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Heat Shock Proteins in the Kidney: What Is Known About Their Role in Kidney Disease

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HSP70 in Human Diseases and Disorders

Part of the book series: Heat Shock Proteins ((HESP,volume 14))

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Abstract

Heat Shock Proteins (HSP) belongs to the family of intracellular proteins that are constitutively expressed and are markedly upregulated by various stressors including heat, oxidative and chemical stress. Expression of HSP helps in numerous reparative processes including the refolding of damaged proteins and removal of irreparably damaged proteins that would accumulate and initiate cellular death or apoptosis. A growing body of evidence in recent times has expanded the role of HSP and defined their physiological and pathological role in various diseases such as neurodegenerative disorders, cancer, ischemic heart disease as well as in kidney diseases. The protective role of HSP in ischemic renal injury has been described recently and HSP impairment has been noted in other forms of kidney injury as well as in post- transplant situation. Further research and better understanding of the role of HSP in prevention of kidney injury will be crucial if translation from the laboratory to patient bedside has to occur. This article aims to be a review of heat shock protein and its relevance to kidney disease.

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Abbreviations

AKI:

acute kidney injury

APC:

antigen presenting cell

CKD:

chronic kidney disease

HSP:

heat shock protein

IL:

interleukin

PKD:

polycystic kidney disease

PLS:

peritoneal dialysis fluid

SLE:

systemic lupus erythematosus

THP:

Tamm- Horsfall Protein

TLR:

toll like receptor

TNF:

tumor necrosis factor

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Authors and Affiliations

  1. Department of Nephrology, K.S. Hegde Medical Academy Medical Sciences Complex, Mangalore, Karnataka, India

    Shobhana Nayak Rao

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  1. Shobhana Nayak Rao
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Editors and Affiliations

  1. Department of Medicine and Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Punit Kaur

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Rao, S.N. (2018). Heat Shock Proteins in the Kidney: What Is Known About Their Role in Kidney Disease. In: Asea, A., Kaur, P. (eds) HSP70 in Human Diseases and Disorders. Heat Shock Proteins, vol 14. Springer, Cham. https://doi.org/10.1007/978-3-319-89551-2_13

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