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The Microbiome in Rheumatic Diseases and Infection pp 97–102Cite as

Rheumatic Complications of Streptococcus pyogenes

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Abstract

Acute rheumatic fever remains one of the major autoimmune disorders known to occur as a result of a specific pathogen, group A Streptococcus (Streptococcus pyogenes), even though the precise mechanism is incompletely understood. Post-streptococcal reactive arthritis and post-streptococcal glomerulonephritis similarly follow group A streptococcal infections. Group A streptococcus-induced autoimmunity via suspected molecular mimicry has ramifications for future microbiome research and management and prevention of rheumatologic diseases.

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Abbreviations

ARF:

Acute rheumatic fever

GAS:

Group A streptococcus

MHC:

Major histocompatibility complex

PSGN:

Post-streptococcal glomerulonephritis

PSRA:

Post-streptococcal reactive arthritis

RHD:

Rheumatic heart disease

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Author information

Authors and Affiliations

  1. Nationwide Children’s Hospital Medical Center, The Ohio State University, Infectious Diseases Section, Columbus, OH, USA

    Guliz Erdem

  2. University of Minnesota Medical School, Department of Pediatrics, Minneapolis, MN, USA

    Edward L. Kaplan

Authors
  1. Guliz Erdem
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  2. Edward L. Kaplan
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Corresponding author

Correspondence to Guliz Erdem .

Editor information

Editors and Affiliations

  1. Faculty of Medicine, Cairo University, Cairo, Egypt

    Gaafar Ragab

  2. University of Alabama, Birmingham, Alabama, USA

    T. Prescott Atkinson

  3. University of Alabama, Birmingham, Alabama, USA

    Matthew L. Stoll

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Erdem, G., Kaplan, E.L. (2018). Rheumatic Complications of Streptococcus pyogenes . In: Ragab, G., Atkinson, T., Stoll, M. (eds) The Microbiome in Rheumatic Diseases and Infection. Springer, Cham. https://doi.org/10.1007/978-3-319-79026-8_9

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  • DOI: https://doi.org/10.1007/978-3-319-79026-8_9

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