Abstract
Varicocele is a common condition in men and is the most surgically correctable cause of male infertility. Proper clinical diagnosis of varicocele is important to avoid overdiagnosis which may lead to unnecessary treatment by varicocelectomy or underdiagnosis which may delay treatment of patients. Clinical diagnosis of varicocele depends upon clinical presentation and physical examination and may be aided by radiological investigations. Generally, varicocele is asymptomatic and is only accidentally discovered during the physical examination of infertile men, athletes, or army recruits. However, varicocele may present with dull aching testicular pain, scrotal swelling, and rarely hypogonadism. Physical examination is the cornerstone for diagnosis of varicocele as recommended by the majority of international guidelines although it may be biased by lack of physician expertise or changes in body structure as seen in obese or men with tight scrotal sac. In case of uncertainty, radiological examination, commonly scrotal Doppler ultrasound, may be used to confirm the diagnosis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Nagler HM, Luntz RK, Martinis FG. Varicocele. In: Lipshultz LI, Howards SS, editors. Infertility in the male. St. Louis: Mosby Year Book; 1997. p. 336–59.
Turner TT. Varicocele: still an enigma. J Urol. 1983;129:695–9.
Kaufman DG, Nagler HM. The varicocele: concepts of pathophysiology present and future. World J Urol. 1986;4:88–91.
Gat Y, Bachar GN, Zukerman Z, Belenky A, Gornish M. Varicocele: a bilateral disease. Fertil Steril. 2004;81:424–9.
Masson P, Brannigan RE. The varicocele. Urol Clin North Am. 2014;41:129–44.
Jungwirth A, Diemer T, Dohle GR, Kopa Z, Krausz C, Tournaye H. EAU guidelines, Male infertility. 2014.
Committee of the American Society for Reproductive Medicine and the Society for Male Reproduction and Urology. Report on varicocele and infertility: a committee opinion practice. Fertil Steril. 2014;102(6):1556–60.
Jarow J, Kolettis PN, Lipshultz LR, McClure RD, Nangia AK, Naughton CK, Prins GS, Sandlow JI, Schlegel PN. The optimal evaluation of the infertile male: AUA best practice statement. 2010.
Abrol N, Panda A, Kekre NS. Painful varicoceles: role of varicocelectomy. Indian J Urol. 2014;30:369–73.
Patrick J. Rowe, Frank H. Comhaire, Timothy B. Hargreave, Heather J. Mellows. WHO manual for the investigation and diagnosis of the infertile couples. 1993.
Agarwal A, Deepinder F, Cocuzza M, Agarwal R, Short RA, Sabanegh E, Marmar JL. Efficacy of varicocelectomy in improving semen parameters: new meta-analytical approach. Urology. 2007;70:532–8.
Majzoub A, Elbardisi H, Arafa M, Agarwal A, Al Said S, Al Rumaihi K. Does the number of veins ligated during varicococele surgery influence post-operative semen and hormone results? Andrology. 2016;4(5):939–43.
Cho CL, Esteves SC, Agarwal A. Novel insights into the pathophysiology of varicocele and its association with reactive oxygenspecies and sperm DNA fragmentation. Asian J Androl. 2016;18(2):186–93.
Ebiloglu T, Aydogmus Y, Kaya E, Oral E, Kaplan O, Kibar Y. The effect of physical activity on varicocele pain and resolution of this pain by different varicocelectomy techniques. Can J Urol. 2016;23(3):828590.
Owen RC, McCormick BJ, Figler BD, Coward RM. A review of varicocele repair for pain. Transl Androl Urol. 2017;6(Suppl 1):S20–9.
Vanlangenhove P, Dhondt E, Everaert E, Defreyne L. Pathophysiology, diagnosis and treatment of varicoceles: a review. Minerva Urol Nefrol. 2014;66:257–82.
Chen SS. Factors predicting symptomatic relief by varicocelectomy in patients with normospermia and painful varicocele nonresponsive to conservative treatment. J Urol. 2012;80(3):585–9.
Shridharani A, Lockwood G, Sandlow J. Varicocelectomy in the treatment of testicular pain: a review. Curr Opin Urol. 2012;22:499–506.
Christiansen CG, Sandlow JI. Testicular pain following vasectomy: a review of postvasectomy pain syndrome. J Androl. 2003;24:293–8.
Mohammed A, Chinegwundoh F. Testicular varicocele: an overview. Urol Int. 2009;82(4):373–9.
Rajfer J, Turner TT, Rivera F, Howards SS, Sikka SC. Inhibition of testicular testosterone biosynthesis following experimental varicocele in rats. Biol Reprod. 1987;36:933–7.
Di Bisceglie C, Bertagna A, Baldi M, Lanfranco F, Tagliabue M, et al. Varicocele sclerotherapy improves serum inhibin B levels and seminal parameters. Int J Androl. 2007;30:531–6.
Pierik FH, Abdesselam SA, Vreeburg JT, Dohle GR, De Jong FH, et al. Increased serum inhibin B levels after varicocele treatment. Clin Endocrinol. 2001;54:775–80.
Zini A, Buckspan M, Berardinucci D, Jarvi K. Loss of left testicular volume in men with clinical left varicocele: correlation with grade of varicocele. Arch Androl. 1998;41(1):37–41.
Dubin L, Amelar RD. Varicocele size and results of varicocelectomy in selected subfertile men with varicocele. Fertil Steril. 1970;21:606–9.
Kim HH, Goldstein M. A new clinical grading system for varicocele. Fertil Steril. 2008;90(Suppl):S467.
Carlsen E, Andersen AG, Buchreitz L, Jorgensen N, Magnus O, et al. Inter‑observer variation in the results of the clinical andrological examination including estimation of testicular size. Int J Androl. 2000;23:248–53.
Trum JW, Gubler FM, Laan R, van der Veen F. The value of palpation, varicoscreen contact thermography and colour Doppler ultrasound in the diagnosis of varicocele. Hum Reprod. 1996;11:1232–5.
Sakamoto H, Saito K, Oohta M, Inoue K, Ogawa Y, Yoshida H. Testicular volume measurement: comparison of ultrasonography, orchidometry, and water displacement. Urology. 2007;69:152–7.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Arafa, M., Elbardisi, H. (2019). Varicocele Clinical Diagnosis and Grading. In: Esteves, S., Cho, CL., Majzoub, A., Agarwal, A. (eds) Varicocele and Male Infertility. Springer, Cham. https://doi.org/10.1007/978-3-319-79102-9_10
Download citation
DOI: https://doi.org/10.1007/978-3-319-79102-9_10
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-79101-2
Online ISBN: 978-3-319-79102-9
eBook Packages: MedicineMedicine (R0)