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Progress of Bioceramic and Bioglass Bone Scaffolds for Load-Bearing Applications

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Orthopedic Biomaterials

Abstract

Despite tremendous advances in the fields of biomaterials science, tissue engineering, and regenerative medicine, it still remains challenging to repair bone defects at load-bearing sites using artificial bone tissue scaffolds. This inefficiency largely originates from the lack of strong scaffolds with appropriate load-bearing capacity during bone regeneration. Bioceramic/bioglass bone scaffolds have developed significantly towards load-bearing applications. This review focuses on the fundamental design concepts and manufacturing methods that are required for the fabrication of load-bearing bioceramic/bioglass scaffolds. Through tailoring microstructure and macrostructure, the mechanical properties of bone scaffolds could be greatly enhanced. This review highlights recent advances in manufacturing, in vitro mechanic characterization, and in vivo assessment of bioceramic and bioglass scaffolds in load-bearing bone defect models. It also gives the perspective on developing strong and tough bone scaffolds by bioinspiration.

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Authors and Affiliations

  1. Affiliated Hospital of Hebei University, Health Science Centre, Hebei University, Baoding, P. R. China

    Jingzhou Yang

  2. Research Centre of Biomedical Materials 3D Printing, National Engineering Laboratory for Polymer Complex Structure Additive Manufacturing, Baoding, P. R. China

    Jingzhou Yang

  3. Hebei Dazhou Smart Manufacturing Technology Co., Ltd., Baoding, P. R. China

    Jingzhou Yang

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  1. Jingzhou Yang
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Editors and Affiliations

  1. Department of Orthopedics School of Medicine, West Virginia University, Morgantown, West Virginia, USA

    Bingyun Li

  2. Department of Chemical Engineering, Northeastern University, Boston, Massachusetts, USA

    Thomas Webster

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Yang, J. (2018). Progress of Bioceramic and Bioglass Bone Scaffolds for Load-Bearing Applications. In: Li, B., Webster, T. (eds) Orthopedic Biomaterials . Springer, Cham. https://doi.org/10.1007/978-3-319-89542-0_18

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