp70

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HSP70 in Human Diseases and Disorders

Part of the book series: Heat Shock Proteins ((HESP,volume 14))

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Abstract

The Hsp70 family is one of the best conserved and abundant member of the heat shock proteins (HSP). This family includes several members and in particular one constitutively expressed member (Hsc70) and another one inducibly expressed under several stress conditions (Hsp70). To date, the intracellular functions of Hsp70 are well defined, and increasing evidences establish its roles in the extracellular environment, such as cytoprotection and immunomodulation. Increasing evidences suggest that several cell types are able to release Hsp70 in the extracellular environment, both under physiological and stress conditions. At the same time many release mechanisms have been identified. This chapter briefly reviews recent advances in our understanding on extracellular Hsp70 role in both physiological and pathological conditions. A better comprehension will be useful to take advantage of its potential as a therapeutic target.

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Abbreviations

APC:

antigen presenting cell

CNS:

central nervous system

CSF:

cerebrospinal fluid

CTL:

cytotoxic T lymphocyte

DC:

dendritic cells

EAE:

experimental autoimmune encephalomyelitis

ECM:

extracellular matrix

ER:

endoplasmic reticulum

EV:

extracellular vesicle

HSP:

heat shock protein

HUVEC:

human umbilical vein endothelial cell

LPS:

lipopolysaccharide

MBP:

myelin basic protein

MHC:

major histocompatibility complex;

MS:

multiple sclerosis

NF-kB:

nuclear factor kB

NK:

natural killer

PBL:

peripheral blood lymphocyte

ROS:

radical oxygen species

TLR:

toll like receptor

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Acknowledgements

This research was supported by grants from the University of Palermo.

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Authors and Affiliations

  1. Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy

    Maria M. Barreca & Fabiana Geraci

  2. Euro-Mediterranean Institute of Science and Technology, Palermo, Italy

    Fabiana Geraci

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  1. Maria M. Barreca
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  2. Fabiana Geraci
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Correspondence to Fabiana Geraci .

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  1. Department of Medicine and Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Punit Kaur

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Barreca, M.M., Geraci, F. (2018). Double Face of eHsp70 in Front of Different Situations. In: Asea, A., Kaur, P. (eds) HSP70 in Human Diseases and Disorders. Heat Shock Proteins, vol 14. Springer, Cham. https://doi.org/10.1007/978-3-319-89551-2_7

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